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The Effect of Adherence to Antihypertensive Therapy and Cardiovascular Risk Among Hypertensive Patients in Purworejo Regency Arwinda, Prili; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007334

Abstract

Uncontrolled hypertension will increase mortality and morbidity rates. The adherence is an important factor in controlling blood pressure. Uncontrolled blood pressure will affect cardiovascular risk. Therefore, hypertensive patients must comply with taking medication to control blood pressure and cardiovascular risk. This study was an analytical observational study with a cross-sectional design. A total of 85 respondents who met the inclusion criteria were measured for adherence using the MPR (Medication Possession Ratio) method and the MARS-5 (Medication Adherence Report Scale-5) questionnaire.  A patient who had blood pressure 140/90 mmHg was categorized as controlled hypertension. The cardiovascular risk was measured using the ACC/AHA criteria method. Data were analyzed using chi-square tests and odds ratio (OR) with 95% confidence interval (CI) and p0.05 considered significant. This study showed that there was a significant association between adherence to antihypertensive therapy to controlled blood pressure, either according to MPR (OR=18.262; 95%CI=5.259-63.412; p=0.000) and MARS-5 (OR=31.607; 95%CI=8.170-122.277; p=0.000). A significant association was found between antihypertensive adherence and cardiovascular risk, either according to MPR (OR=3.733; 95%CI=1.269-10.983; p=0.020) and MARS-5 (OR=9.000; 95%CI=2.702-29.983; p=0.000). Therefore, this study concludes a significant relationship between antihypertensive adherence to controlled blood pressure and cardiovascular risk in Purworejo Regency.
INTENSIFIKASI DAN KETAATAN TERAPI ANTIHIPERTENSI PADA PASIEN GERIATRI DI RSUD X BALI Asri, Ni Komang Intan Prima; Virginia, Dita Maria
Jurnal Farmasi Higea Vol 17, No 1 (2025)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v17i1.700

Abstract

Hipertensi merupakan salah satu penyakit kronis yang umum di Indonesia, dengan prevalensi yang terus meningkat terutama pada kelompok usia lanjut. Kasus hipertensi di Provinsi Bali mengalami peningkatan dari sejak tahun 2013. Hal tersebut menunjukkan urgensi penanganan yang lebih baik pada kelompok geriatri. Penelitian ini bertujuan untuk menganalisis pengaruh intensifikasi dan ketaatan terapi antihipertensi terhadap terkontrolnya tekanan darah pada pasien geriatri di RSUD X Bali. Metode penelitian yang digunakan adalah analisis kuantitatif dengan desain cross-sectional. Data dikumpulkan melalui rekam medis meliputi pengukuran tekanan darah dan riwayat terapi antihipertensi, serta dianalisis menggunakan uji Chi-square. Hasil penelitian menunjukkan bahwa tidak terdapat pengaruh yang signifikan secara statistik antara intensifikasi terapi (OR = 0,290; 95% CI, 0,051-1,639; p-value = 0,143) dan ketaatan terapi (OR = 1,214; 95% CI, 0,427-3,452; p-value = 0,716) terhadap terkontrolnya tekanan darah pasien. Meskipun analisis statistik menunjukkan tidak ada hubungan signifikan, ketaatan terapi tetap dianggap penting karena sebagian besar pasien yang mematuhi terapi menunjukkan tekanan darah terkontrol. Pendekatan yang lebih personal dan komprehensif, termasuk edukasi pasien dan pemantauan yang teratur, tetap penting dalam pengelolaan hipertensi pada pasien geriatri.  
The Relationship of Medication Adherence to Controlled HbA1c and ASCVD Risk in Type II Diabetes Mellitus Patients in Minggir Primary Health Care Dewita, Aquina Nino Rama Dhanti; Hendra, Phebe; Virginia, Dita Maria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007464

