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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JFL : Jurnal Farmasi Lampung JFM (Jurnal Farmasi Malahayati) Jurnal Farmamedika (Pharmamedica Journal) Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Farmasi Jurnal Pengabdian kepada Masyarakat Wahana Usada DEVOTE: Jurnal Pengabdian Masyarakat Global Jurnal Farmasetis Prosiding Seminar Nasional Pengabdian Kepada Masyarakat: Peduli Masyarakat Benzena Pharmaceutical Scientific Journal Journal of Nutraceuticals and Herbal Medicine Jurnal Abdimas Kesehatan SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Muhammad Sa'ad
Sekolah Tinggi Ilmu Kesehatan Nasional
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Determination Of Total Phenolic, Flavonoid Contents, And Antioxidant Activity Evaluation of Ethanolic Extract From Plumeria Alba Attasih, Monicia; Muhtadi; Pambudi, Dwi Bagus; Saad, Muhammad
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3700

Abstract

A polluted environment and an unhealthy lifestyle can result in an increase in the number of free radicals in the body. This condition can be reduced by consuming antioxidant-rich plants. This study aims to determine the antioxidant activity of the ethanol extract of the Cambodian plant (Plumeria alba L.) and its correlation with phenolic and flavonoid levels. Sample extraction was carried out using the maceration method, antioxidant activity was measured using the DPPH and CUPRAC methods, and total flavonoid and phenolic levels were measured using the spectrophotometer method. The results showed that the ethanol extract of P. alba L stems had inactive antioxidant activity, while the ethanol extract of P. alba L flowers and leaves had weak antioxidant activity with IC50 values of 266.72 ppm and 312.96 ppm. The ethanol extract of P. alba L flowers and leaves has an antioxidant capacity of 208.82 and 207.81 mg trolox equivalent/g extract. The total phenolic content measured from the ethanol extract of P alba L flowers and leaves was 2.28 and 48.43 mg gallic acid equivalent/g extract, while the flavonoid content was 29.73 and 31.26 mg quercetin equivalent/g extract. The antioxidant activity of the extract was positively correlated with phenolic and flavonoid levels.
Pembuatan madu lemu (madu, albumin lele, dan ekstrak temulawak) sebagai makanan tinggi protein untuk pencegahan stunting Sa'ad, Muhammad; Ariyanti, Lilik; Semartini, Atur; Pratimasari, Diah
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 6 No. 2 (2025)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v6i2.23746

Abstract

Stunting masih menjadi permasalahan kesehatan serius di Indonesia, termasuk di Desa Polokarto, Sukoharjo, Jawa Tengah. Salah satu upaya pencegahan stunting adalah dengan meningkatkan asupan protein hewani, salah satunya melalui konsumsi albumin ikan. Bahan tersebut dapat dikombinasikan dengan madu untuk memperbaiki rasa dan temulawak sebagai penambah nafsu makan, menjadi produk fungsional bernama Madu Lemu. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan penyuluhan dan pelatihan kepada kader posyandu di Desa Polokarto mengenai pemanfaatan bahan alam tinggi protein serta teknik pembuatan Madu Lemu. Kegiatan dilaksanakan selama Juli–Agustus 2024 kepada 36 kader yang terbagi dalam 12 kelompok. Metode yang digunakan adalah service learning dengan evaluasi melalui instrumen pretest dan posttest. Hasil menunjukkan peningkatan pengetahuan signifikan dari skor rata-rata 62,58 menjadi 95,16. Kegiatan ini terbukti efektif meningkatkan pemahaman kader tentang bahan alam bergizi tinggi dan keterampilan membuat produk Madu Lemu. Para kader juga telah meneruskan pelatihan ini di tingkat RT. Upaya ini merupakan langkah strategis dalam mendukung penurunan angka stunting secara berkelanjutan di tingkat desa.
Edukasi Pencegahan dan Pengendalian Hipertensi dengan Pemanfaatan dan Pembuatan Yogurt Jambu Biji Merah di Desa Langenharjo, Grogol, Sukoharjo Dhurhania, Crescentiana Emy; Sa'ad, Muhammad; Nuryanti, Afiana Elly; Prasista, Alvina Yaffa; Astrilia, Amanda Putri; Kiswara, Attasa Dwina; Puspo, Celsi Suryo; Putri, Ferisa Ratmalia
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 6 No. 2 (2025): Jurnal Pengabdian kepada Masyarakat Nusantara Edisi April - Juni
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v6i2.6209

