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Peningkatan Pengetahuan Tentang Gizi dan Stunting di Wonosari, Gunungkidul, DIY: Improving Knowledge of Nutrition and Stunting in Wonosari, Gunungkidul, DIY Virginia, Dita Maria; Wakitha, Stephanus Satria Wira; Immanuel, Handika; Rohmahtika, Amanda; Travita, Anggi Silva; Djunaedi, Jeniffer Kalyana Paramita; Jannah, Widyatul; Pero, Veronika Giuliany
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 5 No. 1 (2025): Maret
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

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Abstract

Abstrak: Stunting merupakan problem kesehatan masyarakat yang belum dapat dituntaskan. Stunting dipengaruhi oleh minimnya pengetahuan mengenai stunting dan gizi yang baik untuk pencegahan stunting. Program pengabdian bertujuan untuk  pemahaman masyarakat tentang pentingnya asupan gizi seimbang dan suplementasi vitamin dalam mencegah stunting. Angka stunting di Desa Baleharjo masih tinggi. Metode kegiatan pengabdian berupa participatory action service karena melibatkan Puskesmas Wonosari II dengan wilayah kerja Desa Baleharjo, Wonosari. Kegiatan berupa penyuluhan kepada kader dan ibu yang memiliki anak balita serta terdapat kegiatan pendampingan untuk ibu dan anak. Hasil penyuluhan menunjukkan pengetahuan mengenai (1) hal yang harus dilakukan pada periode 1000 HPK (p-value=0,00) dan (2) nutrisi terbaik pada MPASI untuk mencegah stunting (p-value=0,02), meningkat secara signifikan. Pengetahuan lain tidak terdapat peningkatan secara signifikan. Saran untuk pengabdian selanjutnya perlu mempertimbangkan pendampingan secara langsung dari waktu ke waktu dengan meningkatkan peran kader. Kegiatan pengabdian selanjutnya juga perlu mempertimbangkan pengukuran terhadap luaran utama berupa penurunan angka stunting ataupun perubahan perilaku.   Abstract: Stunting is a public health problem that has not been resolved. Stunting is influenced by the lack of knowledge about stunting and good nutrition to prevent stunting. The community service program aimed to provide community knowledge related to the importance of balanced nutritional intake and vitamin supplementation in preventing stunting. The stunting rate in Baleharjo Village is still high. The community service activity method was participatory action service because we involved the Wonosari II Health Center which their working area is ??Baleharjo Village, Wonosari. Activities included counseling for cadres and mothers who have a children aged below 5 years old, and there were mentoring activities for mothers and children. The results of the counseling showed that knowledge about (1) things should to do in the 1000 FDB period (p-value = 0.00) and (2) the best nutrition in MPASI to prevent stunting (p-value = 0.02), has increased significantly. Other knowledge did not increase significantly. Suggestions for further community service need to consider direct mentoring from time to time by increasing the role of cadres. It should consider the measurement of primary outcomes such as the reduction in the number of stunted children or behavioral changes.
HUBUNGAN KONTROL HBA1C TERHADAP PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS SALAH SATU KECAMATAN, YOGYAKARTA Pramono, Zita Dhirani; Virginia, Dita Maria; Hendra, Phebe
Cendekia Journal of Pharmacy Vol 8, No 3 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i3.298

