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All Journal Sari Pediatri Paediatrica Indonesiana FIRM: Journal of Management Studies PREPOTIF : Jurnal Kesehatan Masyarakat JOURNAL LA MEDIHEALTICO Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Theresia Santi, Theresia
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Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Paediatrica Indonesiana

 1 
Evaluation of anti-diphtheria toxoid antibody persistence in school-age children in Jakarta, Indonesia Santi, Theresia; Prayitno, Ari; Munasir, Zakiudin; Hadinegoro, Sri Rezeki S.; Harahap, Alida Roswita; Werdhani, Retno Asti; Sah Bandar, Ivo Novita; Jo, Juandy; Hegar, Badriul
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.447-53

Abstract

Background Diphtheria can be effectively prevented by adequate immunization. A combined vaccine against diphtheria toxoid, pertussis, and tetanus toxoid (DPT) is currently used in routine pediatric immunizations. Outbreaks of diphtheria could emerge in Indonesia as a consequence of declining routine vaccination during the COVID-19 pandemic. Objective To analyze the impact of the first (administered at 18-24 months of age ) and second diphtheria boosters (administered at 5-7 years of age ) in retaining protective levels of anti-diphtheria toxoid antibodies. We also investigated for relevant factors associated with anti-diphtheria toxoid antibody titers. Methods This cross-sectional study was conducted in the Senen District of Jakarta, Indonesia. The inclusion criteria were healthy children aged 6 to 7 years with documented history of DPT vaccination. Primary vaccination defined as 3 doses of DPT at age less than 1 year , first booster was DPT vaccination at 18-24 years of age, and second booster was diphtheria-tetanus (DT) vaccination received at 5 to 7 years of age. Peripheral blood specimens were obtained from participating children, after informed consent was provided by their parents. Antibodies against diphtheria in sera specimens were assessed by commercial anti-diphtheria toxoid immunoglobulin G (IgG) enzyme-linked immunosorbent assay. Results There were 154 children included in the study, with a female majority (61%). Overall, specific humoral immunity against diphtheria was observed in 113 children (73.4%). There was no statistical difference in immunity level between genders. Importantly, children who received the first and second diphtheria booster had significantly higher anti-diphtheria antibody level than those who did not receive both diphtheria booster (P<0.001). Conclusion Booster vaccinations are crucial among school-age children in Indonesia to improve their anti-diphtheria immunity and to minimize a risk of diphtheria outbreaks.
Vitamin D deficiency in newborns: a tropical paradox Dewanto, Naomi Esthernita F.; Santi, Theresia; Sugiri, Zaneth; Napitupulu, Nancy; Jo, Juandy
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

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Abstract

Background  Previous studies have shown a 'tropical paradox' in Indonesia, where despite being a tropical country with abundant sunlight, a widespread vitamin D inadequacy is observed in various populations. This paradox extends to Indonesian children, who predominantly exhibit low vitamin D levels, yet research specifically investigating vitamin D status in the newborn remains notably limited. Objective To determine the prevalence of low level of vitamin D and elucidate its correlation with the conditions of newborns in Jakarta, Indonesia. Methods This retrospective study analyzed data from newborns undergoing assessment at Siloam Hospital Kebon Jeruk, Jakarta, from June 2022 to May 2024. We collected the following data: newborn’s vitamin D level, demographic and clinical characteristics, as well as available maternal data. Serum 25-hydroxyvitamin D [25(OH)D] levels between < 20, 20–29.9 and ≥ 30 ng/mL were classified as deficient, insufficient, and sufficient, respectively. Statistical analyses were used to compare baseline characteristics and outcomes based on vitamin D status. Results Of the 243 newborns studied, 70.4% were classified as vitamin D deficient, 22.2% as insufficient, and 7.4% as sufficient. Subjects’ median vitamin D level was 15.7 (range 1.2 – 57.1)  ng/mL. No significant difference in vitamin D levels was observed between male and female newborns (p=0.190) and between newborns with birthweight < 2,500 and the ones with birth weight ≥2,500 grams (p=0.794). Vitamin D levels were not significantly different between healthy and sick newborns (p=0.537). Maternal vitamin D status was available for only a small proportion (15.6%) of mothers, highlighting the need for further investigation into maternal-newborn vitamin D status. Conclusion Although a high prevalence of newborn with vitamin D deficiency was observed in our study participants, no significant difference in vitamin D levels was observed between healthy and sick newborns. No correlation was observed between sex or birth weight, and vitamin D levels as well. Future inquiries should explore maternal vitamin D status in greater detail and assess the prolonged health consequences of hypovitaminosis D in newborns.  
Co-Authors Agustina Anugrah, Andreas Surya Ardini Saptaningsih Raksanagara, Ardini Saptaningsih Ardini, Ni Putu Ari Prayitno, Ari Badriul Hegar Dewanto, Naomi Esthernita F. Dina Garniasih, Dina Hamik, Welli Harahap, Alida Roswita Ivo Novita Sah Bandar Juandy Jo Lukman, Leni Napitupulu, Nancy Nusasenjaya, Radite Purwoko, Reza Yuridian Retno Asti Werdhani Ridwansyah Ridwansyah Rima Melati Sri Rezeki S. Hadinegoro, Sri Rezeki S. Sugiharto, Jessica Sugiri, Zaneth Tandra, Irene Mutiara Yogi Prawira, Yogi Zakiudin Munasir