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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Berajah Journal JIFI (Jurnal Ilmiah Farmasi Imelda) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Journal of Innovative and Creativity The Journal General Health and Pharmaceutical Sciences Research Compromise Journal : Community Proffesional Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Siti Rufaidah Jurnal Kesehatan Sundaram
Devina Chandra
Universitas Sari Mutiara Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FORMULASI DAN EVALUASI SEDIAAN KRIM DARI TUMBUHAN SUKU ANNONACEAE SEBAGAI ANTIOKSIDAN Devina Chandra; Manumpak Irianto Tampubolon; Dumartina Hutahuruk; Manahan Situmorang; Della Meidyanta; Mariam Kausar; Natasya Elisabet; Febfi Niken
Berajah Journal Vol. 7 No. 1 (2026): Berajah Journal
Publisher : CV. Lafadz Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/bj.v7i1.718

Abstract

Free radicals contribute to oxidative stress, premature aging, and degenerative diseases, while extracts from plants of the Annonaceae family are rich in flavonoids, polyphenols, and alkaloids with strong antioxidant properties. This study aimed to systematically review the formulation, physicochemical characteristics, stability, and activity of topical cream preparations containing Annonaceae plant extracts based on literature published between 2020 and 2025, as well as to identify the most optimal formulation. A systematic literature review following PRISMA guidelines was conducted using Google Scholar and SINTA databases, yielding 10 eligible articles from an initial 100 after duplicate removal and screening, with inclusion criteria covering ethanol maceration extraction, oil-in-water formulations, evaluation of pH, viscosity, spreadability, and DPPH antioxidant testing. The results showed that the creams were stable (pH 5.2–7.0, viscosity 18,000–50,000 cPs, spreadability 4.9–6.4 cm, oil-in-water type, non-irritating), with dose-dependent IC₅₀ values ranging from 10.91 to 88.73 ppm, indicating strong to very strong antioxidant activity (p < 0.05), leading to the conclusion that Annonaceae plant extracts have promising potential as stable active ingredients in optimal topical cream formulations.
Uji Efektivitas Ekstrak Etanol Kulit Jagung (Zea mays L.) Sebagai Antihiperglikemia Pada Mencit (Mus musculus L.) Yang Diinduksi Sukrosa Manuppak Irianto Tampubolon; Devina Chandra; Kesaktian Manurung
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1791

Abstract

Introduction: Hyperglycemia is a metabolic disorder characterized by elevated blood glucose levels and serves as a primary risk factor for diabetes mellitus and its associated complications, including cardiovascular disease, nephropathy, neuropathy, and retinopathy. Corn husk (Zea mays L.) contains flavonoid compounds that exhibit antihyperglycemic activity through inhibition of α-amylase and α-glucosidase enzymes. Objective: This study aimed to identify the presence of flavonoids in corn husk simplicia and evaluate the antihyperglycemic effectiveness of corn husk ethanol extract in sucrose-induced male mice (Mus musculus L.). Methods: An experimental design was employed using 25 male mice randomly assigned into five treatment groups (n=5): negative control (0.5% Na-CMC), positive control (glibenclamide 0.013 mg/20 g BW), and corn husk ethanol extract at concentrations of 10%, 20%, and 40% (equivalent to 500, 1000, and 2000 mg/kg BW, respectively). Hyperglycemia was induced by oral administration of sucrose solution at a dose of 0.81 g/20 g BW. Fasting blood glucose levels were measured at 0, 30, 60, 90, and 120 minutes using a glucometer. Phytochemical screening was performed to detect flavonoid compounds. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (α=0.05). Results: Phytochemical screening confirmed the presence of flavonoids in the ethanol extract. Statistical analysis revealed that extract concentrations of 10% and 20% did not produce significant antihyperglycemic effects (p>0.05). In contrast, the 40% concentration significantly reduced fasting blood glucose levels compared to the negative control (p=0.049), with a percentage reduction of 42.50% at 120 minutes. The glucose-lowering effect of the 40% extract was comparable to that of the glibenclamide positive control (p=0.821). Conclusion: Corn husk ethanol extract demonstrates antihyperglycemic potential in sucrose-induced mice, with the 40% concentration exhibiting the most effective glucose-lowering activity, comparable to glibenclamide. Further studies are warranted to elucidate the molecular mechanisms and conduct clinical trials in humans.
FORMULASI DAN UJI AKTIVITAS SEDIAAN GEL EKSTRAK DAUN KIRINYUH (Chromolaena odorata L.) SEBAGAI PENYEMBUH LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rathus norvegicus) Monica Suryani; Devina Chandra; Peri Peri; Rahma Yuliza
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 10 No. 1 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v10i1.2460

Abstract

In previous research, kirinyuh leaf extract was developed into a gel formulation as an alternative form that is easier to use. The purpose of this study is to formulate Chromolaena odorata leaf extract into a gel, and to evaluate the physical properties of the gel as well as its wound-healing efficacy at various extract concentrations.. F0 without extract, F1 with 5% extract, F2 with 10% extract, and F3 with 15% extract were the four formulations that were created. The formulations organoleptic qualities, homogeneity, spreadability, pH, viscosity, and physical stability were assessed. 24 male Wistar rats with incision wounds seen on days 1, 3, 6, 9, 12, 15, 18, and 21 had their wound-healing activity evaluated. Every formulation had the same spreadability (5–7 cm), pH (4.0–6.0), and viscosity (5,600–10,400 cPs). The formulations remained physically stable during testing. F3 showed the fastest wound reduction, reaching 0.45 cm on day 12 and complete closure on day 18. The gel containing Chromolaena odorata L. leaf extract met the physical quality requirements based on organoleptic properties, homogeneity, pH, spreadability, viscosity, and cycling test, with the preparations remaining homogeneous and stable. Formula F3, containing 15% leaf extract, demonstrated the most effective wound-healing activity, achieving complete wound closure on day 18.
Co-Authors Agus Hardianssah Tafonao Alya Izzani Anisa Hutagalung Betharina Br Tarigan Cidalia Carol Da Conceição Branco Cut Masyithah Thaib Della Meidyanta Dumartina Hutahuruk Evi Astiani Lase Fanny Asdian Febfi Niken Febriana Rianti Siagian Fridelly Mairani Kesaktian Manurung Lidya Revangelina Maharani Maharani Mahlia Puja Manahan Situmorang Mannupak Irianto Tampubolon Manumpak Irianto Tampubolon Manuppak Irianto Tampu Bolon Manuppak Irianto Tampubolon Mariam Kausar Masinia Zai Monica Suryani Monica Suryani Muhammad Ridha Taftanzani Muhammad Samsuri Natanael Priltius Natasya Elisabet Nayla Artika Wulandari Peri Peri Rahma Yuliza Rahmah Rahmah Risa Setiani Sefin Simanihuruk Steven Tandiono Syukur Berkat Waruwu Universitas Sari Mutiara Indonesia