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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Dentika Dental Journal Althea Medical Journal Global Medical and Health Communication Journal of Medicine and Health Medika Kartika : Jurnal Kedokteran dan Kesehatan Majalah Biomorfologi (Biomorphology Journal) Journal of Medicine and Health
Andri Rezano
Department Of Biomedical Sciences, Division Of Cell Biology, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Gallic Acid Content and Antioxidant Activity of Pomegranate Peel Ethanol Extract Diah Dhianawaty; Latifah Rahman Nurfazriah; Andri Rezano
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2108

Abstract

Ethanol extract of Pomegranate peel is proven to have the ability to inhibit the proliferation of cervical cancer HeLa cells. It was reported that this extract contains ellagic acid, gallic acid, and punicalagin which are identified as major effectors of antitumor activity. Gallic acid has been demonstrated to have an antioxidant activity that can influence cancer cell proliferation. The aim of the study was to identify the gallic acid content in pomegranate peel ethanol extract and to measure its antioxidant. This study was an experimental study performed at the Biochemistry and Molecular Biology Laboratory and Central Laboratory of Universitas Padjadjaran Bandung, Indonesia during September-December 2019. Gallic acid concentration was measured by using a high-performance liquid chromatography method (HPLC) and the antioxidant activity was measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The extract contained 616.97 mg/kg of gallic acid with an antioxidant activity of IC50 6.1 µg/mL. In conclusion, gallic acid has cytotoxic and antitumor effects from its ability to modulate antioxidant/pro-oxidant balance and inhibit reactive oxygen species (ROS). Therefore, both gallic acid content and antioxidant activity parameters can be used as markers in pomegranate peel extract which shows activities that inhibit HeLa cell proliferation. Kandungan Asam Galat dan Aktivitas Antioksidan Ekstrak Etanol Kulit DelimaEkstrak etanol kulit buah delima terbukti dapat menghambat proliferasi sel kanker serviks (sel HeLa). Ekstrak ini telah dilaporkan mengandung asam ellagat, asam galat, dan punicalagin yang diidentifikasi sebagai  efektor utama dari aktivitas anti-tumor. Berdasarkan pernyataan sebelumnya, pemeriksaan ekstrak akan dilakukan dengan mengidentifikasi salah satu senyawa tersebut yaitu asam galat. Aktivitas antioksidan dapat mempengaruhi proliferasi sel kanker, oleh karena itu, akan ditentukan pada ekstrak. Penelitian ini dilakukan di Laboratorium Biokimia dan Biologi Molekuler dan Laboratorium Sentral Universitas Padjadjaran periode September-Desember 2019. Kandungan asam galat diukur dengan metode kromatografi cair kinerja tinggi (KCKT) dan aktivitas antioksidan diukur dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Ekstrak mengandung asam galat 616,97 mg/kg dan memiliki aktivitas antioksidan IC50 6,1 μg/mL. Berdasarkan aktivitasnya, asam galat mempunyai efek sitotoksik dan antitumor yang dihasilkan oleh kemampuannya untuk memodulasi keseimbangan antioksidan/pro-oksidan dan menghambat spesies oksigen reaktif. Aktivitas antioksidan yang sangat kuat dari ekstrak juga disebabkan oleh adanya asam galat; asam galat dikenal sebagai antioksidan kuat. Antioksidan mampu melindungi sel normal dengan menurunkan level ROS, sehingga memproteksi sel dari kerusakan. Dengan demikian, kedua parameter tersebut dapat digunakan sebagai bagian dari penanda untuk ekstrak kulit delima yang mempunyai aktivitas menghambat proliferasi sel HeLa.
Knowledge Level towards Breast Cancer and Breast Self-Examination among Medical Students of Indonesia Andri Rezano; Marhendra Satria Utama; Hesti Lina Wiraswati; Savira Ekawardhani; Melia Juwita Adha; Nurul Mufliha Patahuddin; Veronica Oladitha Siagian; Siti Silvia Nur Shofa Shamantri; Erlangga Ing Geni Bisma Pratama; Liana Awalia Lutfunnisa; Asep Wiryasa; Hansen Wangsa Herman
Global Medical & Health Communication (GMHC) Vol 10, No 1 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.144 KB) | DOI: 10.29313/gmhc.v10i1.8942

