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Pengembangan Krim Pewarna Rambut Permanen Mengandung Ekstrak Daun Ketapang (Terminalia catappa L) dan Ekstrak Daun Jambu Biji (Psidium guajava L) Erny Marleny Effendy; Shelly Taurhesia; Anny Victor Purba
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 16 No. 02 Desember 2019
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Perubahan warna rambut menjadi putih pada usia lanjut sering kurang disukai. Keanekaragaman hayati Indonesia mendorong peneliti untuk melakukan pengembangan pewarna rambut dari ekstrak daun ketapang dan daun jambu biji. Ekstrak daun jambu biji mengandung pyrogallol yang berfungsi sebagai pembangkit warna dan ekstrak daun ketapang mengandung punicalagin sebagai polyphenol yang berfungsi sebagai pewarna. Kedua bahan ini diformulasikan dalam sediaan krim dengan tujuan memudahkan dalam pemakaian. Pada penelitian ini digunakan ekstrak daun jambu biji dengan konsentrasi 12,5% dan ekstrak daun ketapang dengan variasi konsentrasi 10; 12,5; dan 15%. Penambahan logam tembaga sulfat 1% (F5B) terhadap formula optimal menjadikan warna lebih tua. Pengujian warna pada pewarna rambut dengan penambahan logam menggunakan alat kromameter memberikan warna merah dengan nilai a (9,00) warna biru dengan nilai b (3,37) warna yang terrefleksi adalah coklat tua, sedangkan pewarna rambut tanpa penambahan logam memberikan warna merah dengan nilai a (7,36), warna biru dengan nilai b (16,96) warna yang terrefleksikan adalah coklat muda. Hasil uji keamanan menggunakan tiga ekor kelinci dengan metode uji iritasi akut dermal dengan indek iritasi nol (0) dinyatakan aman serta tidak mengiritasi.

Formulasi Sediaan Serum Anti Aging dengan Kombinasi dari Ekstrak Buah Tomat (Lycopersicum esculentum L.) dan Ekstrak Kulit Buah Semangka (Citrullus lanatus Thunb.) Rima Apria Purwanti; Yunahara Farida; Shelly Taurhesia
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.864

Aging is a problem for everyone, especially those who have entered middle age and above. Aging can be caused by various factors, namely factors that come from within the body and from outside the body. One of the extrinsic factors were sun exposure, temperature / humidity and free radicals. Skin aging is mostly caused by free radicals, one of which is sunlight radiation. This study aims to produce a serum preparation that functions as an antioxidant with a combination of tomato extract and watermelon rind. The antioxidant activity of tomato extract, watermelon rind extract and combination extract was carried out using the DPPH method, then the anti aging serum was formulated using hydroxy ethyl cellulose, glycerin, DMDM hydantoin, ethoxy diglycol and aqua DM. Evaluation of serum preparations includes physical evaluation (organoleptic examination, dispersibility, homogeneity, viscosity, irritation test), chemistry (pH), and microbiology. Data were analyzed using one way Anova, the results differed significantly when the p-value was less than 0.05 (p <0.05). The results showed that the combination extract had a better IC50 value of 59.19 ppm, tomato extract 69.89 ppm, watermelon rind extract 79.29 ppm. Combined serum preparation at F1 (T: S / 1: 1) IC50 value was 97.37 ppm, F2 (T: S / 1: 2) 80.70 ppm, F3 (T: S / 2: 1) 69.81 ppm so it is included in the category of strong antioxidants.

ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.) Aprilia Fatma Ely; Shelly Taurhesia; Teti Indrawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.809

Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity and good physical stability. This study included an experimental research. The research population was in the form of antibacterial compounds in face toner. The sample was green tea kombucha, which showed antibacterial activity at a concentration of 50% with an 18 mm Diameter of Inhibition Zone (DIZ). And the best formula is F1 with 0.84 mm DIZ, has a pH of 4 which is safe for the skin, clear solution, has clean power, it is also stable during storage at 30o and 40oC, but it has a rather disagreeable scent of toner. Keywords: Acne, Antibacterial, Green Tea Leaves Kombucha, Face Tone

ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.) Aprilia Fatma Ely; Shelly Taurhesia; Teti Indrawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.809

Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity and good physical stability. This study included an experimental research. The research population was in the form of antibacterial compounds in face toner. The sample was green tea kombucha, which showed antibacterial activity at a concentration of 50% with an 18 mm Diameter of Inhibition Zone (DIZ). And the best formula is F1 with 0.84 mm DIZ, has a pH of 4 which is safe for the skin, clear solution, has clean power, it is also stable during storage at 30o and 40oC, but it has a rather disagreeable scent of toner. Keywords: Acne, Antibacterial, Green Tea Leaves Kombucha, Face Tone

Formulasi dan Uji Aktivitas Antioksidan Krim Kombinasi Ekstrak Biji Kopi Hijau (Coffea canephora var Robusta) dan Ekstrak Daun Teh Hijau (Camellia sinensis (L.)) Lamsari, Lamsari; Taurhesia, Shelly; Djamil, Ratna
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol 10, No 2 (2023): October
Publisher : Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v10i2.5082

