Hary Purnamaningsih
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada. Jl. Fauna No.2, Karangmalang, Depok, Sleman. 55281 Yogyakarta

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Brief Review: The Negative Impact Of Mimosin in L. leucocephala in Ruminant Animals and Processing Methods to Reduce Poisoning Effects on Ruminant Livestock Yanuartono Yanuartono; Soedarmanto Indarjulianto; Alfarisa Nururrozi; Slamet Raharjo; Hary Purnamaningsih
Journal of Livestock Science and Production Vol 3, No 2 (2019): Journal of Livestock Science and Production
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jalspro.v3i2.2037

Abstract

Leucaena leucocephala, a high-quality ruminant feed, is essential for livestock production in the tropics, despite the presence of mimosine in the leaves. Mimosine, in high concentrations, can severely affect animal health and performance. Mimosine and its metabolites, 3-hydroxy-4-(1H)-piridon (DHP), are toxic to ruminants and caused hair loss, slow growth, and oral ulceration, whereas DHP is goitrogenic because it is analogous to tyrosine so resulting in goiter. Mimosine and its metabolites are the main hindrance blocks for the utilization of L.leucocephala as animal feed. Characteristic signs of L.leucocephala toxicity are alopecia, anorexia, reduced weight gain, and weight loss, excessive salivation, esophageal lesions, enlarged thyroid and low circulating concentrations of thyroid hormones. Therefore, the research workers had tried to develop different methods to eliminate the toxicological effects of mimosine and its metabolites. This paper aims to briefly review the negative effects of mimosine from L. leucocephala and its processing to reduce the toxic effects on ruminants. Keywords: Leucaena leucocephala, mimosine, toxicity, metabolites
Nematodes Resistance on Anthelmintics Group of Benzimidazole in Ruminants Yanuartono Yanuartono; Soedarmanto Indarjulianto; Alfarisa Nururrozi; Hary Purnamaningsih
Journal of Livestock Science and Production Vol 3, No 1 (2019): Journal of Livestock Science and Production
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jalspro.v3i1.1464

Abstract

One factor that inhibits the increase in ruminant productivity is nematode infection. It’s cause a decrease in feed intake, weight gain, milk production, disease, death, and expensive medical expenses The control of gastrointestinal nematode infections in livestock, over the past decades is primarily based on the preventive or curative use of chemotherapeutics and generally uses broad-spectrum anthelmintic such as benzimidazole, probenzimidazole, imidazothiazole, macrolide and ivermectin. The widespread use of several antelmintic groups now causes an increase in the incidence of gastrointestinal nematodes resistance against anthelmintics. Anthelmintics derived from various types of plants are expected to replace the benzimidazole so that it can reduce the level of resistance of the gastrointestinal nematodes in ruminants. However, for the future there is still a lot of research needed to further improve the ability of natural medicinal drugs to cope with gastrointestinal nematode infections in ruminants. Keywords : benzimidazole, nematode,resistance, ruminants
The Benefits of Teat Dipping as Prevention of Mastitis Yanuartono Yanuartono; Alfarisa Nururrozi; Soedarmanto Indarjulianto; Hary Purnamaningsih; Dhasia Ramandani
Journal of Livestock Science and Production Vol 4, No 1 (2020): Journal of Livestock Science and Production
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jalspro.v4i1.2796

Abstract

Mastitis is the major disease and the most costly disease of the dairy industry worldwide. One of the mastitis control programs that until now has been carried out and proven to be quite effective is the teat dipping method as a form of prevention. Various methods and uses of teat dipping solutions have been widely used and used for this purpose such as iodine, potassium permanganate, chlorhexidine, chlorhexidine gluconate chlorine, iodophor, sodium hypochlorite, lactic acid, phenolics and Dodecyl Benzene Sulfonic Acid (DDBSA). Pre milking and post milking teat disinfection have been recommended widely by veterinarians and adopted by dairy producers in increasing numbers. This procedure is simple to perform, economical, and effective in controlling contagious mastitis pathogens. More recently, teat dipping in association with good udder preparation reduced the rate of intramammary infections by environmental pathogens. This paper aims to provide a brief review of the benefits of teat dipping as a method of controlling the incidence of mastitis in dairy cows. Keywords: mastitis, teat dipping, pathogens, intramammary infections
Kristaluria disertai Azotemia dan Uremia pada Kucing Purnamaningsih, Hary; indarjulianto, Soedarmanto; Yunitasari, Maria; Ahmadi, Maulidina; Santika, Luh Putu Nadya; Widyarini, Sitarina; sugiyono, Sugiyono
Jurnal Sain Veteriner Vol 42, No 3 (2024): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.83220

