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All Journal Health Information : Jurnal Penelitian Journal of Experimental and Clinical Pharmacy (JECP) Pharmaceutical Reports Journal of Noncommunicable Diseases (JOND) Jurnal Katalisator JURNAL KESEHATAN YAMASI MAKASSAR Sahabat Sosial: Jurnal Pengabdian Masyarakat International Journal of Health Sciences
Rahmah Mustarin
Pharmacy Study Program, Faculty of Medicine and Health Sciences, University of Muhammadiyah Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Determination of UV-Vis Spectrophotometry with Differential pH on Total Anthocyanin Levels of Ethanol Extract of Cordyline fruticosa (L.) A. Cheval Leaves Yuri Pratiwi Utami; Ainun Jariah; Rahmah Mustarin
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.232

Abstract

Cordyline fruticosa (L.) A. Cheval is a traditional medicinal plant contains several chemical compounds including saponins, tannins, flavonoids, polyphenols, steroids, and anthocyanins. The purpose of this study was to determine the total anthocyanin levels of red andong leaf extract. In this study, red andong leaf was extracted using the maceration method with 70% ethanol solvent. Furthermore, qualitative testing was carried out by screening the phytochemicals of red andong leaf extract and continued with qualitative-specific testing for anthocyanins. Then the anthocyanin levels were measured using UV-Vis spectrophotometry with differential pH. The results showed that anthocyanins were of cyanidin type. Furthermore, the measurement of total anthocyanin levels was carried out using the differential pH method. Based on these results it can be concluded that the totalanthocyanin levels of andong red leaf extract (Cordyline fruticosa (L.) A. Cheval) 17.76mg/L.
Fraksi Daun Andong Merah (Cordyline fruticose (L.) A. Cheval) Berpotensi sebagai Sitotoksik Metode BSLT Yuri Pratiwi Utami; Imrawati Imrawati; Suwahyuni Mus; Andi Astri Sri Nurul Fardila Astri; Rahmah Mustarin
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 4, No 1 (2024): April 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v4i1.974

Abstract

Andong merah (Cordyline fruticosa (L.) A. Cheval) merupakan tanaman yang banyak digunakan sebagai obat tradisional. Kandungan senyawa yang ada pada tanaman andong merah berupa metabolit sekunder diantaranya polifenol, flavonoid, saponin, alkaloid, steroid dan triterpenoid sedangkan pada daun andong merah mengandung senyawa polifenol, tannin dan flavonoid. Tujuan dari penelitian ini yaitu untuk mengetahui sitotoksisitas fraksi daun andong merah (C. Fruticosa) terhadap larva udang Artemia salina Leach menggunakan metode BSLT. Ekstrak etanol 70% menghasilkan tiga fraksi yaitu fraksi n-heksan, fraksi etil asetat, dan fraksi etanol-air dengan teknik ekstraksi cair-cair (ECC) menggunakan tiga pelarut. Kemudian diuji sitotoksisitasnya dari seri konsentrasi 20 ppm, 40 ppm, 60 ppm, 80 ppm dan 100 ppm serta kontrol negatif. Hasil yang diperoleh dari penelitian ini berupa aktivitas sitotoksik fraksi dengan parameter nilai LC50 yaitu fraksi n-heksan 25,05 ppm ppm, fraksi etil aetat 85,21 ppm dan fraksi etanol-air 32,39 ppm. Kesimpulannya yakni fraksi dari daun andong merah (C. Fruticosa) termasuk dalam kategori sitotoksistas kuat. Cordyline fruticosa (L.) A. Cheval is a plant that is widely used as a traditional medicine. The compounds contained in the red oak plant are secondary metabolites including polyphenols, flavonoids, saponins, alkaloids, steroids and triterpenoids whereas in the leaves of the red andong contain compound polyphenol, tannins and flavanoids. The aim of the study was to determine the cytotoxicity of the C. fruticosa fraction to the larvae of the shrimp Artemia salina Leach using the BSLT method. The 70% ethanol extract produces three fractions namely the n-hexane fraction, the ethyl acetate fraction and the ethanole-water fraction using the liquid-liquid extraction technique (ECC) using three solvents. Then they tested their cytotoxicity from a series of concentrations of 20 ppm, 40 ppm and 60 ppm as well as negative controls. The results obtained from this study were fractional cytotoxic activity with LC50 parameters of 25.05 ppm n-hexane fraction, 85.21 ppm ethyl acetate fraction and 32.39 ppm ethanol-water fraction. The conclusion is that the fraction of the C. Fruticosa leaves belongs to the category of strong cytotoxists
UJI AKTIVITAS GEL HAND SANITIZER EKSTRAK ETANOL BUAH BIDARA CINA (Ziziphus jujuba) TERHADAP PERTUMBUHAN Escherichia coli: Uji Aktivitas Gel Hand Sanitizer Ekstrak Etanol Buah Bidara Cina (Ziziphus jujuba) Terhadap Pertumbuhan Escherichia coli Thahir, Zakiah; Yuyun Sri Wahyuni; Istianah Purnamasari; Rahmah Mustarin
Jurnal Kesehatan Yamasi Makassar Vol. 8 No. 2 (2024): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jurkes.v8i2.351