Abstract

Jawa Tengah masuk dalam 10 besar provinsi dengan prevalensi hipertensi tertinggi. Di Kabupaten Sukoharjo, Puskesmas Grogol memiliki prevalensi hipertensi yang tertinggi. Hal tersebut menunjukkan bahwa pemahaman tentang penyakit hipertensi dan upaya pencegahan serta pengendalian dengan pemanfaatan bahan alam masih perlu ditingkatkan. Salah satu buah yang berpotensi dikembangkan sebagai bahan dasar minuman fungsional kesehatan untuk mencegah dan mengendalikan hipertensi adalah jambu biji merah. Guna memperpanjang masa simpan, meningkatkan kandungan bioaktif dan nilai ekonomis jambu biji merah maka pada kegiatan ini jambu biji merah dibuat menjadi yogurt. Berbagai penelitian telah membuktikan bahwa yogurt mampu menurunkan resiko hipertensi. Kegiatan ini bertujuan untuk memberikan penyuluhan tentang hipertensi dan pelatihan tentang pembuatan serta pemanfaatan yogurt jambu biji merah untuk mencegah dan mengendalikan hipertensi. Sasaran kegiatan ini adalah masyarakat Desa Langenharjo dengan metode penyuluhan, pelatihan, dan evaluasi. Produk yang dihasilkan mendapat respon positif dengan tingkat kepuasan terhadap kekentalan 88%, aroma 90%, rasa 93%, warna 77%, dan tingkat kesukaan 93%. Hasil evaluasi kegiatan menunjukkan bahwa 80% peserta mengalami peningkatan pengetahuan dan keterampilan, sedangkan kepuasan terhadap pelaksanaan kegiatan mencapai 84%. Hasil kegiatan sangat memberikan dampak positif bagi masyarakat Desa Langenharjo dengan meningkatkan pengetahuan dan keterampilan dalam mencegah dan mengendalikan hipertensi melalui pembuatan dan pemanfaatan yogurt jambu biji merah.
EDUKASI GIZI BERBASIS KEARIFAN LOKAL: PEMANFAATAN DAUN KELOR (MORINGA OLEIFERA) SEBAGAI TEH BOOSTER ASI Lilik Ariyanti; Atur Semartini; Muhammad Sa’ad
Devote: Jurnal Pengabdian Masyarakat Global Vol. 4 No. 2 (2025): Devote : Jurnal Pengabdian Masyarakat Global, Juni 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/devote.v4i2.3922

Abstract

Breast milk (ASI) is the best source of nutrition for infants, providing essential nutrients and energy beneficial to their development. An adequate volume of breast milk is a key factor in the success of exclusive breastfeeding. Moringa leaves have the potential to increase ASI production by enhancing prolactin levels and supplying vital nutrients. Moringa is one of the natural ingredients cultivated by the Women's Farmer Group (KWT) Manunggal Sejati in Polokarto and can be used to support household nutrition, particularly for families with toddlers under stunting supervision. Unfortunately, Posyandu (community health post) cadres in Polokarto lack sufficient knowledge on how to process moringa leaves as ASI booster helping mothers prevent stunting. The aim of this initiative was to improve the knowledge and skills of Posyandu cadres regarding the utilization of moringa leaves as an ASI booster. The activities were conducted at the Polokarto Village Hall during June–July 2024. The program was divided into four phases, including education, training on making moringa leaf tea, and monitoring-evaluation. The educational outcomes demonstrated an increase in participants’ knowledge about the use of moringa leaf tea. The average pre-test score of Posyandu cadres was 63.79 increasing to 87.24 in the post-test following the training. The significant improvement in post-test scores indicates the effectiveness of the training in enhancing cadres' knowledge. Training Posyandu cadres is a vital step toward improving child health within the community.
OPTIMASI CARBOPOL DAN CMC-NA PADA GEL TABIR SURYA EKSTRAK KULIT JERUK NIPIS MENGGUNAKAN SIMPLEX LATTICE DESIGN Dwi Saryanti; Arfi Delasafira; Muhammad Sa'ad
Jurnal Farmamedika (Pharmamedica Journal) Vol. 11 No. 1 (2026): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v11i1.595

