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All Journal Jurnal Farmasi Udayana Jurnal Kedokteran Brawijaya BIOTROPIA - The Southeast Asian Journal of Tropical Biology Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasetis Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Borneo Journal of Pharmacy

Dita Maria Virginia

Sanata Dharma University

Author-ID : 615860

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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HUBUNGAN PROCALSITONIN DAN GAMBARAN MORFOLOGI LEUKOSIT PADA INFEKSI BAKTERIAL Fenty Fenty; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Bacterial sepsis increases morbidity and mortality in all ages. Early detection has been shownto be crucial for the improved outcome of patients with sepsis. Till now there is no routine test forscreening. Procalcitonin and morphology of leukocytes are biomarkers of bacterial sepsis. The aim of thisstudy was to determine the relationship between procalcitonin and morphology of leukocytes as marker inbacterial infection. This study was analytical observational with cross sectional design and data collectedprospectively.This study measured simultaneously the value of procalcitonin and morphology of leukocytesexamination in patients with suspected bacterial infection in hospital X of Yogyakarta. Data were analysedby statistics. The results showed immature granulocytes and vacuolization of neutrophils in the leucocytesmorphology has a significant correlation with level of procalcitonin.Keywords: bacterial infection, procalcitonin, morphology of leukocytes

CORRELATION AMONG SLEEP DURATION, BLOOD PRESSURE, AND BLOOD GLUCOSE LEVEL OF MORANGAN PEOPLE, SINDUMARTANI, NGEMPLAK, SLEMAN Gregorius Bhaskara Wikanendra; Rita Suhadi; Christianus Heru Setiawan; Dita Maria Virginia; Phebe Hendra; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Sleep deprivation is a risk factor for cardiovascular and metabolic diseases. There was a high prevalence of high blood pressure and type 2 diabetes in Morangan, Yogyakarta Province. This study aims at studying the correlation between sleep duration, systolic blood pressure and fasting blood glucose levels of people in Morangan. This study was a cross-sectional study conducted in cooperation with a public health care program for people in Morangan. Data collection was done using a questionnaire and health screening procedure during the public health care program. Collected data were covering aspects of systolic blood pressure, fasting blood glucose, sleep duration, and sleep habit. There was a high prevalence of high systolic blood pressure (130mmHg; 66.04%) and high fasting blood glucose level (100mg/dL; 39.62%) in Morangan people. There was a significantly positive correlation between sleep duration and systolic blood pressure (p:0.024; r:0.31) but no significant correlation between sleep duration and fasting blood glucose level. The major contributing habits towards sleep deprivation were caffeine consumption and medium pre-sleep routine. The result of this research will provide help in designing an education program for people of Morangan in preventing and treating high blood pressure and type 2 diabetes.