Abstract

Gel Hand sanitizer menupakan suatu produk antiseptik untuk mencegah dan membunuh mikroorganisme yang ada pada telapak tangan. Bahan alami juga dapat dijadikan sebagai zat antibakteri dan dianggap lebih aman dibandingkan dari bahan kimia Karena bahan alami memiliki efek samping yang lebih kecil. Selain itu bahan alami sangat mudah didapatkan oleh masyarakat untuk dijadikan sebagai salah satu alternatif zat antibakteri dalam mengurangi infeksi bakteri pada kulit. Salah satunya adalah buah bidara cina (Zizipus jujuba). Penelitian ini bertujuan untuk mengetahui efektifitas gel hand sanitizer ekstrak etanol buah bidara cina (Zizipus Jujuba) terhadap pertumbuhan Escherichia coli Dalam Penelitian ini, dibuat formula gel Hand sanitizer dengan perbandingan konsentrasi ekstrak buah bidara 2,5, 3, dan 3,5%. Diuji aktivitas antimikroba dengan metode difusi cakram. Hasil yang diperoleh menunjukan bahwa gel ekstrak etanol buah bidara cina (Zizipus jujuba) dapat menghambat pertumbuhan Escherichia coli dengan efektivitas kuat 19,6 mm pada konsentrasi ekstrak 3,5%.
Identifikasi dan Penetapan Kadar Flavonoid Ekstrak Etil Asetat Daun Mimba (Azadiractha indica A. Juss) Metode Spektrofotometri UV- Vis Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; Mus, Suwahyuni; Jariah, Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1049

Abstract

Flavonoid terdiri dari 15 molekul yang tersusun dalam susunan C6-C3-C6 yang merupakan senyawa polifenol. Senyawa ini berbentuk kerangka karbon dan terurai menjadi dua set: C6 dan C3. Daun mimba (Azadiractha indica A. Juss) mengandung flavonoid yang memiliki sifat antioksidan, antibakteri, dan antikanker. Penelitian ini bertujuan untuk mengidentifikasi kelompok senyawa dalam daun mimba (Azadirachta indica A. Juss) dan menentukan kadar flavonoidnya. Ekstraksi dilakukan menggunakan teknik maserasi dengan pelarut etil asetat untuk mendapatkan ekstrak yang kemudian diuji melalui skrining fitokimia. Pengukuran kadar flavonoid dilakukan dengan metode spektrofotometri UV-Vis. Dari hasil ekstraksi, diperoleh rendemen ekstrak sebesar 5,83%. Hasil skrining fitokimia menunjukkan adanya kandungan flavonoid dan alkaloid. Kadar flavonoid ditentukan menggunakan kuersetin sebagai standar pembanding, dengan persamaan garis y = 0,0739x + 0,0776. Kesimpulannya, ekstrak etil asetat mengandung flavonoid dengan kadar 1,183 ± 0,018%.Flavonoids consist of 15 molecules arranged in a C6-C3-C6 configuration, which are polyphenolic compounds. These compounds form a carbon framework and are divided into two sets: C6 and C3. Neem leaves (Azadirachta indica A. Juss) contain flavonoids that have antioxidant, antibacterial, and anticancer properties. This study aims to identify the group of compounds in neem leaves (Azadirachta indica A. Juss) and determine their flavonoid content. Extraction was carried out using the maceration technique with ethyl acetate as a solvent to obtain an extract that was then tested through phytochemical screening. Flavonoid content was measured using the UV-Vis spectrophotometric method. The extraction process yielded an extract with a percentage of 5.83%. Phytochemical screening results indicated the presence of flavonoids and alkaloids. The flavonoid content was determined using quercetin as a reference standard, with the equation y = 0.0739x + 0.0776. In conclusion, the ethyl acetate extract contains flavonoids with a concentration of 1.183 ± 0.018%.
Pendampingan dan Sosialisasi dalam Pemberian Edukasi dengan Leaflet (brosur) Penggunaan Obat Tetes Telinga Suminar, Saka; Utami, Yuri Pratiwi; Surya, Sara; Mustarin, Rahmah
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2024): Sahabat Sosial: Jurnal Pengabdian Masyarakat (September)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v2i4.450

