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All Journal Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa International Journal of Cell and Biomedical Science Medical Sains : Jurnal Ilmiah Kefarmasian
Purwaningsih, Hesti
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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The Effect of Celery Extract on Caspase-3 and TNF-α Gene Expression in Lead Poisoning-Induced Renal Injury in Rats Purwaningsih, Hesti; Sumarawati, Titiek; Chodidjah, Chodidjah; Putra, Agung; Priyantini, Sri; Fasitasari, Minidian; Ibrahim, Sugeng; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 2 No 6 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i6.42

Abstract

Background To determine the effect of Apium graveolens L (Celery) extract in the TNF-α and caspase-3 gene expression on the lead poisoning-induced renal injury rats’ model. Methods This study is experimental research with post test only control group design. Twenty male Wistar rats were randomly allocated into four groups (n=5). The control group was orally administrated with distillate water. The second group received lead acetate 200mg/kg body weight orally for 14 days, the third group were orally administered lead acetate 200 mg lead acetate/kg body weight and vitamin E 50IU/kg body weight for 14 days. The fourth group was administrated with leas acetate like second group and celery extract 300mg/kg body weight for 14 days. The TNF-a and caspase-3 gene expression was analyses under qRT-PCR. Results The phytochemical analysis of APE indicated the presence of alkaloids, flavonoids, tannins, saponins, and steroids. Leads acetate increased the TNF-α (3.87±0.09) and caspase-3 (7.95±0.23) gene expression. The celery extract was significantly decrease in the TNF-α (3.13±0.34) and caspase-3 (2.48±1.23) gene expression. Conclusion: In conclusion, the presence of celery extract inhibited the renal injury-induced lead acetate toxicity by inhibition of TNF-α proinflammation protein and caspase-3 proapoptosis protein
Sosialisasi Kesesuaian Penulisan Resep BPJS dan Kepuasan Pasien di Rumah Sakit Cahya Kawaluyan Ajie, Whisnu; Purwaningsih, Hesti; Maria, Roma Ave
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 10 (2024): Desember
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i10.1844

Abstract

Tujuan dari pelaksanaan pengabdian masyarakat ini adalah untuk mengetahui efektivitas diseminasi hasil penelitian mengenai hubungan kesesuaian penulisan resep BPJS dengan kepuasan pasien Rumah Sakit. Target dari kegiatan pengabdian masyarakat ini adalah: apoteker dapat menguasai pengetahuan mengenai kesesuaian penulisan resep dengan formularium nasional, dan mengupayakan perbaikan dari faktor-faktor penyebab ketidaksesuaian penulisan. Metode pelaksanaan kegiatan dimulai dari pretest, pemberian materi dan posttest. Hasil kegiatan menunjukkan rerata nilai antara pretest dan posttest berubah menjadi lebih baik setelah pelaksanaan diseminasi penelitian. Berdasarkan perhitungan data, nilai N-gain (gain yang dinormalisasi) sebesar 0,79 dengan kategori Tinggi. Untuk nilai efektivitas pelaksanaan diseminasi sebesar 79%, dengan kategori Efektif. Kesimpulan dalam kegiatan ini adalah kegiatan diseminasi hasil penelitian mengenai hubungan kesesuaian penulisan resep BPJS dengan kepuasan pasien Rumah Sakit termasuk efektif dilaksanakan.
MICROBIAL CONTAMINATION IN MIXED SYRUP CONTAINING ERDOSTEIN AND CETIRIZIN STORED AT DIFFERENT STORAGE TEMPERATURE Cahyanti, Naomi Dwi; Purwaningsih, Hesti; Angelia, Inez; Deki, Yohanes Damasus Natanael; Ramadhan, Gilang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1677

Abstract

Pharmaceutical services include drug dispensing activities, including drug compounding. Drug compounding is the process of mixing or changing ingredients to produce drugs that suit patient needs. Unmonitored storage conditions for compounded drugs in the community can affect the evaluation of the physical, chemical, and microbial contamination stability. The aim of this study was to determine the effect of storage temperature on the results of the evaluation of microbial contamination in compounding syrup pharmaceuticals, so it can provide education to the public about the storage patterns that have been carried out so far. Evaluation of microbial contamination in this study included contamination of the Total Yeast and  Mold Count (TYMC) and Total Plate Count (TPC). The objective of this study was a mixture of Erdostein syrup and cetirizine tablets. The research materials used for the microbial contamination test were mineral water, sterile water, Plate Count Agar (PCA) media, and Potato Dextrose Agar (PDA). The results of the study in the form of TYMC and TPC on day 0 were 0 cfu/mL. After 7 days of storage, microorganisms, namely TYMC, grew at room temperature (<30°C) 4.98x102 cfu/mL and cold temperature (2-8°C) 2.2x102 cfu/mL. The TPC results at room temperature storage (<30°C) were 8.33x102 cfu/mL and at cold temperatures (2-8°C) were 3.67x102 cfu/mL ...
MICROBIAL CONTAMINATION IN MIXED SYRUP CONTAINING ERDOSTEIN AND CETIRIZIN STORED AT DIFFERENT STORAGE TEMPERATURE Cahyanti, Naomi Dwi; Purwaningsih, Hesti; Angelia, Inez; Deki, Yohanes Damasus Natanael; Ramadhan, Gilang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1677

