Nadirah Rasyid Ridha, Nadirah Rasyid
Departemen Ilmu Kesehatan Anak Subdivisi Hematologi-Onkologi Fakultas Kedokteran Universitas Hasanuddin/RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia

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ANALYSIS OF VITAMIN D LEVELS IN CHILDREN WITH THALASSEMIA BETA Nadirah Rasyid Ridha; Johan Gautama; Idham Jaya Ganda
International Journal of Health Science & Medical Research Vol 1, No 1 (2022): February 2022
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.705 KB) | DOI: 10.37905/ijhsmr.v1i1.13585

Abstract

Background : Beta Thalassemia is a genetic disorder inherited by autosomal recessive and has spread throughout the world, including Indonesia. Beta thalassemia requires lifelong transfusions, which can cause an accumulation of iron in the skin, liver, and kidneys, resulting in a decrease in vitamin D synthesis.Purpose : This study aims to analyze the levels of 25-OH-Vitamin D in beta thalassemia.Method : This study used a cross-sectional design and was conducted at Dr. Wahidin Sudirohusodo Hospital from April to July 2021. The population of this study was patients diagnosed with beta thalassemia and non-thalassemia (controls) who met inclusion criteria. This study compared vitamin D levels in beta thalassemia and non-thalassemia patients.Results : This study involved 60 children aged 6 months to 18 years, who were divided into 2 groups: 30 children in the beta thalassemia group and 30 in the non-thalassemia group. In this study, the levels of 25-OH-Vitamin D were lower in beta thalassemia children compared to non-thalassemic children, with a p value =0.012. Children with beta-thalassemia have a 4.33 times higher risk of vitamin D deficiency compared to non-thalassemic children. With a p value =0.023, 25-OH-Vitamin D levels were significantly lower in beta HbE thalassemia children compared to beta thalassemia major children.Conclusion :Levels of 25-OH-Vitamin D in beta thalassemia children were lower than in non-thalassemic children. Levels of 25-OH-Vitamin D in children with beta HbE thalassemia are lower than in children with beta thalassemia major.
REACTIVE TRHOMBOCYTOSIS IN CHILDREN Ayu Hafsari; Nadirah Rasyid Ridha
International Journal of Health Science & Medical Research Vol 1, No 2 (2022): August 2022
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (852.376 KB) | DOI: 10.37905/ijhsmr.v1i2.14134

Abstract

Thrombocytosis is a condition which the platelet count exceeds 450,000/mm3. Thrombocytosis was classified as: mild (450,000-700,000/mm3), moderate (700,000-900,000/mm3), severe (900,000-1,000,000/mm3) and extreme (1,000,000/mm3). Functionally, thrombocytosis is divided into primary (essential) and secondary (reactive). The novelty of this study due to examining reactive thrombocytosis in children. The purpose of this study was to look at reactive thrombocytosis in children.  Essential thrombocytosis is a myeloproliferative disorder due to monoclonal or polyclonal abnormalities of hematopoietic cells or biologic abnormalities of thrombopoietin (Tpo) in the primary regulation of megakaryopoiesis. Meanwhile, reactive thrombocytosis occurs temporarily due to stimulation of megakaryopoiesis with haematological or non-haematological abnormalities. Reactive thrombocytosis is an increase in thrombopoiesis due to reactive process due to infection, chronic inflammation, malignancy, and splenectomy surgery. Bacterial or viral infections are the most common cause (about 37-78%) at any age during childhood. Reactive thrombocytosis are asymptomatic and is usually found incidentally. Based on the guidelines the British Society for Haematology recommends three initial investigations: (1) Peripheral blood smear, (2) Inflammatory markers, and (3) Iron status. Management of reactive thrombocytosis by threated the main diseases, then platelet count returns to normal after the underlying disease is resolved. The overall prognosis depends on the underlying causative condition, approximately 8% of patients with acute infection examined have mild, transient thrombocytosis and show no infectious complications. However, these patients had an increased acute-phase response, prolonged length of stay, more bacteraemia and increased mortality although it only affected a minority of patients. This distinction between essential and reactive thrombocytosis is important because it implies evaluation, prognosis and treatment.Keywords: Reactive Thrombocytosis; Secondary Thrombocytosis; Transient.
THE RELATION BETWEEN HYPERTENSION IN PREGNANCY WITH LOW BIRTH WEIGT IN MAKASSAR CITY Nurul Hudayah; Henny Fauziah; Utami Murti Pratiwi; Fhirastika Annisha Helvian; Muhammad Dahlan; Nadirah Rasyid Ridha; Irwan Irwan
Jambura Journal of Health Sciences and Research Vol 5, No 1 (2023): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v5i1.15766