Effect of Calcium Supplementation During Pregnancy in Maternal Patient to Preterm Birth in One of Private Hospitals in Yogyakarta Albertus I. Brilian; Dita Maria Virginia
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Calcium is one of micronutrients that plays an important role in pregnancy. Insufficient consumption of calcium in pregnant women could lead to preterm birth, which is a major cause of neonatal mortality. This study aimed to determine the maternal patients’ characteristics, relationship between prematurity risk factors such as age, antenatal care, history of abortion and parity as well as calcium supplementation during pregnancy on pregnant women toward preterm birth in one of private hospitals in Yogyakarta. The survey was conducted from May to August 2016 The study was an analytical observation with cross‑sectional research design. In total of 199 medical records of maternal patients that had been included were analyzed using Mann-Whitney and Chi-Square test to see the relationship of calcium supplementation to preterm birth. Fisher’s exact test was used if Chi-Square’s requirement was not fulfilled. The pregnant women’s characteristics in the hospital were expectant mothers with normal gestational age (93%); insufficient calcium supplementation (79%); age ≤30 years (61%); bachelor’s degree (53%); private employees (40%); antenatal care ≥4 (98%) and parity 1 and ≥4 (54%). The result of this study showed there was no relationship between age, antenatal care, history of abortion and parity as well as calcium supplementation toward preterm birth on pregnant women in one of private hospitals in Yogyakarta.Keywords: Calcium supplementation, maternal, preterm birth Pengaruh Suplementasi Kalsium pada Pasien Maternal Selama Kehamilan terhadap Kelahiran Prematur di Salah Satu Rumah Sakit Swasta di YogyakartaKalsium merupakan salah satu mikronutrien yang memainkan peran penting pada masa kehamilan. Pengonsumsian kalsium yang kurang pada ibu hamil dapat menyebabkan kelahiran prematur (kelahiran <37 minggu) yakni penyebab utama kematian neonatal. Penelitian ini bertujuan untuk mengetahui karakteristik pasien maternal, hubungan faktor-faktor risiko seperti antenatal care, umur, riwayat abortus dan paritas serta suplementasi kalsium selama kehamilan terhadap kelahiran prematur di salah satu rumah sakit swasta di Yogyakarta. Penelitian ini dilakukan pada bulan Mei hingga Agustus 2016. Jenis penelitian ini adalah analitik observasional dengan rancangan cross-sectional. Sebanyak 199 rekam medis pasien maternal yang masuk dalam kriteri inklusi dianalisis menggunakan uji Mann-Whitney dan uji Chi-Square. Uji Fisher digunakan apabila syarat uji Chi-Square tidak terpenuhi. Karakteristik pasien maternal di salah satu rumah sakit swasta di Yogyakarta yaitu minggu kelahiran normal (93%), suplementasi kalsium tidak sesuai (79%), umur ≤30 tahun (61%), tingkat pendidikan strata satu (53%), pekerjaan pegawai swasta (40%), antenatal care ≥4 kali (98%) dan paritas 1 dan ≥4 kali (54%). Hasil penelitian ini mengungkapkan tidak terdapatnya hubungan antara umur, antenatal care, riwayat abortus dan paritas serta suplemen kalsium (p>0,05) terhadap kelahiran prematur pada pasien maternal di salah satu rumah sakit swasta di Yogyakarta.Kata kunci: Kelahiran prematur, maternal, suplementasi kalsium

Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC Florentinus Dika Octa Riswanto; Dita Maria Virginia; Dina Christin Ayuning Putri; Sri Hartati Yuliani
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.Â Â

Distribution of cytochrome P450*4 (CYP2A6*4) allele gene among Javanese Indonesian T2DM patients Christine Patramurti; Dita Maria Virginia
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Smoking had been increasing the risk factor of type 2 diabetes mellitus (T2DM), both active and passive smokers, which is caused by nicotine contained in cigarettes. Nicotine has metabolized by cytochrome p450 2a6 (CYP2A6) enzyme coded by the CYP2A6 gene. This gene was a high polymorphism that is the CYP2A6*4 allele gene was inactive. Thus, our objective was to describe the CYP2A6*4 allele gene among active and passive Javanese smokers with T2DM. From this cross-sectional study, we identified this allele gene among 46 of the adults with T2DM, which were consist of 23 active smokers and 23 passive smokers. The CYP2A6*4 allele gene identification has done using polymerase chain reaction (PCR) methods. The CYP2A6*4 allele frequency was analyzed to describe the distribution of this allele among the participants. This study supports the hypothesis that smoking, including cigarette smoke, was an environmentally modifiable risk factor for developing T2DM. Based on our result, the allele frequency among the participants was 42.39%. A high frequency of the CYP2A4 allele gene among the participants was indicating that the CYP2A4 allele gene was also the other risk factor in developing T2DM.

