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All Journal Nexus Kedokteran Klinik The Indonesian Journal of Infectious Diseases Narra J IMTechno: Journal of Industrial Management and Technology Jurnal Penyakit Dalam Indonesia Media Penelitian dan Pengembangan Kesehatan
Susanto, Agung
Fakultas Kedokteran Universitas Sebelas Maret Surakarta
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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The Relationship between Coffee Consumption and Hypertension in the Elderly Yuliana, Erlimia Eka Noor; Susanto, Agung; Hanim, Diffah
Nexus Kedokteran Klinik Vol 4, No 3 (2015): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Coffee contains many potentially active compounds such as caffeine, chlorogenic acids, trigonellin, magnesium, etc. that affect health. Effect of coffee consumption and hypertension is still not known with certainty because of differences in the results of existing research. Therefore, this study aimed to determine the relationship between coffee consumption and hypertension. Methods: This study was conducted with a cross-sectional study of the 103 elderly in Ngudi Sehat Elderly IHC, Surakarta. Samples obtained from the total sample with inclusion and exclusion criteria (n = 90). Independent variable data that is amount and type of coffee consumption obtained from interviews. While the variable dependet taken by measuring blood pressure and categorize by JNC VII. Data were tested with the non-parametric Spearman correlation test and ordinal regression test (α <0.05). Results: The results of the Spearman correlation test showed no significant correlation between the amount of coffee consumption and hypertension (p = 0.432) as well as the type of coffee and hypertension (p = 0.668) in the elderly. Meanwhile, the results of ordinal regression test showed variable that significant influences hypertension are age and body mass index. Conclusion: There is no relationship between coffee consumption and hypertension in the elderly. Elderly with hypertension is recommended to live a healthy lifestyle such as maintaining body weight with physical activity, stop smoking and maintaining intake of nutrient. Keywords: coffee, caffeine, hypertension, elderly, blood pressure
Relationship between Quality of Life and Nutritional Status on Chronic Kidney Disease Patients with Dialysis Type Dewi, Ratih Tri Kusuma; Putranto, Wachid; Susanto, Agung; Suseno, Aryo; Purwanto, Bambang; Mangesti, Rini Dwi; Giani, Maia Thalia; Septian, Muhammad Raditia
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Hubungan Rasio Neutrofil Limfosit terhadap Komplikasi Kardiovaskular pada Pasien Penyakit Ginjal Kronik Hemodialisis Akmal, Thariq Hikmatul; Susanto, Agung; Dewi, Ratih Tri Kusuma; Sunggoro, Agus Jati
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. The neutrophil-to-lymphocyte ratio (NLR) is a simple parameter to assess the inflammatory status, especially in chronic kidney disease (CKD) patients experiencing capillary damage due to increased glomerular capillary pressure. In a state of vascular endothelial inflammation, there is a higher tendency to form atherosclerotic plaques and calcification that can induce cardiovascular events such as heart failure, coronary heart disease, and stroke. This study aimed to determine the relationship between the NLR and cardiovascular complications in CKD patients undergoing hemodialysis. Methods. An analytical observational study with cross-sectional approach was conducted among 119 CKD patients undergoing hemodialysis at Dr Moewardi Regional Hospital who met the inclusion and exclusion criteria. The relationship between the two variables was analyzed using Fisher exact test. Results. The majority of subjects in this study were male (51.3%) and were aged over 50 years old (63.9%). Most subjects experienced complications of heart failure (54.6%), followed by coronary heart disease (19.3%), and stroke (17.7%). Analysis of complete blood count data showed a mean neutrophil count of 77.20% (SD 11.49), lymphocytes 13.64% (SD 8.23), and NLR 10.7 (SD 10.3). Notably, a majority of participants exhibited an NLR value ≥3.5, observed in 95 individuals (79.8%). Fisher exact test results indicated a significant relationship between elevated NLR and cardiovascular complications in hemodialysis CKD patients (p-value= 0.028). Conclusion. There is a significant relationship between NLR and cardiovascular complications in CKD patients undergoing hemodialysis.
Global prevalence and potential factors influencing willingness for renal transplantation in end-stage renal disease patients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Susanto, Agung; Enggriani, Yesica T.; Beluan, Maria IS.; Mirino, Reychell; Farida, Lia D.; Hastutya, Diana V.; Puspitasari, Dewi A.; Putri, Yama S.; Susanto, Jefri P.; Dzhyvak, Volodymyr
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.964

