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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Biologi Tropis Dinamisia: Jurnal Pengabdian Kepada Masyarakat JFL : Jurnal Farmasi Lampung Tirtayasa Medical Journal Innovative: Journal Of Social Science Research Tirtayasa Medical Journal
Titin Sulastri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect of HPMC and PVP Bases on the Formulation of Physical Properties and Transdermal Stability of Patch Estrak leaves of Jarak Pagar (Jatropha curcas L.) Makkayu, Juand Valentino; Suwitono, Marvel Reuben; Sulastri, Titin
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8783

Abstract

Open wounds are tissue damage that increases the risk of infection and requires proper treatment. Castor leaves (Jatropha curcas L.) contain flavonoids, saponins, and tannins, which have anti-inflammatory and antiseptic properties, aiding in tissue regeneration and infection prevention. To enhance its effectiveness, the extract is formulated into a transdermal patch, allowing direct drug absorption through the skin with stable release and convenient application. This study aims to determine the best formulation and optimal concentration of Hydroxypropyl Methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) in transdermal patches to improve stability and release effectiveness of the active compounds from castor leaf extract while evaluating their potential in accelerating wound healing. The transdermal patches were prepared using three variations of HPMC and PVP concentrations: F1 (HPMC 1 g : PVP 0.5 g), F2 (HPMC 0.75 g : PVP 0.75 g), and F3 (HPMC 0.5 g : PVP 1 g). Evaluations included organoleptic tests, pH, thickness, folding endurance, and moisture absorption. The results showed that F1 was the optimal formulation, exhibiting favorable physical characteristics and meeting the required standards, as it had the best mechanical properties with higher folding endurance, optimal thickness, and uniform weight distribution, ensuring better flexibility, durability, and stability. These findings indicate that variations in HPMC and PVP concentrations significantly affect the formulation and stability of transdermal patches, with F1 being the most effective formulation for potential wound healing applications.
Skrining Fitokimia Dan Aktivitas Antioksidan Ekstrak Bunga Mawar (Rosa damascene Mill) Sinambela, Romisna Wati; Sulastri, Titin; Suwitono, Marvel Reuben; Turuallo, Duma
Innovative: Journal Of Social Science Research Vol. 4 No. 4 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i4.14239

Abstract

Bunga mawar (Rosa damascena Mill.) telah lama dikenal memiliki berbagai manfaat bagi kesehatan. Penelitian ini bertujuan untuk mengungkap potensi antioksidan bunga mawar melalui skrining fitokimia dan uji aktivitas antioksidan. Hasil skrining fitokimia menunjukkan bahwa ekstrak bunga mawar mengandung senyawa bioaktif seperti Saponin, Tanin, Fenolat, Terpenoid, dan Flavonoid yang memiliki aktivitas antioksidan yang signifikan. Pengujian daya hambat antioksidan menggunakan metode DPPH menghasilkan nilai konsentrasi hambat (IC50) sebesar 32,37%. Temuan ini mendukung pemanfaatan bunga mawar sebagai bahan alami tradisional untuk pengobatan dan kosmetik. Penelitian lebih lanjut diperlukan untuk mengisolasi dan mengkarakterisasi senyawa aktif serta mengevaluasi potensi aplikasinya dalam produk kesehatan dan kecantikan.
Instant Red Ginger Drink Making Training to Increase Family Immunity and Economy in Cihanjuang Rahayu Village: Pelatihan Pembuatan Minuman Jahe Merah Instan untuk Meningkatkan Imunitas dan Perekonomian Keluarga di Desa Cihanjuang Rahayu Sulastri, Titin; Suwitono, Marvel Reuben
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 9 No. 2 (2025): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v9i2.23684

Abstract

Pengabdian masyarakat ini dilakukan di Desa Cihanjuang Rahayu dengan tujuan meningkatkan pengetahuan kader PKK sebanyak 62 orang tentang manfaat jahe merah serta pengolahannya menjadi minuman instan yang sehat. Metode yang digunakan meliputi seminar, pelatihan, dan evaluasi menggunakan kuesioner untuk mendapatkan umpan balik yang konstruktif dari peserta. Hasil menunjukkan peningkatan pengetahuan peserta sebesar 84%, yang mengindikasikan keberhasilan program ini. Selain itu, produk jahe merah instan diterima dengan baik oleh peserta berdasarkan uji organoleptik, dengan persentase 76%. Peserta juga melihat bahwa pelatihan ini bermanfaat (89%) untuk memperluas pengetahuan mengenai jahe merah sebagai bahan kesehatan, meningkatkan imunitas masyarakat, dan mendorong pengembangan ekonomi desa melalui produk lokal yang berkualitas. Dengan demikian, kegiatan ini tidak hanya meningkatkan pengetahuan, tetapi juga berkontribusi positif terhadap kesejahteraan masyarakat setempat.
Formulation and Physical Evaluation of Ointment Containing Ageratum conyzoides L. Leaf Extract as a Herbal Medicine Mailani, Senfia Liberti; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10687