Proporsi peresepan probiotik pada gastroenteritis akut pasien pediatri di bangsal rawat inap RS X pada Februari 2015 Dita Maria Virginia
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pediatric patients are one of the target groups of the National Health System in Indonesia that requires special attention in therapy because their anatomy physiology was immature. A lot of probiotics indicated for acute gastroenteritis (AGE) for pediatric patients. Probiotic prescribing includes the types of probiotic, dosage and duration for AGE has not been discussed clearly. The aim of our study was to determine the proportion of probiotic that have prescribed for acute gastroenteritis topediatric agedin hospitalized. This study was analytical observational with cross sectional design. Data was obtained retrospectively with non-purposive sampling.Samplesize was based on cross-sectional design calculation and obtained a number of 200 medical records from Hospital X, IndonesiaonFebruary 2015. This study used secondary data from medical records. Data collected was patient identity, patientaged, probiotic prescribing includes the types of probiotic, dosage and duration. Data have been analyzed in descriptive and Mann-Whitney to observe the difference between types of probiotic, dosage and duration probiotic used topediatric aged. This study showed this hospital only used 5 probiotic brands. Group aged <2 years is more used of 3 types of probiotic species while at the age of> 2 years is prefer to use 6 types. The mean dose of probiotic is greater in the group aged >2 years. Probiotic duration in the group <2 years is for 4 days while in those aged >2 years in duration 5 days. The number of cases that do not fit with the recommended dose packs is more commonly found at age <2 years. There is a different proportion between type of probiotic (p=0.000), dose of probiotic (p=0.040), and probiotic duration (p=0.008) with pediatric aged. There was a statistically significant difference between types of probiotic, dosage and duration probiotic used to pediatric aged.

CYTOTOXIC ACTIVITY OF Anredera cordifolia LEAF EXTRACT ON HELA CELLS Dita Maria Virginia; Roni Permana Saputra; Agustina Setiawati
BIOTROPIA - The Southeast Asian Journal of Tropical Biology Vol. 26 No. 1 (2019)
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2019.26.1.863

Cervical cancer is the second most frequently occurring cancer among females all over the world. Since the best strategy against cancer is to kill the cancer cells without endangering the normal cells, discovering a potentially selective anticancer agent from plants has become very challenging for researchers worldwide. A previous study on Anredera cordifolia, known as binahong in Indonesia, revealed its cytotoxic activity on HeLa cervical cancer cells with IC50 75 Âµg/mL. However, the selectivity of the chemical agent and its molecular target was not investigated. Thus, this study was aimed at determining the selectivity of ethanolic extract of Anredera cordifolia leaf (EAC) on Vero cells and its molecular target on HeLa cells. The extracts were prepared by macerating A. cordifolia leaf powder in 70% ethanol. The viability of Vero cells was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. While the cell cycle of HeLa cells was analyzed using the flow cytometry, the molecular target of the extract was investigated by using the immunocytochemical staining. The results exhibited the selective cytotoxicity of EAC on HeLa cells compared to Vero cells with a Selectivity Index (SI) of 17.36. It arrested the G1/S phase of the cell cycle and suppressed the Bclâ€“2 expression, the anti-apoptotic protein, which also regulates the cell cycle. These findings confirmed the use of A. cordifolia leaf extract as a promising anticancer agent against cervical cancer, particularly the HeLa cells.

CORRELATION BETWEEN ANTHROPOMETRIC MEASUREMENTS AND RISK OF ANEMIA AMONG RURAL COMMUNITY IN CANGKRINGAN, SLEMAN Dita Maria Virginia; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Anemia has been detected on various age groups. Measurement of hemoglobin (Hb) levels is a standard for deciding anemia conditions. The measurement requires certain costs, medical professional, and is invasive. People in rural areas need an economical, easy and simple examination to identify the risk of anemia. Anthropometric measurement is expected to be an appropriate measurement model for rural communities. The objective of the study is to obtain the best anthropometric measurement predictors for detecting anemia in rural communities. This was an observational study using a cross-sectional design. The inclusion criteria of the subjects of the study were residents of Cangkringan, who were between 40 and 60 years old. The subjects were chosen using random sampling cluster technique. The sample size was 100 respondents and was taken based on cluster. Descriptive analysis was used to determine the prevalence of anemia. Analysis the difference in proportion was conducted using Mann-Whitney. Correlation analysis was performed to determine the relationship between Hb levels and anthropometric measurements by using Spearman. The results showed that only 5% of the subjects are in the status of anemia based on their Hb levels. There is a significant difference between Hb levels in the normal and obese groups based on the waist hip circumference ratios (WHR) (p = 0.002). The waist circumference has a weak correlation (r = 0.238, p = 0.017) and WR has a moderate correlation (r = 0.483, p = 0.000) with Hb levels. The results of this study are not appropriate in which central obese patients should be more at risk of anemia. This study concludes that there is a significant positive moderate correlation between anthropometry, which is the waist circumference parameters and WHR, to the Hb levels in rural communities.

