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Surya Sumantri Abdullah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Mathematics Medicine & Pharmacology Physics Public Health

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Journal : PHARMACON

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DOCTOR’S PERCEPTION OF THE ROLE OF PHARMACISTS IN CLINICAL PHARMACY SERVICES AT RSUP PROF. DR. R. D. KANDOU MANADO Florence Jewelly Gabriella Raintama; Widya Lolo; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Abstract

In providing pharmaceutical services, collaboration between pharmacists and doctors is needed to improve therapeutic outcomes. For this reason, this study aims to describe doctors' perceptions about the role of pharmacists in carrying out pharmaceutical work at RSUP Prof. Dr. R. D. Kandou Manado in order to determine the extent to which doctors understand the pharmaceutical services provided by pharmacists. This research is a descriptive research with survey method and data processing is done quantitatively. Research respondents are doctors who work at RSUP Prof. Dr. R. D. Kandou Manado consisting of 75 respondents. The tool used in this research is a questionnaire using the Guttman scale which has been through validity and reliability tests. Data analysis was carried out by describing it in the form of a frequency distribution to find out how health workers perceive the role of pharmacists in pharmaceutical services at RSUP Prof. Dr. R.D. Kandou Manado. The results showed that doctors' perceptions tended to agree with the average value for opinions of 81.54% and for expectations of 94%. The conclusion of this study is that doctors have good opinions and expectations about the role of pharmacists in accordance with Pharmaceutical Service Standards.
FORMULATION AND TEST OF ANTIOXIDANT ACTIVITY LOTION ETHYL ACETATE FRACTION OF CORN SILK (Zea mays L.) Nadyavenza Yratxe Fabiola Karamoy; Paulina M.Si; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Corn Silk (Zea mays L.) is a plant that contains various active compounds such as flavonoids and fenols that function as antioxidants. This study aimed to test the effectivity of the antioxidant lotion ethyl acetate fraction of corn silk used the DPPH method and evaluated the physical preparations with physical properties test parameters. Corn silk was extracted using maceration method with 96% ethanol as solvent and fractionated with ethyl acetate as solvent.Lotion preparation were made into 5 formulas (F1-F5) with variations in the concentration of corn silk ethyl acetate fraction (2%-10%). The results showed that the lotion of the ethyl acetate fraction of corn silk had IC50 values respectively 128,96 ppm; 116,87 ppm; 102,96 ppm; 90,98 ppm; 64,68 ppm. F5 continued to evaluate the physical properties of the preparation. The results of the physical evaluation of the preparation showed that the lotion preparation filled the organoleptic requirements, homogeneity, pH, adhesion, spreadability. Based on the results of the study, it can be concluded that the lotion of the ethyl acetate fraction of corn silk has the effectivity as an antioxidant and fulfills the requirements for the parameters of the physical properties of the preparation.
Formulation and Antibacterial Activity Test of Peel-Off Gel Mask Ethyl Acetate Fraction of Cocoa Pods (Theobroma cacao L.) against Staphylococcus aureus as Anti-Acne Immanuela Irene Mandias; Paulina Yamlean; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Cocoa pods (Theobroma cacao L.) is a part of the Cocoa plant which contains active compounds such as flavonoids, alkaloids, saponins and tannins that have the potential as antibacterial. This study aimed to formulate a peel-off gel mask preparation of the ethyl acetate fraction which is physically good and to test the inhibitory power of the peel-off gel mask with concentrations of 2, 4, 8, 10, and 12% against Staphylococcus aureus. This research used laboratory experimental method. The results showed that the peel-off gel mask filled the requirements for physical evaluation, that is organoleptic, homogeneity, pH, spreadability, adhesion and drying time. The antibacterial activity test using the well diffusion method showed that the average diameter for F1 to F5 respectively was 7,5; 8,58; 12; 12,75; and 14 mm. Based on the result of the study it can be included that the overall formulation of the peel-off gel mask filled the requirements of the parameters of the physical properties of the preparation and provides the greatest antibacterial activity that is formula 5 with a concentration of 12%, which is 14 mm.
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF TOOTHPASTE ETHYL ASETATE FRACTION OF LEILEM LEAVES (Clerodendrum minahassae L.) AGAINTS Streptococcus mutans Anggun Ciquita Nichelse Egam; Hosea Edy; Surya Sumantri Abdullah
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42906