Abstract

Type II diabetes mellitus (DM) therapy can be evaluated from the controlled HbA1c. Another aspect that needs to be controlled in patients with DM is lipid levels. Lipid levels should be controlled in a patient with type II DM to prevent atherosclerotic cardiovascular disease (ASCVD). The study was conducted to determine the relationship between medication adherence with controlled HbA1c and ASCVD risk in patients with type II DM. The study was an analytical observational study with a cross-sectional research design used to examine the relationship between medication adherence with controlled HbA1c and ASCVD risk. Our respondents were patients following a chronic disease management program at Minggir Primary Health Care. The level of medication adherence was measured using the Medication Adherence Report questionnaires. The ASCVD risk was measured using the American College of Cardiology/American Heart Association tools. The chi-squared test was applied to determine the relationship between medication adherence with HbA1c values and ASCVD risk in patients with type II DM. Most patients with type II DM had high medication adherence (60%), controlled HbA1c values (56.4%), and high ASCVD risk (70.9%). There was no significant relationship between medication adherence in type II DM patients with controlled HbA1c values and ASCVD risk.
Peningkatan Pengetahuan Tentang Gizi dan Stunting di Wonosari, Gunungkidul, DIY: Improving Knowledge of Nutrition and Stunting in Wonosari, Gunungkidul, DIY Virginia, Dita Maria; Wakitha, Stephanus Satria Wira; Immanuel, Handika; Rohmahtika, Amanda; Travita, Anggi Silva; Djunaedi, Jeniffer Kalyana Paramita; Jannah, Widyatul; Pero, Veronika Giuliany
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 5 No. 1 (2025): Maret
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak: Stunting merupakan problem kesehatan masyarakat yang belum dapat dituntaskan. Stunting dipengaruhi oleh minimnya pengetahuan mengenai stunting dan gizi yang baik untuk pencegahan stunting. Program pengabdian bertujuan untuk  pemahaman masyarakat tentang pentingnya asupan gizi seimbang dan suplementasi vitamin dalam mencegah stunting. Angka stunting di Desa Baleharjo masih tinggi. Metode kegiatan pengabdian berupa participatory action service karena melibatkan Puskesmas Wonosari II dengan wilayah kerja Desa Baleharjo, Wonosari. Kegiatan berupa penyuluhan kepada kader dan ibu yang memiliki anak balita serta terdapat kegiatan pendampingan untuk ibu dan anak. Hasil penyuluhan menunjukkan pengetahuan mengenai (1) hal yang harus dilakukan pada periode 1000 HPK (p-value=0,00) dan (2) nutrisi terbaik pada MPASI untuk mencegah stunting (p-value=0,02), meningkat secara signifikan. Pengetahuan lain tidak terdapat peningkatan secara signifikan. Saran untuk pengabdian selanjutnya perlu mempertimbangkan pendampingan secara langsung dari waktu ke waktu dengan meningkatkan peran kader. Kegiatan pengabdian selanjutnya juga perlu mempertimbangkan pengukuran terhadap luaran utama berupa penurunan angka stunting ataupun perubahan perilaku.   Abstract: Stunting is a public health problem that has not been resolved. Stunting is influenced by the lack of knowledge about stunting and good nutrition to prevent stunting. The community service program aimed to provide community knowledge related to the importance of balanced nutritional intake and vitamin supplementation in preventing stunting. The stunting rate in Baleharjo Village is still high. The community service activity method was participatory action service because we involved the Wonosari II Health Center which their working area is ??Baleharjo Village, Wonosari. Activities included counseling for cadres and mothers who have a children aged below 5 years old, and there were mentoring activities for mothers and children. The results of the counseling showed that knowledge about (1) things should to do in the 1000 FDB period (p-value = 0.00) and (2) the best nutrition in MPASI to prevent stunting (p-value = 0.02), has increased significantly. Other knowledge did not increase significantly. Suggestions for further community service need to consider direct mentoring from time to time by increasing the role of cadres. It should consider the measurement of primary outcomes such as the reduction in the number of stunted children or behavioral changes.
HUBUNGAN KONTROL HBA1C TERHADAP PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS SALAH SATU KECAMATAN, YOGYAKARTA Pramono, Zita Dhirani; Virginia, Dita Maria; Hendra, Phebe
Cendekia Journal of Pharmacy Vol 8, No 3 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i3.298