Abstract

Paparan sinar matahari yang berkepanjangan berdampak buruk pada kulit, meningkatkan risiko eritema, sengatan matahari, dan berpotensi kanker kulit akibat radiasi UV-B yang berbahaya. Flavonoid, fenol, dan tanin dalam kulit jeruk nipis dapat berfungsi sebagai agen tabir surya alami, karena kemampuannya untuk mengurangi intensitas paparan UV. Studi ini bertujuan untuk mengidentifikasi agen pembentuk gel yang ideal dengan mengevaluasi kombinasi karbopol dan CMC-Na dalam formulasi gel ekstrak etanol kulit jeruk nipis (EKJN) untuk digunakan sebagai tabir surya. Pembuatan EKJN dilakukan melalui proses maserasi dengan etanol 70% sebagai pelarut. Optimasi karbopol dan CMC-Na dilakukan dengan menggunakan pendekatan Simplex Lattice Design, dengan pH, viskositas, daya rekat, dan daya sebar sebagai faktor respons dalam formulasi. Formula terbaik dievaluasi efektivitas tabir suryanya dengan spektrofotometer UV-Vis, dan daya tahan gel optimal diperiksa melalui siklus beku-cair (freeze thaw). Hasil optimasi menunjukkan kombinasi optimal carbopol:CMC-Na adalah 0,5g: 4,5g. Gel yang dihasilkan berwarna kuning kecokelatan, berbau khas jeruk nipis, homogen dengan pH 6,36 ± 0,15, daya sebarr 7,30 ± 0,05 cm, daya lekat 7,27 ± 0,15 detik dan nilai viskositas 250,33 ± 1,52 dPa.s. Nilai SPF 29,75 ± 0,40 dikategorikan sebagai perlindungan sedang. Uji stabilitas freeze-thaw cyling selama 6 siklus menunjukkan sediaan gel tetap stabil selama penyimpanan. Gel EKJN dengan formulasi yang optimum berpotensi sebagai tabirr surya yang efektif dan stabil.
Antioxidant Activity and Total Phenolic Content in Decoction and Infusion Suruhan Herb (Peperomia pellucida) Muhammad Sa'ad; Retnowati Adiningsih; Iffatul Fauziah; Naswa Salsabila Raiqah Putri
BENZENA Pharmaceutical Scientific Journal Vol 5 No 01 (2026): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v5i01.7948

Abstract

Background: Suruhan herb (Peperomia pellucida (L.) Kunth) is a traditional medicinal plant with various pharmacological activities. One of these is its antioxidant activity due to its content of secondary metabolites such as phenols. Phenolic compounds have biological activity as natural antioxidants that can ward off free radicals that cause cell damage and various degenerative diseases. Objective: This study aimed to determine the phytochemical content and determine which extraction method yields the highest total phenol content and antioxidant activity in boiling and brewing of suruhan herb using the DPPH method. Method: Total phenol content was determined using UV-Vis spectrophotometry with gallic acid as the standard. The DPPH method was used to determine antioxidant activity, with vitamin C as a positive control. Results: The results showed that the boiled and brewed of suruhan herb contained phenols, flavonoids, alkaloids, saponins, and tannins. The highest yield was obtained with the boiled method at 56.4%, while the brewed method yielded 21.53%. The total phenol content of the boiled extract was 50.308±0.337 mg GAE/g, while the brewed was 44.649±0.079 mg GAE/g. The antioxidant activity test results showed that the boiled extract had an IC50 value of 28.316 ppm, the brewed 33.942 ppm, and vitamin C, as a positive control, was 4.084 ppm. Conclusion: The antioxidant activity of the boiled extract and the brewed was categorized as very strong, with the boiled extract showing higher antioxidant activity, consistent with the results of total phenol measurements, which also showed higher levels in the boiled extract.
Solvent Variation Effects on Secondary Metabolites Content of Suruhan Herbs and Antioxidant Activity Using DPPH Method Indira Esterina Putri; Muhammad Sa'ad; Retnowati Adiningsih
BENZENA Pharmaceutical Scientific Journal Vol 5 No 01 (2026): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v5i01.7981