Abstract

The prevalence of willingness to undergo renal transplantation and its potentially associated factors have been documented in multiple prior studies across different regions, yet certain findings are conflicting. The aim of this study was to determine the global prevalence of willingness for renal transplantation and identify its associated factors through meta-analysis methods. Databases such as Scopus, PubMed, and Embase were utilized for the search strategy, covering the period from April to May 2024. Data collection focused on gathering information regarding the prevalence and potential contributing factors of renal transplantation. Statistical analysis involved examining the cumulative prevalence of willingness for renal transplantation using single-arm meta-analysis. Factors associated with willingness for renal transplantation were analyzed using the Mantel–Haenszel test for categorical variables and the inverse variance method for numerical variables. A total of nine articles, covering 3935 patients with end-stage renal disease (ESRD) were included. The pooled estimates revealed that the overall prevalence of willingness to undergo renal transplantation among ESRD patients was 57% (95%CI: 0.46–0.67). Furthermore, we observed a higher likelihood of willingness among men and those of younger age, attainment of at least a bachelor's degree or higher in education, employment status, higher income levels, and a shorter duration of hemodialysis (<5 years). Our study has documented the global prevalence and potential associated factors of willingness to undergo renal transplantation, providing valuable insights for policymakers aiming to enhance the acceptance of renal transplantation.
Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Gersom, Camoya; Wicaksono, Ramadi S.; Tupamahu, Alvira R.; Huda, Fariz N.; Sari, Fitria R.; Dela, Jamaludin A.; Putri, Irawati E.; Sutrisno, Muhammad A.; Putra, Riyantono; Dwinata, Michael; Friatna, Yudha; Albaar, Thoha M.; Susanto, Agung; Dewi, Ratih TK.; Suseno, Aryo; Samsu, Nur
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1782

Abstract

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.
ANALYSIS OF BIOACTIVE COMPOUNDS POTENTIAL IN ETHANOL EXTRACT OF WATERMELONS (Citrullus lanatus) MESOCARP Fauziah, Melinda; Susanto, Agung; Yudhani, Ratih Dewi
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3252

Abstract

Semangka (Citrullus lanatus) merupakan buah tropis yang banyak dibudidayakan dan dikonsumsi di Indonesia. Namun, konsumsi masyarakat umumnya terbatas pada bagian daging buah, sedangkan mesokarp (lapisan putih antara kulit dan daging buah) sering kali dibuang sebagai limbah. Kondisi ini turut menyumbang peningkatan limbah organik dari sektor hortikultura yang belum dimanfaatkan secara optimal. Selain itu, mesokarp semangka diketahui mengandung senyawa bioaktif seperti flavonoid, fenolik, dan alkaloid yang memiliki aktivitas antioksidan, antiinflamasi, dan antidiabetik. Meskipun potensinya telah banyak dilaporkan, namun pemanfaatannya secara optimal dalam pengembangan agen terapi alami masih terbatas. Penelitian ini bertujuan untuk mengeksplorasi kandungan senyawa bioaktif dari ekstrak etanol mesokarp semangka dengan dua konsentrasi pelarut berbeda, yaitu etanol 70% dan etanol 96%, menggunakan metode maserasi. Desain penelitian yang digunakan berupa eksperimental laboratorik. Simplisia mesokarp semangka diekstraksi, kemudian dianalisis kadar total flavonoid, fenolik, dan alkaloid menggunakan metode spektrofotometri UV-Vis. Hasil menunjukkan rendemen pada etanol 70% sebesar 51.7%, lebih tinggi dibandingkan etanol 96% sebesar 44.65%. Kandungan flavonoid dan alkaloid lebih tinggi ditemukan pada ekstrak etanol 70% (masing-masing 4,01% dan 1438,03 µg/g), sementara kandungan fenolik lebih tinggi ditemukan pada etanol 96% (5,92%). Penelitian ini mengindikasikan bahwa pemilihan konsentrasi pelarut yang tepat sangat menentukan keberhasilan ekstraksi senyawa bioaktif dari mesokarp semangka, sehingga berpotensi dimanfaatkan sebagai bahan dasar dalam pengembangan agen antioksidan alami.
Pengaruh Suplementasi Ekstrak Kulit Manggis Terhadap Kadar IL-8 dan Limfosit Pada Pasien COVID-19 dengan Cedera Hati Akut Muhammad Zuhdan Fannani; Triyanta Yuli Pramana; Robert Satriyo Budhi Susilo; Susanto, Agung
The Indonesian Journal of Infectious Diseases Vol. 10 No. 1 (2024): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v10i1.187