Abstract

Diabetes melitus merupakan suatu penyakit kronis yang memiliki tingkat prevalensi tinggi di Indonesia. HbA1c menjadi prediktor pada kontrol glikemik pada pasien diabetes melitus. Nilai HbA1c yang tinggi menyebabkan kondisi peningkatan profil lipid baik trigliserida, LDL (Lipoprotein Kepadatan Rendah) , total kolesterol maupun penurunan kadar HDL (lipoprotein kepadatan tinggi). Penelitian ini bertujuan untuk mengetahui adanya hubungan kadar HbA1c terhadap profil lipid pada pasien diabetes melitus di Puskesmas salah satu kecamatan di Sleman, Yogyakarta. Penelitian ini dilakukan secara cross sectional, dengan subjek penelitian sebanyak 36 pasien yang telah memenuhi kriteria inklusi dan eksklusi.  Analisis statistika dilakukan secara univariat dan uji korelasi pearson antar variabel. Penelitian ini menunjukkan 26 pasien (72,2%) berjenis kelamin perempuan yang mengalami diabetes dan hipertensi pada kelompok peserta prolanis. Selain itu, 22 pasien memiliki umur berkisar antara 60-75 tahun, juga diketahui rata-rata pasien memiliki nilai sistolik yang didominasi sebesar 140-159 mmHg (33,3%) dan diastolik sebesar 85 mmHg (44,4%). Adanya 28 pasien (77,8%) memiliki nilai LDL ?100 mg/dL, 20 pasien (55,6%) memiliki nilai  HDL 50 mg/dL, 20 pasien (55,6%) memiliki nilai kolesterol total ?200 mg/dL, dan trigliserida. Kontrol glikemik yang ditunjukkan dengan kadar HbA1c pada subjek penelitian belum terkontrol dengan kadar ?7% sebanyak 23 orang (63,9%).  Hasil uji korelasi antar variabel diketahui bahwa terdapat korelasi kadar HbA1c terhadap profil lipid trigliserida, dengan nilai korelasi sebesar 0,480 (p0,05), dan tidak adanya korelasi antara kadar HbA1c terhadap profil lipid lainnya seperti LDL -0,057 (p0,05); HDL -0,290 (p0,05); Kolesterol Total   0,007 (p0,05). Sehingga dapat disimpulkan bahwa terhadap hubungan kontrol HbA1c terhadap profil trigliserida pada pasien diabetes melitus tipe 2. 
Genetic CYP2A6 Polymorphism May Worsen Glycohemoglobin Levels: Study among Javanese Indonesian Smokers Patramurti, Christine; Virginia, Dita Maria
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5467

Abstract

We have examined the inactive CYP2A6 alleles gene, including CYP2A6*4, CYP2A6*7, and CYP2A6*9, associated with glycohemoglobin levels among Javanese Indonesian smokers. There are 106 smokers participating in this study. Due to the number of cigarettes smoked per day, there are three groups of smokers: light, intermediate, and heavy smokers, with 98.7% being light and intermediated smokers while the rest are heavy smokers. All participants had smoked for more than 10 years, indicating they had been exposed to nicotine for a long time. Based on their genotype, there were four groups of smokers, including fast, intermediate, slow, and poor metabolizers. Most fast and intermediate metabolizers have HbA1c levels in the normal range (<5.7). On the other hand, most slow metabolizers have Hb1c levels >5.7, and all fast metabolizers have HbA1c levels >5.7, indicating that they the prediabetes and diabetes. The chi-square test showed a relationship between CYP2A6 polymorphism and HbA1c levels among the participants (P-value 0.000 <0.005 and χ2=54.6, df=1). The presence of an inactive allele will worsen the HbA1c levels in smokers.
Evaluasi Tingkat Pengetahuan, Sikap dan Tindakan Ibu Pemberdayaan dan Kesejahteraan Keluarga Terkait Penggunaan Antibiotika di Kecamatan Kubu Karangasem Bali: Evaluation of the Level of Knowledge, Attitudes, and Actions of Empowerment and Family Welfare Mothers Related to the Use of Antibiotics in the Kubu Sub-District Karangasem Bali Distya Pratiwi, Luh Anggi; Virginia, Dita Maria; Priyatni, Nunung
Jurnal Surya Medika (JSM) Vol. 10 No. 3 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i3.8984

