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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB Journal of Islamic Medicine JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Jurnal Klinik dan Riset Kesehatan Asian Journal of Health Research Media Dermato-Venereologica Indonesiana
Lita Setyowatie, Lita
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Profile of Syphilis Risk Factors in The Productive Age Group at Dermatology and Venereology Clinic RSUD DR. Saiful Anwar, Malang Indonesia Rona Lintang Harini; Setyowatie, Lita
Journal of Community Medicine and Public Health Research Vol. 4 No. 2 (2023): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v4i2.46170

Abstract

Syphilis is a sexually transmitted infection that has the potential to cause serious complications and is closely related to the human immunodeficiency virus (HIV) infection, thus making syphilis a major public health problem. Understanding the characteristics of risk factors could be used to prevent future transmission and occurrences of syphilis. This study aimed to determine the demographic data and risk factors of syphilis in productive age at the Dermatology and Venereology Clinic, RSUD. DR. Saiful Anwar, Malang, Indonesia. This study used a descriptive approach using secondary data from the medical records of syphilis patients from January to December 2021. Sample collection was carried out using a total sampling technique. Twenty medical records that met the inclusion criteria were included, all of which belonged to the productive age group. The majority of the sample were male (70%), aged 17-25 years (45%) and 26-35 years (45%), had a high school education (55%), were private sector workers (40%), were unmarried (70%), had anogenital sexual activity (50%), never used condoms (50%), had more than one sexual partner (85%), were in the primary stage of syphilis (35%), and were HIV positive. Among male patients with syphilis-HIV coinfection, 80% of cases were homosexual. The risk factors for syphilis at a productive age include anogenital intercourse, irregular condom use, multiple sexual partners, the primary stage of syphilis, HIV infection, and homosexuality. A program focused on detecting and treating syphilis among people living with HIV/AIDS, especially those in high-risk populations such as men who have sex with men (MSM), is needed.
Profile of Syphilis Compliance and Success of Therapy at Dermatology and Venereology Clinic RSUD Dr. Saiful Anwar Malang: A Descriptive Study Donoseputro, Intan Wasaputri; Setyowatie, Lita
Journal of Community Medicine and Public Health Research Vol. 5 No. 1 (2024): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v5i1.47714

Abstract

Syphilis is a chronic progressive sexually transmitted infection, that causes a life-threatening condition if left untreated. In lower-middle-income countries, the burden of disease might appear to be lower due to a lack of reports. This study aimed to report the epidemiological profile, the profile of compliance, and the success of therapy of syphilis at the Dermatology and Venereology Outpatient Clinic in RSUD dr. Saiful Anwar Malang, Indonesia. This study used a descriptive approach using secondary data from the medical records of newly diagnosed syphilis patients at Dermatology and Venereology Clinic RSUD dr. Saiful Anwar Malang from January 2021 - December 2021. Sample collection was using a total sampling technique. Eighteen medical records met the inclusion criteria. The majority of samples were men (77.8%), aged 17-25 years (44.4%) and 26-35 years (44.4%), had a high school education (55.6%), HIV positive (50%) and HIV negative (50%). All 18 patients got intramuscular injections of a single 2.4 million U or 7.2 million U Benzathine Penicillin G according to the syphilis stage. It was found that eight patients (44.4%) had a successful therapy, two patients (11.2%), experienced failure, and the remaining eight patients (44.4%) were unknown due to loss of follow-up. Several factors are associated with better patient compliance including older age, higher educational level, type of the disease, and lower complexity of treatment schedules. Overall, therapeutic compliance of syphilis patients is good, but monitoring compliance needs to be improved. Benzathine Penicillin G remains the drug of choice for syphilis and has a high success rate.
Electrosurgery and 5% Imiquimod Cream as a Combination Therapy for Perianal Condyloma Acuminata in a HIV Patient Setyowatie, Lita; Faradila, Anandita
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.142-146

Abstract

Background: Condyloma acuminata (CA) is a common sexually transmitted infection caused by the human Papillomavirus (HPV) infection. It is characterized by single or multiple lesions in the anogenital area accompanied by itching, discharge, or bleeding. CA in HIV (human immunodeficiency virus) - positive patients can experience a low response to various therapeutic modalities, which may lead to consideration of choosing combination therapy to increase the effectiveness of therapy. Case: We report a case in a twenty-one-year old male with multiple warts on the perianal area. Within four months, the warts had covered the perianal area, with hemorrhoids emerging as complications. The patient had trichloroacetic acid treatment three times but did not respond. The patient is male who have sex with male, and there has been a history of multisexual partners. The diagnosis was made by clinical and histopathological examinations. The patient is HIV-positive and has been receiving antiretrovirals regularly. He got a combination therapy of electrosurgery and 5% imiquimod cream for 9 weeks and showed excellent results. Discussion: Standard topical medication is an effective treatment for condyloma acuminata, but infiltrative and recurrent lesions often require ablative and surgical treatment. Conclusion: Electrosurgery in combination with imiquimod proved to be effective and shortening the treatment regimen in the treatment of perianal CA.
Cimetidine Sebagai Terapi Adjuvan pada Pasien Kondiloma Akuminata Perianal Ko-Infeksi Human Immunodeficiency Virus dengan Elektrodesikasi Setyowatie, Lita; Dwiputra Prawira, Muhammad Edel
Journal of Islamic Medicine Vol 9, No 2 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i2.35174