Abstract

Babadotan leaves (Ageratum conyzoides L.) are a plant that has long been used in traditional medicine due to their anti-inflammatory, antibacterial, and wound healing properties. This study aims to formulate and evaluate ointment preparations containing babadotan leaf extract as a herbal medicine. This study used a descriptive method in the laboratory and described the tests obtained. The extract was obtained through maceration using 96% ethanol solvent. Formulation evaluation included organoleptic tests, homogeneity, pH, spreadability, adhesiveness, and viscosity. The results showed that formulations F1, F2, and F3 were yellowish green with a distinctive smell of babadotan leaves and were solid because they contained thick babadotan leaf extract. All ointment formulations had homogeneous properties, indicated by the absence of coarse grains in the ointment. The spreadability of formulas F2 and F3 met the criteria, while F1's spreadability was slightly below the lower limit. All three formulas had higher adhesiveness than the standard. The pH values of F2 and F3 were within normal limits and safe to use, while F1 was slightly more alkaline but still acceptable for topical use. All formulas were within the appropriate range for ointments, namely 2,000–50,000 cp. In conclusion, the ointment formulation based on babadotan leaf extract has the potential to be an effective herbal remedy and can be further developed in the pharmaceutical field.
Formulation and Physical Stability of Ointment Preparation Ethanol Extract of Piper betle L Taryono, Ribka Mutiara; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10706

Abstract

Betel leaves are commonly used to treat mouth ulcers, eliminate body odor, itching, burns, and vaginal discharge. Inflammation is the body's natural protective response to tissue damage caused by physical trauma, exposure to harmful chemicals, or microbial infection. This study aimed to formulate and evaluate the physical stability of ointment preparations containing ethanol extract of Piper betle L. Three types of ointment bases hydrocarbon, absorption, and water-soluble were developed using 8.67 g of Piper betle extract. The formulations were assessed for organoleptic characteristics, homogeneity, pH, adhesion, spreadability, and viscosity. The extraction process yielded 26.92 g of thick extract (13.5%), with active compounds such as essential oils, alkaloids, flavonoids, tannins, and saponins known for their anti-inflammatory properties. Evaluation results showed that all formulations had a semi-solid consistency, homogeneous texture, and stable color and odor. The pH of all samples was 5, within the safe range for topical use. The water-soluble base exhibited the highest adhesion (6.46 seconds) and spreadability (6.53 cm), while the absorption base exhibited the highest viscosity (8,604 mPa·s). These results indicate that all ointment formulations met the required physical standards and were stable during storage. The ethanol extract of Piper betle L. can therefore be developed as a safe and effective herbal topical anti-inflammatory preparation.
EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN RAWAT INAP DENGAN INFEKSI SALURAN PERNAPASAN AKUT DI SALAH SATU RUMAH SAKIT DI KOTA BANDUNG: EVALUATION OF ANTIBIOTIC USE IN HOSPITALIZED PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTIONSAT A PRIVATE HOSPITAL IN BANDUNG Pamula, Tira Pala’langan; Allo, Duma Turu; Sulastri, Titin
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/96fxg731

Abstract

Infeksi Saluran Pernapasan Akut (ISPA) merupakan salah satu penyakit infeksi dengan angka kejadian dan kematian yang tinggi di Indonesia, terutama pada kelompok usia anak dan balita. Penggunaan antibiotik yang tidak tepat dalam terapi ISPA dapat menyebabkan resistensi bakteri, peningkatan biaya perawatan, dan menurunkan efektivitas pengobatan. Penelitian ini bertujuan untuk mengevaluasi pola penggunaan antibiotik pada pasien rawat inap dengan ISPA di salah satu rumah sakit di Kota Bandung. Jenis penelitian ini adalah deskriptif non-eksperimental dari data rekam medis pasien periode Januari–Maret 2025. Sebanyak 201 data pasien dianalisis berdasarkan karakteristik demografis, golongan dan jenis antibiotik, rute pemberian, serta diagnosis klinis. Hasil menunjukkan bahwa pasien laki-laki mendominasi (56,72%), dan kelompok usia balita (0–5 tahun) merupakan kelompok terbanyak (83,08%). Golongan antibiotik yang paling banyak digunakan adalah sefalosporin generasi ketiga (62,00%), terutama Cefotaxime (40,80%) dan Ceftriaxone (15,42%). Rute intravena digunakan pada 68,7% pasien dengan efektivitas terapi mencapai 100%. Diagnosis terbanyak adalah Bronkopneumonia (80,6%). Hasil ini menunjukkan bahwa penggunaan antibiotik di rumah sakit tersebut sudah sesuai dengan kondisi klinis pasien, meskipun diperlukan evaluasi berkala untuk mencegah resistensi antibiotik.
Development of a Topical Gel Preparation with Joastic Plant (Jatropha curcas L) Leaf Extract and White Turmeric (Curcuma zedoaria) as Anti-Inflammatory Anggelia, Anggelia; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10828