Abstract

AbstrakHipertensi dalam kehamilan merupakan penyebab utama morbiditas akut yang berat, cacat jangka panjang, dan kematian ibu. Hipertensi dalam kehamilan dapat berlanjut hingga ke masa persalinan yang akan menyebabkan gangguan pertumbuhan janin yang akan mempengaruhi berat badan lahir bayi sehingga pada ibu yang memiliki tekanan darah tinggi memiliki resiko melahirkan bayi berat lahir rendah lebih tinggi. Kebaruan dalam penelitian ini karena meneliti tentang hubungan antara hipertensi dalam kehamilan dengan kejadian bayi berat lahir rendah. Penelitian ini bertujuan untuk mengetahui hubungan antara hipertensi dalam kehamilan dengan kejadian bayi berat lahir rendah. Penelitian ini merupakan penelitian analitik observasional dengan menggunakan pendekatan cross sectional. Sampel penelitian ini diambil menggunakan metode consecutive sampling. Adapun jumlah sampel dalam penelitian ini sebanyak 350 orang sampel. Teknik analisis data menggunakan uji Chi-Square. Hasil uji Chi Square menunjukkan adanya hubungan yang bermakna antara hipertensi dalam kehamilan dengan kejadian berat bayi lahir rendah (p value ≤ 0,05). Hasil perhitungan Prevalence Ratio (PR) menunjukkan bahwa ibu hamil yang mengalami hipertensi berisiko 1,661 kali mengalami kejadian bayi berat lahir rendah (95% CI 1,284-4,849). Kesimpulan pada penelitian ini adalah terdapat hubungan antara hipertensi dalam kehamilan dengan kejadian bayi berat lahir rendah di Kota Makassar.Kata Kunci: Hipertensi Dalam Kehamilan; Bayi Berat Lahir Rendah; Ibu Hamil. AbstractHypertension in pregnancy is considered to be the major cause of severe acute morbidity, long-term disability, and maternal death. Hypertension in pregnancy can continue until the day of labor which may cause fetal growth disorders that will affect the baby's birth weight. Therefore, a pregnant mother with a high blood pressure tends to have a higher risk of having a low-birth weight baby. The novelty in this study is because it examines the relationship between hypertension in pregnancy and the incidence of low birth weight babies. The major objective of this study was to investigate the relationship between hypertension in pregnancy and the occurrences of low-birth weight in babies. The methodological approach used in this research was an observational analytical study by using a cross sectional approach. The samples of this research were selected by using a consecutive sampling method where 350 samples were selected as samples of this research. The data analysis was conducted by using Chi-Square test.Based on the Chi-Square test, it was apparent that there was a significant relationship between hypertension in pregnancy and the occurrences of low birth weight with the p value of 0.05. The calculation results of the Prevalence Ratio (PR) showed that pregnant women with hypertension were at risk at 1.661 times to have low-birth weight babies (95% CI 1.284- 4.849). It could be concluded  from this research that there was a relationship  between hypertension in pregnancy and the occurrences of low birth weight in Makassar.Keyword: Hypertension in Pregnancy; Low-birth Weight Babies; Pregnancy.
FACIAL NERVE PARALYSIS AND INTUSSUSCEPTION AS CLINICAL PRESENTATIONS OF LYMPHOBLASTIC LYMPHOMA: A RARE PEDIATRIC CASE REPORT Musdalipa Musdalipa; Nadirah Rasyid Ridha; Setia Budi Salekede; Hadia Angriani
International Journal of Health Science & Medical Research Vol 2, No 1 (2023): February 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i1.16436