Kopi robusta mengandung senyawa alkaloid, flavonoid, saponin, tanin, kafein dan fenol, sedangkan daun teh hijau mengandung senyawa katekin. Senyawa fenol pada kopi dan katekin pada daun teh hijau memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengembangkan formulasi krim dari kombinasi ekstrak biji kopi hijau dan daun teh hijau, yang memiliki aktivitas antioksidan. Biji kopi hijau diekstraksi secara maserasi kinetik menggunakan pelarut kombinasi Isopropanol : air (60:40) sedangkan daun teh hijau diekstraksi dengan pelarut Etanol 70%. Setelah diperoleh ekstrak kental, kemudian dilakukan uji mutu ekstrak serta uji aktivitas antioksidan menggunakan metode DPPH. Nilai IC50 ekstrak biji kopi hijau (EBKH) adalah 22.37 ppm, ekstrak daun teh hijau (EDTH) adalah 7.02 ppm, sedangkan kombinasi EBKH : EDTH (1:1) adalah 11.59 ppm. Kemudian dikembangkan formula krim mengandung kombinasi kedua ekstrak dengan variasi perbandingan EBKH : EDTH = 1:2 (F1) ; 1:1 (F2) dan 2:1 (F3). Diperoleh Krim tipe M/A, berwarna putih kekuningan, berbau khas, tekstur lembut, homogen, rentang pH 7.3 – 7.5, viskositas 190.000 – 205.000 cPs, diameter daya sebar 5.9 – 6.3 cm, dan nilai aktivitas antioksidan tertinggi diperoleh dari F1 sebesar 25.62 ppm. Ketiga formula stabil pada suhu 40 °C selama 4 minggu penyimpanan, dan hasil uji iritasi menunjukkan F2 memberikan respon iritasi sangat ringan.

Formulasi Masker Peel Off Gel dari Kombinasi Minyak Atsiri Sereh dan Cengkeh untuk Menghambat Bakteri Penyebab Jerawat Manus, Noriko; Taurhesia, Shelly; Setyahadi, Siswa; Manus, Widya Christine
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.11497

Acne is a chronic skin disease involving inflammation of the pilosebaceous units with the main bacteria Staphylococcus epidermidis and Propionibacterium acnes has prompted the creation of cosmetic masks containing antibacterial agents. This study aims to evaluate the antibacterial activity of Lemongrass and Clove essential oils and to determine the synergistic effects of combining these essential oils in a peel-off gel mask formulation. The study was conducted using the liquid dilution method to determine the minimum inhibitory concentration and the disk diffusion method to test the inhibition zone diameter. Additionally, tests are conducted to determine the antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis, as well as to analyse the stability of the product both chemically and physically during storage. The results of the study showed that (1) the formulation containing a combination of 25% lemongrass and 18% cloves showed high inhibitory power and good stability, but caused moderate irritation; (2) lemongrass and clove essential oils were effective against Propionibacterium acnes and Staphylococcus epidermidis, but it was recommended to reduce the active ingredients to prevent potential irritation.

Formulation and test of mosquito repellent lotion from the extract of kecombrang (Etlingera elatior (Jack)) and beluntas (Pluchea indica) leaves extract Taurhesia, Shelly; Endah, Endah; Basuki, Witono; Djamil, Ratna
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1521

Dengue fever is an infectious disease which is transmitted by Aedes aegypti mosquitoes and commonly occurs in Indonesia. The use of natural ingredients for mosquito repellent is becoming a trend. Kecombrang (Etlingera elatior (Jack)) is known as a medicinal plant which contains alkaloids, saponins, tannins, phenolics, flavonoids, triterpenoids, steroids, and glycosides. Beluntas (Pluchea indica) contains tannins, alkaloids, flavonoids, phenols, saponins and essential oils. This study aims to develop mosquito repellent lotion using combined leaf extracts of E. elatior and P. indica at different ratios (1:1; 1:2; 2:1). The materials used in this study were E. elatior and P. indica leaves, Aedes aegypti mosquitoes, 96% ethanol, stearic acid, triethanolamine, white oil, methyl paraben, cetyl alcohol, and distilled water. The repellent activity is tested using a standard method of WHO, comparing control group and treatment group, repeating for four times, then the protection level was calculated. The three formulas of lotion fulfilled both physical and chemical requirements and had a repellent activity of above 80%. The formulae of F3, a lotion containing both E. elatior and P. indica leaf extracts of 2:1, gave the highest protection of 88.1%.

