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All Journal Indonesian Journal of Pharmaceutical Science and Technology Indonesia Natural Research Pharmaceutical Journal (INRPJ) Pharmacy Action Journal Sciences of Pharmacy Scientica: Jurnal Ilmiah Sains dan Teknologi Seroja Husada: Jurnal Kesehatan Masyarakat
Rahmi Hutabarat
Universitas 17 Agustus 1945 Jakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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FORMULATION OF FILM SOAP CONTAINING 96% ETHANOL EXTRACT OF ARECA NUT (Areca catechu L.) AND ANTIMICROBIAL ACTIVITY TEST AGAINST Candida albicans Linawaty, Linawaty; Septiyani, Anisah; Hutabarat, Rahmi
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.8741

Abstract

Vaginal infections causing leukorrhea (fluor albus) are a major reproductive health issue affecting many women, with the prevalence of Candida albicans fungal infections reaching 25–50%. Areca nut (Areca catechu L.) seeds are known to possess antimicrobial properties. This study aimed to develop a film soap formulation using 96% ethanol extract of areca nut seeds and to evaluate its antimicrobial effectiveness. The research was conducted experimentally in the laboratory, including sample collection and identification, preparation of 96% ethanol extract of areca nut seeds, and testing of antimicrobial activity against Candida albicans using the disk diffusion method. The results showed that the 96% ethanol extract of areca nut seeds contained several phytochemical compounds, including alkaloids, flavonoids, saponins, tannins, phenols, triterpenoids/steroids, and glycosides. Evaluation of the film soap included organoleptic tests, homogeneity, thickness measurement (0.13–0.4 mm), pH determination (4.67–5.00), and foaming ability (1.3–1.8 cm), all of which met the required standards. However, water content (36.45–43.40%) and weight uniformity (0.26–0.39 g) did not meet the requirements, indicating the need for further optimization. The antimicrobial activity test of the film soap showed average inhibition zone diameters at extract concentrations of 0%, 2.5%, 3%, and 3.5% were 10.4 mm, 15.3 mm, 17.4 mm, and 20.8 mm, respectively. These values indicated moderate to strong antimicrobial activity. The optimal concentration of antimicrobial film soap from areca nut extract was found at 3.5% (F3), as demonstrated by the inhibition zone diameter of 20.8 mm. This study concludes that the 96% ethanol extract of areca nut seeds can be formulated into film soap with antimicrobial activity comparable to that of the positive control.
Co-Authors Aileen Tanuwijaya Anton Bahtiar Guanse, Yovi Herman Suryadi Idrus, Alfandi Pratama Linawaty, Linawaty Losari, Ririn Putri, Hervita Resmi, Juniar Kalpika Septiyani, Anisah Silvia Surini Sitoastri, Karina Wahyu Theodorus Rexa Handoyo Wijaya, Bagas Eva Yuniarti, Mauliah