Abstract

Lymphoblastic lymphoma (LBL) is a highly aggressive lymphoblast neoplasm due to the presence of clonal hematopoietic stem cell abnormalities of B or T cell origin. LBL represents 30% of pediatric non-Hodgkin's lymphomas. We report a 2-year-11-month-old boy with complaints of a lump in the abdomen and facial paralysis on the left side. weight loss of 3 kg in 3 months, frequent nausea and vomiting, and constipation. On physical examination, the face was not symmetrical on the left and right. palpable mass from the right iliac region to the left iliac, measuring 17.5 x 10 x 5 cm, immobile, rubbery consistency. There is lymphadenopathy right inguinal region et sinistra. Abdominal ultrasound without contrast showed ileocolic intussusception, with histopathological results showing malignant non-Hodgkin's lymphoma. The therapy given was chemotherapy according to the protocol for non-Hodgkin's lymphoma. Facial nerve paralysis and intussusception are rare clinical features of LBL. It is important to consider a differential diagnosis such as LBL in a patient with a lump accompanied by facial nerve paralysis and intussusception. Histopathological and immunohistochemical examination were needed.Keywords:  Lymphoblastic Lymphoma; Facial Nerve Paralysis; Intussusception
DETERMINANT ANALYSIS OF HYPERTENSION RISK FACTORS IN CITY TRANSPORT DRIVERS IN GORONTALO CITY Irwan Irwan; Nadirah Rasyid Ridha; Deliyana I. Katili
Jambura Journal of Health Sciences and Research Vol 5, No 1 (2023): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v5i1.17111

Abstract

AbstrakHipertensi adalah penyakit nonepidemik tetapi faktor risiko dari beberapa penyakit berhubungan dengan kardiovaskular terutama koroner. Masalah hipertensi sering terjadi secara tidak terduga dan menyebabkan kasus kematian. Sebagian besar penyakit ini disebabkan oleh perilaku tidak sehat seperti merokok, mengonsumsi alkohol,  kopi, dan kurang berolahraga. Kebaruan dalam penelitian ini karena peneliti menganalisis determinan faktor risiko hipertensi pada sopir angkutan kota. Penelitian ini bertujuan untuk menganalisis hubungan antara kejadain hipertensi dengan perilaku mengkonsumsi kopi, merokok, berolahraga dan stres pada sopir angkutan kota di Kota Gorontalo, Metode penelitian menggunakan case control,  Sampel kasus sebanyak 36 sopir angkuatan kota dengan masalah hipertensi dan kontrolnya 36 so[ir angkutran kota tanpa masalah hipertensi.  Analisis data menggunakan odds rasio (OR) dengan α = 0,05.  Hasil penelitian terdapat hubungan kejadian hipertensi dengan variabel ; kebiasaan minum kopi (p = 0,016) dengan Odds Rasio (OR) = 3,35(95%C I 1,11OR10,35),  kebiasaan merokok (p = 0,0178) dengan Odds Rasio (OR) = 3,18 (95%CI 1,09OR9,49), dan stres (p = 0,026) dengan Odss Rasio (OR) = 3,13 (1,01OR9,94). Kebiasaan berolahraga tidak berhubungan dengan masalah hipertensi pada pengemudi Angkutan kota dengan  nilai p = 0,598,  Kesimpulan ada hubungan kejadian hipertensi pada sopir angkutan kota di Terminal Kota Gorontalo dengan Kebiasaan minum kopi, merokok dan stress, sedangkan kebiasaan olahraga tidak berhubungan dengan masalah hipertensi pengemudi angkutan kota.Kata kunci: Hipertensi; Perilaku; Sopir angkutan kota. AbstractHypertension is a nonepidemic disease but a risk factor for some cardiovascular-related diseases, mainly coronary. Hypertensive problems often occur unexpectedly and lead to cases of death. Most of these diseases are caused by unhealthy behaviors such as smoking, consuming alcohol, coffee, and lack of exercise. This study's novelty is that researchers analyzed the determinants of hypertension risk factors in city transport drivers. This study aims to explore the relationship between hypertension and the behavior of consuming coffee, smoking, exercising, and stress in city transportation drivers in Gorontalo City. The research method uses case-control Samples of cases as many as 36 city transportation drivers with hypertension problems, and the control is 36 so[ir city transportation without hypertension problems. Data analysis using odds ratio (OR) with α = 0.05. The results of the study had a relationship between the incidence of hypertension and the variables; coffee drinking habits (p = 0.016) with Odds Ratio (OR) = 3.35(95%C I 1.11OR10.35), smoking habits (p = 0.0178) with Odds Ratio (OR) = 3.18 (95%CI 1.09OR9.49), and stress (p = 0.026) with Odds Ratio (OR) = 3.13 (1.01OR9.94). Exercise habits are not related to hypertension problems in city transportation drivers with a p-value = 0.598; in conclusion, there is a relationship between the incidence of hypertension in city transportation drivers at Gorontalo City Terminal with the habit of drinking coffee, smoking, and stress. In contrast, exercise habits are not related to hypertension problems of city transport drivers.Keywords: Hypertension; Behaviour; City transport driver.
COMPARISON OF TRANSFERRIN SATURATION LEVELS IN ANEMIA OF CHRONIC DISEASE AND IRON DEFICIENCY ANEMIA: A CROSS-SECTIONAL STUDY Andi Ayu Hafsari; Nadirah Rasyid Ridha; Ema Alasiry; Syarifuddin Rauf; Setia Budi Salekede; Kwari Januar Satriono
International Journal of Health Science & Medical Research Vol 2, No 2 (2023): August 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i2.18769

