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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Farmako Bahari ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Dina Permata Wijaya
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Sriwijaya University Jl. Raya Palembang-Prabumulih Km. 32, Indralaya, Sumatera Selatan, 30662, Indonesia
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Accute Toxicity of Extract From Melinjo (Gnetum Gnemon L) Leaf With Fixed Dose Procedure Method Herlina Herlina; Annisa Amriani; Dina Permata Wijaya; Ayu Adelia Lestari
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33683

Abstract

Melinjo leaves has several benefits as antidiabetic, antihyperglycemia, antioxidant and diuretic. In this experiment the acute toxicity test of ethanol extract of melinjo (Gnetum gnemon L). leaves on male white rats of wistar strain with fixed dose procedure method. The result of the screening of the phytochemical showed that the leaves of beluntas contained alcaloid, flavonoid, saponin, fenolic, and tanin. Ethanol extract of melinjo leaves was obtained by maceration using ethanol 70%. From the observational study, the dose 2000 mg/kg BW was chosen as starting dose for the main study. Experimental animal subject used in the main study were 10 male white rats of wistar which were divided into 2 group, normal group and treatment group with a dose of 2000 mg/kgBW. The result showed that there were no death or toxicity sign in all experimental animals. During the 14 days observation period, there were no significant changes in body weight of rats either in normal control group and treatmen group with a dose of 2000 mg/kg BW (p>0.05). Melinjo leaves had no effect on the macroscopic organs of liver, kidneys and heart of the test animals (p>0.05). The average level of biochemical parameters in the normal group is SGOT 54.13±11.428 U/L, SGPT 47.476±21.655 U/L, creatinine 0.632±0.199 mg/dL, and urea 14.46±2.267 mg/dL, while the 2000 mg/kg BW dose group is SGOT 60.192±14.198 U/L, SGPT 55.968±22.998 U/L, creatinine 0.756±0.204 mg/dL, and urea 16±2.561 mg/dL. It showed that the ethanol extract of melinjo leaves with a dose of 2000 mg/kgBW are the category of practically non-toxic.
Preparation and Characterization of Petai Pods Extract (Parkia speciosa Hassk.) Loaded Ethosomes Fitrya Fitrya; Najma Annuria Fithri; Annisa Amriani; Annisa Haryati; Dina Permata Wijaya
Science and Technology Indonesia Vol. 6 No. 1 (2021): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.739 KB) | DOI: 10.26554/sti.2021.6.1.19-24

Abstract

Preparation of petai pods extract (Parkia speciosa) into ethosome aim to increased penetration through the skin. The method of cold is used in preparing petai pods extract encapsulation by ethosome with variation in concentration of soya lecithin, propylene glycol, and ethanol. The proportion of optimum formula ethosome consisted were 0,2 g soya lecithin, 1 ml propylene glycol, and 4 ml ethanol that response values obtained pH of 4,74, viscosity of 0,950 cP, %EE of 74,326%, and stability of 7,288%. The resulted of optimum formula obtained were PDI of 0,23, zeta potential of -7,5 mV, and particle size of 818,7 nm. Ethosome showed spheric particle using Transmissin Electron Microscopy. The diffusion analysis showed highest on ethosome of petai pods extract (9,525%) than petai pods extract (5,466%). The interaction study used FTIR show no chemical interaction extract pods and ethosome components
PENYULUHAN DAN PELATIHAN PEMANFAATAN BUNGA TELANG MENJADI PRODUK KAYA ANTIOKSIDAN UNTUK MENINGKATKAN KESEHATAN DI DESA ULAK KERBAU BARU TANJUNG RAJA Dina Permata Wijaya; Herlina Herlina; Dian Wahyuni; Puspa Ayu Pitayati
Jurnal Abdi Insani Vol 10 No 2 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i2.944