KORELASI RASIO LINGKAR PINGGANG PANGGUL (RLPP) TERHADAP PROFIL LIPID PADA PRA-GERIATRI DAN GERIATRI Linawati Yunita; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Abnormality of lipid profile is one of cardiovascular risk factors which increases with aging.Anthropometric measurement is one of the predictors of abnormal lipid profile without invasive methodsand affordable cost. One of the anthropometric measurements that could be used as a predictor is waist tohip ratio (WHR). The aim of this study was to determine the correlation between WHR with abnormality oflipid profile which were related to total cholesterol, Low Density Lipoprotein (LDL), High DensityLipoprotein (HDL), and triglyceride (TG) in pre-geriatrics and geriatrics group. This study was analyticalobservational with cross sectional design. Statistical analysis used Kolmogorov-Smirnov followedbivariable analysis with confidence interval (CI) 95%. The correlation statistical test used Pearson andSpearman. The results showed no statistically significant correlation between WHR with total cholesterol(r=-0.054, p 0.05), LDL (r=-0.047, p 0.05), TG (r=0.018, p 0.05), and HDL (r=0.016, p 0.05).Keywords: lipid profile, waist-to-hip ratio (WHR), pre-geriatric, geriatri

Peran Apoteker dalam Pengelolaan Penyakit Degeneratif di Dusun Mergan Sendangmulyo, Sleman, D.I. Yogyakarya Dita Maria Virginia; Aris Widayati
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 1, No 1 (2018): April 2018
Publisher : Universitas Sanata Dharma

Findings of the preliminary survey showed a high proportion of geriatric people in Dusun Mergan, Sendangmulyo, Sleman, which leads to high risk of cardiovascular and other degenerative diseases. This community service program aimed to identify the health status of Mergan’s people through health screening and to help them to maintain their health. This program was conducted in collaboration between the Faculty members and students of Pharmacy Faculty of Universitas Sanata Dharma Yogyakarta (USD). There were two consecutive periods; the first was in 7th of May and the second was in 22nd of October 2018. Health education, health screening, and health examination were conducted in each period. There were 93 people involved in the first period and 64 people in the second; however, only 32 persons who completely attended the two meeting periods. The program resulted data of 60.7% Mergan’s people with a risk of dyslipidemia, and 59.0% with hyperglycemic. There was no significant difference between the first and the second periods of examination of glucose level, cholesterol, and uric acid. Therefore, it is urgent to educate people in Mergan Village to promote and maintain a healthy lifestyle in order to decrease morbidity of degenerative disease in the community.

Co-Authors Agustina Setiawati Albertus I. Brilian Aris Widayati Aris Widayati Ariyanti, Ni Kadek Nining Arwinda, Prili Asri, Ni Komang Intan Prima Brilian, Albertus I. Christianus Heru Setiawan Christine Patramurti Christine Patramurti Co’o, Maria Dolorosa Dewita, Aquina Nino Rama Dhanti Dina Christin Ayuning Putri Djaswadi Dasuki Djunaedi, Jeniffer Kalyana Paramita Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty, Fenty Florentinus Dika Octa Riswanto Gollumawo, Serly Sofia D. Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Immanuel, Handika Jago Uko, Maria Anjeline Jannah, Widyatul Leonardo Susanto Utomo Linawati Yunita Lisa Kurnia Sari, Lisa Kurnia Luh Anggi Distya Pratiwi Nunung Priyatni Nur, Lisa Febriana Pero, Veronika Giuliany Phebe Hendra Phebe Hendra Phebe Hendra Phebe Hendra, Phebe Pinaryanto, Kartono Pramono, Zita Dhirani Pratiwi, Vera Dwi Priyatni, Nunung Putu Dyana Christasani Rita Suhadi Rohmahtika, Amanda Roni Permana Saputra Sari, Theresia Maria Fioretty Ine Sri Hartati Yuliani Travita, Anggi Silva Tunjung Wibowo Wakitha, Stephanus Satria Wira Wiracana, I Made Yunita Linawati

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