Abstract

ABSTRAKKristaluria merupakan salah satu gangguan yang sering ditemukan pada kucing, yang apabila tidak segera ditangani dapat menyebabkan kematian. Laporan kasus ini menyampaikan diagnosis dan terapi kucing penderita kristaluria disertai Azotemia dan Uremia. Laporan kasus ini menggunakan kucing mixdom, jantan, berumur dua tahun, bobot badan 6 kg, yang diperiksakan  karena kucing tidak dapat urinasi selama 5 hari disertai nafsu makan dan minum menurun. Kucing diperiksa secara fisik dan laboratorik, serta diterapi berdasar hasil diagnosis. Hasil pemeriksaan fisik menunjukkan ekspresi muka waspada, kondisi tubuh sangat gemuk dengan body condition score (BCS) 5/5. Frekuensi nafas 80x/menit; frekuensi pulsus 116x/menit; dan suhu tubuh 38,2°C. Palpasi vesica urinaria (VU) kucing teraba mengalami distensi dan terdapat respon nyeri. Saat dilakukan palpasi VU, urin dapat keluar dan tampak berwarna kemerahan (hematuria).  Pemeriksaan urin di bawah mikroskop terlihat adanya kristal magnesium amonium fosfat (struvite). Urinalisis menunjukkan kucing mengalami leukosituria, proteinuria, glukosuria, dan hematuria. Pemeriksaan hematologi dan kimia darah menunjukkan kucing mengalami anemia normositik-normokromik, leukositosis dengan neutrofilia dan limfopenia, azotemia, dan uremia. Kucing didiagnosis mengalami kristaluria disertai azotemia dan uremia dengan prognosis dubius-infausta. Terapi yang diberikan adalah pemijatan VU sampai urin keluar dan VU teraba kosong. Pasien diberikan terapi  Amoxicillin 10% dengan dosis 10 mg/kg bb, IM, 1 x pemberian,  diphenhydramine HCl dengan dosis 1 mg/kg bb, IM 1x pemberian. Selanjutnya diberikan amoxicillin secara oral dengan dosis 12,5 mg/kg bb,diberikan 2x sehari. Obat oral Shi Lin Tong 2x sehari sebanyak 2 tablet. Kondisi kucing menurun di hari kedua pengobatan dan berujung kematian. Perubahan makroskopis organ yang teramati yaitu pulmo mengalami edema dan hemoragi, vesica urinaria mengalami distensi dan hemoragi, ginjal mengalami hemoragi pada corticomedullary junction. Hasil pemeriksaan histopatologis menunjukkan adanya perubahan/gangguan pada vesika urinaria berupa nekrosis sebagian epithel mukosa, hemoragi subepithelial, oedema submukosa, infiltasi netrofil dan limfosit di tunika mukosa sampai tunika muskularis secara diffuse Pada ginjal terlihat vakuola berbatas jelas di sitoplasama epithel tubuli derajat berat, masa homogen eosinofilik dalam jumlah sedang di lumen tubuli. Sebagian kecil epithel tubuli mengalami nekrosis. Kongesti kapiler intraglomerular. Ginjal juga terlihat dilatasi lumen tubuli dengan epithel yang memipih. Urethra terlihat hemoragi (ekstravasasi eritrosit) di subepithelial tunika mukosa disertai infiltrasi limfosit dan neutrophil di tunika mukosa sampai submucosa Gambaran nekropsi pada organ vesica urinaria, ginjal dan urethra mendukung diagnosis berdasar pemeriksaan antemortem.  Kata-kata kunci: kristaluria, azotemia, uremia, struvit 
Case report Diagnosis dan Penanganan Feline Panleukopenia Nareswari, Anggitya; Indarjulianto, Soedarmanto; Yanuartono, Yanuartono; Purnamaningsih, Hary; Widiyono, Irkham
Jurnal Sain Veteriner Vol 42, No 3 (2024): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.100434