Abstract

Antibiotika merupakan golongan obat yang paling banyak digunakan di dunia terkait dengan banyaknya kejadian infeksi bakteri. Kurangnya pengetahuan tentang penyakit dapat menyebabkan kesalahan pemilihan obat yang digunakan untuk terapi. Salah satu kurangnya pengetahuan masyarakat yaitu terkait dengan kerasionalan penggunaan antibiotika. Penelitian ini dilakukan untuk mengetahui pengaruh metode seminar terhadap pengetahuan, sikap dan tindakan ibu pemberdayaan dan kesejahteraan keluarga terkait antibiotika di Kecamatan Kubu Karangasem Bali. Penelitian ini merupakan penelitian Analytical Quasi Experimental dengan rancangan two group pre-post test. Pengambilan sampel dilakukan secara purposive sampling melibatkan 84 responden yang dibagi dengan 42 responden pada kelompok kontrol dan 42 responden pada kelompok perlakuan. Data untuk penelitian terkait peningkatan pengetahuan, sikap dan tindakan diperoleh melalui pengisian kuesioner pretest, posttest I, posttest II, dan posttest III. Uji hipotesis pada kelompok perlakuan ini dilakukan untuk membandingkan nilai pretest dengan posttest I, pretest dengan posttest II, pretest dengan posttest III dalam aspek pengetahuan, sikap dan tindakan pada semua dimensi yaitu pada kelompok kontrol aspek pengetahuan dengan nilai 0,726 (pre-post I), 0,558 (pre-post II), 0,533 (pre-post III). Aspek sikap 0,463 (pre-post I), 0407 (pre-post II), 0,543 (pre-post III). Aspek tindakan 0,789 (pre-post I), 0,408 (pre-post II), 0,496 (pre-post III). Hasil yang diperoleh yaitu p > 0,05 yang artinya tidak ada perbedaan yang bermakna pada kelompok kontrol. Sedangkan pada kelompok perlakuan memperoleh nilai pada aspek pengetahuan dan sikap 0,000 (pre-post I, pre-post II, pre-post III). Aspek tindakan 0,000 (pre-post I), 0,003 (pre-post II), 0,011 (pre-post III). Hasil tersebut memperoleh nilai p < 0,05 yang artinya adanya perbedaan bermakna. Kesimpulan dalam penelitian ini adalah adanya intervensi dengan metode seminar mengakibatkan adanya peningkatan terhadap pengetahuan, sikap dan tindakan responden terkait dengan antibiotika.
Smoking as a risk factor for dyslipidemia: study among type 2 diabetes mellitus patients on private hospital in Yogyakarta Patramurti, Christine; Virginia, Dita Maria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1720

Abstract

Smoking behavior is known to be a significant factor that has adverse effects on people with type 2 diabetes (T2DM). Nicotine in cigarettes stimulate adrenoreceptors and promotes lipolysis, leading to the synthesis of free fatty acids, which in turn increase the susceptibility to dyslipidemia and the development of cardiovascular disorders. This study aimed to examine the relationship between smoking status and the occurrence of dyslipidemia in patients with T2DM in a private hospital in Yogyakarta. A total of 107 T2DM patients participated in this cross-sectional observational study. Through live interviews, we collected smoking status conducted using the Fagerström Test for Nicotine Dependence (FTND) questionnaire. The fasting blood samples taken from participants were used to analyze the lipid profiles, including triglycerides (TG), total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The chi-square test revealed a significant association between smoking status and the risk of dyslipidemia among the participants, with χ²(2) = 13.463, p = 0.001. The findings suggest that smoking increases the risk of dyslipidemia among T2DM patients. These results highlight the importance of smoking cessation as a preventive measure to reduce metabolic complications in individuals with T2DM.
CYTOTOXIC ACTIVITY OF Anredera cordifolia LEAF EXTRACT ON HELA CELLS Virginia, Dita Maria; Saputra, Roni Permana; Setiawati, Agustina
BIOTROPIA Vol. 26 No. 1 (2019): BIOTROPIA Vol. 26 No. 1 April 2019
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2019.26.1.863

