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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Eduvest - Journal of Universal Studies SEGARA : Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Meditek Jurnal Info Kesehatan
Marlina Dewiastuti, Marlina
FK UPN Veteran Jakarta
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Relationship between Muscle Mass and Fasting Blood Glucose with Vascular Elasticity in Medical Students Purba, Raja Soaloon; Bustamam, Nurfitri; Thadeus, Maria Selvester; Dewiastuti, Marlina
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 17 No 4 (2025): JIKM Vol 17, Issue 4, November 2025
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v17i4.799

Abstract

Background: Low vascular elasticity is one of the key determinants of cardiovascular disease risk. Sedentary lifestyles and high-glucose diets may decrease muscle mass and increase blood glucose levels, potentially reducing vascular elasticity. This study aimed to analyze the relationships among muscle mass, fasting blood glucose levels, and vascular elasticity in medical students. Methods: A cross-sectional study was conducted involving 53 medical students aged 18—22 years using a stratified random sampling technique. Eligible participants were non-smokers, non-alcohol consumers, and had no history of diabetes, hypertension, or the use of medications affecting blood pressure, blood glucose, or cholesterol levels. Muscle mass, fasting blood glucose, and vascular elasticity were measured using a bioelectrical impedance analyzer, capillary blood testing, and an accelerated photoplethysmograph, respectively. Data were analyzed using a Chi-square tests and multivariable Logistic Regression. Results: There were no significant differences in age, blood pressure, BMI, or eating habits between the suboptimal and normal/optimal vascular elasticity groups (p > 0.05). Multivariable analysis showed that muscle mass was significantly associated with vascular elasticity (p = 0.009; OR = 9.656; CI = 1.757–53.075), after adjustment for fasting blood glucose levels (p = 0.386; OR = 2.329; CI = 0.344–15.776). Participants with higher muscle mass were nearly 10 times more likely to have better vascular elasticity. Conclusion: Muscle mass is significantly associated with vascular elasticity in young adults, independent of fasting blood glucose levels. These findings highlight the importance of maintaining adequate muscle mass. Promoting muscle mass through healthy lifestyle habits may help preserve vascular elasticity and reduce the risk of cardiovascular disease.
Rapid Progressive Glomerulonephritis In Drug-Induced Bullous Pemphigoid Dewiastuti, Marlina; Bonar, Maruhum
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i4.64174

Abstract

Rapidly progressive glomerulonephritis (RPGN) is a nephrologic emergency characterized by a rapid decline in renal function over days to weeks and is often associated with active urinary abnormalities. Drug-induced bullous pemphigoid (DIBP) is an autoimmune subepidermal blistering disease triggered by medication exposure and typically shows complement involvement. We report a case of a 62-year-old man with diabetes mellitus who developed pruritic urticarial plaques and tense bullae with erosions and hemorrhagic crusts on the trunk and extremities, predominantly on the dorsal hands and forearms, two days after starting acarbose. During hospitalization, renal function deteriorated rapidly within days, accompanied by significant albuminuria. The Naranjo Adverse Drug Reaction Probability Scale score was 5, indicating a probable drug-related reaction. Acarbose was discontinued and the patient received high-dose systemic corticosteroids (500 mg/day for three days). After seven days of therapy, renal parameters improved. Although renal biopsy and comprehensive serologic work-up were not performed to confirm the exact subtype of crescentic glomerulonephritis, the temporal association, probable causality assessment, and clinical response support an immune-mediated process with concurrent skin and kidney involvement. This case highlights the importance of early renal evaluation and multidisciplinary management in patients with suspected DIBP, as prompt drug withdrawal and immunosuppressive therapy may prevent irreversible kidney damage.
Co-Authors Annela Manurung Arnold Harahap Aulia Chairani, Aulia Bonar, Maruhum cantika Edi Mulyana Edi Mulyana, Edi Fedrizal, Fenandri Fadillah Fenandri Fadillah Fedrizal Harahap, Arnold Irma Fathul Hasanah Irma Fathul Hasanah, Irma Fathul Makkiyah, Feda Anisah Manurung, Annela Maria Selvester Thadeus Melly Kristanti Mohammad Sadhyo Prabhasworo Nabilah, Dini Nikko Darnindro Nikko Darnindro Nurfitri Bustamam Pangaribuan, Kia Iglesias Prabhasworo, Mohammad Sadhyo Purba, Raja Soaloon Purna Sari, Santi Ryan Herardi Simanjuntak, Kristina Theodore, Ishak Ramos theresa, Ria Maria Theresa