Abstract

Feline panleukopenia (FPL) adalah penyakitinfeksi Feline panleukopenia virus yang menyebabkan mortalitas tinggi pada kucing. Penelitianini bertujuan melaporkan diagnosis dan penanganan kasus FPL. Studi kasus ini menggunakan seekor kucing persia mix, betina, berumur empat bulan yang diperiksa secara klinis, uji FPV-Ag dan hematologi. Hasil anamnesis dan pemeriksaan klinis didapatkan bahwa kucing lesu, tidak mau makan, muntah, dan mengalami diare berwarna coklat, suhu tubuh 40,3⁰C, dehidrasi, dan selaput lendir anemis. Hasil pemeriksaan hematologi menunjukkan kucing mengalami leukopenia, anemia dan FPV-Ag test positif, sehingga kucing didiagnosis menderita FPL. Kucing diberi terapi infus Ringer Lactate 30ml/kgBB/ hari IV, enrofloxacin 5 mg/ kgBB/hari SID SC dan Amoxicilin 10 mg/kgBB dua hari sekali IM, hematopoietin  0,1 ml/kgBB BID IV, vitamin-Asam amino 0.1 ml/ kgBB BID IM. Kucing dirawat secara intensif dan mati pada hari ketiga. Disimpulkan bahwa kucing pada kasus ini didiagnosis FPL berdasar gejala klinis, leukopenia dan reaksi positip tes FPV-Ag. Kucing penderita FPL tersebut telah diberi terapi cairan, antibiotik, dan vitamin, tetapi tidak berhasil disembuhkan.
Karakterisasi Gejala Klinis pada Kucing dengan Gangguan Gastrointestinal yang Disertai Leukopenia Ramadhani, Mungky Ema; Yanuartono, Yanuartono -; Indarjulianto, Soedarmanto; Purnamaningsih, Hary; Widyarini, Sitarina; Airin, Claude Mona
Jurnal Sain Veteriner Vol 43, No 1 (2025): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.70783

Abstract

Abstract               Gastrointestinal is one of the digestive system disorders in cats that can be characterized by leucopenia. This study aimed to evaluate the clinical symptoms of cats with digestive disorders with leucopenia. This study used 30 cats of various breeds, ages, and genders that had symptoms of digestive disorders with leucopenia. All cats were physically and laboratory examined for hematology. The data obtained were analyzed descriptively. The results showed 18/30 (60%) cats aged 1-6 months, 9/30 (30%) aged 7-12 months, and 3/30 cats (10%) aged >12 months, had gastrointestinal disorders with leucopenia. Leucopenia conditions were more common in male cats (53.3%) than female cats (46.7%). Cats with leucopenia, 10 (33.3%) with a leukocyte count <1,000 cells/mm3, 14 (46.7%) with a leukocyte count of 1,001-2,500 cells/mm3 and 6 (20%) with a leukocyte count of 2,501-<5,500 cells/mm3. Clinical symptoms found in this study included lethargy, anorexia, fever, dehydration, diarrhea, vomiting, halitosis, hypersalivation, anemia, lacrimation, epistaxis and jaundice. Concluded that gastrointestinal disorders with leucopenia were more common in young cats and male cats. Clinical symptoms of lethargy, anorexia, fever, dehydration, diarrhea and vomiting, can be used as a reference to determine the diagnosis of gastrointestinal disorders with leucopenia in cats. Key words:  cats; clinical sign; gastrointestinal; leucocytes
GAMBARAN VAKSINASI FELINE PANLEUKOPENIA PADA KUCING DI KLINIK DEPARTEMEN ILMU PENYAKIT DALAM FKH -UGM DESCRIPTION OF FELINE PANLEUKOPENIA VACCINATION IN CAT AT THE CLINIC OF THE DEPARTMENT OF INTERNAL MEDICINE FKH UGM Purnamaningsih, Hary; Indarjulianto, Soedarmanto; Widiyono, Irkham; Hartati, Sri; Yanuartono, Yanuartono; Raharjo, Slamet; Nururrozi, Alfarisa
Jurnal Sain Veteriner Vol 43, No 1 (2025): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.70828

