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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Science and Technology Indonesia Majalah Farmaseutik BULETIN AL-RIBAATH Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Sasambo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Rise Desnita, Rise
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Comparison Ability of Polymers Acrycoat S100 And HPMC K4M to Entrapment Efficiency Domperidone in Microspheres Pratiwi Apridamayanti; Nora Nurlina Sinaga; Rise Desnita
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.18461

Abstract

Domperidone is a prokinetic and antiemetic agent which has low bioavaibility. To increase the bioavaibility of drug, it can be modified into microsphere that can hold drug more longer in gastric to improve the bioavaibility. The microsphere preparation requires a polymer that can make matrix system to protect and deliver the drugs. Acrycoat S100 and HPMC K4M are the usual polymers that used for encapsulation and  have biodegradable characteristic. The aim of this research is to know the comparison ability of two different polymers to entrapment the drug in microsphere. Microsphere domperidone made by solvent evaporation method in 6 formula. F1, F2 and F3 using 50 mg, 100 mg and 150 mg Acrycoat S100 polymer, while F4, F5 and F6 using 50 mg, 100 mg and 150 mg HPMC K4m polymer. The tests were conducted by the determination of the percentage of entrapment efficiency using UV spectrophotometer and evaluation of organoleptic, particle measurement and surface microsphere morphology. The results showed that F3 with Acrycoat S100 polymer has a greater entrapment efficiency of 78,712% ± 4,260% compared to the highest percentage efficiency of HPMC K4M polymer of 4,734±0,390.Key words: Acrycoat S100, domperidone, entrapment efficiency, HPMC K4M, microsphere
Co-Authors ., Saraswati Anastasia, Desy Siska Anggraini, Silvana Anugrah, Gusti Alfi Apridamayanti, Pratiwi Arianda, Muhammad Fikri Arief Nurrochmad Dea Pertiwi Dean Vuai, Felix Ryan Eka Kartika Untari Eka Noviana Hairunnisa, Syarifah Halim, Clara Maretta Hariyanto IH Herlina, Tutun Isnindar Isnindar kasim, zainab Kasim, Zainab Kurniawan, Uray Sandy Luliana, Sri Mariasy, Henny Muhammad Akib Yuswar Mutiara Dinda Putri Nera Umilia Purwanti, Nera Umilia Nora Nurlina Sinaga Novi Yana Santika Nur Atikah Oktavia, Ayu Diah Pratiwi Apridamayanti Putri, Mutiara Dinda Ronny Martien Salim, Suaina Sari, Putri Kemala Sehro Sehro Sehro, Silvana Anggraini Siska Anastasia, Desy Sulaiman, Teuku Nanda Saifullah Tamara, Olivia Utia Mufliha Variandini Aldhila Kharis Variandini Aldhila Kharis, Variandini Aldhila VENI LESTIAWATI Yuswar, Muhammad Akib zai, Khadijah Zainab Kasim