Abstract

About 33 percent of the global population is anemic. Anemia of chronic disease (ACD) is caused by chronic inflammation. Iron deficiency anemia (IDA) is caused by a decrease in the body's iron reserves to form red blood cells. There are many clinical and laboratory similarities between ACD and IDA, but the treatment is very different. Transferrin saturation level can be used to differentiate between the two. This research is novel because it compares transferrin saturation levels in chronic and iron deficiency anemia. This study aims to determine the transferrin saturation level in patients with ACD and IDA. This research method uses a cross-sectional study. Data taken from medical records. The sample for this study were children with ACD and IDA aged 1 month to 18 years at Wahidin Sudirohusodo Hospital, Makassar. The results showed that the mean transferrin saturation value in DKA children (19.40%) was higher than that in ADB children (5.66%). The Mann-Whitney test showed that there was a significant difference between the two groups (p=0.001) with a transferrin saturation cut-off point between the DKA and IDA groups of 6.5% with a sensitivity of 73.6%, a specificity of 72.5%, positive predictive value (PPV) of 78%, negative predictive value (NPV) of 67%, and odds ratio (OR) of 19,476 (95% CI). In conclusion, transferrin saturation levels can differentiate IDA and ACD using a cut-off point of 6.5%.
ANALYSIS OF MALONDIALDEHYDE LEVELS IN CHILDREN WITH BETA THALASSEMIA: A CROSS-SECTIONAL STUDY Syarifah Raehana Mardiah Alaydrus; Nadirah Rasyid Ridha; Ema Alasiry; Amiruddin L; Hadia Angriani; Kwari Januar Satriono
International Journal of Health Science & Medical Research Vol 2, No 2 (2023): August 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i2.18810

Abstract

AbstractBeta thalassemia is an autosomal recessive genetic condition affecting people worldwide, including in Indonesia. Malondialdehyde levels, a peroxidation product, can be used to see if there is an iron buildup in the body due to lifelong transfusions. This research is a novelty because it analyzes malondialdehyde levels in children with beta-thalassemia: a cross-section study. The study aims to analyze malondialdehyde levels in children with beta-thalassemia. Methods in this study, a cross-sectional investigation was carried out at Dr. Hospital Wahidin Sudirohusodo, Makassar. The study was carried out between April and August of 2022. The study sample consisted of participants diagnosed with beta-thalassemia and non-thalassemia (controls) eligible to participate. Patients with and without beta-thalassemia had their malondialdehyde levels measured. The study results showed that the 60 children, aged six months until 18 years, were separated into two groups, 30 of whom had beta-thalassemia and another 30 who did not. With a significant P-value of 0.000, it was determined that beta-thalassemia children had more substantial amounts of malondialdehyde than children without the condition. Children with beta-thalassemia major had significantly higher malondialdehyde levels than those with beta-thalassemia HbE (P-value = 0.000). The conclusion was that malondialdehyde levels were more significant in beta-thalassemia kids than non-thalassemia kids. Malondialdehyde values are more effective in kids with beta-thalassemia major than those with beta-HbE thalassemia.Keywords: Malondialdehyde; Beta thalassemia; Transfusion; Children.
Analysis of Erythrocyte Indices and Reticulocyte Hemoglobin Equivalent in Iron Deficiency Anemia on Treatment Agnes Theresia Motulo; Rachmawati Muhiddin; Nadirah Rasyid Ridha; Mansyur Arif; Agus Alim Abdullah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1991