Abstract

Leilem leaves (Clerodendrum minahassae L.) is one type of plant that can be used as an antibacterial because it contains active chemical compounds such as phenols, flavonoids, alkaloids, steroids, and terpenoids. This study aimed to formulate the ethyl acetate fraction of leilem leaves toothpaste that is physically good and to obtain the optimum toothpaste inhibition with dosage concentrations of 7.5%, 10%, and 12.5% against the growth of Streptococcus mutans bacteria. This research uses laboratory experimental method. The results showed that the ethyl acetate fraction toothpaste preparation filled the physical evaluation requirements, that is organoleptic, homogeneity, spreadability, adhesion and pH. The antibacterial activity testing of the leilem leaves fraction toothpaste showed that the average diameter for F1 was 9.75 mm, F2 was 11.75 mm, and F3 was 13.08 mm. Based on the results of the study, it can be concluded that all formulations of the ethyl acetate fraction of leilem leaves provide antibacterial activity and filled the requirements of the physical test of the preparation and the greatest antibacterial activity is at F3 of 13.08 mm with a dosage concentration of 12.5%.
FORMULASI SEDIAAN KRIM ANTIBAKTERI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes) TERHADAP BAKTERI Staphylococcus aureus Agnes S. G. Sahuleka; Hosea Jaya Edy; Surya Sumantri Abdullah
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37414

Abstract

ABSTRACTWater hyacinth (E. crassipes) leaves contain alkaloids, flavonoids, polyphenols, and saponins which have antibacterial properties. The aim of this study was to formulate an ethanol extract cream from the leaves of Eceng Gondok (E. crassipes) and to test the antibacterial activity of cream preparations with concentrations of 5%, 10%, and 15%. This study uses a laboratory experimental method. The formulation of the Eceng Gondok (E. crassipes) leaf ethanol extract cream was tested for organoleptic, pH, homogeneity, dispersion, and adhesion, the results were in accordance with predetermined conditions, namely having a distinctive water hyacinth odor, green color, and no grains. coarse, has a pH value of 5.58-6.33, dispersion of 5.7 cm for F1, 5.58 cm for F2, and 5.03 cm for F3, adhesion to F1 6.34 seconds, F2 5, 25 seconds, and F3 4.20 seconds. Testing of antibacterial activity against the growth of S. aureus was carried out by the diffusion method. The results of the antibacterial activity test of the ethanol extract of the Eceng Gondok (E.crassipes) leaf extract were able to inhibit S. aureus bacteria, with concentrations of 10% and 15% which had moderate inhibitory power with diameters of 6.5mm and 7.8mm.Keywords:Cream, Water Hyacinth Leaves, Antibacterial.  ABSTRAKDaun Eceng Gondok (E. crassipes) memiliki kandungan senyawa alkaloid, flavonoid, polifenol, dan saponin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan krim ekstrak etanol daun Eceng Gondok (E. crassipes) serta menguji aktivitas antibakteri sediaan krim dengan konsentrasi 5%, 10%, dan 15%. Penelitian ini menggunakan metode ekperimental laboratorium. Formulasi sediaan krim ekstrak etanol daun Eceng Gondok (E. crassipes) ini dilakukan pengujian organoleptik, pH, homogenitas, daya sebar, dan daya lekat yang hasilnya sesuai dengan syarat yang telah ditentukan yaitu memiliki bau khas eceng gondok, berwarna hijau, tidak memiliki butiran-butiran kasar, memiliki nilai pH 5,58-6,33, daya sebar sebesar 5,7 cm untuk F1, 5,58 cm untuk F2, dan 5,03 cm untuk F3, daya lekat pada F1 6,34 detik, F2 5,25 detik, dan F3 4,20 detik. Pengujian aktivitas antibakteri terhadap pertumbuhan S. aureus dilakukan dengan metode difusi. Hasil uji aktivitas antibakteri krim ekstrak etanol daun Eceng Gondok (E. crassipes) yang diperoleh dapat menghambat bakteri S. aureus, dengan konsentrasi 10% dan 15% yang memiliki daya hambat sedang dengan diameter 6,5mm dan 7,8mm. Kata Kunci: Krim, Daun Eceng Gondok, Antibakteri.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN SIRSAK (Annona muricataL.) UNTUK MENURUNKAN KADAR GULA DARAH TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Siska Sefrida Pandaleke; Edwin de Queljoe; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39144

