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All Journal Jurnal Kedokteran Diponegoro Journal of Health Education Indonesian Journal of Medicine Journals of Ners Community Medica Hospitalia
Willy Yusmawan, Willy
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Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health

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Effect of Administration of Phaleria Macrocarpa on Liver Function of Nasopharyngeal Carcinoma Patients who Receive Cisplatin Chemotherapy Akbar, Adi Januar; Yusmawan, Willy; Farokah, Farokah; Nugroho, Nur Iman
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.248 KB)

Abstract

Background: Nasopharyngeal cancer (NPC) is a malignant tumor located in the nasopharynx, which can be treated by Cisplatin, a chemotherapy that has a side effect of increasing the production of Reactive Oxygen Species (ROS) that can damage the liver. We aim to determine the effect of giving Mahkota Dewa (Phaleria macrocarpa) as an antioxidant on liver function of NPC patients receiving Cisplatin chemotherapy. Subjects and Method: Forty subjects of stage III and IV Nasopharyngeal Carcinoma patients were divided into treatment and control groups. Subjects will be tested for SGOT SGPT before cisplatin chemotherapy. The treatment group was given Phaleria macrocarpa capsules 300 mg/24 hours for 5 weeks since a week before chemotherapy. The control group was given placebo capsules/24 hours for 5 weeks since a week before chemotherapy. The patients received two series of cisplatin chemotherapy with an interval of 3 weeks, then a second blood sample was taken 1 week after the second series of cisplatin chemotherapy.Results: There was a significant difference in SGOT levels in the post-treatment group of Phaleria macrocarpa and control, as well as the difference in the pre- and post- treatment group between the Phaleria macrocarpa and control groups. Also, there was a significant difference in SGPT levels in the pre- and post- treatment in the Phaleria macrocarpa and control groups.Conclusion: The administration of Phaleria macrocarpa has an effect on decreasing the levels of SGOT and SGPT in NPC patients receiving Cisplatin chemotherapy therapyKeywords: Phaleria macrocarpa, SGOT, SGPT, Nasopharyngeal Carcinoma, CisplatinCorrespondence: Adi Januar Akbar. ENT Department of Diponegoro University. Prof. Sudarto Street No. 13, Tembalang, Tembalang Sub-district, Semarang City, Central Java, 50275. Email: diaz17akbarsaleh­@gmail.com. +628161455179.Indonesian Journal of Medicine (2022), 07(01): 1-8https://doi.org/10.26911/theijmed.2022.07.01.01
Split Thickness Skin Graft Pada Pasien Abses Submandibula Dengan Ulkus Regio Colli Dextra Aditomo, Rano; Yusmawan, Willy
Journals of Ners Community Vol 14 No 1 (2023): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.2563

Abstract

Skin graft is a surgical procedure in which part or all of the thickness of the skin is removed from a region of origin (donor) without being accompanied by vascularity to another area (recipient) to cover a defect. Indication of skin graft performed on primary non-sealable wounds. The purpose of writing this case report is to report one case of a patient who was split thickness skin graft (STSG) and provide knowledge to colleagues on how to do it considering the very rare cases in ORL-HNS department. This article reported a 61-year-old male with complaints of a reddish open wound on the right neck and diagnosed with necrosis of the colli dextra region due to a submandibular abscess. Patients are carried out management of wound tissue closure with STSG technique, with good treatment the grafting results can be successful without complications after the patient controls 1 month post-STSG and no secondary infection is obtained at 6 months post-STSG.
Split Thickness Skin Graft Pada Pasien Abses Submandibula Dengan Ulkus Regio Colli Dextra Aditomo, Rano; Yusmawan, Willy
Journals of Ners Community Vol 14 No 1 (2023): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.2563

Abstract

Skin graft is a surgical procedure in which part or all of the thickness of the skin is removed from a region of origin (donor) without being accompanied by vascularity to another area (recipient) to cover a defect. Indication of skin graft performed on primary non-sealable wounds. The purpose of writing this case report is to report one case of a patient who was split thickness skin graft (STSG) and provide knowledge to colleagues on how to do it considering the very rare cases in ORL-HNS department. This article reported a 61-year-old male with complaints of a reddish open wound on the right neck and diagnosed with necrosis of the colli dextra region due to a submandibular abscess. Patients are carried out management of wound tissue closure with STSG technique, with good treatment the grafting results can be successful without complications after the patient controls 1 month post-STSG and no secondary infection is obtained at 6 months post-STSG.
Co-Authors Aditomo, Rano Akbar, Adi Januar Antono, Dwi Budiarti, Rery Dewi, Anna Mailasari Kusuma Dewi, Julita Melisa Dewi, Nila Santia Farokah, Farokah Handayani, Peny Hariyati, Riece Inardi, Yoke Kurniawan Kanti Yunika, Kanti Kusulistyo, Farryanto Kusuma Dewi, Anna Mailasari Marliyawati, Dwi Muhammad Yusuf MUYASSAROH Muyassaroh Muyassaroh Nugroho, Nur Iman Pratama, Yudistira Pujo Widodo, Pujo Rio Sanjaya Sarah, Diah Ayu Siti Suprihati - Widodo , Pujo Yunika, Kanthi Zulfikar Naftali, Zulfikar