Abstract

Latar belakang: Kondiloma akuminata (KA) perianal merupakan proliferasi jinak dari epitel anogenital yang disebabkan oleh Human Papillomavirus (HPV). Penanganan KA masih menjadi permasalahan dikarenakan angka rekurensi yang cukup tinggi terutama pada pasien dengan HIV. Cimetidine sebagai agen immunomodulator telah banyak diteliti untuk terapi KA. Tujuan dari laporan kasus ini adalah untuk mengkaji lebih lanjut efektivitas terapi adjuvan per oral Cimetidine pada kasus KA. Laporan Kasus: Pada studi ini, dilaporkan dua kasus pasien dengan KA yang diterapi dengan elektrodesikasi dan pemberian oral Cimetidine sebagai terapi adjuvan. Kesimpulan:  Pemberian Cimetidine 2x600mg selama 3 bulan dapat membantu perbaikan klinis dan menurunkan angka rekurensi pada pasien. Cimetidine dapat meningkatkan proliferasi limfosit T, produksi sitokin seperti Interleukin(IL)-2 dan interferon-gamma (INF-γ), serta memperbaiki fungsi sel T supresor. Cimetidine juga mempengaruhi respon imun bawaan (innate) dan adaptif. Cimetidine merupakan terapi adjuvan yang efektif pada kasus KA perianal ko-infeksi HIV yang diterapi dengan elektrodesikasi selama 3 bulan.
Injeksi Vaksin Bacillus Calmette-Guérin (BCG) Sebagai Agen Imunoterapi Pada Kasus Kondiloma Akuminata Setyowatie, Lita; Deltania, Rasinta Ayudya
Journal of Islamic Medicine Vol 9, No 2 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i2.35175

Abstract

AbstrakLatar Belakang: Kondiloma akuminata adalah infeksi menular seksual yang disebabkan Human Papillomavirus (HPV). Bacille-Calmette-Guerin (BCG) adalah vaksin hidup yang dilemahkan dan termasuk salah satu agen imunoterapi yang dapat menjadi alternatif terapi kondiloma akuminata.. Laporan Kasus: Perempuan berusia 23 tahun dengan keluhan muncul kutil sewarna kulit sejak 1 bulan tanpa disertai gatal dan nyeri. Pemeriksaan venereologi tampak papul sewarna kulit, multipel, batas tegas, bentuk dan ukuran bervariasi Acetowhite (+).Pasien didiagnosis kondiloma akuminata dan diberikan terapi vaksin BCG injeksi intralesi 0,5 ml dosis tunggal. Kesimpulan : Vaksin BCG meningkatkan aktivitas berbagai sel imun yang dapat merangsang penyembuhan kutil kelamin. Terapi injeksi intralesi  tunggal 0,5 ml menunjukkan penurunan lesi pasca 1 bulan injeksi. Injeksi vaksin BCG intralesi dapat menjadi pilihan terapi untuk kondiloma akuminata dengan keuntungan seperti keamanan, harga lebih murah, dan mudah didapatkan
CORONAVIRUS DISEASE 2019 (COVID-19) DARI PERSPEKTIF DERMATOLOGI Sitaresmi, Adya; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.1.4

Abstract

Coronavirus Disease 2019 (COVID-19) is a new disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Common clinical manifestations are respiratory system disorders. However, COVID-19 can also manifest as extrapulmonary symptoms, one of which is dermatology. The exact mechanism of COVID-19 cutaneous manifestations is still not fully understood, but is suspected to be caused by the direct effects of the virus on keratinocyte, excessive immune response, or drugs used to treat COVID-19. Cutaneous manifestations of COVID-19 can be divided into five groups, namely pseudo-chilblains, vesicular, urticaria, erythematous maculopapular, and vascular lesions. Erythematous maculopapular (44.18%) and chilblains (19.72%) are the most common lesions. Vesicular and vascular lesions are less common. Chilblains lesions are usually found before or together with the onset of other COVID-19 symptoms, and often appear in close contact or asymptomatic patients, so early recognition of it can be used to detect the presence of COVID-19.
Peran Centela Asiatica Sebagai Moisturizer Faradila, Anandita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.4

