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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Farmako Bahari ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Dina Permata Wijaya
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Sriwijaya University Jl. Raya Palembang-Prabumulih Km. 32, Indralaya, Sumatera Selatan, 30662, Indonesia
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HYPOGLYCEMIA POTENTIAL OF ETHANOL EXTRACT OF MELINJO LEAVES (Gnetum gnemon L.) ON WISTAR MALE WHITE RATS Herlina, Herlina; Dina Permata, Wijaya; Viva, Starlista; Annisa, Amriani; Herin, Noviarny
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.2011

Abstract

Male rats were used in the study to evaluate the ethanol extract of melinjo leaf (Gnetum gnemon L.) for hypoglycemia after being given alloxan and having their pancreatic histology observed. Secondary metabolites with antidiabetic properties found in melinjo leaf include flavonoids, tannins, saponins, and phenolics. This study sought to ascertain the ethanol extract of melinjo leaves' ED50 as well as its impact on lowering blood glucose levels and monitoring pancreatic histology. The doses of melinjo leaf ethanol extract were varied to 125, 250, and 500 mg/kgBW. An insulin dosage of 1 IU/kgBW served as the positive control, a 0.5% Na CMC suspension served as the negative control, and a normal control group did not receive any therapy. Rats were tested by utilizing a DTN-410-K photometer to measure their fasting blood glucose levels on days 0, 10, 15, and 20 using the GOD-PAP enzymatic method. Hematoxylin-eosin staining was used in histopathology preparations, which were prepared in accordance with established protocols. Melinjo leaf ethanol extract dosages of 125, 250, and 500 mg/kgBW resulted in three treatment groups with corresponding the percentage of blood glucose reduction (%BGR) of 31.48, 34.39, and 42.90%, whereas the positive control had an average BGR of 40.68%. Melinjo leaf ethanol extract has an ED50 of 720.86 mg/kgBW. According to the histological image, the positive control group and the three treatment groups showed improvement, whereas the negative group's Langerhans islet endocrine cells showed necrosis. The 500 mg/kg BW dosage group shows the greatest improvement.
Optimization of oil-based liquid lipstick formula from sesame seed oil (Sesamum indicum L.) and antibacterial activity test against Staphylococcus aureus Miksusanti, Miksusanti; Wijaya, Dina Permata; Kovalina, Yosi; Wardana, Mutia Sari; Herlina, Herlina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1712

Abstract

Liquid lipstick is a type of lip color cosmetic that consumers highly favor. However, repeated use of liquid lipstick can promote the growth of Staphylococcus aureus (S. aureus) bacteria. The formulation of liquid lipstick involves several components, including a mixture of wax, oil, and other additives. Sesame seed oil (Sesamum indicum L.), incorporated into the formulation, serves as both a base and preservative due to its fatty acid content, which is expected to inhibit the growth of S. aureus bacteria. Microcrystalline wax is added to achieve a good texture and enhance the adhesion properties of the formulation. This study aimed to determine the optimum formula and evaluate the antibacterial activity of the liquid lipstick formulation. The formula was developed using a 2² factorial design method, with sesame seed oil and microcrystalline wax as variables. The optimum formula was analyzed using Design Expert® 13 software based on parameters such as viscosity, spreadability, and adhesion. The final optimum formula consisted of 70% sesame seed oil and 5% microcrystalline wax. The formulation demonstrated good stability during the cycling test, maintaining red color, vanilla and sesame-like aroma, liquid texture, and pH 5. The viscosity was 11797.51 cP, the spreadability was 6.06 cm, and the adhesion time was 64 seconds. Antibacterial activity, assessed using the disk diffusion method, yielded an inhibition zone diameter of 15±1.322 mm, indicating a strong inhibition zone. Based on the research findings, it was concluded that the optimum sesame seed oil-based liquid lipstick formula exhibited good product characteristics, stability, and strong antibacterial activity.
Co-Authors Adik Ahmadi Amriani S, Annisa Angraeni, Via Annisa Amriani Annisa Amriani Annisa Haryati Annisa, Amriani Ayu Adelia Lestari Budi Untari Budi Untari Daniel Happy Putra Dian Wahyuni Elsa Fitria Apriani Fauziyah Filla Nur Oktriliansih Firana, Ario Firnando Firnando Fitrya . Fitrya Fitrya Herin, Noviarny Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Herlina Indah Solihah Khazanah Nurain Kovalina, Yosi Mardiyanto Mardiyanto Mardiyanto Mardiyanto Miksusanti Miksusanti Miksusanti Miksusanti Mustikasanti Mustikasanti Mutia Sari Wardana Nabilah Putri, Hadiani Najma Annuria Fithri Najma Annuria Fithri Najma Annuria Fitri Najmatul Asriah Novelia, Detri Novita, Rennie Puspa Puspa Ayu Pitayati Putri Siti Rahayu Regina Astryani Shaum Shiyan Starlista, Viva Sternatami Liberitera Veriza Agistin Vitri Agustiarini Viva Starlista Viva, Starlista