Abstract

Cervical cancer is the second most frequently occurring cancer among females worldwide. Since the best strategy against cancer is to kill cancer cells without endangering normal cells, discovering a potentially selective anticancer agent from plants has become a major focus for researchers globally. A previous study on Anredera cordifolia, known as binahong in Indonesia, revealed its cytotoxic activity on HeLa cervical cancer cells with an IC₅₀ value of 75 µg/mL. However, the selectivity of the chemical agent and its molecular target was not investigated. Therefore, this study aimed to determine the selectivity of ethanolic extract of Anredera cordifolia leaf (EAC) on Vero cells and its molecular target on HeLa cells. The extract was prepared by macerating A. cordifolia leaf powder in 70% ethanol. The viability of Vero cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while the cell cycle of HeLa cells was analyzed using flow cytometry. The molecular target of the extract was further investigated using immunocytochemical staining. The results demonstrated the selective cytotoxicity of EAC against HeLa cells compared to Vero cells, with a Selectivity Index (SI) of 17.36. The extract induced cell cycle arrest at the G1/S phase and suppressed Bcl-2 expression, an anti-apoptotic protein that also regulates cell cycle progression. These findings support the potential use of A. cordifolia leaf extract as a promising anticancer agent against cervical cancer, particularly HeLa cells.
The The Impact of Antidiabetic Dose Appropriateness Based on Renal Function on Therapeutic Outcomes among Geriatric at Bali, Indonesia Sugiastana, Bagus N.; Hendra, Phebe; Virginia, Dita Maria
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.330-341

Abstract

Background: Diabetes mellitus is a significant global health issue, especially in the older population. Appropriate drug dosing is crucial in geriatric patients because renal function generally declines with age. A decline in renal function is directly associated with the adverse effects of antidiabetic drugs, particularly hypoglycemia, rather than their therapeutic efficacy. Objective: The objective of the present study was to assess the effect of antidiabetic dose appropriateness according to renal function on therapeutic outcomes among geriatric patients at three hospitals in Bali Province. Methods: The research was designed as an observational analytic study with a cross-sectional design. The study involved patients with diabetes aged ≥ 60 years, with or without renal function impairment. Medical records from January to December 2024 were also reviewed for this study. The suitability of antidiabetic drug dosing was evaluated using the estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation. The prescribed doses were compared with the dosage guidelines based on the renal function. A Chi-square analysis was performed to assess the relationship between the appropriateness of the antidiabetic dose and the therapeutic outcomes. Moreover, multivariate analysis was performed using logistic regression after adjusting for other factors. Results: Among the included patients, 27.6% were diagnosed with CKD and 28.4% had renal function classified as stage G2. A total of 51.5% of patients received appropriately adjusted antidiabetic doses. Dose appropriateness was significantly associated with primary clinical outcomes (p<0.05) but not with secondary clinical outcomes. Conclusion: In conclusion, appropriate dose adjustment is essential for enhancing diabetes treatment strategies for geriatric patients with diverse stages of kidney dysfunction.
THE EFFECT OF PHARMACIST INTERVENTION THROUGH TELEPHARMACY SERVICES ON COMPLIANCE AND FASTING BLOOD SUGAR LEVELS IN DIABETES MELLITUS TYPE 2 PATIENTS AT NATALIA FARMA PHARMACY Dharmawan, Nancy Natalia; Virginia, Dita Maria; Priyatni, Nunung
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.13120

