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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Berkala Kedokteran Majalah Kesehatan FKUB Journal of Islamic Medicine Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Jurnal Klinik dan Riset Kesehatan Asian Journal of Health Research Media Dermato-Venereologica Indonesiana
Lita Setyowatie, Lita
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Therapy of Dequalinium Chloride Vaginal Tablets in Pregnant Women with Vulvovaginal Candidiasis Setyowatie, Lita; Larasaty, Nanda Shaskia
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 4 October2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i4.2296

Abstract

Background: Vulvovaginal candidiasis (VVC) is a Candida infection on vulva and vagina region. The most common etiology is C. albicans. Besides being the risk factor for developing VVC, pregnancy also limits the possible medication. This report presents the efficacy of Dequalinium Chloride (DQC) on VVC during pregnancy due to C. albicans. Case: A third-trimester primigravidae, 27-year-old, complained first odorless thick curd-like consistency vaginal discharge accompanied with pruritus (VAS 9/10) and pain since 3 months prior to admission. Venerology examination showed erythema on the labia majora and a great amount of thick vaginal discharge on the labia minora, vaginal, and cervix area. Vaginal discharge examination using KOH 10% showed pseudohyphae. Gram examination found pseudohyphae and polymorphonuclear (PMN) cells >30 in the vagina, and pseudohyphae on the cervix’s discharge. VITEK-2 culture showed fluconazole-sensitive C. albicans. The patient was given DQC intravaginal tablets for 10 days and showed remarkable clinical and microscopic examination improvement. Conclusion: Intravaginal DQC is effective in treating pregnant patients with VVC. VVC in pregnancy should be treated appropriately to prevent perinatal adverse effects. Keywords: Vulvovaginal Candidiasis, dequalinium chloride, pregnancy, C. albicans
Co-Authors Adya Sitaresmi Aslam, Achmad Bayhaqi Nasir Deltania, Rasinta Ayudya Dharsono, Agita Danaparamita Dhelya Widasmara Donoseputro, Intan Wasaputri Dwiputra Prawira, Muhammad Edel Faradila, Anandita Firdausiya, Fitri Kusumaningsih, Emy Larasaty, Nanda Shaskia Pardina, Nathasia Ayunda Pramita, Vina Listy Rahmawati, Yustian Devika Retnani, Diah Prabawati Rona Lintang Harini Wahdah, Rina Auliya Widiatmoko, Arif Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yuniasih, Dwi Intan