Abstract

ABSTRACTSoursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds function as antidiabetic. The purpose of this study was to determine the effect of soursop leaf extract in reducing blood sugar levels in male white rats induced by alloxan. This study used 4 treatment groups, negative control was not given treatment, positive control was treated with 9 mg metformin, treated with the first dose of 7.2 mg and the last group was treated with the second dose of 14.4 mg. Before being given the treatment, the rats were fasted first and then checked for blood sugar, then the rats were induced by alloxan intraperitoneally (ip) then observed the development of the increase in blood sugar in the rats for 3 days and checked blood sugar levels once a day for 5 days. After that, it was continued with giving soursop leaf ethanol extract every day for 5 days. The results showed that soursop leaf extract can reduce blood sugar levels seen on days H4- H8 with a decrease of 6.67 mg/mL for the treatment group sample 1 and 5.66 mg/mL for the treatment sample 2. The test results using the Kruskal test -Wallis at 0.05 level showed that there was no significant difference using soursop leaf ethanol extract and metformin in lowering blood sugar levels.Keywords: Soursop leaves(Annona muricata L), Male White Rat, Flavonoids, Blood Glucose, AlloxanABSTRAKDaun Sirsak (Annona muricata L.) mempunyai kandungan senyawa flavonoid. Senyawa flavonoid berfungsi sebagai antidiabetes. Tujuan dari penelitian ini untuk mengetahui pengaruh ekstrak daun sirsak dalam penurunan kadar gula darah pada tikus putih jantan yang diinduksi oleh aloksan. Penelitian ini menggunakan 4 kelompok perlakuan yaitukontrol negatif tidak diberikan perlakuan, kontrol positif diberikan perlakuan dengan metformin 9 mg, perlakuan dengan dosis pertama 7,2 mg dan kelompok terakhir perlakuan dengan dosis kedua 14,4 mg. Tikus dipuasakan terlebih dahulusebelumdiberiperlakuan, kemudian diperiksa gula darah, selanjutnya tikus diinduksi aloksan secara intraperitonial (ip) kemudian dilihat perkembangan kenaikan gula darah pada tikus selama 3 hari dan dilakukan pemeriksaan kadar gula darah sehari sekali selama 5 hari, kemudiandiberikan ekstrak etanol daun sirsak setiap hari selama 5 hari. Hasil penelitian menunjukan bahwa ekstrak daun sirsak dapat menurunkan kadar gula darah dilihat pada hari H4-H8 dengan penurunan sebesar 6,67 mg/ml untuk kelompok perlakuan sampel 1 dan 5,66 mg/ml untuk perlakuan sampel 2. Hasil uji menggunakan uji Kruskal-Wallis pada taraf 0,05 menunjukan bahwa tidak terdapat perbedaan yang signifikan menggunakan ekstrak etanol daun sirsak dan metformin dalam menurunkan kadar gula darah.Kata kunci: Daun sirsak (Annona muricata L), Tikus Putih Jantan, Flavonoid, Glukosa Darah, Aloksan
FORMULASI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) Vyta N Sari Sinrang; Hosea Jaya Edy; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39147

Abstract

ABSTRACTAreca Nut (Areca catechu L.) is a plant that contains many active compounds, one of them is alkaloid compound that has efficacy as an antifungal. This study aimed to formulate a mouthwash of areca nut ethanol extract that was physically good and to test the antifungal activity of the mouthwash of areca nut ethanol with concentrations 5%, 7,5%, 10% and 15% against the Candida albicans The conclusion were the ethanol extract of Areca nut could be formulated into a mouthwash preparation that was physically good and had the most significant antifungal activity at 15% concentration (F4) with a diameter of 25,4 mm.Keywords: areca nut (Areca catechu L.), mouthwash, antifungal.ABSTRAKPinang (Areca catechu L.) merupakan tanaman yang mengandung banyak senyawa aktif, salah satunya senyawa alkaloid yang berkhasiat sebagai antijamur. Penelitian bertujuan untuk memformulasikan obat kumur ekstrak etanol biji pinang yang baik secara fisik dan menguji Aktivitas Antijamur Obat Kumur Ekstrak Etanol Biji Pinang dengan konsentrasi 5%, 7,5%, 10% dan 15% terhadap jamur Candida albicans. Kesimpulannya, ekstrak etanol biji pinang dapat diformulasikan menjadi sediaan obat kumur yang baik secara fisik dan memiliki aktivitas antijamur paling nyata yaitu pada konsentrasi (F4) dengan diameter 25,4 mm.Kata kunci: pinang (Areca catechu L.), obat kumur, antijamur
TEKNOLOGI PENGOLAHAN PANGAN ALTERNATIF, TINUTUAN INSTAN SOLUSI STUNTING DAN PEMASTIAN MUTU KADAR GIZINYA Ath Thariq Fadhli Adhimul Ghanny; Shalsa Shafira Firdaus; Dewi Ekatanti Wulan Fitri; Dita Wulan Cahyani Susanto; Aulia Shafannisa Maswonggo; Surya Sumantri Abdullah
PHARMACON Vol. 11 No. 2 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.41725

