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All Journal Jurnal Kesehatan Medika Saintika Jurnal Jamu Indonesia Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Jurnal Ilmiah Farmasi Farmasyifa Jurnal Pengabdian Kepada Masyarakat PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) Jurnal Medika: Medika Indonesian Journal of Jamu
Chindiana Khutami
Universitas Adiwangsa Jambi
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Journal : PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA

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Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Chindiana Khutami
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35141/pharm.v2i1.773

Abstract

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Khutami, Chindiana
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
Co-Authors Adria Wuri Lastari Agung Kurniawan Amraini Amelia anggriani, Adelia Camelia, Leonyta Hanifahzin Khatami Muchtaridi Muchtaridi Oktavia, Nazifa Rahmadevi Rahmah, Vindi Annisa Rizki, Widya Twini Rizki, Widya Twiny Siti Jamilah Siti Marwah Lestari Yesi Mustika Sari Yuni Andriani