Abstract

The development of a topical gel preparation with (Jatropha curcas L). joastic plant leaf extract and (Curcuma zedoaria) white turmeric aims to produce a product with optimal anti-inflammatory activity. This study involves the formulation of the gel with a combination of extracts from these two plants, which were extracted using ethanol as a solvent. Organoleptic tests for F1, F2, and F3 revealed a deep green gel with the distinctive odor of Jatropha leaves and White Turmeric, and a semi-solid gel. Homogeneity tests showed that F1, F2, and F3 were evenly distributed without any coarse grains. Meanwhile, pH tests for F1 (5), F2 (5.67), and F3 (6.33) met the pH standard for safe use on the skin. Viscosity tests for F1 (8.584cps), F2 (8.604cps), and F3 (8.666cps) indicated a good gel viscosity range. The spreadability test was conducted to measure the gel's ability to spread on the skin surface, while the adhesion test assessed the length of time the gel adhered to the skin with results of F1 5.23cm; F2 5.36cm and F3 5.71cm. The results of the F1 adhesion test were 3 seconds; F2 5 seconds and F3 9.33 seconds. Overall test results showed that the formulated gel had good physical properties, with an appropriate pH, stable viscosity, and satisfactory spreadability and adhesion. These findings suggest that the topical gel containing (Jatropha curcas L) and (Curcuma zedoaria) extracts holds potential as an alternative for topical anti-inflammatory treatment.
Preparation and Quality Evaluation of Lip Balm Using Aloe Vera Gel Yanti, Rut Damai; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10831

Abstract

Aloe vera has been used for generations, and its mucilage has been shown to contain 75 beneficial active compounds. This study aimed to formulate and evaluate the physical stability of lip balm preparations containing Aloe vera gel. This study included laboratory experiments with a formulation and evaluation approach to lip balm preparations. Organoleptic evaluation showed that all formulations exhibited a stable semi-solid texture with consistent color and aroma. Homogeneity tests ensured that each preparation was evenly mixed without any coarse particles. All formulations were within the physiological pH range of the skin suitable for topical use. All formulations showed a melting point of 50°C, consistent with the basic characteristics of standard lip balms. Hedonic tests showed varying levels of panelist preference across all formulations in terms of ease of application (F3) (4.2); aroma (F3) (4.3); and physical appearance (F3) (4.2). Overall, the aloe vera gel-based lip balm formulations exhibited good physical stability and acceptable sensory characteristics, indicating their potential to be developed as natural lip care products.
The Effect of Variations in Babadotan Leaf Extract Concentration (Ageratum conyzoides L.) on the Physical Properties and Stability of Topical Gel Preparations as an Anti-Inflammatory Sundari, Vivin; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10832

Abstract

Abstract:  Inflammation is a body defense response to antigen exposure, infection, cell damage, allergens, irritants, and injury. The antibacterial activity of babadotan leaves can prevent inflammation due to microbial infections. This study aims to create and evaluate a topical gel preparation containing babadotan leaf extract (Ageratum conyzoides L.) as an anti-inflammatory agent. Babadotan leaf extract was obtained through a maceration method using 96% ethanol. The resulting gel preparation was then evaluated through various tests, including homogeneity, organoleptic properties, adhesiveness, spreadability, pH, and viscosity. The results of the study obtained a homogeneity test for all gel formulas were uniform. The organoleptic results of the gel had a distinctive odor of babadotan leaves, a thick, slightly sticky texture. The spreadability test found a range of 5.5-6.6 cm where the gel had good consistency. The adhesiveness test met the requirements of F1 5 seconds; F2 6 seconds; F3 9 seconds. The pH test F1 6.2; F2 6.0; F3 5.8. And the viscosity test F1 8.431 mPa·s; F2 8.604 mPa·s; F3 8.792 mPa·s, for aroma, F1 and F2 received a positive response (70–90% of panelists liked it). The conclusion is that the gel preparation containing babadotan leaf extract has good physical properties and shows stability during storage under various conditions.
Co-Authors Allo, Duma Turu Anggelia, Anggelia Aris Ma’ruf Desi Trisnawati En Purmafitriah Evi Fatmi Utami Fernanda Desmak Pertiwi Firman Rezaldi Firman Rezaldi Happy Sevday Sihotang Hari Hariadi Kusumiyati M. Fariz Fadillah Mailani, Senfia Liberti Makanoneng, Dawna Stacey Derose Makkayu, Juand Valentino Marvel Reuben Suwitono Pamula, Tira Pala’langan Purmafitriah, En Ratu, Renike Lyana Monalisa Rina Nurmaulawati Sarumpaet, Ines Rianty Sinambela, Romisna Wati Siska Dwi Anggraeni Sugito, Esther Shirley Sundari, Vivin Susanti Erikania Tampubolon, Stephanie Angelica Rinjani Taryono, Ribka Mutiara Turuallo, Duma Utami, Evi Fatmi Yanti, Rut Damai