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All Journal Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm
Bone, Mahfuzun
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Penetapan Sifat Fisikokimia Ekstrak Etanol Daun Mimba (Azadiractha indica A. Juss) : Penelitian Eksperimen Berskala Laboratorium Pratiwi Utami, Yuri; Imrawati, Imrawati; Jariah, Ainun; Mustarin, Rahmah; Bone, Mahfuzun; Bachri, Nurjannah
Health Information : Jurnal Penelitian Vol 16 No 3 (2024): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v16i3.1298

Abstract

Daun mimba (Azadirachta indica A. Juss) banyak digunakan sebagai obat tradisional yaitu untuk mengobati malaria, kencing manis, diare, penurun panas, dan antitukak lambung. Aktivitas suatu ekstrak dapat dipengaruhi oleh senyawa aktif yang terkandung di dalamnya yang bergantung pada sifat fisikokimia dari ekstrak. Penelitian ini bertujuan untuk menentukan sifat fisikokimia ekstrak etanol daun mimba (A. indica A. Juss.). Penelitian bersifat experimental berskala laboratorium yang dimulai dengan sampel diproses hingga menjadi simplisia; kemudian, simplisia diekstraksi melalui metode maserasi dengan pelarut etanol 70%. Penetapan sifat fisikokimia meliputi beberapa parameter yaitu rendemen, organoleptik, kadar senyawa terlarut, penetapan kadar senyawa terlarut, skrining fitokimia, dan penetapan kadar flavonoid total. Hasil penelitian menunjukkan bahwa ekstrak etanol menghasilkan sifat fisikokimia yaitu rendemen ekstrak 19,438 %, organoleptik ekstrak (bentuk (kental); warna (hijau kehitaman); bau (khas); dan rasa (pahit)), penetapan kadar senyawa terlarut (senyawa terlarut air (62.5%); senyawa terlarut pada etanol (71.3%)), skrining fitokimia mengandung (alkaloid, flavonoid, saponin, steroid dan tannin), dan kadar flavonoid total ekstrak yaitu 1.829%.  Dapat disimpulkan bahwa ekstrak etanol daun mimba (A. indica A. Juss.) dapat ditetapkan sifatnya secara fisikokimia dengan beberapa parameter yang telah diuji untuk mengetahui karakteristiknya sehingga disarankan ekstrak ini dapat dikembangkan dalam bentuk sediaan obat bahan alam.
Antioxidant Activity of Bajakah Kuning (Arcangelisia flava (L.) Merr) Herman, Herman; Almaida, Maria; Haeruddin, Haeruddin; Bone, Mahfuzun; Rusman, Arman
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.652

Abstract

Indonesia is a tropical country with potential plants that have been used as traditional medicine for generations. One of them is bajakah. This study aims to determine the phenolic content and antioxidant activity of yellow bajakah extract and the relationship between phenolic content and antioxidant activity. The study began with making yellow bajakah extract using maceration method. The bajakah extract obtained then analysed the phenolic content quantitatively using the Folin-Ciocalteu method. Antioxidant activity was tested using the DPPH and ABTS methods. The results showed that yellow bajakah extract contained phenolic compounds with levels of 27.15 ± 1.28 mg/g GAE. IC50 measurements to determine antioxidant activity obtained a value of 47.01 ± 1.16 µg / ml in the DPPH method and 61.21 ± 0.83 µg / ml in the ABTS method. Based on these results, yellow bajakah skin is known to have antioxidant activity with a strong category and phenolic content in yellow bajakah skin has an influence on antioxidant activity.
Secondary Metabolites and Cytotoxicity of Kitolod Leaf Extract (Hippobroma longiflora (L.) G. Don to Shrimp Larvae (Artemia salina Leach): Metabolit Sekunder dan Sitotoksisitas Ekstrak Daun Kitolod (Hippobroma longiflora (L.)) terhadap Larva Udang (Artemia salina Leach) Ibrahim, Arsyik; Bulan, Adisty Sindi; Ramadhan, M. Rahmad; Bone, Mahfuzun; Rija'i, Hifdzur Rashif; Rusman, Arman; Arifuddin, M.; Junaidin, Junaidin; Rijai, Laode
Jurnal Riseta Naturafarm Vol. 2 No. 1 (2025): Jurnal Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v2i1.3342