Abstract

Pharmaceutical services include drug dispensing activities, including drug compounding. Drug compounding is the process of mixing or changing ingredients to produce drugs that suit patient needs. Unmonitored storage conditions for compounded drugs in the community can affect the evaluation of the physical, chemical, and microbial contamination stability. The aim of this study was to determine the effect of storage temperature on the results of the evaluation of microbial contamination in compounding syrup pharmaceuticals, so it can provide education to the public about the storage patterns that have been carried out so far. Evaluation of microbial contamination in this study included contamination of the Total Yeast and  Mold Count (TYMC) and Total Plate Count (TPC). The objective of this study was a mixture of Erdostein syrup and cetirizine tablets. The research materials used for the microbial contamination test were mineral water, sterile water, Plate Count Agar (PCA) media, and Potato Dextrose Agar (PDA). The results of the study in the form of TYMC and TPC on day 0 were 0 cfu/mL. After 7 days of storage, microorganisms, namely TYMC, grew at room temperature (<30°C) 4.98x102 cfu/mL and cold temperature (2-8°C) 2.2x102 cfu/mL. The TPC results at room temperature storage (<30°C) were 8.33x102 cfu/mL and at cold temperatures (2-8°C) were 3.67x102 cfu/mL ...
Sosialisasi Peracikan Sediaan Obat Cair dengan Tablet Pada Tenaga Kefarmasian di Rumah Sakit Cahya Kawaluyan Purwaningsih, Hesti; Mercya, Yovita; Ajie, Whisnu Tri Seno
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 2 (2024)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v5i2.4349

Abstract

Peracikan obat merupakan praktik umum dilakukan oleh tenaga kefarmasian di Indonesia, terutama di rumah sakit, untuk menyediakan obat-obatan yang sesuai dengan kebutuhan individu pasien. Salah satu contoh racikan yang sering dilakukan adalah pembuatan sediaan sediaan obat cairdengan penambahantablet. Menurut teori, pembuatan sediaan obat cair dengan zat aktif yang tidak larut dalam air memerlukan penambahan suspending agent agar menghasilkan suatu suspense yang stabil. Namun, penelitian sebelumnya menyatakan bahwa tanpa penambahan suspending agent Na-CMC, sediaan obat cair yang diracik dengan tablet masih memenuhi persyaratan viskositas, sedimentasi, dan redispersibilitas pada hari ke-14. Program ini bertujuan untuk memberikan pemahaman tenaga kefarmasian melalui sosialisasi hasil penelitian mengenai peracikan sediaan obat cairdengan penambahan tablet sehingga akan mengurangi waktu yang diperlukan dalam proses peracikan dengan tetap memberikan pelayanan yang berkualitas. Program ini dilakukan dengan menggunakan metode ceramah dan diikuti 30 tenaga kefarmasian di Rumah Sakit Cahya Kawaluyaan pada 6 Februari 2024. Pada pelaksanaannya, dilakukan pre-test, pemberian materi dan post test. Hasil rata-rata nilai pengetahuan tenaga kefarmasian sebelum dilakukan intervensi sebesar 47,77 dan setelah intervensi menjadi 89,03. Meskipun telah dilakukan pre-test dan post-test untuk mengukur peningkatan pengetahuan, namun tidak secara langsung mempengaruhi kualitas peracikan obat yang dilakukan oleh tenaga kefarmasian. Disarankan untuk melakukan evaluasi terhadap keterampilan praktis dan penerapan pengetahuan dalam program pemberdayaan berikutnya
Co-Authors Agung Putra Ajie, Whisnu Tri Seno Amalina, Nur Dina Angelia, Inez Cahyanti, Naomi Dwi Chodidjah Chodidjah Deki, Yohanes Damasus Natanael Gilang Ramadhan Ibrahim, Sugeng Minidian Fasitasari Roma Ave Maria Sri Priyantini Titiek Sumarawati Whisnu Trie Seno Ajie Yovita Mercya