Abstract

Various drug-related problems can be caused by the community's lack of understanding about the use and proper handling of drugs. Providing education on how to use special drugs such as ear drops is very important because there are critical points in ear drops, especially in the method of instillation. Providing incomplete and unclear information on how to use drugs will result in less than optimal therapy so that the drug will not achieve the desired therapeutic effect. This community service activity aims to increase public knowledge about how to use ear drops properly. This service is carried out by providing information through leaflets and explaining directly to the community. Providing education on how to administer ear drops to the community received a good response because most people do not know how to use them properly. The presence of 36 participants and the participants who attended were very enthusiastic in listening to the explanation and actively asked questions related to the use of ear drops and their handling. This can support the realization of government programs in improving health services for the community. This counseling received significant results. Therefore, the PkM TEAM hopes that with this counseling, it can share information about the correct use and handling of ear drops with their family members.
Study of Narcotics Management in One of the Private Pharmacies in Makassar City Mustarin, Rahmah; Utami, Yuri Pratiwi; Massolo, Selpi
International Journal of Health Sciences Vol. 2 No. 2 (2024): IJHS : International Journal of Health Sciences
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/ijhs.v2i2.364

Abstract

Drug management is an important aspect of management, because its inefficiency will have a negative impact on health facilities both medically and economically. Drug management includes the stages of planning, procurement, receipt, storage, delivery, destruction, control, recording and reporting. The purpose of this research is to determine the suitability of the management of Narcotic drugs in one of the Makassar City Pharmacies with the regulations stipulated in the Minister of Health Regulation No.73 of 2016 concerning pharmaceutical service standards in Pharmacies and the Food and Drug Supervisory Agency No.4 of 2018 concerning management supervision drugs, medicinal substances, narcotics, psychotropics and pharmaceutical precursors in pharmaceutical service facilities. The type of research used was descriptive using interview and direct observation methods at one of the Makassar City pharmacies. From the results of interviews and observations, the management of narcotic drugs in pharmacies is in accordance with the regulations stipulated in the Minister of Health Regulation No. 73 of 2016 concerning standards of pharmaceutical services in pharmacies and the Food and Drug Supervisory Agency No. 4 of 2018 concerning supervision of the management of drugs and materials. drugs, narcotics, psychotropics and pharmaceutical precursors in pharmaceutical service facilities.
OPTIMIZATION OF ANTIOXIDANT ACTIVITY OF 96% ETHANOL EXTRACT OF Chromolaena odorata L. ABTS RADICAL PROPHYLACTIC Yuri Pratiwi Utami Usman; Rahmah Mustarin; Imrawati; Nurzadrina Wahyuddin; Suhaera; Besse Yuliana
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2817

Abstract

Choromolaena odorata L. is one of the plants used as an antioxidant. This research aims to determine the optimization of the antioxidant activity of 96% ethanol extract of C. odorata L. leaves using the ABTS method, a variety of drying techniques. Previous research has tested antioxidant activity using one drying technique, whereas this research uses a variety of drying techniques because the sample drying technique will affect its activity. Simplicia is obtained from various drying techniques. Then the simplicia was organoleptically tested and its water content was measured using the distillation method. The ethanol extract of Tacklean leaves was carried out using the maceration method using 96% ethanol solvent, then phytochemical screening was carried out using the TLC method and the antioxidant activity test of the ethanol extract of C. odorata L leaves was carried out using the ABTS method. The formation of the ABTS radical cation [2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) forms the basis of one of the spectrophotometric methods that has been applied to the measurement of total antioxidant activity of plants. The research results from the three drying techniques (50°C oven, direct sun drying, and air drying) showed organoleptic results in successive colors (brown, chocolate and dark green), while for shape and odor, namely dry leaves and a distinctive odor. The water content of simplicia ranges from 7.52-9.31%, soaked extract 8.4-10.3% and IC50 23.287-29.064 µg/mL and quarcetin as a comparison with IC50 2.292 µg/mL. Phytochemical screening results contain alkaloids, flavonoids, steroids and tannins. Oven drying at 50°C produced the greatest antioxidant activity with an IC50 value of 23.287 µg/mL which indicates very strong antioxidant power, although the antioxidant activity with a variety of drying techniques was all in the very strong category because it was <50 µg/mL.
Penetapan Sifat Fisikokimia Ekstrak Etanol Daun Mimba (Azadiractha indica A. Juss) : Penelitian Eksperimen Berskala Laboratorium Pratiwi Utami, Yuri; Imrawati, Imrawati; Jariah, Ainun; Mustarin, Rahmah; Bone, Mahfuzun; Bachri, Nurjannah
Health Information : Jurnal Penelitian Vol 16 No 3 (2024): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v16i3.1298