Abstract

Background: Suruhan herb (Peperomia pellucida (L.) Kunth) had great potential as a natural antioxidant source due to its secondary metabolite content. Objective: This study aimed to determine the effect of solvent polarity (n-hexane, ethyl acetate, and distilled water) on the secondary metabolite profiles and antioxidant activity of suruhan herb extracts using the DPPH method. Method: Samples were extracted via maceration at a 1:10 ratio. Ethyl acetate and n-hexane extracts were concentrated using a rotary evaporator, while the distilled water extract was dried using a freeze dryer. Results: Phytochemical screening showed that all extracts contained alkaloids, flavonoids, tannins, and phenols. N-hexane and ethyl acetate extracts contained steroids/terpenoids and essential oils, while the distilled water extract contained saponins. One-way ANOVA showed highly significant differences in antioxidant activity. All extracts were categorized as very strong, with the lowest IC50 produced by ethyl acetate (29.37 µg/mL), followed by n-hexane (30.60 µg/mL) and distilled water (30.91 µg/mL). For comparison, Vitamin C had an IC50 of 4.08 µg/mL. Conclusion: Solvent polarity directly influenced the secondary metabolite profiles and antioxidant activity of the extracts. All variations exhibited very strong antioxidant activity (IC50 < 50 µg/mL), with statistically significant differences among the groups and the positive control. Each solvent yielded a significantly different antioxidant potency, ranking: ethyl acetate, n-hexane, and distilled water. Statistical analysis confirmed that ethyl acetate was the most effective solvent for extracting antioxidant compounds.
Formulasi dan Penetapan Kadar Flavonoid Total Sediaan Lip Serum Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L.) Sebagai Antioksidan Dwi Saryanti; Erka Yullita Prameswari; Muhammad Sa&#039;ad
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 2 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i2.270

Abstract

Natural antioxidants are necessary to protect the lips from the drying out, chapping, and accelerated ageing caused by free radicals caused by UV radiation. One possible antioxidant found in starfruit leaves (Averrhoa bilimbi L.) is a flavonoid. The objective of this research is to synthesise lip serum formulations using an ethanol extract of starfruit leaves, then measure the antioxidant activity and total flavonoid content. A 70% ethanol solvent was used for the extraction process, which is known as maceration. There were three different concentrations of extract used to make the lip serum namely, 0,1%, 0,2%, and 0,3%. Methods such as organoleptic evaluation, homogeneity, pH, viscosity, and irritation were used to assess the preparations. The antioxidant activity was evaluated using the DPPH technique, and the total flavonoid content was determined using the AlCl3 colorimetric method with UV-Vis spectrophotometry. The findings demonstrated that every recipe was free of irritating ingredients and fulfilled the physical quality standards of the medicines. Formulas I, II, and III each had a total flavonoid content of 4.287 ± 0.040 mgQE/g, 4.408 ± 0.033 mgQE/g, and 4.497 ± 0.029 mgQE/g, respectively. Strong antioxidants were indicated by the IC50 values of Formula I (64.819 ± 0.363 ppm), Formula II (62.162 ± 0.136 ppm), and Formula III (60.518 ± 0.254 ppm). Total flavonoid content and IC50 value are both affected by the concentration of the extract; the former rises as the latter falls
Co-Authors Alip Desi Suyono Saputri Ardiany, Meliska Lintang Arfi Delasafira Ariyanti, Lilik Astrilia, Amanda Putri Attasih, Monicia Atur Semartini Bryan Dwi Multi Dhurhania, Crescentiana Emy Dwi Saryanti Erka Yullita Prameswari Feronica, Donna Iffatul Fauziah Indira Esterina Putri Iwan Setiawan Kiswara, Attasa Dwina Lilik Ariyanti Muhtadi Naswa Salsabila Raiqah Putri Nova Ramadhan Krisdiyanto Nuryanti, Afiana Elly Pambudi, Dwi Bagus Prahesti, Maya Tesa Prasista, Alvina Yaffa Pratimasari, Diah Puspo, Celsi Suryo Putri Maharani Putri, Ferisa Ratmalia Retnowati Adiningsih Saputri, Alip Desi Suyono Semartini, Atur Susi Rahmawati Susilowati Susilowati