Abstract

Abstract              Feline Panleukopenia is a disease caused by a DNA type virus, family Parvoviridae with high morbidity and mortality in the Felidae family group (Kruse et al., 2010; Hartmann, 2017). The study also shows that the prevalence rate of the disease has increased for 3 years since 2015. The report of Kusumawardani et al (2015) shows that 97 cases of cats were diagnosed with FPV. The vaccination program has not been implemented optimally by the cat-keeping community. The incidence of the disease is still common and cases can increase in certain seasons. Several cases handled at the Clinic of the Department of Internal Medicine, FKH-UGM ended in death. There has been no report on the implementation of vaccination in animal health care places. It is necessary to study the vaccination program for cats carried out by the cat-keeping community as an effort to prevent Feline Panleukopenia disease so that it can provide information about FPV vaccination as a basis for optimizing the implementation of FPV vaccination in cats. The study used ambulatory card data from cat examinations as clinical patients of the Department of Internal Medicine, FKH UGM in 2019.  Recap data collected in the form of ambulances for cat patients who requested vaccination. Patient data provided with vaccination services are grouped based on cat identity, age, sex, cat breed/race and maintenance system. The data obtained were tabulated and analyzed descriptively. Based on the results of the recap of ambulatory data for cat patients in 2019 who were vaccinated against feline panleukopenia, 236 individuals were obtained. The age of vaccinated cats at the age of <6 months were 128 animals (54%) and 108 cats (46%). there were 108 cats (46%) male cats and 128 (54%) female cats vaccinated against Feline panleukopenia. Types/breeds of cats, which were vaccinated against feline panleukopenia in purebred cats (Persi, Angora and others) as many as 128 (54%), 35 domestic cats (15%) and 73 mixed-breed cats (31%) ). Based on the study of this research data, it can be concluded that the feline panleukopenia virus vaccination program in male domestic cats is still low compared to purebred cats Keywords : Feline Panleukopenia Virus, cat, vaccination
Perkembangan penyakit mulut kuku dan lumpy skin disease pada peternakan rakyat di wilayah Kabupaten Gunung Kidul: The progress of foot mouth disease and lumpy skin disease on folk farming in the Gunung Kidul District Area Guntari, Guntari Titik Mulyani; Indarjulianto, Soedarmanto; Widiyono, Irkham; Tjahajati, Ida; Wuryastuty, Hastari; Purnamaningsih, Hary; Yanuartono, Yanuartono; Raharjo, Slamet; Datrianto, Dwi S.; Widyastuti, Retno
IGKOJEI: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2024): IGKOJEI: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Peternakan Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46549/igkojei.v5i2.447

