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All Journal Jurnal Farmasi Udayana Jurnal Kedokteran Brawijaya BIOTROPIA - The Southeast Asian Journal of Tropical Biology Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasetis Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Borneo Journal of Pharmacy
Dita Maria Virginia
Sanata Dharma University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Dislipidemia sebagai Faktor Risiko Penurunan Nilai Estimasi Laju Filtrasi Glomerulus (eLFG) pada Diabetes Mellitus Tipe II DITA MARIA VIRGINIA; FENTY FENTY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.863 KB)

Abstract

Prevalence of diabetes mellitus type II is high in the world as well as in Indonesia which is 55% patient get dyslipidemia. The risk of cardiovascular disease arises on patient DM type 2 with dyslipidemia so that it is possible to make vasoconstriction in renal artery getting worse. Renal function value can mark from estimated glomerular filtration rate (eGFR). The aim of this study is to determine dyslipidemia in DM type II as risk factor on declining renal function which is marked from decreasing eGFR. This study was analytical observational with cross sectional design. This study compared eGFR between DM type II patient with and without dyslipidemia in Hospital X, Central Java, Indonesia. A hundred subject participated in this study. Data have analyzed in descriptive and Chi-Square using SPSS. Result showed Dyslipidemia on patient Diabetes Mellitus (DM) type II was not risk factor for declining renal function based on eGFR value (OR=0,711, CI95%= 0,270 – 1,875).
Sindrom Metabolik pada Pasien Kanker di Yogyakarta, Indonesia Dita Maria Virginia
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5729

Abstract

Provinsi DI Yogyakarta memiliki prevalensi kanker tertinggi di Indonesia. Di sisi lain, pasien kanker mungkin memiliki risiko penyakit kardiovaskular akibat kemoterapi yang diterima. Penelitian ini bertujuan untuk mengobservasi sindrom metabolik pada pasien kanker di Yayasan Kanker Indonesia di Yogyakarta, sehingga dapat digunakan sebagai skrining awal dan langkah preventif mengurangi risiko penyakit kardiovaskuler maupun relapsing kanker. Jenis penelitian ini adalah observasional analitik dengan desain potong lintang (cross-sectional) dengan mengikutsertakan responden di Yayasan Kanker Indonesia selama bulan Agustus 2018. Kriteria inklusi subyek penelitian adalah pasien terdiagnosa kanker, berusia 20-74 tahun, dan bersedia ikut serta dalam penelitian dengan menandatangani informed consent. Analisis komparatif kategorik digunakan untuk melihat pengaruh jenis diagnosa kanker, stage, dan lama terapi terhadap sindrom metabolik dengan menggunakan Chi-Square. Kanker nasofaring merupakan kanker yang paling banyak ditemui dengan 36,9% pasien pada stage 3 dan 4, serta 55% pasien telah menjalani terapi >3 bulan. Jumlah pasien dengan gula darah sewaktu (GDS)>200 mg/dL, status obesitas [berdasarkan Body Mass Index (BMI) dan lingkar pinggang (LP)], dan hipertensi masing-masing sebesar 6,3; 50,5; dan 47,7%. Terdapat perbedaan proporsi BMI yang bermakna secara statistik (p=0,03) terhadap jenis kanker, namun tidak ditemukan pada variabel yang lain. Untuk bisa mengambil kesimpulan yang lebih baik, perlu adanya peninjuan lebih dalam ke pihak rumah sakit melalui rekam medis terkait dengan stage dan terapi yang diterima oleh pasien.
Sleep quality and duration during pandemic uninvolved to impaired fasting glucose and hyperuricemia among health care practitioners Phebe Hendra; Fenty Fenty; Christianus Heru Setiawan; Leonardo Susanto Utomo; Gregorius Bhaskara Wikanendra; Putu Dyana Christasani; Dita Maria Virginia
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.161 KB) | DOI: 10.12928/pharmaciana.v12i2.20998