The Kombinasi Ekstrak Kulit Buah Nanas Dan Mangga Yang memiliki Aktivitas Antioksidan Dan Inhibisi Tirosinase Krismayadi, Krismayadi; Taurhesia, Shelly; Noor, Siti Umrah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The peel of pineapple (Ananas comosus (L.) Merr.) and mango (Mangifera indica L.) contain polyphenolics that have antioxidant activity and tyrosinase inhibitor. Both of these activities are useful for skin lightening treatments. The purpose of this study was to determine the value of the antioxidant and tyrosinase inhibitor activity of each pineapple peel extract (EKBN) and mango peel extract (EKBM), and their combination with a ratio of 2:1; 1:1; 1:2. The combination that gives the best value for antioxidant activity and tyrosinase inhibitor may be made for cosmetic preparations. The antioxidant activity of each extract and its combination was determined by the DPPH method, after the antioxidant IC50 value was obtained, then the tyrosinase enzyme inhibitory activity was tested. The results showed that EKBN; EKBM; the combination of EKBN and EKBM with a ratio of 2:1, 1:1, 1:2 has antioxidant activity with IC50 values: 618.42 ppm, 10.29 ppm, 30.73 ppm, 20.20 ppm and 18.04 ppm, has tyroinase inhibitory activity with IC50 of 5,019.98 ppm, 930.85 ppm, 1.992.31 ppm, 2.070.89 ppm and 2.839.75 ppm, respectively. There is a correlation between the IC50 of the combined extract and its weight. the combination of EKBN and EKBM, 1:2 gave the best antioxidant activity results with an IC50 value of 18.04 ppm (very strong) and the combination of EKBN and EKBM, 2:1 gave tyrosinase inhibitory activity with an IC50 value of tyrosinase 1.992.31 ppm. The combination of EKBN and EKBM, 1:2 may be developed further as cosmetic preparations such as serum, liquid spray, and others.

In vitro assessment of antioxidant and photoprotective activities of torch ginger leaf extract (Etlingera elatior (Jack.) R.M.Sm.) Taurhesia, Shelly; Kristanty, Yosepha; Winsari, Crisya
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30650

The torch ginger plant (Etlingera elatior (Jack) R.M.Sm.) is a member of the Zingiberaceae family and is frequently called kecombrang in Java. This plant has been used as a traditional medicine and food flavor enhancer but is limited as a cosmetic ingredient. Flavonoids and phenolic compounds are examples of secondary metabolites found in this plant. Most flavonoid compounds show sunscreen activity due to the chromophore groups (conjugated single double bonds) capable of absorbing UV A and UV B radiation. According to BPOM Decree No. 17/2022, only listed ingredients in Annex 4 are considered as UV filters but natural herbal compounds with antioxidant properties are applied as sunscreens. This study focused on the in vitro assessment of antioxidant and photoprotective activity from E. elatior leaf extract. First, extracting a 70% ethanol extraction of torch ginger leaves, then evaluated the extract’s quality, its antioxidant activity via the DPPH assay, and its in-vitro photoprotective activity using a UV spectrophotometer. The results showed that the extract from E. elatior leaves possesses remarkably strong antioxidant properties, as shown by its IC50 value of 47.46 μg/mL, and the extract at concentration of 1000 μg/mL provided photoprotection activity calculated as an SPF of 24.05 (ultra protection), erythema transmission value of 1.18% (extra protection) and pigmentation transmission value of 3.49% (total block). It can be concluded that torch ginger leaf extract has high potential as a cosmetic natural ingredient because of very strong antioxidant activity and photoprotective ultra protection.

Formulasi dan Uji Aktivitas Antioksidan Krim Kombinasi Ekstrak Biji Kopi Hijau (Coffea canephora var Robusta) dan Ekstrak Daun Teh Hijau (Camellia sinensis (L.)) Lamsari, Lamsari; Taurhesia, Shelly; Djamil, Ratna
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 10 No. 2 (2023): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v10i2.5082

Kopi robusta mengandung senyawa alkaloid, flavonoid, saponin, tanin, kafein dan fenol, sedangkan daun teh hijau mengandung senyawa katekin. Senyawa fenol pada kopi dan katekin pada daun teh hijau memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengembangkan formulasi krim dari kombinasi ekstrak biji kopi hijau dan daun teh hijau, yang memiliki aktivitas antioksidan. Biji kopi hijau diekstraksi secara maserasi kinetik menggunakan pelarut kombinasi Isopropanol : air (60:40) sedangkan daun teh hijau diekstraksi dengan pelarut Etanol 70%. Setelah diperoleh ekstrak kental, kemudian dilakukan uji mutu ekstrak serta uji aktivitas antioksidan menggunakan metode DPPH. Nilai IC50 ekstrak biji kopi hijau (EBKH) adalah 22.37 ppm, ekstrak daun teh hijau (EDTH) adalah 7.02 ppm, sedangkan kombinasi EBKH : EDTH (1:1) adalah 11.59 ppm. Kemudian dikembangkan formula krim mengandung kombinasi kedua ekstrak dengan variasi perbandingan EBKH : EDTH = 1:2 (F1) ; 1:1 (F2) dan 2:1 (F3). Diperoleh Krim tipe M/A, berwarna putih kekuningan, berbau khas, tekstur lembut, homogen, rentang pH 7.3 – 7.5, viskositas 190.000 – 205.000 cPs, diameter daya sebar 5.9 – 6.3 cm, dan nilai aktivitas antioksidan tertinggi diperoleh dari F1 sebesar 25.62 ppm. Ketiga formula stabil pada suhu 40 °C selama 4 minggu penyimpanan, dan hasil uji iritasi menunjukkan F2 memberikan respon iritasi sangat ringan.

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