Abstract

ABSTRACT  Foot and mouth disease (FMD) and Lumpy Skin Disease (LSD) have been designated as an infectious disease outbreak in livestock in Indonesia. The spread of this case has reached most farms in Indonesia, including livestock warehouses in the Special Region of Yogyakarta, namely Gunung Kidul district. The aim of this activity is to monitor and handle cases of PMK and LSD in Semanu, Playen and Panggang in Gunung Kidul Regency. This community service activity was carried out jointly with the Semanu, Playen and Panggang health centers in Gunung Kidul Regency, the Department of Internal Medicine, FKH UGM, and large animal internal clinic co-assistance students from the PPDH FKH UGM study program. Based on reports from breeders who entered the Puskeswan in June and July 2023, clinical trials were carried out on livestock and livestock treatment. In the Semanu area there was a decrease in FMD cases from one case to no cases, for LSD cases there was also a decrease from 10 to 6 cases. The decline in FMD cases also occurred in Playen District, from one case to zero cases, while LSD cases increased from five cases to seven cases. FMD cases increased in Panggang sub-district from one case to two cases, and LSD cases decreased from 22 to 4 cases. The conclusion from this activity is that cases of FMD and LSD are still found in the Semanu, Playen and Panggang Districts, but are decreasing. Treatment of sick animals and vaccination of healthy animals is the advice given.  Keywords: Gunung Kidul; LSD; Livestock; PMK   ABSTRAK Penyakit mulut dan kuku (PMK) telah ditetapkan sebagai wabah penyakit menular pada peternakan di Indonesia. Bersamaan dengan kejadian PMK, juga ditemukan penyakit Lumpy Skin Disease (LSD) di Provinsi Riau pada Februari 2022. Penyebaran kasus ini telah mencapai di sebagian besar peternakan di wilayah Indonesia, termasuk gudang peternakan di  Daerah Istimewa Yogyakarta yaitu kabupaten Gunung Kidul.  Tujuan kegiatan ini adalah untuk monitoring dan penanganan kasus PMK dan LSD di Semanu, Playen dan Panggang di Kabupaten Gunung Kidul. Kegiatan pengabdian kepada masyarakat ini dilaksanakan bersama sama dengan puskeswan Semanu, Playen dan Panggang Kabupaten Gunung Kidul, Departemen Ilmu Penyakit Dalam FKH UGM, dan mahasiswa koasistensi klinik interna hewan besar prodi PPDH FKH UGM. Dari laporan peternak yang masuk ke Puskeswan pada bulan Juni dan Juli 2023,  dilakukan uji klinis pada ternak dan pengobatan ternak. Di wilayah Semanu terjadi penurunan kasus PMK dari satu kasus  menjadi tidak ada kasus,  untuk kasus LSD juga terjadi penurunan dari 10 menjadi 6 kasus. Penurunan kasus PMK juga terjadi di Kecamatan Playen, yaitu satu kasus menjadi nol kasus, sedangkan kasus LSD meningkat dari lima kasus menjadi tujuh kasus. Kasus PMK meningkat di kecamatan Panggang dari satu kasus menjadi dua kasus, dan kasus LSD menurun dari 22 menjadi 4 kasus. Kesimpulan dari kegiatan ini adalah masih ditemukan kasus PMK dan LSD masih terjadi di Kecamatan Semanu, Playen, dan Panggang, namun mengalami penurunan. Pengobatan terhadap hewan yang sakit dan vaksinasi terhadap hewan yang sehat adalah saran yang diberikan. Kata kunci: Gunung Kidul; LSD; PMK; Ternak
Diagnosis of Feline Panleukopenia Based on Clinical Signs and Polymerase Chain Reaction in Various Ages of Cats Ramadhani, Mungky Ema; Indarjulianto, Soedarmanto; Yanuartono, Yanuartono; Raharjo, Slamet; Purnamaningsih, Hary; Widyarini, Sitarina; Milla, Yunita Apriana
Jurnal Sain Veteriner Vol 42, No 1 (2024): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.79590

Abstract

Feline panleukopenia (FPL) is a viral infectious disease caused by the feline panleukopenia virus (FPV) that affects cats of all ages. Clinical symptoms that appear in each individual cat vary greatly, depending on age, immune status, and the presence or absence of secondary infection. The aim of this research was to diagnose the FPL based on clinical signs and polymerase chain reaction (PCR) in cat with various ages. This study used 15 cats that showed one of clinical symptoms including lethargy, anorexia, fever, diarrhea, and vomiting. All cats were examined physically and by PCR of blood, then analyzed descriptively. The results showed that 10/15 (66.7%) cats were <7 months, 4/15 (26.7%) were 7-12 months, and 1/15 (6.6%) was >1 year old. Identification by PCR showed that 100% of the samples positive, so that all of cats diagnosed FPL. Clinical signs that commonly appeared in this study included anorexia (80%), fever (80%), vomiting (73.3%), lethargy (66.7%), and diarrhea (40%). Young cats <7 months commonly showed anorexia, fever, vomiting, and lethargy, cats aged 7-12 months commonly showed anorexia, fever, vomiting, and diarrhea, cat aged >12 months experienced anorexia and vomiting. Concluded that the predominant clinical symptoms of FPL in young cats were anorexia, fever, vomiting and lethargy, whereas in adult cats anorexia, fever, vomiting, and diarrhea. Clinical symptoms can be used for initial screening of FPL, but the causative diagnosis needs to be determined by polymerase chain reaction.