Abstract

Assessment of treatment response is needed in the management of iron deficiency anemia (IDA). This study aims to analyze erythrocyte indices (MCH, MCV, MCHC) and Ret-He as indicators of IDA diagnosis and treatment response. A prospective cohort study in children ages 2-18 years old in orphanages throughout Makassar. Grouped into normal group and therapy group, consisting of IDA and iron deficiency groups. Elemental iron therapy 3mg/kg/day was given. Levels of MCV (fl), MCH (pg), MCHC (g/dL), and Ret-He (pg) were measured before and on the 8th day of therapy. The normality test of numerical variable data used the Kolmogorov-Smirnov test. The statistical test used the Mann-Whitney test, Wilcoxon Signed Rank test, and the Kruskal-Wallis test.  Diagnostic value and cut-off determination using ROC curve analysis. Test results were significant if p<0.05. The sample consisted of 40 subjects each in both normal and therapy groups. The therapy group was divided into 7 IDA and 33 iron deficiency. ROC IDA curve on MCV obtained a cut-off of 76 fl, a sensitivity of 100%, a specificity of 95%, NPP of 77.8%, NPN of 100%, MCH obtained a cut-off of 25 pg, a sensitivity of 100%, 97.5% specificity of 97.5%, NPP of 87.5%, NPN of 100%, Ret-He obtained cut-off 29 pg, sensitivity of 100%, specificity of 95%, NPP of 77.5%, NPN of 100%. MCV levels increased by 7.3% (p<0.05) while Ret-He increased by 19.6% (p<0.05) after therapy. The ROC curve coordinate on IDA showed that cut-off levels of MCV 76 fl, MCH 25 pg, and Ret-He 29 pg provided optimal sensitivity and specificity. Increasing MCV after therapy described increasing levels in erythrocyte and hematocrit synthesis. Increasing Ret-He after therapy described improving erythropoiesis quality. MCV, MCH, and Ret-He as indicators of diagnosing IDA. MCV and Ret-He monitor the success of IDA treatment response.
Serum transforming growth factor-beta levels and severity of retinoblastoma in children M Farid Huzein; Nadirah Rasyid Ridha; Dasril Daud
Paediatrica Indonesiana Vol 63 No 3 (2023): May 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.3.2023.169-72

Abstract

Background Transforming growth factor-? (TGF-?) expression contributes to the growth of retinoblastoma. TGF-? is produced or released by infiltrating cells such as lymphocytes and monocytes/macrophages. TGF-? levels are a potential marker of disease severity. Objective To assess the difference in serum TGF-? levels before chemotherapy in patients with retinoblastoma grades III and IV. Methods This cross-sectional observational study was done at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia from January to November 2019. Subjects were pediatric patients with grade III and IV retinoblastoma who had not undergone chemotherapy. Patients who met the inclusion criteria provided blood specimens for TGF-? testing. We analyzed the difference in serum TGF-? level between grade III and grade IV patients. Results We obtained 38 subjects, consisting of 13 grade III and 25 grade IV retinoblastoma patients. Mean TGF-? levels were in 1,061 ng/L in grade III and 988 ng/L in grade IV patients. The Mann-Whitney U test revealed no significant difference between the levels of TGF-?, retinoblastoma grade III and IV (P=0.655). However, TGF-? levels in both groups were markedly above the normal value (100 ng/L). Conclusion TGF-? levels are markedly increased in grade III and IV retinoblastoma patients. There was no significant difference in TGF-? level between grade III and IV patients. Our findings suggest that TGF-? plays an important role in tumor cell development. Further research on differences in TGF-? levels between late stages (grades III and IV) and early stages (grades I and II) of retinoblastoma to elucidate the role of TGF-? as a marker of retinoblastoma severity.
DIFFUSE LARGE CELL NON HODGKIN LYMPHOMA AT RETROBULBAR OCCULUS SINISTRA MASS Viqa Faiqah; Nadirah Rasyid Ridha
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 7, No 4 (2023): OKTOBER: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMU
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v7i4.20751

Abstract

Non-Hodgkin’s Lymphoma (NHL) is a large group of malignant neoplasms originating in the lymph nodes and extra nodes of lymphoid tissues. This kind of malignancy is quite common in the world with 3% of all cancer cases. In Indonesia, NHL is the 6th most common cancer and is the third most rapidly progressive cancer after melanoma and lung cancer. The novelty in this study is diffuse large cell non hodgkin lymphoma at retrobular occulus sinistra mass. A 15-years-old boy came with complaints of a protruding left eye since 2 months ago, begin with reddish eyes which gradually enlarged and decrease of visual function. Biopsy confirmed the diagnose as a stage 2 non-Hodgkin's lymphoma with Diffuse large cells. This patient underwent a chemotherapy procedure according to the non-Hodgkin's lymphoma’s protocol for 1 year that turn out in decrease of tumor progression and good result of the chemotherapy. A case of retrobulbar mass occulus sinistra et causa non-Hodgkin's lymphoma in a 15 year old boy. Diagnose is based on history, physical examination, laboratory tests and biopsy. Treatment of this patient using chemotherapy regimens according to the non-Hodgkin's lymphoma protocol.