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All Journal Majalah Kedokteran Bandung EJOIN : Jurnal Pengabdian Masyarakat
Endah Wahjuningsih, Endah
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Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats Pargaputri, Agni Febrina; Wahjuningsih, Endah; Andriani, Dwi
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3569

Abstract

The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active substances, promoting pathological processes. This study aimed to evaluate the correlation between the number of Kupffer cells and liver parenchymal cell damages in immunosuppressed, drug-induced rats. The study was conducted from July to December 2019 at the Oral Biology Laboratory of the Faculty of Dentistry and the Biochemical Laboratory of the Faculty of Medicine at Universitas Hang Tuah Surabaya. Twelve healthy male Wistar rats were divided into two groups: Healthy (H) and Immunosuppressed Drug-Induced (ID) groups. Immunosuppression was induced using dexamethasone (0.5 mg/day/rat), administered orally for 14 days, combined with tetracycline (1%/day/rat). Liver samples from all rats were examined for Kupffer cell count and parenchymal cell damages were assessed using a light microscope with 400x magnification. Results revealed a significant difference in the number of Kupffer cells and liver parenchymal cell damages between the H and ID groups (p<0.05). Pearson correlation analysis indicated a significant correlation between Kupffer cell number and parenchymal cell damages (p=0.000). Continuous administration of immunosuppressive drugs may activate Kupffer cells, leading to damage of liver parenchymal cells. In conclusion, the infiltration of Kupffer cells is associated with liver parenchymal cell damages, mediated by various factors in the immunosuppressed drug-induced rat model.
SPECIAL METHODS OF SCHOOL HEALTH PROGRAMME FOR SPECIAL NEEDS CHILDREN IN DENTISTRY Pranoto, Amelia Elizabeth; Wahjuningsih, Endah; Paramita, Ayulistya; Tsurayya, Nur; Wardhani, Istien; Apsari, Anindita; Puspita, Sinta; Teguh, Paulus Budi; Juniar, Eriza; Ayu, Dyah; Sarianoferni, Sarianoferni; Prameswari, Noengki; Rahardjo, Pambudi; Rizal, Mohammad Basroni; Hermanto, Eddy
EJOIN : Jurnal Pengabdian Masyarakat Vol. 1 No. 12 (2023): EJOIN : Jurnal Pengabdian Masyarakat, Desember 2023
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v1i12.2014

Abstract

School health program is a program of preventive promotional activities in the field of dentistry using the method “trainer of trainer” or abbreviated as ToT. The program is organized by the Indonesian Association of Dentists (PDGI) together with dental faculties across Indonesia as trainers and multinational company as facilitator. The goal of this program is to create a generation of a nation that will be free of tooth cavities by 2030. Teachers and parents of students with special needs are the target audience for this training, enabling them to carry out morning and night toothbrushing activities for good dental and oral health. ToT's activities include two things: giving advice to teachers and students' parents and brushing their teeth in the morning and evening for 21 days. The problem is that children with special needs do not have the same abilities as other children in terms of receiving information, responding to teaching, and applying what has been taught. Low levels of independence and varying levels of learning difficulties are challenges for trainees. Special methods in teaching morning and night toothbrush activities should be applied well to both teachers and parents of students with special needs, such as how to brush their teeth, the habits of brushing the teeth properly, the use of special brushes, and tips and tricks that can be implemented by the teacher and parents so that children with special requirements can run the program.
Co-Authors Apsari, Anindita Dwi Andriani, Dwi Dyah Ayu, Dyah Eddy Hermanto Juniar, Eriza Noengki Prameswari Pambudi Rahardjo Paramita, Ayulistya Pargaputri, Agni Febrina Pranoto, Amelia Elizabeth Puspita, Sinta Putra, Edward Perdana Rima Parwati Sari, Rima Parwati Rizal, Mohammad Basroni Sarianoferni Sarianoferni, S Tsurayya, Nur Wardhani, Istien