Abstract

Sleep quality and sleep duration might be more disturbed throughout the pandemic of Covid-19 among health care practitioners (HCPs). It could influence impaired fasting glucose (IFG) and hyperuricemia. Therefore, the objective of this study was to assess the association between sleep with IFG and hyperuricemia among HCPs throughout the pandemic of Covid-19. We conducted a cross-sectional study that enrolled 58 HCPs in the tertiary hospital. Self-reported questionnaire related to their sleep quality and duration using the Pittsburg Sleep Quality Index (PSQI) were performed by participants. Fasting plasma glucose (FPG) and uric acid (UA) were examined after 10-12 hours of fasting to define IFG and hyperuricemia. A total of 58 HCPs detected 34.5% had IFG and 24.1% had hyperuricemia. We could not identify any statistically significant participants characteristic based on IFG. HCPs who shift workers were 21.4% hyperuricemia compared to 54.4 non-hyperuricemia (p=0.03). There were no different characteristics according to the quality and duration of sleep, where 72.4% HCPs had good quality and duration of sleep. However, we found that sleep medication used scores were higher in IFG group (0.30 ± 0.57) than non-IFG (0.03 ± 0.16) (p<0.01). This study could not detect a significant relationship between quality and/or duration of sleep, with IFG and hyperuricemia. Shift worker significant associated with hyperuricemia (p<0.05). The association between quality and duration of sleep with IFG and hyperuricemia was not found among HCPs, especially during the Covid-19 pandemic. An alert where the IFG group had high sleep medication used scores, and shift workers had a lower risk of hyperuricemia.
THE EFFECT OF HEALTH INSURANCE ON ASTHMA CONTROL IN RESPONDENTS WITH ASTHMA IN YOGYAKARTA, INDONESIA Rita Suhadi; Fenty Fenty; Dita Maria Virginia; Christianus Heru Setiawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.753 KB) | DOI: 10.24071/jpsc.001176

Abstract

Asthma is a chronic disease with recurrent breath shortness. Until now, there is no particular therapy to cure the disease and long-term treatment is needed to control the disease. Health insurance has the benefit to support the asthma therapy. This study aimed to assess the effect of health insurance on the asthma control based on Asthma Control Test (ACT) score. The study was done with a cross-sectional design on respondents with asthma who agreed to sign informed consent forms in Yogyakarta. The asthma respondents (n=36) were selected non-randomly, consisting of 23 respondents with health insurance, including universal health coverage or UHC (n=15), UHC and private insurance (n=7), and private insurance only (n=1). The ratio and categorical data were analyzed with the independent T-test or Mann-Whitney test and chi-square statistics, respectively. The study demonstrated that the profiles and number of medicines were similar between groups, except for lower smoking proportion among health insurance groups; the respondents with and without health insurance had the median ACT score at 22 (partial control) and 15 (bad control) respectively, though the scores were not statistically different. Conclusion: the asthma respondents with and without health insurance were not statistically different in the asthma control.
Genetic CYP2A6 Polymorphism May Worsen Glycohemoglobin Levels: Study among Javanese Indonesian Smokers Christine Patramurti; Dita Maria Virginia
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5467

Abstract

We have examined the inactive CYP2A6 alleles gene, including CYP2A6*4, CYP2A6*7, and CYP2A6*9, associated with glycohemoglobin levels among Javanese Indonesian smokers. There are 106 smokers participating in this study. Due to the number of cigarettes smoked per day, there are three groups of smokers: light, intermediate, and heavy smokers, with 98.7% being light and intermediated smokers while the rest are heavy smokers. All participants had smoked for more than 10 years, indicating they had been exposed to nicotine for a long time. Based on their genotype, there were four groups of smokers, including fast, intermediate, slow, and poor metabolizers. Most fast and intermediate metabolizers have HbA1c levels in the normal range (<5.7). On the other hand, most slow metabolizers have Hb1c levels >5.7, and all fast metabolizers have HbA1c levels >5.7, indicating that they the prediabetes and diabetes. The chi-square test showed a relationship between CYP2A6 polymorphism and HbA1c levels among the participants (P-value 0.000 <0.005 and χ2=54.6, df=1). The presence of an inactive allele will worsen the HbA1c levels in smokers.
Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar Ariyanti, Ni Kadek Nining; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a disease caused by chronic metabolic disorders accompanied by increased blood glucose levels. Adherence to treatment is very important to achieve therapeutic success in type 2 diabetes mellitus (T2DM) patients and prevent complications. HbA1c value is one of the parameters used to see the success of T2DM therapy. This study was conducted to determine the relationship between compliance with antihyperglycemic therapy for T2DM patients and the patient's HbA1c value. This study used a cross-sectional research design and data collection was carried out by non-random sampling with purposive sampling technique. The research subjects were 100 T2DM patients at RSU Prima Medika Denpasar, Bali with the age of 40-70 years. The level of patient compliance in taking medication was measured by the Medication Possession Ratio (MPR) method based on patient treatment records. The results showed 78% aged 40-59 years, 53% female, 86% T2DM with comorbidities 62% received combination therapy, 87% were compliant with taking medication. There was no significant relationship between the characteristics of T2DM patients and compliance (p-value > 0.05). There was a significant association between medication adherence and controlled HbA1c values in patients with T2DM (p-value < 0.05; OR (95%CI) : 4,902 (1,026 - 23,430)).
Drug Interaction Study of Antihypertension in Geriatric Patients Diagnosed Hypertension at Puskesmas Mauponggo, Nusa Tenggara Timur Virginia, Dita Maria; Jago Uko, Maria Anjeline
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.84773