Abstract

Butterfly pea flower is a flower plant that can grow in the yard or can live ini the forest. Butterfly pea flowers have secondary metabolites that can be used for health, including flavonoids, phenols, anthocyanins, alkaloids, steroid triterpenoids, and flavonol glycosides. Butterfly pea flower ia a plant that has been widely consumed by the public as a functional food and beverage ingredient which has the benefit of being an antioxidant so it can improve helath. The purpose of this activity is to increase public understanding regarding the importance of improving post endemic COVID-19 by consuming antioxidant-rich foods and drinks and improving the economy in Ulak Kerbau Baru Tanjung Raja Village. Methods of community service activities in the form of counselling and providing education, product manufacturing practices, and assistance. Products made in this community service activity are jelly candy and carbonated drinks made from butterfly pea flowers. Community service activities wera carrued out in approximately 2 month for the people of Ulak Kerbau Baru Tanjung Raja Village. Prior to the practice of making jelly candy and carbonated drinks from butterfly pea flowers, the community was given material related to the use of butterfly pea flowers to improve helath because they contain lots of antioxidants. Many people in Ulak Kerbau Baru Village dont know that butterfly pea flowers can improve helath and can be used as food and drink products that taste delicious. Making simple jelly and carbonated drinks so that people can make them ath homen can also be used as products for businesses. Based on the results of this community service activity, there is an increase in public knowledge of the importance of improving health and the utilization of butterfly pea flowers into food and beverage products with a delicious taste and the community gaining skills to made jelly candy and carbonated drinks product form butterfly pea flowers.
Formulation and Characterization Liposome of Oxcarbazepine Dina Permata Wijaya; Budi Untari; Herlina Herlina; Putri Siti Rahayu
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 2 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i2.33707

Abstract

Oxcarbazepine (OXC) was used as first line therapy or additional therapy for treatment of partialand secondary of seizures. The penetration of OXC into nasal mucosa can be enhanced by formingliposome. This research has the aim to prepare and characterize iposome laoding OXC. The OXCliposome formula was composed by using soya lechitin and cholesterol with various amount usingthin film hydration method. Characterization by determining the encapsulation efficiency (%EE), pH,viscosity, particle size, polydispersity of index, zeta potential, and in vitro release. The liposome ofOXC was also analyzed for its stability based on heating-coling cycle method. The proportion of bestformula was obtained at the amount of cholesterol of 42,11 mg yield %EE of 92,63%, pH of 8,47,viscosity of 1,10 cP, and decreased amount of OXC in stability test of 0,34%. The results of particlediameter were 579 nm, polydispersity index (PDI) of 0,34, and zeta potential of -99,38 mV. The in vitrorelease of the liposome of OXC was studied and compared with OXC. The result of in vitro releaseliposome OXC (F2) ahowed increase (62,26%) than (41,97%).
Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes Fitrya Fitrya; Elsa Fitria Apriani; Adik Ahmadi; Dina Permata Wijaya; Khazanah Nurain
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37608

Abstract

Introduction: Artocarpus heterophyllus LMK. leaves contain flavonoids, tannins, and saponins, which have the potential to be antibacterial. Aims: This study aims to test the antibacterial activity of A. heterophyllus leaves ethanol extract, which is formulated in a gel preparation. Methods: Antibacterial testing was done on the acne-causing bacteria Propionibacterium acnes. The gel formula is designed with an extract concentration of 5, 10, or 15% with Carbopol 940 and HPMC as the bases. The antibacterial activity test was carried out using the well diffusion method. Result: The results of the study showed that the concentration of the extract affected pH, adhesive power, removability, and viscosity. Antibacterial activity tests showed that the gel of A. heterophyllus extract could inhibit Propionibacterium acnes bacteria. The higher the concentration of the extract, the greater the antibacterial activity. Conclusion: It can be concluded that the gel with an extract concentration of 15% gave the strongest antibacterial activity with an inhibition zone of 10.9 ± 1.18 mm.
Antibacterial Edible Coating of Ipomea batatas Incorporated with Lactobacillus acidophilus Miksusanti miksusanti; Najmatul Asriah; Indah Solihah; Dina Permata Wijaya
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v2i2.23933

Abstract

This study was conducted to analyze the effect of variations concentration of Lactobacillus acidophilus in edible coatings and their antibacterial activity against E. coli using the well diffusion method. This study used an edible coating of Prebiotic from purple sweet potato starch and Lactobacillus acidophilus with dilution variations (10-6, 10-7, 10-8, 10-9) as probiotics. In this study physical properties were tested for edible coatings such as color tests with visual observations, water content by the gravimetric method and viscosity using Viscometer Ostwald. The content of organic acids in edible coating solutions was measured using the HPLC method. Organoleptic test was conducted with taste and color parameters on the A-E scale of 30 respondents. Research results showed edible coating discoloration before and after incorporation from deep purple to brown. The value of water content and viscosity also changed from 62,8% to 71,4% and 569,97 cp to 486,64 cp respectively. The best antibacterial activity of edible coating incorporation with Lactobacillus acidophilus was 263,76 mm2. Organoleptic test on grapes that have been coated with edible coating showed that covered with edible coating contains probiotics (Lactobacillus acidophilus) has no effect on respondents' perception. Lactic acid and acetic acid were exist in edible coating which were incorporated with Lactobacillus acidophilus.
Edukasi Pemanfaatan Teh Kombinasi Sereh dan Kayu Manis untuk Pencegahan Diabetes Masyarakat Ulak Kerbau Baru Wijaya, Dina Permata; Herlina, Herlina; Liberitera, Sternatami; Starlista, Viva; Sari Wardana, Mutia
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 2 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i2.418