Abstract

Latar belakang: Hati merupakan organ utama detoksifikasi dan metabolisme tubuh sehingga penting dalam pengobatan COVID-19. Salah satu pengobatan tradisional yang memiliki sifat hepatoprotektif adalah kulit manggis (Garcinia mangostana L.). Tujuan:Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis terhadap kadar IL-8 dan limfosit pada pasien COVID-19. Metode: Penelitian eksperimental ini dilakukan pada pasien positif COVID-19 di RS. Dr. Moewardi Surakarta. Sebanyak 40 pasien COVID-19 dibagi menjadi 2 kelompok: kelompok kontrol (tanpa terapi adjuvant) dan kelompok perlakuan (dengan suplementasi dry powder kapsul ekstrak kulit manggis dosis 3x1200 mg. Setelah 14 hari, pasien diperiksa kadar sitokin proinflamasi (IL-8) dan limfositnya. Data dianalisis menggunakan program SPSS 25.0 dan hasil dianggap bermakna bila nilai p <0,05. Hasil: Penurunan (selisih post-pre) kadar IL-8 kelompok kontrol (76.4 +234.6, 45.3%) lebih rendah secara bermakna daripada kelompok perlakuan (155.2+408.5, 54.3%) dengan p=0.048. Sedangkan peningkatan (selisih pre-post) kadar limfosit kelompok kontrol (2.2± 4.7, 13.9%) lebih rendah secara bermakna dari kelompok perlakuan (8.1±5.8, 50.9%) dengan p=0.001. Kesimpulan: pemberian ekstrak kulit manggis efektif menurunkan kadar IL-8 dan meningkatkan kadar limfosit pada pasien COVID-19 dengan cedera hati akut. Pemberian suplementasi dry kapsul ekstrak kulit manggis dapat menurunkan kadar IL-8 dan meningkatkan kadar limfosit secara bermakna pada pasien COVID-19 dengan cedera hati akut.  
Pengembangan Warehouse Management System Berbasis Web untuk Inventaris Menggunakan Agile Susanto, Agung; Mutiara, Tika Adilah; Hardi, Nila; Fauziah, Sifa
IMTechno: Journal of Industrial Management and Technology Vol. 7 No. 1 (2026): Vol. 7 No. 1 (2026): Januari 2026
Publisher : LPPM Universitas Bina Sarana Informatika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31294/imtechno.v7i1.11879

Abstract

Pertumbuhan pesat era digital dan Revolusi Industri 4.0 menuntut perusahaan untuk mengotomatisasi proses bisnis guna mencapai operasi yang lebih cepat, efisien, dan terintegrasi. Salah satu bentuk transformasi ini adalah adopsi sistem informasi berbasis web untuk mendukung manajemen gudang dan logistik, yang sebelumnya ditangani secara manual. Studi ini mengembangkan Warehouse Management System (WMS) berbasis web secara internal untuk mengatasi keterbatasan sistem vendor yang seringkali kurang fleksibel, sulit diintegrasikan, dan mahal untuk dipelihara. Sistem ini dirancang untuk mendukung digitalisasi gudang, termasuk manajemen barang, pengendalian stok, pengambilan barang, dan pengiriman antar gudang. Proses pengembangan menerapkan metodologi Agile dengan kerangka kerja Scrum, memungkinkan peningkatan sistem yang iteratif, adaptif, dan responsif sesuai dengan kebutuhan operasional. Desain divisualisasikan melalui diagram UML untuk merepresentasikan alur kerja dan hubungan antar komponen sistem. Hasil menunjukkan bahwa WMS yang diusulkan meningkatkan efisiensi kerja, meningkatkan akurasi data, mengurangi kesalahan manual, dan mengurangi ketergantungan pada pihak ketiga, sehingga mendukung transformasi digital dalam manajemen gudang di era Industri 4.0.
Co-Authors Akmal, Thariq Hikmatul Albaar, Thoha M. Bambang Purwanto Beluan, Maria IS. Camoya Gersom Dela, Jamaludin A. Dewi, Ratih TK. Dwinata, Michael Dzhyvak, Volodymyr Enggriani, Yesica T. Farida, Lia D. Fauziah , Sifa Fauziah, Melinda Fredo Tamara, Fredo Friatna, Yudha Giani, Maia Thalia Hanim, Diffah Hastutya, Diana V. Huda, Fariz N. Jonny K. Fajar Mangesti, Rini Dwi Mirino, Reychell Muhammad Zuhdan Fannani Nila Hardi Nur Samsu Puspitasari, Dewi A. Putra, Riyantono Putranto, Wachid Putri, Irawati E. Putri, Yama S. Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Robert Satriyo Budhi Susilo Sari, Fitria R. Septian, Muhammad Raditia Sunggoro, Agus Jati Susanto, Jefri P. Suseno, Aryo Sutrisno, Muhammad A. Tika Adilah M Triyanta Yuli Pramana Tupamahu, Alvira R. Wicaksono, Ramadi S. Yudhani, Ratih Dewi Yuliana, Erlimia Eka Noor