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Profile of Syphilis Risk Factors in The Productive Age Group at Dermatology and Venereology Clinic RSUD DR. Saiful Anwar, Malang Indonesia Rona Lintang Harini; Setyowatie, Lita
Journal of Community Medicine and Public Health Research Vol. 4 No. 2 (2023): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v4i2.46170

Abstract

Syphilis is a sexually transmitted infection that has the potential to cause serious complications and is closely related to the human immunodeficiency virus (HIV) infection, thus making syphilis a major public health problem. Understanding the characteristics of risk factors could be used to prevent future transmission and occurrences of syphilis. This study aimed to determine the demographic data and risk factors of syphilis in productive age at the Dermatology and Venereology Clinic, RSUD. DR. Saiful Anwar, Malang, Indonesia. This study used a descriptive approach using secondary data from the medical records of syphilis patients from January to December 2021. Sample collection was carried out using a total sampling technique. Twenty medical records that met the inclusion criteria were included, all of which belonged to the productive age group. The majority of the sample were male (70%), aged 17-25 years (45%) and 26-35 years (45%), had a high school education (55%), were private sector workers (40%), were unmarried (70%), had anogenital sexual activity (50%), never used condoms (50%), had more than one sexual partner (85%), were in the primary stage of syphilis (35%), and were HIV positive. Among male patients with syphilis-HIV coinfection, 80% of cases were homosexual. The risk factors for syphilis at a productive age include anogenital intercourse, irregular condom use, multiple sexual partners, the primary stage of syphilis, HIV infection, and homosexuality. A program focused on detecting and treating syphilis among people living with HIV/AIDS, especially those in high-risk populations such as men who have sex with men (MSM), is needed.
Profile of Syphilis Compliance and Success of Therapy at Dermatology and Venereology Clinic RSUD Dr. Saiful Anwar Malang: A Descriptive Study Donoseputro, Intan Wasaputri; Setyowatie, Lita
Journal of Community Medicine and Public Health Research Vol. 5 No. 1 (2024): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v5i1.47714

Abstract

Syphilis is a chronic progressive sexually transmitted infection, that causes a life-threatening condition if left untreated. In lower-middle-income countries, the burden of disease might appear to be lower due to a lack of reports. This study aimed to report the epidemiological profile, the profile of compliance, and the success of therapy of syphilis at the Dermatology and Venereology Outpatient Clinic in RSUD dr. Saiful Anwar Malang, Indonesia. This study used a descriptive approach using secondary data from the medical records of newly diagnosed syphilis patients at Dermatology and Venereology Clinic RSUD dr. Saiful Anwar Malang from January 2021 - December 2021. Sample collection was using a total sampling technique. Eighteen medical records met the inclusion criteria. The majority of samples were men (77.8%), aged 17-25 years (44.4%) and 26-35 years (44.4%), had a high school education (55.6%), HIV positive (50%) and HIV negative (50%). All 18 patients got intramuscular injections of a single 2.4 million U or 7.2 million U Benzathine Penicillin G according to the syphilis stage. It was found that eight patients (44.4%) had a successful therapy, two patients (11.2%), experienced failure, and the remaining eight patients (44.4%) were unknown due to loss of follow-up. Several factors are associated with better patient compliance including older age, higher educational level, type of the disease, and lower complexity of treatment schedules. Overall, therapeutic compliance of syphilis patients is good, but monitoring compliance needs to be improved. Benzathine Penicillin G remains the drug of choice for syphilis and has a high success rate.
Electrosurgery and 5% Imiquimod Cream as a Combination Therapy for Perianal Condyloma Acuminata in a HIV Patient Setyowatie, Lita; Faradila, Anandita
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.142-146

Abstract

Background: Condyloma acuminata (CA) is a common sexually transmitted infection caused by the human Papillomavirus (HPV) infection. It is characterized by single or multiple lesions in the anogenital area accompanied by itching, discharge, or bleeding. CA in HIV (human immunodeficiency virus) - positive patients can experience a low response to various therapeutic modalities, which may lead to consideration of choosing combination therapy to increase the effectiveness of therapy. Case: We report a case in a twenty-one-year old male with multiple warts on the perianal area. Within four months, the warts had covered the perianal area, with hemorrhoids emerging as complications. The patient had trichloroacetic acid treatment three times but did not respond. The patient is male who have sex with male, and there has been a history of multisexual partners. The diagnosis was made by clinical and histopathological examinations. The patient is HIV-positive and has been receiving antiretrovirals regularly. He got a combination therapy of electrosurgery and 5% imiquimod cream for 9 weeks and showed excellent results. Discussion: Standard topical medication is an effective treatment for condyloma acuminata, but infiltrative and recurrent lesions often require ablative and surgical treatment. Conclusion: Electrosurgery in combination with imiquimod proved to be effective and shortening the treatment regimen in the treatment of perianal CA.
CORONAVIRUS DISEASE 2019 (COVID-19) DARI PERSPEKTIF DERMATOLOGI Sitaresmi, Adya; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.1.4