Abstract

Diabetes melitus merupakan suatu penyakit kronis yang memiliki tingkat prevalensi tinggi di Indonesia. HbA1c menjadi prediktor pada kontrol glikemik pada pasien diabetes melitus. Nilai HbA1c yang tinggi menyebabkan kondisi peningkatan profil lipid baik trigliserida, LDL (Lipoprotein Kepadatan Rendah) , total kolesterol maupun penurunan kadar HDL (lipoprotein kepadatan tinggi). Penelitian ini bertujuan untuk mengetahui adanya hubungan kadar HbA1c terhadap profil lipid pada pasien diabetes melitus di Puskesmas salah satu kecamatan di Sleman, Yogyakarta. Penelitian ini dilakukan secara cross sectional, dengan subjek penelitian sebanyak 36 pasien yang telah memenuhi kriteria inklusi dan eksklusi.  Analisis statistika dilakukan secara univariat dan uji korelasi pearson antar variabel. Penelitian ini menunjukkan 26 pasien (72,2%) berjenis kelamin perempuan yang mengalami diabetes dan hipertensi pada kelompok peserta prolanis. Selain itu, 22 pasien memiliki umur berkisar antara 60-75 tahun, juga diketahui rata-rata pasien memiliki nilai sistolik yang didominasi sebesar 140-159 mmHg (33,3%) dan diastolik sebesar 85 mmHg (44,4%). Adanya 28 pasien (77,8%) memiliki nilai LDL ?100 mg/dL, 20 pasien (55,6%) memiliki nilai  HDL 50 mg/dL, 20 pasien (55,6%) memiliki nilai kolesterol total ?200 mg/dL, dan trigliserida. Kontrol glikemik yang ditunjukkan dengan kadar HbA1c pada subjek penelitian belum terkontrol dengan kadar ?7% sebanyak 23 orang (63,9%).  Hasil uji korelasi antar variabel diketahui bahwa terdapat korelasi kadar HbA1c terhadap profil lipid trigliserida, dengan nilai korelasi sebesar 0,480 (p0,05), dan tidak adanya korelasi antara kadar HbA1c terhadap profil lipid lainnya seperti LDL -0,057 (p0,05); HDL -0,290 (p0,05); Kolesterol Total   0,007 (p0,05). Sehingga dapat disimpulkan bahwa terhadap hubungan kontrol HbA1c terhadap profil trigliserida pada pasien diabetes melitus tipe 2. 
Genetic CYP2A6 Polymorphism May Worsen Glycohemoglobin Levels: Study among Javanese Indonesian Smokers Patramurti, Christine; Virginia, Dita Maria
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5467

Abstract

We have examined the inactive CYP2A6 alleles gene, including CYP2A6*4, CYP2A6*7, and CYP2A6*9, associated with glycohemoglobin levels among Javanese Indonesian smokers. There are 106 smokers participating in this study. Due to the number of cigarettes smoked per day, there are three groups of smokers: light, intermediate, and heavy smokers, with 98.7% being light and intermediated smokers while the rest are heavy smokers. All participants had smoked for more than 10 years, indicating they had been exposed to nicotine for a long time. Based on their genotype, there were four groups of smokers, including fast, intermediate, slow, and poor metabolizers. Most fast and intermediate metabolizers have HbA1c levels in the normal range (<5.7). On the other hand, most slow metabolizers have Hb1c levels >5.7, and all fast metabolizers have HbA1c levels >5.7, indicating that they the prediabetes and diabetes. The chi-square test showed a relationship between CYP2A6 polymorphism and HbA1c levels among the participants (P-value 0.000 <0.005 and χ2=54.6, df=1). The presence of an inactive allele will worsen the HbA1c levels in smokers.
Evaluasi Tingkat Pengetahuan, Sikap dan Tindakan Ibu Pemberdayaan dan Kesejahteraan Keluarga Terkait Penggunaan Antibiotika di Kecamatan Kubu Karangasem Bali: Evaluation of the Level of Knowledge, Attitudes, and Actions of Empowerment and Family Welfare Mothers Related to the Use of Antibiotics in the Kubu Sub-District Karangasem Bali Distya Pratiwi, Luh Anggi; Virginia, Dita Maria; Priyatni, Nunung
Jurnal Surya Medika (JSM) Vol. 10 No. 3 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i3.8984