Abstract

Diabetes Mellitus is a disease that cannot be cured; thus, it requires high compliance to control blood sugar levels and prevent complications. Telepharmacy can help improve Type 2 Diabetes Mellitus Patients (T2DM) compliance by providing information and education about the disease, medications, and how to use the medication appropriately. The purpose of this study is to analyze the level of compliance and the fasting blood sugar levels of T2DM patients after receiving telepharmacy services by pharmacists at Natalia Farma Pharmacy. This study uses a cohort design with a purposive sampling technique. The research population is the diabetic patients at Natalia Farma Pharmacy in Ende Regency, with a sample size of 60 subjects. In this study, there were two groups observed, namely the intervention and control groups. The intervention group received additional telepharmacy services through WhatsApp for 3 months, including education, drug therapy monitoring, and reminders to take medication. Patient compliance and blood sugar measurement were carried out before and after administering the intervention. The data obtained were then analyzed using SPSS with the t-test. The results showed that telepharmacy affected both patient compliance and fasting blood sugar level, with p-values of 0.002 and 0.009, respectively. Therefore, the existence of telepharmacy intervention can significantly enhance patient compliance and help to control fasting blood sugar levels in T2DM patients at Natalia Farma Ende Pharmacy
Association of glutathione S-transferase M1 (GSTM1) null genotype polymorphism with the effectiveness of metformin monotherapy in type 2 diabetes mellitus (T2DM) patients Ni Luh Made Noviana Dewi; Dwi Aris Agung Nugrahaningsih; Dita Maria Virginia
Indonesian Journal of Pharmacology and Therapy Vol 7 No 1 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.17812

Abstract

Genetic variations may contribute to the development of diabetes and influence individual susceptibility to the disease. One of the relevant genes is glutathione S-transferase M1 (GSTM1). Alterations in the expression of GST enzymes can lead to inefficient detoxification processes. Such genetic variations are believed to contribute to interindividual variability in metformin response, potentially affecting therapeutic outcomes. This study aimed to evaluate the effect of the GSTM1 null genotype on the effectiveness of metformin monotherapy in patients with type 2 diabetes mellitus (T2DM). This was an observational study with a case–control design. The case group consisted of T2DM patients who failed to achieve the target HbA1c level. Detection of the GSTM1 null genotype was performed using polymerase chain reaction (PCR). The association between GSTM1 genotype and the effectiveness of metformin was analyzed using the Chi-square test. Disease risk associated with the genetic polymorphism was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI). There was no significant association between GSTM1 genotype groups and the effectiveness of metformin monotherapy (OR = 0.487; p = 0.318). In conclusion, the GSTM1 null genotype does not significantly influence the therapeutic effectiveness of metformin monotherapy in patients with T2DM.
Genetic study on the impact of rs320 lipoprotein lipase polymorphism on dyslipidemia among Javanese Indonesians with type 2 diabetes mellitus Christine Patramurti; Dita Maria Virginia
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.31349

Abstract

Dyslipidemia commonly co-occurs with type 2 diabetes mellitus (T2DM), acting as a major factor in the elevated incidence of cardiovascular disease (CVD) within this population. One of the factors that raises the risk of dyslipidemia in people with T2DM is lipoprotein lipase (LPL) polymorphisms, particularly the rs320 variant. Associated with lipid metabolic pathways, the LPL rs320 genetic variant is considered a potential contributor to the dyslipidemia observed in several populations with T2DM. The influence of rs320 on dyslipidemia in individuals with T2DM, particularly among Javanese, remains uncertain. The objective of this study is to examine how the rs320 polymorphism affects dyslipidemic profiles among Javanese Indonesian individuals suffering from T2DM. This study included 103 Javanese individuals with T2DM. We detected the rs320 allele using the tetra-primer amplification refractory mutation system-based polymerase chain reaction (T-ARMS-PCR) method. We analyzed the participants' lipid profiles, with enzymatic methods used to measure serum triglycerides (TGs), total cholesterol (TC), and both high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C). We assessed the association of the rs320 allele with dyslipidemia using chi-square tests. Our findings indicated that the rs320 allele was not significantly associated with dyslipidemia among Javanese individuals diagnosed with T2DM (χ² = 0.016, p = 0.900). This suggests the rs320 allele may not contribute to dyslipidemia, although other factors may play a role in Javanese people with type 2 diabetes. Further investigation is needed to identify genetic determinants of dyslipidemia in patients with type 2 diabetes and to potentially enhance personalized medicine based on individual genetics.