Abstract

Coronavirus Disease 2019 (COVID-19) is a new disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Common clinical manifestations are respiratory system disorders. However, COVID-19 can also manifest as extrapulmonary symptoms, one of which is dermatology. The exact mechanism of COVID-19 cutaneous manifestations is still not fully understood, but is suspected to be caused by the direct effects of the virus on keratinocyte, excessive immune response, or drugs used to treat COVID-19. Cutaneous manifestations of COVID-19 can be divided into five groups, namely pseudo-chilblains, vesicular, urticaria, erythematous maculopapular, and vascular lesions. Erythematous maculopapular (44.18%) and chilblains (19.72%) are the most common lesions. Vesicular and vascular lesions are less common. Chilblains lesions are usually found before or together with the onset of other COVID-19 symptoms, and often appear in close contact or asymptomatic patients, so early recognition of it can be used to detect the presence of COVID-19.
Peran Centela Asiatica Sebagai Moisturizer Faradila, Anandita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.4

Abstract

Moisturizer is the main component of daily basic skin care especially if there is a change in the epidermal barrier and reduced water content in the epidermis layer. When the amount of water drop below 10%, the skin become dry. One of herbal plants that affect skin hydration is Centella asiatica. C. asiatica is known as Pegagan in Indonesia and belongs to the Umbelliferae/Apiaceae family. Extracts from the leaves of C. asiatica have been reported to have potential as antioxidants, antimicrobial agents, collagen synthesis agents, and even act as wound healing properties. The active components of C. asiatica include pentacyclic triterpenes, particularly asiaticoside, madecassoside, asiatic acid and madecassic acid. C. asiatica is used as an active compound in skin care preparations due to its hydrating, antioxidant, anti-inflammatory, anti-cellulite and anti-aging activities. A formulation containing a concentration of C. asiatica extract showed efficacy in increasing skin moisture by increasing the hydration state of the skin surface and reducing the occurrence of transepidermal water loss (TEWL). This literature review aims to add insight about Centella asiatica and its mechanism of action that can be used as a moisturizer for the skin. Centella asiatica can be used as a cosmetic formulation that can treat dry and sensitive skin. More research is needed to identify and determine the chemical compound C. asiatica which is responsible for various therapeutic activities, especially as an effective, safe, easy and inexpensive moisturizer.
Peran Tanaman Artemisia pada Akne Vulgaris Dharsono, Agita Danaparamita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 2 No 1 (2022): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.1.4

Abstract

Akne vulgaris merupakan masalah yang sering kali menjadi alasan pasien berobat. Akne vulgaris dapat mengganggu kualitas hidup penderitanya karena dapat menurunkan rasa percaya diri, terutama pada derajat berat. Terapi yang ada saat ini seperti retinoid dan antibiotik sering kali memicu masalah lain seperti iritasi akibat penggunaan retinoid dan resisten akibat penggunaan antibiotik topikal jangka panjang. Saat ini telah banyak dilakukan penelitian untuk mencari terapi alternatif pilihan untuk akne vulgaris, salah satu alternatif yang sedang dikembangkan adalah dengan menggunakan ekstrak dari tanaman Artemisia atau lebih banyak dikenal dengan Mugwort. Tanaman ini banyak digunakan sebagai tanaman obat tradisional karena memiliki berbagai aktivitas, seperti antioksidan, anti bakteri, anti jamur, dan anti parasit. Peran anti bakteri pada ekstrak tanaman Artemisia dapat menghambat pertumbuhan berbagai bakteri seperti Pseudomonas aeruginosa, Staphylococcus aureus, dan Propionibacterium acnes. Penggunaan ekstrak tanaman ini dilaporkan memiliki efek samping yang lebih minimal dibandingkan dengan penggunaan bahan kimia. Pemanfaatan ekstrak tanaman Artemisia pada terapi akne vulgaris dapat dipertimbangkan karena kemampuan anti bakteri yang dimilikinya.
TIGA KOMBINASI TERAPI PADA PERIANAL GIANT CONDYLOMA ACUMINATA DENGAN KOINFEKSI HIV Firdausiya, Fitri; Setyowatie, Lita
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.306