Abstract

Antibiotika merupakan golongan obat yang paling banyak digunakan di dunia terkait dengan banyaknya kejadian infeksi bakteri. Kurangnya pengetahuan tentang penyakit dapat menyebabkan kesalahan pemilihan obat yang digunakan untuk terapi. Salah satu kurangnya pengetahuan masyarakat yaitu terkait dengan kerasionalan penggunaan antibiotika. Penelitian ini dilakukan untuk mengetahui pengaruh metode seminar terhadap pengetahuan, sikap dan tindakan ibu pemberdayaan dan kesejahteraan keluarga terkait antibiotika di Kecamatan Kubu Karangasem Bali. Penelitian ini merupakan penelitian Analytical Quasi Experimental dengan rancangan two group pre-post test. Pengambilan sampel dilakukan secara purposive sampling melibatkan 84 responden yang dibagi dengan 42 responden pada kelompok kontrol dan 42 responden pada kelompok perlakuan. Data untuk penelitian terkait peningkatan pengetahuan, sikap dan tindakan diperoleh melalui pengisian kuesioner pretest, posttest I, posttest II, dan posttest III. Uji hipotesis pada kelompok perlakuan ini dilakukan untuk membandingkan nilai pretest dengan posttest I, pretest dengan posttest II, pretest dengan posttest III dalam aspek pengetahuan, sikap dan tindakan pada semua dimensi yaitu pada kelompok kontrol aspek pengetahuan dengan nilai 0,726 (pre-post I), 0,558 (pre-post II), 0,533 (pre-post III). Aspek sikap 0,463 (pre-post I), 0407 (pre-post II), 0,543 (pre-post III). Aspek tindakan 0,789 (pre-post I), 0,408 (pre-post II), 0,496 (pre-post III). Hasil yang diperoleh yaitu p > 0,05 yang artinya tidak ada perbedaan yang bermakna pada kelompok kontrol. Sedangkan pada kelompok perlakuan memperoleh nilai pada aspek pengetahuan dan sikap 0,000 (pre-post I, pre-post II, pre-post III). Aspek tindakan 0,000 (pre-post I), 0,003 (pre-post II), 0,011 (pre-post III). Hasil tersebut memperoleh nilai p < 0,05 yang artinya adanya perbedaan bermakna. Kesimpulan dalam penelitian ini adalah adanya intervensi dengan metode seminar mengakibatkan adanya peningkatan terhadap pengetahuan, sikap dan tindakan responden terkait dengan antibiotika.
Smoking as a risk factor for dyslipidemia: study among type 2 diabetes mellitus patients on private hospital in Yogyakarta Patramurti, Christine; Virginia, Dita Maria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1720