Abstract

One of the plants used by the people of East Kalimantan, especially the people of West Kutai, as a medicinal plant is Kitolod (Hippobroma longiflora L.). The plant parts used are the leaves and flowers. The secondary metabolites contained in Kitolod leaves are alkaloids, saponins, flavonoids and polyphenols. The aim of this research is to identify secondary metabolite groups and test the cytotoxicity of Kitolod leaf extracts and fractions. Secondary metabolites are identified qualitatively using various chemical reagents and metabolites characterized by the presence or absence of color changes or the presence of sediment or foam. Cytotoxicity testing was carried out using the Brine Shrimp Lethality Test (BSLT) method. The data research was analyzed using the Reed and Muench method to determine the Lethality Concentration 50% value. The results of research on the metabolite content of ethanol extract, fractions: n-hexane, ethyl acetate and n-butanol contain alkaloid, flavonoids and phenolic/polyphenols compounds. The bioactivity test results for the ethanol extract had an LC50 value of 592.93 ppm, the n-hexane fractions of 582.77 ppm, the ethyl acetate fraction of 531.37 ppm, and the n-butanol fraction of 119.48 ppm. These results indicate that the n-butanol fraction of Kitolod leaves has stronger cytotoxic activity than other extracts. .
Upaya Peningkatan Kesehatan Melalui Pemeriksaan Kesehatan Gratis pada Masyarakat Desa Bangun Rejo Kecamatan Tenggarong Seberang Kabupaten Kutai Kartanegara sebagai Upaya Deteksi Dini Penyakit Tidak Menular Arifuddin, Muhammad; Samsul, Erwin; Riki; Rija'i, Hifdzur Rashif; Rusli, Rolan; Ibrahim, Arsyik; Febrina, Lizma; Bone, Mahfuzun; Junaidin; Herman; Rusman, Arman; Hikmawan, Baso Didik; Ahmad, Islamudin
Jurnal Abdita Naturafarm Vol. 2 No. 1 (2025): J Abdita Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jan.v2i1.1925

Abstract

Non-communicable diseases (NCDs) have become a significant global health challenge. Conditions such as heart disease, diabetes, and hypertension contribute to more than 70% of deaths worldwide. This community service activity aims to provide free health screenings to the community, particularly to the residents of Desa Bangun Rejo, with the goal of early detection of NCDs. The community service activities involved health screenings followed by direct education to the participants. The results showed that 40 participants attended and gained knowledge about their current health conditions, including blood pressure, blood glucose levels, and uric acid levels. The findings from the health screenings will serve as a reference for participants to understand the importance of regular health check-ups in mitigating future risks Penyakit tidak menular (PTM) menjadi salah satu tantangan kesehatan global yang signifikan. termasuk penyakit jantung, diabetes, dan hipertensi menyumbang lebih dari 70% kematian di seluruh dunia. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemeriksaan Kesehatan gratis kepada masyarakat khususnya masyarakat Desa Bangun Rejo yang bertujuan untuk deteksi dini PTM. Metode kegiatan pengabdian yang dilakukan berupa pemeriksaan Kesehatan dan dilanjutkan pemberian edukasi langsung kepada peserta. Hasil kegiatan pengabdian kepada masyarakat ini menunjukkan peserta yang hadir sebanyak 40 orang mengetahui tentang kondisi saat ini berupa tekanan darah, kadar glukosa darah, dan asam urat. Hasil pemeriksaan yang didapatkan dijadikan sebagai rujukan untuk peserta lebih memahami pentingnya melakukan pemeriksaan kesehatan secara rutin guna menanggulangi resiko yang lebih besar untuk kedepannya
An Innovative Strategy for the Green Synthesis of Nanochitosan Using Plant Extracts and Their Possible Applications: A Review Riki, Riki; Ahmad, Islamudin; Herman, Herman; Ibrahim, Arsyik; Rusman, Arman; Samsul, Erwin; Rusli, Rolan; Arifuddin, Muhammad; Junaidin, Junaidin; Bone, Mahfuzun; Rijai, Hifdzur Rashif; Hikmawan, Baso Didik
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100148

