Article Per Year (5 Year)
p-Index From 2020 - 2025
1.405
P-Index
This Author published in this journals
All Journal Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Gotong Royong : Jurnal Pengabdian, Pemberdayaan Dan Penyuluhan Kepada Masyarakat (J-P3KM) Riset Informasi Kesehatan Jurnal Abdimas Kesehatan Jurnal Akademika Baiturrahim Jambi
M. Henityo Agung As'adi
Unknown Affiliation
Religion Chemistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Riset Informasi Kesehatan

 1 
Formulation of fenofibrate nanocrystals with wet milling method M. Henityo Agung As'adi; Ilham Kuncahyo; Teuku Nanda Saifullah Sulaiman
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.761

Abstract

Background: Fenofibrate is an antihyperlipidemic belonging to BCS class II, practically insoluble in water and has high lipophilicity, so it is proven that the inhibitor of the rate of absorption of fenofibrate from the digestive tract is slow to dissolve. This study aims to increase the solubility of fenofibrate by forming nanocrystals. Method: Formation of nanocrystals using the wet milling method Result: The fenofibrate nanocrystals produced a particle size of 775.966 nm, a zeta potential of -21.302 mV, and a solubility of 5.977 μg/mL. Conclusion : The optimum formula with tween 80 components, grinding speed and grinding time in the manufacture of fenofibrate nanocrystals using the Factorial Design method obtained 0.2% tween 80, grinding speed of 500 rpm and grinding time of 1 hour. The critical parameter test results for the optimum formula obtained a particle size of 775.966 nm, a zeta potential of -21.302 mV and a solubility of 5.977 µg/mL. The DSC test showed that there was a difference in the melting point peaks and a decrease in crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The FTIR test showed no difference in functional groups between pure fenofibrate and fenofibrate nanocrystals. The XRD test showed that there was a difference in peak crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The SEM analysis shows that there are differences in shape and magnification used between pure fenofibrate and fenofibrate nanocrystals.
Co-Authors 'Aliyah, Siti Hamidatul Achmad Noerkhaerin Putra Ahmad Rozan Dewansyah Aisa Dinda Mitra AMANDA, REGINA Arista, Dina Dewansyah, Ahmad Rozan Hafsari, Winda Galuh Hasanah, Rifdatul Hayeti, Triana Najma Ibriyanti, Silda Ilham Kuncahyo, Ilham Indra Gunawan Indri Meirista Lili Andriani Mitra, Aisa Dinda Nabhaki, Firelza Novira, Tita Aulya Nurhayati Nurhayati Prianggie, Sherly Alensia Putri, Dzakiah Adillah Regina Amanda Ripani, Izani Fathya Rizky Yulion Ruri Putri Mariska Sandy, Sapna Ari Santi Perawati, Santi Sundari, Popy Susanti, Siti Melvy Teuku Nanda Saifullah Sulaiman Tita Aulya Novira Trifah, Rahmadha Wahyuni, Intan Sri Wiwik Lestari Yulion, Rizky