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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Masyarakat Sari Pediatri Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Amerta Nutrition Jurnal Pengabdian Masyarakat Kedokteran Journal of Health and Nutrition Research Gema Lingkungan Kesehatan International Journal of Cell and Biomedical Science
Sri Priyantini
Department Of Pediatric, Faculty Of Medicine, Universitas Islam Sultan Agung Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Effect of Topical Noni (Morinda citrifolia L.) Extract Cream on Interleukin-1 and PDGF Expression in a Rat Incision Wound Model Putri, Ariyanti; Priyantini, Sri; Setiawan, Eko
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.716

Abstract

Wound healing involves complex biological processes influenced by inflammation and tissue regeneration, where excessive interleukin-1 (IL-1) activity can delay recovery, while platelet-derived growth factor (PDGF) plays a pivotal role in fibroblast proliferation and collagen deposition. This study aimed to evaluate the effect of topical Noni (Morinda citrifolia L.) extract cream on IL-1 levels and PDGF expression in incised skin tissue. A post-test only control group design was conducted using 30 male Wistar rats randomly allocated into five groups: healthy control, negative control with basic cream, positive control with povidone iodine, treatment with 15% Noni cream, and treatment with 30% Noni cream. Incised wounds were created on the dorsal skin and treated once daily for seven days, followed by analysis of IL-1 using ELISA and PDGF expression using RT-qPCR. Statistical analysis showed no significant differences among groups (p=0.088 for IL-1; p=0.056 for PDGF), yet descriptive results revealed lower IL-1 levels in the 30% Noni group and higher PDGF expression in the 15% group, while povidone iodine produced the least favorable outcomes. These findings suggest a dose-dependent dual action of Noni extract cream, with the 30% formulation tending to attenuate inflammation and the 15% formulation enhancing regenerative activity.  These findings descriptively showed the lowest IL-1 levels, although the difference was not statistically significant. Within the limitations of this study, topical Noni extract cream demonstrates potential as a safe and natural adjunctive therapy for wound management, warranting further investigation with larger sample sizes, extended observation periods, and histopathological confirmation
Co-Authors Agung Putra Amalina, Nur Dina Anisa Nurmalitasari Chodidjah Chodidjah Chodidjah Denawati, Denawati Dipayana, Setya Eko Setiawan Hesti Wahyuningsih Karyadini Ibrahim, Sugeng Joko Wahyu Wibowo Laili R Issanti Masyhudi AM Masyhudi, AA Meidona Nurul Milla Minidian Fasitasari Muhyi, Ahmad Nugraha, Mahardika Adhitya Nuha, Mohamad Purnasari, Perez Purwaningsih, Hesti Putri, Ariyanti Rahim, Denasa Dwi Sopandita Riris Purbaningrum Setyo Trisnadi Siti Thomas Zulaikhah Suprihati Winarto Titiek Sumarawati