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All Journal English Review: Journal of English Education Jurnal Kebidanan Midwiferia REZ PUBLICA The Indonesian Biomedical Journal Jurnal Kesehatan Midwifery Journal: Jurnal Kebidanan UM. Mataram Jurnal Bidang Ilmu Kesehatan Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Pengabdian Dharma Bakti Jurnal Ners Journal of Telenursing (JOTING) Science Midwifery Jurnal Kebidanan Indonesia INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Jurnal Pengabdian Kepada Masyarakat Patikala Prosiding Seminar Nasional Program Pengabdian Masyarakat Abdi Geomedisains Jurnal Riset Kebidanan Indonesia JHeS (Journal of Health Studies) PEDAMAS (Pengabdian Kepada Masyarakat) Journal Research Midwifery Politeknik Tegal Jurnal SMART Kebidanan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Sri Ratna Ningsih, Sri Ratna
Universitas Aisyiyah Yogyakarta
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Journal : The Indonesian Biomedical Journal

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Liposome-based Nanoparticles Encapsulating Vitamin D3 Attenuate IL-6 and TNF-α in a Menopausal Mouse Model Kusuma, Baskara Wiku Adi; Dwiningsih, Sri Ratna; As’adi, Ashon; Wahyuningsih, Sri Puji Astuti
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3796

Abstract

BACKGROUND: Vitamin D3 is an essential regulator of immune function, however its bioavailability is limited. Liposomes as nanocarriers can enhance vitamin D3 absorption and delivery, however the application of liposomal vitamin D3 in postmenopausal remains underexplored, particularly in preclinical models. Estrogen deficiency during menopause promotes immune dysregulation and elevates proinflammatory cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. This study was conducted to evaluate the effects of liposomal vitamin D3 supplementation on serum vitamin D3, IL-6, and TNF-α levels in an ovariectomy-induced menopausal mouse model.METHODS: Mice were randomly divided into four groups comprising non-surgical control (N), ovariectomized without treatment (D−), conventional vitamin D3-treated (D+), and liposomal vitamin D3-treated (LD). Treatments were administered daily via oral gavage for two months. Serum vitamin D3, IL-6, and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA). IL-6 and TNF-α data were analyzed by ANOVA with Duncan’s post-hoc test, while vitamin D3 data were analyzed using the Brown-Forsythe test with Games-Howell post-hoc test (p<0.01).RESULTS: Ovariectomy significantly decreased vitamin D3 levels and increased IL-6 and TNF-α levels in the D− group. Conventional vitamin D3 supplementation (D+) significantly decreased serum vitamin D3 levels and slightly decreased IL-6 and TNF-α levels. Liposomal vitamin D3 (LD3) significantly increased vitamin D3 levels and decreased TNF-α, only slightly decreasing IL-6. Correlation analysis showed a negative association between serum vitamin D3 levels and both cytokines.CONCLUSION: Administration of vitamin D3 liposomes was able to increase vitamin D3 levels and suppress IL-6 and TNF-α towards normal levels. LD3 offers enhanced bioavailability and anti-inflammatory effects, making it a promising therapeutic strategy for managing menopause-associated inflammation and related systemic disorders.KEYWORDS: menopause, liposomal VD3, inflammation, IL-6, TNF-α
Co-Authors Adrian Tawai Al Farizi, Sofia Annisa Trissatharra, Annisa Aprilawati, Dwi Artiani, Litri Astuti, Andari Wuri As’adi, Ashon Atik Sunarmi Budi Prasetyo Dharma, Nindya Soraya Drisa, Retna Eltira Dwi Ernawati Ekaputri, Rista Erina Chintya Angraini Ermiatun Evi Nurhidayati, Evi Faradila, Naura Annisa Febriyani, Putri Agus Fitriahadi, Enny Hanifah, Lilik Haryanti, Elismi Hasanah, Atin Zulfarida Hasnita, Reni Hidamansyah, Murfi Ika Lestari Damayanti Iyen Nurlaelawati Jaelani, Lalu Muhamad jayanti, ova Johan, Reza Bintangdari Kartini, Farida Khairunnsa Kharisma, Binta Ulfatul Khulasoh, Khulasoh Kusuma, Baskara Wiku Adi Linadi Yulia Putri, Jasmin Listian, Ayu Lulu Laela Amalia Medi Tri Laksono D. Mufdlilah, Mufdlilah Murfi Hidamansyah Mutiara Putri, Intan Nirwidiarni, Hikma Sri Pohan, Sakinah Yusro Pratiwi, Cesa Septiana Purnomo Suryantoro Rabbihim, Inda Rahayu, Linda Sri Ratna Sofaria Munir, Ratna Sofaria Rosmita Nuzuliana, Rosmita Rospia, Evi Diliana Sabrina, Rania Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sulistiawati Sulistiawati Sunarmi, Atik Suyani Suyani, Suyani Taufik3, Taufik Utami, Fitria Siswi Widarni, Widarni Yayuk Puji Lestari Yusran, Sartiah Zahara, Emi Laksmi