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Bangkit Riska Permata
Pogram Studi Farmasi, Fakultas Kesehatan, Universitas Duta Bangsa, Surakarta
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Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Formulasi dan uji aktivitas antibakteri serum antijerawat yang mengandung naringenin 2.5% Putri Rovita Sari; RR Sri Wulandari; Iqbal Wahid Abdullah; Bangkit Riska Permata
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3838

Abstract

Background: Facial serums are advanced cosmetic formulations designed to deliver high concentrations of active ingredients, allowing for intensive penetration into deeper layers of the skin. Naringenin at a concentration of 2.5% can inhibit Staphylococcus aureus bacteria with an inhibition zone of 15.10 mm, indicating strong antibacterial activity. S. aureus is one of the bacteria responsible for causing acne. Purpose: This study aims to develop a facial serum containing the active ingredient naringenin, which is expected not only to meet physical quality standards and be safe for the skin but also to effectively treat acne due to the antibacterial properties of 2.5% naringenin. Method: The method used was a laboratory experiment in which a naringenin (NAR) serum preparation was made, followed by an evaluation of its physical properties, including a homogeneity test, a pH test, a spreadability test, an adhesion test, a viscosity test, and an antibacterial test. Results: The results showed that, in the organoleptic test, the preparation was a blue, odorless semisolid. The NAR serum had a homogeneous texture with a pH of 5.7; a spreadability of 6.8 cm; an adhesion time of 7.8 seconds; a viscosity of 3,707 Cps; and an inhibition zone diameter of 14.3 mm, classified as strong. Conclusion: The NAR serum preparation exhibits good physical quality in accordance with standards and may possess strong antioxidant activity. This indicates that NAR serum has great potential as an agent for combating S. aureus, the bacterium that causes acne.   Keyword: Acne Serum; Antibacterial; Naringenin; Serum; Staphylococcus Aureus.
Formulasi Sediaan Pomade dan Uji Efektivitas Ekstrak Daun Salam (Syzygium Polyanthum) terhadap Pertumbuhan Rambut Kelinci New Zealand White Putri Barlian Nur Cahyaning Tyas; Bangkit Riska Permata; Rizka Wahyu Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8332

Abstract

Bay leaves are known to contain flavonoids, tannins, saponins, and essential oils, which have been empirically proven to promote healthy hair. This study aimed to determine the potential of bay leaf extract (Syzygium polyanthum) as an active ingredient in pomade and its effectiveness on hair growth in New Zealand White rabbits. The research method used was an experimental laboratory with four variations of pomade formulations: F0 (without extract), F1 (20%), F2 (25%), and F3 (30%). Evaluations were conducted on physical quality parameters such as organoleptic properties, pH, homogeneity, spreadability, viscosity, and adhesion. Effectiveness testing was conducted on the rabbits' backs for 28 days, measuring hair growth. The results of the study showed that pomade preparations with bay leaf extract had physical qualities that met the requirements for hair growth with various extract effectiveness on the 28th day of peak testing showing Formula I (20%) 0.4 cm, formula II (25%) 0.4 cm, Formula III (30%) 1.0 cm, providing the highest hair growth results, namely Formula III compared to other formulas. The results of SPSS statistical analysis with a significance value <0.05 resulted in differences between treatments. So it can be concluded that bay leaf extract can be formulated into an effective pomade preparation in stimulating hair growth.
Co-Authors Anita Dwi Septiarini Annisa Nurlaila Sari Annissha Azzahra Wurnasari Christy Natalia Limbu Datu Danang Raharjo Desy Ayu Irma Permatasari Dian Fatimatus Salwa Dian Nur Aisyah Iqbal Wahid Abdullah Kharisma Jayak Pratama Kharisma Jayak Pratama Kusumaningtyas Siwi Artini Mei Ika Nurul Khotimah Novi Alfi Ramadhani Nur Jannah Putri Barlian Nur Cahyaning Tyas Putri Martani Nur Afifah Putri Rovita Sari Putri Solihah Kartika Sari Rahmat Hidayat Rizka Wahyu Syahputra RR Sri Wulandari Sabrina Karim Siti Fatimah Tatiana Siska Wardani