Abstract

Diabates merupakan penyakit sistem metabolik yang melibatkan peningkatan kadar glukosa dalam darah yang tidak terkontrol. Masyarakat banyak yang belum mengetahui terkait pengetahuan tentang penyakit diabetes melitus, pola hidup sehat, dan pemanfaatan sereh dan kayu manis sebagai tanaman yang dapat mencegah penyakit diabetes. Pengabdian kepada masyarakat ini memiliki tujuan untuk memberikan edukasi terkait penyakit diabetes dan cara pencegahan penyakit diabetes serta sosialisasi pemanfaatan tanaman sereh dan kayu manis sebagai minuman seduh berupa teh celup sebagai produk untuk pencegahan penyakit diabetes. Kegiatan pengabdian kepada masyarakat ini dilakukan di Desa Ulak Kerbau Baru. Metode pelaksanaan pengabdian kepada masyarakat ini adalah edukasi dan pelatihan pembuatan minuman seduh berupa teh celup yang berasal dari sereh dan kayu manis. Peserta yang mengikuti kegiatan pengabdian kepada masyarakat ini adalah perempuan atau ibu rumah tangga yang memiliki potensi dalam ketertarikan terhadap minuman seduh berupa teh celup yang berasal dari sereh dan kayu manis. Hasil dari kegiatan pengabdian kepada masyarakat ini menunjukkan bahwa masyarakat mengerti terkait penyakit diabetes dan pencegahan penyakit diabetes serta memiliki ketertarikan dalam mengolah sereh dan kayu manis menjadi minumah seduh berupa teh celup dan cara pengolahannya. Kegiatan ini memiliki manfaat dalam meningkatkan kesehatan dan dapat berpotensi dalam meningkatkan ekonomi masyarakat karena menghasilkan produk yang dapat dijadikan peluang usaha.
Pemberdayaan Masyarakat Dalam Pemanfaatan Daun Kelor Sebagai Langkah Pencegahan Stunting Wijaya, Dina Permata; Herlina; Viva Starlista; Sternatami Liberitera; Veriza Agistin
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 5 No. 3 (2025): Mei 2025 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v5i3.695

Abstract

Stunting merupakan permasalahan yang banyak terjadi pada anak-anak di Indonesia yang kekurangan gizi. Daun kelor memiliki metabolit sekunder dan nutrisi yang dapat dimanfaatkan untuk kesehatan. Daun kelor menjadi tanaman yang sudah banyak dikonsumsi oleh masyarakat sebagai makanan fungsional sehingga dapat menjadi bahan untuk mencegah stunting. Kegiatan pengabdian masyarakat ini dilakukan di Desa Burai Ogan Ilir. Metode pengabdian kepada masyarakat yang digunakan berupa edukasi berupa materi terkait pemanfaatan daun kelor serta memberikan pelatihan pembuatan gummy dari daun kelor. Berdasarkan hasil dari pengabdian kepada masyarakat yang telah dilakukan menghasilkan masyarakat yang memiliki ketertarikan terhadap makanan fungsional berupa gummy yang berasal dari daun kelor sehingga dapat dimanfaatkan untuk mencegah stunting pada anak.
Evaluasi Penggunaan Antibiotika pada Pasien Anak dengan Diare Akut Novita, Rennie Puspa; Amriani S, Annisa; Wijaya, Dina Permata; Novelia, Detri
Jurnal Penelitian Sains Vol 25, No 1 (2023)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v25i1.719