Abstract

ABSTRACTTinutuan or Manado porridge is a typical food from Manado, North Sulawesi made from various kinds of vegetables. Generally, Manado tinutuan or porridge is served immediately after cooking, but in this study it was made in an instant form so that it was easy and practical. The purpose of the study was to find out how to make instant tinutuan and analyze the nutritional levels contained in instant tinutuan in an effort to overcome the problem of stunting. The method of making instant tinutuan using the extraction method. In this study, carbohydrates, fats, and proteins were tested. The results showed that tinutuan contained carbohydrates, fat, and protein with samples of rice, garlic, spinach, basil, onion, pumpkin, cassava, and corn. Carbohydrate test results obtained per 100 grams, 0.570; 0.828; 0.160; 0.779; 0.800; 4,335; 0.524; 5,253. Fat test results obtained per 100 grams of sample, 27.7%; 5.6%; 5.8%; 21.4%; 4.9%; 3.8%; 7.4%; 17.6%. The results of protein testing of samples obtained per gram of sample, 4.3%; 3.8%; 47.1%; 10%; 7.4%; 17.1%; 7%; 8.5%. Based on the results of the study, tinutuan contains high levels of nutrients (carbohydrates, fat, and protein) and can be recommended to overcome the problem of stunting. Keywords: Instant Tinutuan, Stunting, Nutritional Levels ABSTRAKTinutuan atau bubur Manado adalah makanan khas Manado, Sulawesi Utara yang terbuat dari berbagai macam sayuran. Umumnya tinutuan atau bubur Manado langsung disajikan setelah dimasak, tetapi pada penelitian ini dibuat dalam bentuk instan sehingga mudah dan praktis. Tujuan penelitian ialah mengetahui cara pembuatan tinutuan instan dan menganalisis kadar gizi yang terkandung dalam tinutuan instan sebagai upaya dalam mengatasi masalah stunting. Metode pembuatan tinutuan instan menggunakan metode ekstraksi. Pada penelitian ini dilakukan pengujian karbohidrat, lemak, dan protein. Hasil penelitian menunujukkan bahwa tinutuan mengandung karbohidrat, lemak, dan protein dengan sampel beras, bawang putih, bayam, kemangi, bawang merah, labu, singkong, dan jagung. Hasil pengujian karbohidrat yang didapat per 100 gram, 0,570; 0,828; 0,160; 0,779; 0,800; 4,335; 0,524; 5,253. Hasil pengujian lemak yang didapat per 100 gram sampel, 27,7%; 5,6%; 5,8%; 21,4%; 4,9%; 3,8%; 7,4%; 17,6%. Hasil pengujian protein sampel yang didapat per gram sampel, 4,3%; 3,8%; 47,1%; 10%; 7,4%; 17,1%; 7%; 8,5%. Berdasarkan hasil penelitian, tinutuan mengandung kadar gizi (karbohidrat, lemak, dan protein) dan dapat disarankan untuk mengatasi masalah stunting. Kata Kunci: Tinutuan Instan, Stunting, Kadar Gizi
Uji aktivitas antihiperurisemia ekstrak etanol daun salam (Sygium Polyanthum) pada tikus putih (Rattus Norvegicus) Meivita Alfriani Sahensolar; Edwin De Queljoe; Surya Sumantri Abdullah
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42183