Abstract

Smoking behavior is known to be a significant factor that has adverse effects on people with type 2 diabetes (T2DM). Nicotine in cigarettes stimulate adrenoreceptors and promotes lipolysis, leading to the synthesis of free fatty acids, which in turn increase the susceptibility to dyslipidemia and the development of cardiovascular disorders. This study aimed to examine the relationship between smoking status and the occurrence of dyslipidemia in patients with T2DM in a private hospital in Yogyakarta. A total of 107 T2DM patients participated in this cross-sectional observational study. Through live interviews, we collected smoking status conducted using the Fagerström Test for Nicotine Dependence (FTND) questionnaire. The fasting blood samples taken from participants were used to analyze the lipid profiles, including triglycerides (TG), total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The chi-square test revealed a significant association between smoking status and the risk of dyslipidemia among the participants, with χ²(2) = 13.463, p = 0.001. The findings suggest that smoking increases the risk of dyslipidemia among T2DM patients. These results highlight the importance of smoking cessation as a preventive measure to reduce metabolic complications in individuals with T2DM.
CYTOTOXIC ACTIVITY OF Anredera cordifolia LEAF EXTRACT ON HELA CELLS Virginia, Dita Maria; Saputra, Roni Permana; Setiawati, Agustina
BIOTROPIA Vol. 26 No. 1 (2019): BIOTROPIA Vol. 26 No. 1 April 2019
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2019.26.1.863

Abstract

Cervical cancer is the second most frequently occurring cancer among females worldwide. Since the best strategy against cancer is to kill cancer cells without endangering normal cells, discovering a potentially selective anticancer agent from plants has become a major focus for researchers globally. A previous study on Anredera cordifolia, known as binahong in Indonesia, revealed its cytotoxic activity on HeLa cervical cancer cells with an IC₅₀ value of 75 µg/mL. However, the selectivity of the chemical agent and its molecular target was not investigated. Therefore, this study aimed to determine the selectivity of ethanolic extract of Anredera cordifolia leaf (EAC) on Vero cells and its molecular target on HeLa cells. The extract was prepared by macerating A. cordifolia leaf powder in 70% ethanol. The viability of Vero cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while the cell cycle of HeLa cells was analyzed using flow cytometry. The molecular target of the extract was further investigated using immunocytochemical staining. The results demonstrated the selective cytotoxicity of EAC against HeLa cells compared to Vero cells, with a Selectivity Index (SI) of 17.36. The extract induced cell cycle arrest at the G1/S phase and suppressed Bcl-2 expression, an anti-apoptotic protein that also regulates cell cycle progression. These findings support the potential use of A. cordifolia leaf extract as a promising anticancer agent against cervical cancer, particularly HeLa cells.
The The Impact of Antidiabetic Dose Appropriateness Based on Renal Function on Therapeutic Outcomes among Geriatric at Bali, Indonesia Sugiastana, Bagus N.; Hendra, Phebe; Virginia, Dita Maria
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.330-341

Abstract

Background: Diabetes mellitus is a significant global health issue, especially in the older population. Appropriate drug dosing is crucial in geriatric patients because renal function generally declines with age. A decline in renal function is directly associated with the adverse effects of antidiabetic drugs, particularly hypoglycemia, rather than their therapeutic efficacy. Objective: The objective of the present study was to assess the effect of antidiabetic dose appropriateness according to renal function on therapeutic outcomes among geriatric patients at three hospitals in Bali Province. Methods: The research was designed as an observational analytic study with a cross-sectional design. The study involved patients with diabetes aged ≥ 60 years, with or without renal function impairment. Medical records from January to December 2024 were also reviewed for this study. The suitability of antidiabetic drug dosing was evaluated using the estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation. The prescribed doses were compared with the dosage guidelines based on the renal function. A Chi-square analysis was performed to assess the relationship between the appropriateness of the antidiabetic dose and the therapeutic outcomes. Moreover, multivariate analysis was performed using logistic regression after adjusting for other factors. Results: Among the included patients, 27.6% were diagnosed with CKD and 28.4% had renal function classified as stage G2. A total of 51.5% of patients received appropriately adjusted antidiabetic doses. Dose appropriateness was significantly associated with primary clinical outcomes (p<0.05) but not with secondary clinical outcomes. Conclusion: In conclusion, appropriate dose adjustment is essential for enhancing diabetes treatment strategies for geriatric patients with diverse stages of kidney dysfunction.