Abstract

Diare akut merupakan jenis diare berdasarkan lama waktu berlangsungnya dan dapat didefinisikan sebagai bentuk tinja yang cair dan lembek dengan jumlah lebih banyak dari normal, berlangsung kurang dari 14 hari.Tujuan dari penelitian ini adalah untuk menentukan dan menganalisis pola penggunaan antibiotika pada anak dengan diare akut yang meliputi jenis obat dan regimentasi yang digunakan serta mengevaluasi penggunaan antibiotika yaitu secara kualitatif dan kuantitatif. Penelitian ini merupakan penelitian observasional deskriptif dengan pendekatan case series yang  dilakukan pada pasien anak dengan diare akut. Evaluasi kualitatif penggunaan antibiotika dianalisis menggunakan alur kriteria Gyssen dalam kategori 0-VI dan evaluasi kuantitatif dianalisis dengan menggunakan sistem ATC/DDD yang ditetapkan oleh WHO. Kriteria inklusi adalah pasien anak dengan diare akut yang dirawat inap di RSI Siti Khadijah Palembang yang mendapat terapi antibiotika pada periode Januari 2019 sampai Desember 2019. Data yang didapatkan sebanyak 64 sampel yang memenuhi kriteria inklusi. Antibiotika yang paling banyak digunakan yaitu ceftriaxone (82,8%). Pola penggunaan antibiotika pada pasien anak dengan diare akut adalah ceftriaxone dengan dosis 20–80 mg/kgBB sehari sekali, gentamisin dengan dosis 2-5 mg/kgBB dua kali sehari, ampicilin dosis 100-200 mg/kgBB tiga kali sehari, ceftazidime 25-50mg/kgBB dua kali sehari secara intravena dan cefixime dengan dosis 10-15 mg/kgBB dua kali sehari secara per oral. Hasil evaluasi secara kualitatif menunjukkan kepatuhan penggunaan antibiotika sesuai pedoman pediatri (kategori 0) sebesar  82,8% dan konsumsi antibiotika secara kuantitatif adalah ceftriaxone (19,86 DDD/100 patient days).Kata Kunci: anak, antibiotika, ATC/DDD system, diare akut, Gyssen
OPTIMIZATION OF BUTTERFLY PEA EXTRACT PEEL-OFF MASK WITH VARIATIONS OF POLYVINYL ALCOHOL AND IOTA CARRAGEENAN USING FACTORIAL DESIGN Dina Permata, Wijaya; Shaum, Shiyan; Nabilah Putri, Hadiani; Herlina, Herlina; Mutia Sari, Wardana
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.1798

Abstract

ABSTRACT The butterfly pea flower (Clitoria ternatea) contains antioxidants that help combat premature skin aging. Peel-off masks are popular with consumers as topical formulations because they are unique and practical. An essential component of peel-off masks is the gelling agent Polyvinyl Alcohol (PVA), which acts as a film-forming agent. However, PVA at the wrong concentration can result poor mask physical properties. Combining PVA with other gelling agents can obtain peel-off masks with better physical properties. This study aims to identify the effect of PVA and iota carrageenan on the optimal formula of peel-off masks regarding physical properties, stability, and antioxidant activity. Butterfly pea flower extract was obtained by maceration in 70% ethanol. Optimization of PVA and iota carrageenan was conducted using a factorial design method, observing responses such as viscosity, spreadability, and drying time. Peel-off masks with butterfly pea flower extract were prepared with concentration variations of PVA (6%, 10%) and iota carrageenan (0.5%, 1%). The optimal formula was then tested for stability using cycling test method and for antioxidant activity using DPPH method. Increasing concentrations of PVA and iota carrageenan significantly affects viscosity, spreadability, and drying time, with a p-value < 0.05. The optimal peel-off mask formula contained 16% PVA and 0.5% iota carrageenan, with a viscosity of 16.473 cPs, spreadability of 5.6 cm, and drying time of 23 minutes and 11 seconds. The optimal formula demonstrated good stability during storage, with a significance p-value > 0.05, and was categorized as having weak antioxidant activity with an IC50 value 171.738 µg/mL.
Co-Authors Adik Ahmadi Amriani S, Annisa Angraeni, Via Annisa Amriani Annisa Amriani Annisa Haryati Annisa, Amriani Ayu Adelia Lestari Budi Untari Budi Untari Daniel Happy Putra Dian Wahyuni Elsa Fitria Apriani Fauziyah Filla Nur Oktriliansih Firana, Ario Firnando Firnando Fitrya . Fitrya Fitrya Herin, Noviarny Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Indah Solihah Khazanah Nurain Kovalina, Yosi Mardiyanto Mardiyanto Mardiyanto Mardiyanto Miksusanti Miksusanti Miksusanti Miksusanti Mustikasanti Mustikasanti Mutia Sari Wardana Nabilah Putri, Hadiani Najma Annuria Fithri Najma Annuria Fithri Najma Annuria Fitri Najmatul Asriah Novelia, Detri Novita, Rennie Puspa Puspa Ayu Pitayati Putri Siti Rahayu Regina Astryani Shaum Shiyan Starlista, Viva Sternatami Liberitera Veriza Agistin Vitri Agustiarini Viva Starlista Viva, Starlista