Abstract

The numerous applications of nanochitosan in a variety of sectors, including medicine, food, and agriculture, attract researchers to work toward the development of environmentally favorable, safe, and efficient synthesis methods. Currently, a biological approach is being developed to synthesize nanochitosan to address the limitations of conventional methods. The synthesis of biogenic pathways employs biological entities, including plant extracts and microorganisms, as nanoparticle-forming agents. The use of extracts is more desirable due to the simple working procedure, the absence of hazardous chemicals, the economic benefits, and the use of basic equipment. This article highlights the role of biomolecules in plant extracts, including polyphenols, terpenoids, citric acid, alkaloids, and polysaccharides, in the synthesis of nanochitosan. Nanoparticle preparation protocols and characterization using zeta potential analysis techniques, scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) are briefly described. The potential applications of green nanochitosan are also discussed, considering the results of biological activity testing and the potential mechanisms associated with these activities. According to the results of numerous studies highlighted in this review, nanochitosan synthesis utilizing plant extracts appears to be a promising alternative approach to conventional methods.
Aktivitas Antihiperglikemia Infusa Daun Sambung Nyawa (Gynura Procumbens) dengan Metode Toleransi Glukosa pada Mencit Jantan (Mus Musculus): Antihyperglycemic Activities of Sambung Nyawa Leaves (Gynura Procumbens) Infusion using a Glucose Tolerance Method in Male Mice (Mus Musculus) Ridhotulloh, Yusuf Isro; Rijai, Laode; Mus, Nurul Muhlisa; Arifuddin, M.; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Faisal, Muhammad; Rusman, Arman; Riki, Riki; Almeida, Maria; Bone, Mahfuzun; Arifian, Hanggara; Samsul, Erwin
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2421

Abstract

Hyperglycemia is a condition where blood sugar increases significantly which can lead to diabetes mellitus. Sambung Nyawa (Gynura Procumbens) leaves are a plant that is empirically believed to reduce hyperglycemia and has been scientifically proven based on several studies, however there has been no research that provides information about sembung nyawa leaves in infusion form. This study aims to determine the content of secondary metabolites in the infusion of the leaves of Gynura Procumbens and its antihyperglycemia activity in male males. This study consisted of phytochemical and antihyperglycemia screening using a tolerance method induced by glucose monohydrate at a dose of 2g/kgBW. The test group consisted of a negative control group (Na CMC 1%), a positif group (Glibenclamide), and 3 groups of sambung nyawa leaf infusion (5%, 10%, 15%). The results of the research showed that the infusion of sembung nyawa leaves contained secondary metabolites, namely tannins, phenolics, flavonoids and saponins. The effect of reducing blood sugar levels in test animals showed a significant reduction (0.00<0.05) at a 10% concentration infusion compared to the negative control and not significant to the positive control. The conclusion shows that the infusion of sambung nyawa leaves has an antihyperglycemic effect. Keywords:          Antihyperglycemic, Sambung Nyawa Leaves, Glucose Monohydrate   Abstrak Hiperglikemia merupakan kondisi peningkatan gula darah yang cukup signifikan yang akan berubah menjadi kondisi diabetes mellitus. Daun sambung nyawa (Gynura Procumbens) merupakan tumbuhan yang dipercaya secara empiris menurunkan hiperglikemia dan terbukti secara ilmiah berdasarkan beberapa penelitian dalam bentuk ekstrak. Penelitian ini bertujuan mengetahui kandungan metabolit sekunder pada infusa daun sambung nyawa dan aktivitas antihiperglikemia pada mencit jantan. Penelitian ini terdiri dari skrining fitokimia dan antihiperglikemia menggunakan metode toleransi yang dinduksi glukosa monohidrat dengan dosis 2g/kgBB. Kelompok uji terdiri dari kelompok kontrol negatif (Na CMC 1%), positif (Glibenklamid), dan 3 kelompok infusa daun sembung nyawa (5%, 10%, 15%). Hasil penelitian menunjukkan infusa daun sambung nyawa mengandung metabolit sekunder yaitu tanin, fenolik, flavonoid dan saponin. Efek penurunan kadar gula darah pada hewan uji menunjukkan penurunan yang signifikan (0,00<0,05) pada infusa konsentrasi 10% dibandingkan dengan kontrol negatif dan tidak signifikan terhadap kontrol positif. Kesimpulan menunjukkan bahwa infusa daun sambung nyawa mempunyai efek antihiperglikemia. Kata Kunci:         Antihiperglikemia, Daun Sambung Nyawa, Glukosa Monohidrat  
Formulasi Sediaan Toner Ekstrak Bunga Telang (Clitoria ternatea) sebagai Antioksidan Kulit Herman, Herman; Almeida, Maria; Devara, Rachel; Bone, Mahfuzun; Zamruddin, Nur Masyithah
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.811