Abstract

Moisturizer is the main component of daily basic skin care especially if there is a change in the epidermal barrier and reduced water content in the epidermis layer. When the amount of water drop below 10%, the skin become dry. One of herbal plants that affect skin hydration is Centella asiatica. C. asiatica is known as Pegagan in Indonesia and belongs to the Umbelliferae/Apiaceae family. Extracts from the leaves of C. asiatica have been reported to have potential as antioxidants, antimicrobial agents, collagen synthesis agents, and even act as wound healing properties. The active components of C. asiatica include pentacyclic triterpenes, particularly asiaticoside, madecassoside, asiatic acid and madecassic acid. C. asiatica is used as an active compound in skin care preparations due to its hydrating, antioxidant, anti-inflammatory, anti-cellulite and anti-aging activities. A formulation containing a concentration of C. asiatica extract showed efficacy in increasing skin moisture by increasing the hydration state of the skin surface and reducing the occurrence of transepidermal water loss (TEWL). This literature review aims to add insight about Centella asiatica and its mechanism of action that can be used as a moisturizer for the skin. Centella asiatica can be used as a cosmetic formulation that can treat dry and sensitive skin. More research is needed to identify and determine the chemical compound C. asiatica which is responsible for various therapeutic activities, especially as an effective, safe, easy and inexpensive moisturizer.
Peran Tanaman Artemisia pada Akne Vulgaris Dharsono, Agita Danaparamita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 2 No 1 (2022): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.1.4

Abstract

Akne vulgaris merupakan masalah yang sering kali menjadi alasan pasien berobat. Akne vulgaris dapat mengganggu kualitas hidup penderitanya karena dapat menurunkan rasa percaya diri, terutama pada derajat berat. Terapi yang ada saat ini seperti retinoid dan antibiotik sering kali memicu masalah lain seperti iritasi akibat penggunaan retinoid dan resisten akibat penggunaan antibiotik topikal jangka panjang. Saat ini telah banyak dilakukan penelitian untuk mencari terapi alternatif pilihan untuk akne vulgaris, salah satu alternatif yang sedang dikembangkan adalah dengan menggunakan ekstrak dari tanaman Artemisia atau lebih banyak dikenal dengan Mugwort. Tanaman ini banyak digunakan sebagai tanaman obat tradisional karena memiliki berbagai aktivitas, seperti antioksidan, anti bakteri, anti jamur, dan anti parasit. Peran anti bakteri pada ekstrak tanaman Artemisia dapat menghambat pertumbuhan berbagai bakteri seperti Pseudomonas aeruginosa, Staphylococcus aureus, dan Propionibacterium acnes. Penggunaan ekstrak tanaman ini dilaporkan memiliki efek samping yang lebih minimal dibandingkan dengan penggunaan bahan kimia. Pemanfaatan ekstrak tanaman Artemisia pada terapi akne vulgaris dapat dipertimbangkan karena kemampuan anti bakteri yang dimilikinya.
TIGA KOMBINASI TERAPI PADA PERIANAL GIANT CONDYLOMA ACUMINATA DENGAN KOINFEKSI HIV Firdausiya, Fitri; Setyowatie, Lita
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.306

Abstract

Giant condyloma acuminata (GCA) atau tumor Buschke- Löwenstein, merupakan varian kutil anogenital yang jarang dan unik. Kondisi imunokompromais terutama infeksi Human Immunodeficiency Virus (HIV) berkaitan dengan perkembangan GCA. Sampai saat ini belum ada pedoman baku emas dalam penatalaksanaan GCA dan masih menjadi tantangan bagi dokter spesialis dermatologi dan venereologi, karena ukuran lesi yang besar, kemungkinan invasi dan transformasi maligna, serta tingginya risiko rekurensi. Dilaporkan sebuah kasus GCA perianal pada pasien laki-laki berusia 20 tahun dengan koinfeksi HIV. Gejala klinis berupa vegetasi bertangkai sewarna kulit, permukaan verukosa, berbentuk cauliflower, multipel, berukuran 5 x 2 x 2,5 cm di regio perianal sampai menutup regio anal dengan beberapa papul verukosa kecil di sekitarnya. Diagnosis ditegakkan berdasarkan pemeriksaan fisik, tes acetowhite positif dan pemeriksaan histopatologis. Pasien diberikan terapi kombinasi menggunakan elektrokauter dan Trichloroacetic Acid (TCA) 90% setiap minggu serta cimetidine per oral dengan dosis 3 x 500 mg setiap hari selama 3 bulan. Resolusi pada seluruh lesi GCA setelah 5 minggu terapi dan tidak didapatkan rekurensi pada follow up bulan ke-5. Tiga kombinasi terapi: elektrokauter, TCA dan cimetidine dapat dipertimbangkan sebagai penatalaksanaan GCA dengan koinfeksi HIV karena teknik invasif minimal dan cimetidine sebagai imunomodulator bekerja sinergis mendorong resolusi dan mencegah rekurensi GCA.
Co-Authors Adya Sitaresmi Aslam, Achmad Bayhaqi Nasir Deltania, Rasinta Ayudya Dharsono, Agita Danaparamita Dhelya Widasmara Donoseputro, Intan Wasaputri Dwiputra Prawira, Muhammad Edel Faradila, Anandita Firdausiya, Fitri Kusumaningsih, Emy Pardina, Nathasia Ayunda Pramita, Vina Listy Rahmawati, Yustian Devika Retnani, Diah Prabawati Rona Lintang Harini Wahdah, Rina Auliya Widiatmoko, Arif Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono