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All Journal VALENSI Althea Medical Journal Jurnal Kartika Kimia Jambura Journal of Chemistry Jurnal Abdimas Kartika Wijayakusuma Kartika : Jurnal Ilmiah Farmasi al Kimiya : Jurnal Ilmu Kimia dan Terapan
Yenny Febriani Yun, Yenny Febriani
Universitas Jenderal Achmad Yani
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Efektivitas Berbagai Pengawet Alami Terhadap Daya Simpan Bahan Pangan: Studi Kontekstual Bagi Guru MGMP Kimia Di Kabupaten Kuningan Purbaya, Sari; Kusumaningtyas, Valentina Adimurti; Aisyah, Lilis Siti; Budiman, Senadi; Yun, Yenny Febriani; Yuliana, Trisna; Mulyani, Rahmaniar; Agustini, Dewi Meliati; Suprabawati, Anggi
Jurnal Abdimas Kartika Wijayakusuma Vol 6 No 3 (2025): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v6i3.968

Abstract

Penggunaan bahan pengawet sintetis secara berlebihan dalam makanan menjadi isu penting karena dapat berdampak negatif pada kesehatan konsumen. Salah satu alternatif yang lebih aman dan ramah lingkungan adalah penggunaan pengawet alami, seperti bawang putih dan ekstrak tanaman berkhasiat. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan guru MGMP Kimia di Kabupaten Kuningan tentang penggunaan dan prinsip kerja pengawet alami. Metode kegiatan meliputi penyuluhan interaktif dan demonstrasi praktikum untuk pengaplikasian pengawet alami pada makanan. Sampel hasil olahan mi dan bakso dengan pengawet alami menggunakan ekstrak bawang putih dan lemak biji tengkawang dibawa ke lokasi kegiatan untuk ditunjukkan kepada peserta sebagai contoh produk siap konsumsi. Hasil pengujian menunjukkan bahwa penggunaan ekstrak bawang putih dan minyak biji tengkawang secara signifikan meningkatkan daya simpan mi basah dibandingkan dengan kontrol tanpa bahan tambahan. Selain itu, terdapat peningkatan signifikan dalam pemahaman peserta serta antusiasme untuk mengintegrasikan materi ini ke dalam pembelajaran kimia pada siswa kelas menengah.
Antioxidant Properties of The Ethyl Acetate Extract of Endophytic Fungus Penicillium Citrinum from Kalanchoe Millotii Stem Through Secondary Metabolites Aisyiyah, Isma Nur; Rahmawati, Heni; Agustini, Dewi Meliati; Purbaya, Sari; Aisyah, Lilis Siti; Yun, Yenny Febriani
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 10 No. 2 (2023): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v10i2.30323

Abstract

Kalanchoe, as Cocor Bebek, is a genus of plants that is often used in traditional medicine because it has various biological activities, one of which is as an antioxidant. The development of research was carried out on the secondary metabolites compounds of endophytic fungi from the stem of K. millotii as the Cocor Bebek species. Endophytic fungi are microorganisms that live in plant tissues, generally producing secondary metabolites that have bioactivities such as anticancer, antioxidant, and antibacterial. One of the endophytic fungi isolated from the stem of K. millotii was identified as Penicillium citrinum. The potential antioxidant activity of the secondary metabolites contained in the ethyl acetate extract of the endophytic fungus P. citrinum is interesting to study. The sample extract was extracted using non-polar, semi-polar, and polar solvents. The ethyl acetate extract was separated and purified by various chromatographic methods to obtain 8 mg compound 1, as a yellow solid. The chemical structure was determined by spectroscopic methods. Based on spectrum analysis of 1D-NMR, 2D-NMR, FTIR, and UV-Vis, compound 1 was identified as 4-(2-ethylbutoxy)-3,5-dimethoxybenzaldehyde. Antioxidant activity testing of ethyl acetate extract and compound 1 was carried out using the DPPH (2,2-diphenyl-1-pikrilhidrazyl) method. The test results on the extract showed weak activity with an IC50 value of 401.01 ppm while compound 1 showed moderate activity with an IC50 value of 221.41 ppm
Molecular Docking and ADMET Analysis of Flavonoid Compounds from Bajakah Tampala Stem (Spatholobus littoralis Hassk.) Targeting VEGFR-2 and c-MET Ismail, Dzava Prawinsyah Fairus; Shafa, Nafis; Pendy, Violent Irene; Devon, George Patrick; Yun, Yenny Febriani
Jurnal Kartika Kimia Vol 8 No 2 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i2.982

Abstract

Cancer is a condition marked by abnormal and uncontrolled cell growth, with VEGFR-2 and c-MET receptors contributing to tumor angiogenesis, metastasis, and resistance to therapy. Bajakah tampala stem (Spatholobus littoralis Hassk.) is a traditional plant from Kalimantan that is rich in flavonoid compounds that may interact with these molecular targets. This study aimed to evaluate the molecular interactions, drug-likeness, and pharmacokinetic properties of Bajakah flavonoid compounds through in silico approaches. Lipinski's rule of five and ADMET predictions indicated favorable drug-likeness and absorption profiles for most compounds, although some displayed moderate intestinal absorption and potential mutagenicity. Among the evaluated compounds, hesperetin showed the most favorable predicted binding affinity toward VEGFR-2 (binding energy -9.57 kcal/mol; predicted Ki 97.00 nM), while apigetrin demonstrated the lowest predicted binding energy toward c-MET (-9.43 kcal/mol; predicted Ki 122.94 nM). Both compounds exhibit interactions comparable to reference drugs cabozantinib and crizotinib, suggesting their potential as natural lead compounds for anticancer therapy. Further in vitro and in vivo studies are warranted to confirm their efficacy and safety.
Co-Authors Achmad Zainuddin Achmad Zainuddin Achmad Zainuddin Ade Kania Ningsih Ade Kania Ningsih, Ade Kania Agma, Muljadji Agustini, Dewi Meliati Aisyiyah, Isma Nur Anceu Murniati Anggi Suprabawati Aprina, Lutfia Silva Arie Hardian Arif Rahman Hakim Arif Rahman Hakim Arif Rahman Hakim Budiman, Senadi Devon, George Patrick Dewi Meliati Agustini Euis Julaeha Euis Julaeha Euis Julaeha Evi Sovia Fadlilah, Gina Faizal Hermanto Farizi, Rinaldi Heni Rahmawati Isma Nur Aisyiyah Ismail, Dzava Prawinsyah Fairus Jasmansyah, Jasmansyah Kusumaningtyas, Valentina Adimurti Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah, Lilis Siti Mulyani, Rahmaniar Nur Mala Nurhabibah Nurhabibah Nurhadianti, Adilfi Risma Pendy, Violent Irene Purbaya, Sari Purwoko, Agus Rahmawati, Heni Safi'i, Abdi Wadud Sari Purbaya Sari Purbaya Shafa, Nafis Sujono, Hernandi Sutrisno, Sutrisno Tati Herlina Tati Herlina Tri Reksa Saputra Tri Reksa Saputra Tri Reksa Saputra, Tri Reksa Unang Supratman Unang Supratman Valentina Adimurti Kusumaningtyas Widianingsih, Sopi Yuliana, Trisna Zahra, Nurul Sausan