Abstract

Hypertension is one of the main causes of mortality and morbidity in Indonesia. Treatment of hypertension in geriatric patients has the potential to increase the risk of drug-drug interactions because geriatric patients tend to experience polypharmacy. This study aims to analyze differences in mean blood pressure based on the interaction of antihypertensive drugs with other therapies in geriatric patients who suffer from hypertension at the Mauponggo Health Center, Nagekeo, East Nusa Tenggara. This research is a type of analytic observational research using a research design cross sectional. Data collection was carried out retrospectively. Data was collected using medical records collected from January to December 2021. In this study, a sample of 101 patients was obtained who met the predetermined inclusion and exclusion criteria. Data analysis using unpaired T test to analyze the difference of mean blood pressure based on the presence of antihypertensive drug interactions in geriatric patients, regarding on a significance level of p<0.05. The results showed that drug interactions had no effect on the mean systolic (p-value 0.063), or average diastolic (pvalue 0.392) in geriatric patients suffering from hypertension at the Mauponggo Health Center, Nagekeo, East Nusa Tenggara. Antihypertensive drug interactions did not affect the average blood pressure in geriatric patients in this study. Further research is required to classify the types of antihypertensive drugs that significantly impact blood pressure.
The Analysis of Cardiovascular Disease Risk in Type 2-Diabetes Mellitus and Hypertension Patients Consuming Metformin Sari, Theresia Maria Fioretty Ine; Gollumawo, Serly Sofia D.; Co’o, Maria Dolorosa; Virginia, Dita Maria; Hendra, Phebe; Pramono, Zita Dhirani
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.13057

Abstract

Increased blood sugar levels indicate a metabolic disease known as diabetes mellitus (DM). DM is often accompanied by hypertension. Antidiabetic therapy that can be used is metformin, either monotherapy or combined with other drugs such as glimepiride. This study aimed to analyze the risk of heart disease based on creatine phosphokinase (CPK) in patients with type 2 DM and hypertension who are taking metformin and a combination of metformin and glimepiride. We conducted an analytic observational using a cross-sectional design and applied a purposive sampling technique. The study subjects were type 2 DM patients with hypertension who met the inclusion criteria. The data analysis used univariate analysis, Mann-Whitney, and Fisher’s. The results showed that women aged 60-75 years old with uncontrolled FBS, duration of DM < 5 years, and high CPL level were dominated by our respondents. We found that there was no difference in CPK values (p=0.916), and there was no relationship between the use of metformin monotherapy or the combination of metformin and glimepiride on the risk of heart disease in type 2 DM patients with hypertension (p=0.693). In conclusion, metformin consumption in type 2 DM patients has no significant association with heart disease risk.
Pengaruh Interaksi Obat dan ADR Antiretroviral dengan Tingkat Kepatuhan Minum Obat Pasien HIV Nur, Lisa Febriana; Virginia, Dita Maria
Jurnal Farmasetis Vol 13 No 2 (2024): Jurnal Farmasetis: Mei 2024
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/far.v13i2.2255

Abstract

Indonesia merupakan negara dengan penyebaran HIV/AIDS tercepat di antara lima negara Asia Tenggara. Orang yang terinfeksi HIV saat ini ingin memulai pengobatan ARV tidak lebih dari tiga pil per hari di mana mereka biasanya meminumnya sekali sehari. Manajemen kepatuhan dan interaksi obat diperlukan untuk menjaga konsentrasi ARV untuk mencegah replikasi virus. Kepatuhan ARV di Indonesia masih di bawah 95%. Terapi antiretroviral harus seumur hidup tanpa henti karena sekali dihentikan, jika pasien berhenti minum obat, maka HIV akan bertambah jumlahnya. Oleh karena itu, kami meninjau dampak interaksi obat dan ADR ARV terhadap kepatuhan pengobatan. Tujuan penelitian Untuk mengetahui pengaruh interaksi obat dan adr antiretroviral dengan tingkat kepatuhan minum obat pasien hiv. Metode penelitian Dilakukan dengan menggunakan pencarian Pubmed dan google scholar artikel dari tahun 2012 hingga 2022, dengan kata kunci sebagai berikut: HIV/AIDS, interaksi obat, efek samping obat, efek samping, kepatuhan, kepatuhan, ARV. Ada 23 makalah dari google scholar dan 18 makalah dari Pubmed disaring relevansinya dan dipertimbangkan untuk ditinjau lebih lanjut. Berdasarkan hasil penelitian pada tahun 2012 sampai tahun 2022 bahwa kepatuhan minum obat antiretroviral berpengaruh nyata pada pasien dengan penyakit penyerta. Efek samping obat timbul karena penggunaan obat lain bersamaan dengan obat antiretroviral. kepatuhan minum obat ARV lebih dari tiga tahun, 90% memiliki kepatuhan optimal. Penelitian di Malang menyatakan kepatuhan ODHA berada pada tingkat sedang yaitu 60%. Sementara di Papua, 10 perempuan pengidap HIV patuh minum obat dari 20 pasien perempuan pengidap HIV. Studi menunjukkan bahwa kemanjuran obat ARV pada pasien HIV secara signifikan mempengaruhi kepatuhan minum obat. Selain khasiat obat ARV, munculnya efek samping jangka panjang pada pasien HIV dengan hipertensi dan gagal ginjal kronis membuat angka kepatuhan minum obat ARV lebih tinggi 78% dibandingkan obat antihipertensi kronis yang mencapai 68%. Ketidakpatuhan juga dapat dipengaruhi oleh konsumsi alkohol, mariyuana, dan kokain.
Ketaatan Terapi Antihipertensi dengan Terkontrolnya Tekanan Darah pada Pasien Hipertensi Komorbid DM Tipe2 di Puskesmas Kabupaten Sleman Pratiwi, Vera Dwi; Hendra, Phebe; Virginia, Dita Maria
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 10, No 1 (2024): JMK Yayasan RS.Dr.Soetomo, Pertama 2024
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v10i1.1909

Abstract

Hipertensi dan diabetes melitus (DM) tipe2 seringkali terjadi secara bersamaan dan merupakan penyakit degeneratif, namun perburukan prognosis dapat dikendalikan dengan perubahan gaya hidup dan pengobatan. Ketaatan pasien terhadap terapi antihipertensi mempunyai peranan penting dalam manajemen terapi tekanan darah. Tingkat ketaatan terapi dihitung menggunakan metode MPR (Medication Possession Ratio) berdasarkan catatan pengobatan pasien. Penelitian ini bertujuan untuk menganalisis pengaruh ketaatan terapi antihipertensi dengan terkontrolnya tekanan darah pada pasien hipertensi dengan komorbid DM tipe2 di Puskesmas Kabupaten Sleman. Penelitian ini menggunakan desain cross-sectional dan pengambilan data menggunakan teknik non-probability dengan jenis purposive sampling. Sebanyak 116 pasien rawat jalan telah memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan responden didominasi oleh pasien perempuan, usia 60-70 tahun, tekanan darah terkontrol, overweight, tidak polifarmasi, dan menggunakkan BPJS PBI. Ketaatan berhubungan signifikan terhadap terkontrolnya tekanan darah (p-value <0,001, OR (95%CI) = 4,526 (2,071-9,899)). Jenis kelamin, usia, IMT, polifarmasi, status jaminan kesehatan tidak mempengaruhi ketaatan secara signifikan (p-value >0,05). Penelitian ini menyimpulkan bahwa ketaatan terapi berpengaruh signifikan terhadap terkontrolnya tekanan darah pada pasien hipertensi dengan komorbid DM tipe2 di Puskesmas Kabupaten Sleman. Kata kunci : Ketaatan, MPR, Antihipertensi, Komorbid
Co-Authors Agustina Setiawati Albertus I. Brilian Aris Widayati Aris Widayati Ariyanti, Ni Kadek Nining Arwinda, Prili Asri, Ni Komang Intan Prima Brilian, Albertus I. Christianus Heru Setiawan Christine Patramurti Christine Patramurti Co’o, Maria Dolorosa Dewita, Aquina Nino Rama Dhanti Dina Christin Ayuning Putri Djaswadi Dasuki Djunaedi, Jeniffer Kalyana Paramita Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty, Fenty Florentinus Dika Octa Riswanto Gollumawo, Serly Sofia D. Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Immanuel, Handika Jago Uko, Maria Anjeline Jannah, Widyatul Leonardo Susanto Utomo Linawati Yunita Lisa Kurnia Sari, Lisa Kurnia Luh Anggi Distya Pratiwi Nunung Priyatni Nur, Lisa Febriana Pero, Veronika Giuliany Phebe Hendra Phebe Hendra Phebe Hendra Phebe Hendra, Phebe Pinaryanto, Kartono Pramono, Zita Dhirani Pratiwi, Vera Dwi Priyatni, Nunung Putu Dyana Christasani Rita Suhadi Rohmahtika, Amanda Roni Permana Saputra Sari, Theresia Maria Fioretty Ine Sri Hartati Yuliani Travita, Anggi Silva Tunjung Wibowo Wakitha, Stephanus Satria Wira Wiracana, I Made Yunita Linawati