Abstract

Giant condyloma acuminata (GCA) atau tumor Buschke- Löwenstein, merupakan varian kutil anogenital yang jarang dan unik. Kondisi imunokompromais terutama infeksi Human Immunodeficiency Virus (HIV) berkaitan dengan perkembangan GCA. Sampai saat ini belum ada pedoman baku emas dalam penatalaksanaan GCA dan masih menjadi tantangan bagi dokter spesialis dermatologi dan venereologi, karena ukuran lesi yang besar, kemungkinan invasi dan transformasi maligna, serta tingginya risiko rekurensi. Dilaporkan sebuah kasus GCA perianal pada pasien laki-laki berusia 20 tahun dengan koinfeksi HIV. Gejala klinis berupa vegetasi bertangkai sewarna kulit, permukaan verukosa, berbentuk cauliflower, multipel, berukuran 5 x 2 x 2,5 cm di regio perianal sampai menutup regio anal dengan beberapa papul verukosa kecil di sekitarnya. Diagnosis ditegakkan berdasarkan pemeriksaan fisik, tes acetowhite positif dan pemeriksaan histopatologis. Pasien diberikan terapi kombinasi menggunakan elektrokauter dan Trichloroacetic Acid (TCA) 90% setiap minggu serta cimetidine per oral dengan dosis 3 x 500 mg setiap hari selama 3 bulan. Resolusi pada seluruh lesi GCA setelah 5 minggu terapi dan tidak didapatkan rekurensi pada follow up bulan ke-5. Tiga kombinasi terapi: elektrokauter, TCA dan cimetidine dapat dipertimbangkan sebagai penatalaksanaan GCA dengan koinfeksi HIV karena teknik invasif minimal dan cimetidine sebagai imunomodulator bekerja sinergis mendorong resolusi dan mencegah rekurensi GCA.
Therapy of Dequalinium Chloride Vaginal Tablets in Pregnant Women with Vulvovaginal Candidiasis Setyowatie, Lita; Larasaty, Nanda Shaskia
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 4 October2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i4.2296

Abstract

Background: Vulvovaginal candidiasis (VVC) is a Candida infection on vulva and vagina region. The most common etiology is C. albicans. Besides being the risk factor for developing VVC, pregnancy also limits the possible medication. This report presents the efficacy of Dequalinium Chloride (DQC) on VVC during pregnancy due to C. albicans. Case: A third-trimester primigravidae, 27-year-old, complained first odorless thick curd-like consistency vaginal discharge accompanied with pruritus (VAS 9/10) and pain since 3 months prior to admission. Venerology examination showed erythema on the labia majora and a great amount of thick vaginal discharge on the labia minora, vaginal, and cervix area. Vaginal discharge examination using KOH 10% showed pseudohyphae. Gram examination found pseudohyphae and polymorphonuclear (PMN) cells >30 in the vagina, and pseudohyphae on the cervix’s discharge. VITEK-2 culture showed fluconazole-sensitive C. albicans. The patient was given DQC intravaginal tablets for 10 days and showed remarkable clinical and microscopic examination improvement. Conclusion: Intravaginal DQC is effective in treating pregnant patients with VVC. VVC in pregnancy should be treated appropriately to prevent perinatal adverse effects. Keywords: Vulvovaginal Candidiasis, dequalinium chloride, pregnancy, C. albicans
A MULTIDISCIPLINARY APPROACH TO A CASE OF CONDYLOMA ACUMINATA IN AN ADOLESCENT FEMALE FOLLOWING SEXUAL ABUSE – CASE REPORT Sakinah, Dyah Ayu; Setyowatie, Lita
Journal of Psychiatry Psychology and Behavioral Research Vol. 7 No. 1 (2026): Multidimensional Perspectives on Mental Health Across the Lifespan and Social C
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jppbr.2026.007.01.8

Abstract

Introduction: Condyloma acuminata (CA) is a sexually transmitted disease caused by human papillomavirus (HPV) and typically presents as exophytic, verrucous lesions on moist mucocutaneous surfaces, including the anogenital region. The infection is highly transmissible and may occur as solitary or multiple lesions of varying sizes. In pediatric and adolescent populations, the identification of sexually transmitted infections may represent an early clinical indicator of sexual abuse. The aim of this report to highlight the role of a multidisciplinary approach in comprehensive patient management. Methods: A 15-year-old female presented with genital warty lesions. Dermatovenereological examination revealed multiple skin-colored verrucous papules involving the labia majora and minora, without tenderness or bleeding. Detailed anamnesis obtained from the patient and her caregiver disclosed a history of sexual abuse. The clinical diagnosis was confirmed by histopathological examination of biopsied lesions. Results: The patient was diagnosed with condyloma acuminata associated with HPV infection in the context of sexual abuse. Management involved collaboration among dermatovenereologists, pediatricians, psychiatrists, and pediatric surgeons to address both medical conditions and psychological trauma. Discuss: Management of this patient required a multidisciplinary approach involving pediatrics for underlying aplastic anemia, dermatovenereology for genital warts, psychiatry for psychological trauma, and pediatric surgery for definitive lesion management. Such coordinated care was essential to address both the medical and psychosocial complexities associated with condyloma acuminata following adolescent sexual abuse. Conclusion: The presence of condyloma acuminata in children or adolescents should prompt careful evaluation for possible sexual abuse. Early diagnosis and coordinated multidisciplinary management are crucial to achieving optimal medical treatment and psychological recovery.  Keywords: pseudobulbar affect, stroke, antidepressant.