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All Journal JCES (Journal of Character Education Society) KACANEGARA Jurnal Pengabdian pada Masyarakat JURNAL KESEHATAN PERINTIS JURNAL FARMASIMED (JFM) Jurnal Farmamedika (Pharmamedica Journal) MAHESA : Malahayati Health Student Journal Jurnal EduHealth Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) JURNAL FARMASI DAN KESEHATAN INDONESIA Folia Medica Indonesiana
Sarah Puspita Atmaja
Universitas Kristen Immanuel
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Aktivitas Antibakteri Fraksi N-Heksan, Etil Asetat, N-Butanol Daun Jambu Mete (Annacardium occidentale) terhadap Bakteri Penyebab Ulkus Diabetik (Staphylococcus aureus dan Escherichia coli) Wahyukurnia, Pilar Tesalonika; Yuhara, Novena Adi; Atmaja, Sarah Puspita
JURNAL KESEHATAN PERINTIS Vol. 10 No. 2 (2023): Jurnal Kesehatan Perintis
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33653/jkp.v10i2.1039

Abstract

Daun jambu mete (Anacardium occidentale L.) mengandung senyawa flavonoid, tanin dan saponin yang memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk mengetahui konsentrasi minimum dan perbedaan zona hambat 5%, 10%, 20% ekstrak, fraksi n-heksan, etil asetat dan n-butanol daun jambu mete pada pertumbuhan bakteri Staphylococcus aureus dan Eschericia coli. Metode fraksinasi yang digunakan adalah metode partisi. Ekstrak dan fraksi daun jambu mete dilakukan pengujian konsentrasi hambat minimum (KHM) dengan metode dilusi padat. Hasil KHM dilanjutkan dengan pengujian konsentrasi bunuh minimum (KBM). Dilakukan penapisan senyawa fitokimia dan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa terdapat perbedaan bermakna (p<0,05) antar konsentrasi ekstrak, fraksi etil asetat, n-butanol daun jambu mete terhadap diameter zona hambat pertumbuhan bakteri uji. Rata-rata terkuat diameter zona hambat bakteri S.aureus pada ekstrak 20% (14,5mm), fraksi etil asetat 20% (13,3mm), fraksi n-butanol 20% (12,23mm). Pada bakteri E.coli yaitu 20% ekstrak (10,6mm), fraksi etil asetat (15,3mm), fraksi n-butanol (9mm). Konsentrasi 5% ekstrak, fraksi etil asetat, n-butanol memiliki nilai KHM, namun tidak memiliki nilai KBM pada kedua bakteri uji. Fraksi n-heksan tidak memiliki zona hambat terhadap kedua bakteri uji. Kesimpulan dari penelitian ini fraksi N-Heksan tidak memiliki zona hambat terhadap pertumbuhan kedua bakteri, namun ekstrak, fraksi etil asetat dan n-butanol daun jambu mete mampu menghambat pertumbuhan bakteri S.aureus dan E.coli dibandingkan kontrol negatif. Zona hambat yang dihasilkan tidak lebih kuat dibandingkan kontrol positif, kecuali pada fraksi etil asetat 20% memiliki diameter zona hambat sedikit lebih besar dan berbeda namun tidak signifikan (p>0,05) dibanding kontrol positif (15,33mm vs 15mm) terhadap bakteri E.coli.
Effect of hydroxyethyl starch 200/0.5 on von willebrand factor serum level and activated partial thromboplastin time (aptt) Atmaja, Sarah Puspita; Khotib, Junaidi; Rahardjo, Eddy; Shinta, Dewi Wara; Rahmadi, Mahardian; Suprapti, Budi
Folia Medica Indonesiana Vol. 51, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hydroxyethyl starch (HES) is a colloid administered frequently for intravascular volume expansion during perioperative period. Impairment of haemostasis have been reported during HES administration, but the volume of solution administered was usually higher than 20 ml.kg-1. The objective of this study was to evaluate the effect of Hydroxyethyl starch 200/0.5 dose less than 20 ml.kg-1 on von Willebrand factor serum level and activated partial thromboplastin time. A prospective, observational study was conducted to evaluate von Willebrand factor and activated partial thromboplastin time of patients receiving Hydroxyethyl starch 200/0.5. Inclusion criteria were patients undergoing elective surgery who were going to receive Hydroxyethyl starch 200/0.5 intraoperatively. Fourty six patients were divided into patients receiving crystalloid only group (n=23 patients) and hydroxyethyl starch (n=23 patients). Coagulation variables were assesed 30 minute after insicion and 60 minute after infusion of crystalloid or colloid. Measurement of von Willebrand within each group after crystalloid or HES 200 infusion showed significant decrease, from (mean±SE) 97.688±15.219 ng/ml to 31.611±10.058 ng/ml (p< 0.001) in crystalloid group and 92.884±15.208 ng/ml to 27.378±6.399 ng/ml (p<0.001) in HES 200 group. Activated partial thromboplastin time change was statistically significant (mean±SE) 31.27±1.39 to 35.61±1.62 in HES group only (p=0.007), but this change was not clinically significant. In conclusion, there was neither significant difference in von Willebrand serum level nor in activated partial thromboplastin time between the two groups. There was no coagulation influence with clinically significant effect in the use of HES 20 ml/kg BW in patients undergoing elective surgery.
Co-Authors Ari Widhiarso Budi Suprapti Dewi Wara Shinta Eddy Rahardjo Ellsya Angeline Rawar Estevany Priliansi Felik Felik Grace Joy Christiani Happy Elda Murdiana, Happy Elda Junaidi Khotib Kusumiati, Marna Laka, Lusiana Cindy Putri Lea Oktavining Tyas Losi Yenni Florindha Luon, Magdalena Ohe Mahardian Rahmadi Marna Kusumiati Nikasius Jonet Sinangjoyo Novena Adi Yuhara Soegiantoro, Didiek Hardiyanto Wahyukurnia, Pilar Tesalonika Yosua Adi Kristariyanto