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Journal : Pharmaciana: Jurnal Kefarmasian

In vitro penetration of alpha arbutin niosome span 60 system in gel preparation Desnita, Rise; Luliana, Sri; Anggraini, Silvana
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.211 KB) | DOI: 10.12928/pharmaciana.v7i2.6799

Abstract

Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 µmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100µmol has an optimum enterapment efficiency by 99.09%±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%±2.32 compared to alpha arbutin in gel without niosome system about 73.00%±0.94.7.
Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; kasim, zainab
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.287 KB) | DOI: 10.12928/pharmaciana.v8i2.7696

Abstract

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.
Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Rise Desnita; Sri Luliana; Zainab Kasim
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.416 KB) | DOI: 10.12928/pharmaciana.v8i2.7696

Abstract

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.
In vitro penetration of alpha arbutin niosome span 60 system in gel preparation Rise Desnita; Sri Luliana; Silvana Anggraini
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.266 KB) | DOI: 10.12928/pharmaciana.v7i2.6799

Abstract

Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 µmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100µmol has an optimum enterapment efficiency by 99.09%±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%±2.32 compared to alpha arbutin in gel without niosome system about 73.00%±0.94.7.
Total flavonoid contents and in silico study of flavonoid compounds from Meniran (Phyllanthus niruri L.) towards alpha-amylase and alpha-glucosidase enzyme Sri luliana; Rise Desnita; Ronny Martien; Arief Nurrochmad
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.307 KB) | DOI: 10.12928/pharmaciana.v9i1.10416

Abstract

Meniran (Phyllanthus niruri L.) is a plant that is reported to contain flavonoids and shows the activity as a type 2 anti-diabetic by a mechanism of inhibiting the absorption of glucose. Flavonoid compounds such as rutin, quercetin and hesperidin shows anti-diabetic activity. This research aims to determine the levels of total flavonoids and docking studies of flavonoids from meniran against α-amylase and α-glucosidase. Analysis of content of total flavonoids utilizes colorimetric method using AlCl3 and routine standard, the docking study uses Autodock Vina (version 1.1.2) program with the assistance of AutoDockTools (ADT) and visualization of docking results using Discovery Study. The results of the determination of total flavonoids level was 12.32 ± 0.53 mgRE/g extract whereas in ethyl acetate fraction and water each were 19.33±0,68 and 20.07±1.23 mgRE/g respectively. Results of all flavonoids dicking study shows the potential to bind to both receptors, rutin has better binding energy towards α-amylase whereas against α-glucosidase is demonstrated by 3-O -β-D-glucopyranosyl-(2-1)-O-β-D-xylopyranoside quercetin.
Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; Kasim, Zainab
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.7696

Abstract

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.