Abstract

Bunga telang (Clitoria ternatea) dikenal sebagai tanaman obat yang mengandung antosianin dengan potensi sebagai antioksidan. Penelitian ini bertujuan merumuskan dan mengevaluasi sediaan toner berbahan dasar ekstrak bunga telang sebagai antioksidan untuk perawatan kulit. Ekstrak diperoleh melalui maserasi menggunakan etanol 70%, kemudian diuji kandungan metabolit sekunder serta aktivitas antioksidan dengan metode DPPH. Toner diformulasikan menggunakan basis gliserin 5% dan dievaluasi melalui uji organoleptik, pH, stabilitas, dan aktivitas antioksidan selama empat siklus suhu. Hasil menunjukkan rendemen ekstrak sebesar 7,88% dengan kandungan alkaloid, flavonoid, terpenoid, dan tanin. Aktivitas antioksidan ekstrak tergolong kuat dengan nilai IC50 sebesar 67,73 ppm dan persen peredaman tertinggi 30,603% pada konsentrasi 90 ppm. Toner dengan formula basis gliserin 5% memenuhi kriteria organoleptik dan menunjukkan aktivitas antioksidan tertinggi sebesar 25,145% pada suhu 4?, meskipun nilai pH sediaan belum seluruhnya berada dalam rentang ideal.
Workshop Pembuatan Gummy Candy Madu Kelulut Di Desa Bangun Rejo Kabupaten Kutai Kartanegara Samsul, Erwin; Junaidin, Junaidin; Rijai, Laode; Ibrahim, Arsyik; Herman, Herman; Rusli, Rolan; Ahmad, Islamudin; Febrina, Lizma; Farah, Harra Ismi; Hikmawan, Baso Didik; Rija’i, Hifdzur Rashif; Supriatno, Supriatno; Rusman, Arman; Almeida, Maria; Riki, Riki; Arifuddin, M; Bone, Mahfuzun; Arifian, Hanggara; Setiawaty, Agus
Journal of Community Research and Service Vol. 9 No. 2: July (2025)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jcrs.v9i2.69839

Abstract

A workshop on making gummy candy based on stingless bee honey was held in Bangun Rejo Village, Kutai Kartanegara Regency, as an effort to empower the community through innovation in locally processed food products. The aim of this activity was to improve the skills of MSME actors and village residents in producing stingless honey gummy candy, and to elevate the added value of local honey. The methods used included a short theoretical session about the composition of stingless bee honey and the technical process of gummy candy production, a live demonstration, group practice among participants, as well as evaluation via pre-test and post-test on understanding and skills. The workshop was attended by 50 participants from various MSMEs and community groups. Results showed that after training there was an increase in participant understanding by approximately 75% compared to before the training. Furthermore, participants succeeded in making gummy candy with a chewy texture, the natural sweetness of stingless bee honey, and a distinctive aroma that was well accepted in organoleptic tests. This workshop made a tangible contribution to local product diversification, increasing production capacity, and the potential enhancement of village income through signature products based on stingless bee.
Co-Authors Agus Setiawaty Ainun Jariah Almeida, Maria Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Baso Didik Hikmawan Bulan, Adisty Sindi Devara, Rachel Farah, Harra Ismi Febrina, Lizma Haeruddin Haeruddin Herman Herman Hikmawan, Baso Didik Ibrahim, Arsyik Islamudin Ahmad Islamudin Ahmad Junaidin, Junaidin Laode Rijai M. Arifuddin, M. Mar’atun Jannah, Imrawati, Muzakkir Baitz, Muhammad Faisal Mus, Nurul Muhlisa Nurjannah Bachri, Nurjannah Pratiwi Utami, Yuri Rahmah Mustarin Ramadhan, M. Rahmad Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusli, Rolan Rusman, Arman Samsul, Erwin Sugeng, Santoso Supriatno Zamruddin, Nur Masyithah