Abstract

MEIVITA ALFRIANI SAHENSOLAR . Uji aktivitas antihiperusrisemia ekstrak etanol daun salam (Syzgium Polyanthum) pada tikus putih (Rattus Norvegicus)dibawah bimbingan EDWIN DE QUELJOE sebagai ketua dan SURYA SUMANTRI sebagai anggota.Daun salam memiliki kandungan kimia seperti minyak atsiri yang mengandung sitral, eugenol, tannin, dan flavonoida. Penelitian ini bertujuan untuk mengetahui adanya efek antihiperurisemia ekstrak etanol daun salam dengan 3 tingkatan dosis yaitu, 200mg, 400mg, dan 800mg. Perbandingan daun Salam sebanyak 5 kelompok yang terdiri dari 3 ekor tikus disetiap kelompok perlakuan, yaitu CMC 1% (kontrol negatif), Allopurinol 100mg (kontrol positif), ekstrak etanol daun salam dalam dosis 200mg, 400mg, dan 800 mg,yang diinduksi kalium oksonat. Pengamatan dilakukan selama 6 jam. Data diuji dengan menggunakan ANOVA (Analisis Of Variant) ,uji HOMOGENITAS (Test of Homogenity of Variance) dan dilanjutkan dengan uji LSD (Least Significant Different). Hasil uji statistik menunjukan bahwa Dari ketiga dosis, penurunan kadar asam urat terbaik terdapat pada dosis 400 mg. Kata Kunci: Ekstrak Daun Salam (Syzgium Polyanthum) , Antihiperusemia
Identifikasi Medication Discrepancies Pada Proses Rekonsiliasi Obat Di Instalasi Rawat Inap Bedah Prof. Dr. R. D. Kandou Manado Clarencia Kojongian; Surya Sumantri Abdullah; Weny Indayany Wiyono
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.50017

Abstract

Rekonsiliasi merupakan proses yang dapat dilakukan untuk mencegah terjadinya kesalahan pengobatan. Penelitian ini bertujuan untuk mengidentifikasi perbedaan pengobatan berdasarkan hasil rekonsiliasi obat pada 56 pasien periode penelitian Januari – Maret 2020. Penelitian ini merupakan jenis penelitian kuantitatif dengan rancangan deskriptif dengan pengambilan data secara prospektif di Instalasi Rawat Inap Bedah RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian berdasarkan karakteristik pasien menunjukkan mayoritas pasien adalah laki-laki yaitu sebanyak 43 pasien (76,79%) dan jumlah pasien terbanyak pada kelompok usia dewasa (18-44) sebanyak 26 pasien (46,43%). Berdasarkan karakteristik jumlah obat pada data BPMH (Best Possible Medication History) menunjukan bahwa mayoritas pasien mengkonsumsi <5 jenis obat sebanyak 55 pasien (98,21%), di IGD sebagian besar mengkonsumsi <5jenis obat yaitu sebanyak 45 pasien (80,36%), pada karakteristik jumlah obat di instalasi mayoritas mengkonsumsi <5 jenis obat (53,57%) dan saat keluar rumah sakit mayoritas pasien diberikan <5 jenis obat yaitu 46 pasien (82,14%). Persentase Medication Discrepancies yaitu Incomplete prescription sebesar (28,57%), Omission medication (14,29%), dan perbedaan yang disengaja (100%). Kata Kunci : Rekonsiliasi obat, medication discrepancies.
Co-Authors Agnes S. G. Sahuleka Anggun Ciquita Nichelse Egam Ath Thariq Fadhli Adhimul Ghanny Aulia Shafannisa Maswonggo Clarencia Kojongian Dewi Ekatanti Wulan Fitri Dita Wulan Cahyani Susanto Edwin de Queljoe Florence Jewelly Gabriella Raintama Hosea Edy Hosea Jaya Edy Imam Jayanto Immanuela Irene Mandias Irma Antasionasti Karlah L. R. Mansauda Meilani Jayanti Meivita Alfriani Sahensolar Nadyavenza Yratxe Fabiola Karamoy Paulina M.Si Paulina yamlean Rezky Putri Indarwati Abdullah Ryan Irwanto Tunggal Shalsa Shafira Firdaus Siska Sefrida Pandaleke Vyta N Sari Sinrang Weny Indayany Wiyono Widya Lolo Zulfahmidah