Abstract

Daun mimba (Azadirachta indica A. Juss) banyak digunakan sebagai obat tradisional yaitu untuk mengobati malaria, kencing manis, diare, penurun panas, dan antitukak lambung. Aktivitas suatu ekstrak dapat dipengaruhi oleh senyawa aktif yang terkandung di dalamnya yang bergantung pada sifat fisikokimia dari ekstrak. Penelitian ini bertujuan untuk menentukan sifat fisikokimia ekstrak etanol daun mimba (A. indica A. Juss.). Penelitian bersifat experimental berskala laboratorium yang dimulai dengan sampel diproses hingga menjadi simplisia; kemudian, simplisia diekstraksi melalui metode maserasi dengan pelarut etanol 70%. Penetapan sifat fisikokimia meliputi beberapa parameter yaitu rendemen, organoleptik, kadar senyawa terlarut, penetapan kadar senyawa terlarut, skrining fitokimia, dan penetapan kadar flavonoid total. Hasil penelitian menunjukkan bahwa ekstrak etanol menghasilkan sifat fisikokimia yaitu rendemen ekstrak 19,438 %, organoleptik ekstrak (bentuk (kental); warna (hijau kehitaman); bau (khas); dan rasa (pahit)), penetapan kadar senyawa terlarut (senyawa terlarut air (62.5%); senyawa terlarut pada etanol (71.3%)), skrining fitokimia mengandung (alkaloid, flavonoid, saponin, steroid dan tannin), dan kadar flavonoid total ekstrak yaitu 1.829%.  Dapat disimpulkan bahwa ekstrak etanol daun mimba (A. indica A. Juss.) dapat ditetapkan sifatnya secara fisikokimia dengan beberapa parameter yang telah diuji untuk mengetahui karakteristiknya sehingga disarankan ekstrak ini dapat dikembangkan dalam bentuk sediaan obat bahan alam.
Implementasi Fungsi Sebagai Apoteker Dalam Terapi Pengobatan Swamedikasi Diare Pada Anak Di Sulawesi Selatan Utami, Yuri Pratiwi; Mustarin, Rahmah; Humang, Rezki Ihsan; Imrawati, Imrawati; Amody, Zahira
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 3 No. 3 (2025): Sahabat Sosial: Jurnal Pengabdian Masyarakat (Juni)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v3i3.688

Abstract

Diarrhea is one of the main causes of morbidity and mortality in children, especially in areas with limited access to health services. Self-medication is the main alternative for some people, but is often done without adequate understanding. This community service activity aims to improve parents' understanding of self-medication for diarrhea in children and implement the role of pharmacists in providing education and monitoring rational drug use. Activities are carried out in several areas in South Sulawesi through counseling, training, and individual consultations. The results of the activity show an increase in knowledge and more appropriate behavior in the use of antidiarrheal drugs. The implementation of the role of pharmacists has proven effective in encouraging safe and rational self-medication in the community.
Profile of Pulmonary Tuberculosis Treatment at Kaluku Bodoa Health Center, Makassar City, 2023 Imrawati, Imrawati; Utami, Yuri Pratiwi; Mustarin, Rahmah; Jariah, Ainun; Humang, Rezki Ihsan; Amody, Zahira; S, St. Mujahida
International Journal of Health Sciences Vol. 3 No. 2 (2025): IJHS : International Journal of Health Sciences
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/ijhs.v3i2.752

Abstract

Global TB Report 2022 recorded more than 700 thousand TB cases. This figure is the highest since TB became a National Priority Program. In Indonesia, the highest number of TB cases is found in the productive age group, especially those aged 45 to 54 years. This study aims to determine the profile of pulmonary tuberculosis treatment at the Kaluku Bodoa Health Center. The research design used is a non-experimental study with data collection conducted retrospectively using medical records, including individual characteristics (age, gender, education, occupation), patient type, type of Directly Observed Treatment (DOT) supervisor, and treatment category. Based on the research conducted at the Kaluku Bodoa Health Center, data showed a total of 201 pulmonary tuberculosis patients. In terms of individual characteristics, there were 44 patients aged 46-55 years, 123 male patients, the majority of whom had a primary education level (97 patients), and most of the patients were working (174 patients). Based on patient type, there were more new patients, totaling 177. All patients had a family DOT supervisor, totaling 201 patients. The treatment category used is category 1 for 197 patients.
Co-Authors Ainun Jariah Ainun Jariah Amody, Zahira Andi Astri Sri Nurul Fardila Astri Besse Yuliana Bone, Mahfuzun Humang, Rezki Ihsan Imrawati Imrawati Imrawati Istianah Purnamasari Mar’atun Jannah, Imrawati, Muzakkir Baitz, Massolo, Selpi Mus, Suwahyuni Nurjannah Bachri, Nurjannah Nurzadrina Wahyuddin Pratiwi Utami, Yuri S, St. Mujahida Suhaera Suminar, Saka Surya, Sara Suwahyuni Mus Thahir, Zakiah Utami, Yuri Pratiwi Yuri Pratiwi Utami Yuri Pratiwi Utami Usman Yuyun Sri Wahyuni