Abstract

Breast cancer is a life-threatening disease among Indonesian women. The etiology of breast cancer is still uncertain, and therefore adequate primary prevention is difficult. Early diagnosis improves cancer prognosis while also reducing medical costs, substantially reducing mortality rates. Knowledge and awareness of breast cancer risk factors and their screening may help women take preventive measures. The community service program aimed to assess the level of understanding of undergraduate medical students on breast cancer and breast self-examination (BSE). It was a one-group pretest-postest quasi-experimental study to measure the level of knowledge of 100 medical students in Indonesia from August 20th, 2020, to February 27th, 2021. The participants were asked 36 questions, which was an adaptation of previous questionnaires. A mini-lecture managed the program that focuses on risk factors and early detection. Furthermore, pretest and post-test were conducted to analyze the knowledge level before and after the dissemination. The participants included in this study were mostly 20 years and above (62%). The average recognition of breast cancer and its early detection was not high. The knowledge of breast cancer among medical students was found to be moderate. The efficacy of dissemination among medical students was apparent in knowledge change. However, good cancer awareness, especially breast cancer, needs to be established and integrated through effective cancer educational programs in the medical curricula. Hence, modification of the medical curriculum through extensive training on breast cancer preventive measures and early diagnosis is required.
Knowledge Level towards Cervical Cancer Among Students of Baabul Kamil Vocational High School Windi Nurdiawan; Chrestella Odillia; Monica Risnadena Priyas; Yosefa Resti Radinda; Nabila Alifia Ahmad; Nur Agustina Ningsih; Qhonita Anif Febian; Andri Rezano
Global Medical & Health Communication (GMHC) Vol 8, No 3 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.897 KB) | DOI: 10.29313/gmhc.v8i3.6275

Abstract

Cervical cancer is one of the most common causes of cancer-related death in women worldwide that is mostly preventable and treatable. Knowledge and awareness of cervical cancer screening programs allow the implementation of the prevention of cervical cancer. The community service program is aimed to increase the knowledge of adolescents about cervical cancer and its screening. It was a one-group pretest-posttest quasi-experimental study to measure the level of knowledge of 45 female students of Baabul Kamil Vocational High School, Jatinangor, Sumedang. The study was conducted in May–June 2018. The participants were asked 15 questions, which was an adaptation of previous questionnaires. The program was managed by a mini-lecture that focuses on cervical cancer risk factors and early detection. Furthermore, pretest and posttest were conducted to analyze the level of knowledge on the aforementioned aspects before and after the dissemination descriptively. The participants included in this study were mostly 16 years old (67%). The average recognition of cervical cancer and its early detection was not high. The knowledge of cervical cancer among students of Baabul Kamil Vocational High School was found to be moderate. There is a significant improvement in knowledge level after dissemination. The efficacy of dissemination among female students at Baabul Kamil Vocational High School was apparent in knowledge change. However, good cancer awareness, especially cervical cancer, needs to be established and integrated through effective cancer educational programs in the school curriculum. Key intervention strategies are required to raise cancer awareness in support of taking precautions and early detection measures. TINGKAT PENGETAHUAN SISWI SMK BAABUL KAMIL TENTANG KANKER SERVIKSKanker serviks merupakan salah satu penyebab paling umum kematian terkait kanker pada wanita di seluruh dunia yang sebagian besar dapat dicegah dan diobati. Pengetahuan dan kesadaran tentang program deteksi dini kanker serviks merupakan upaya pencegahan kanker serviks. Program pengabdian pada masyakat ini bertujuan meningkatkan pengetahuan remaja mengenai kanker serviks dan deteksi dininya. Penelitian ini merupakan penelitian one-group pretest-posttest quasi-experimental untuk mengukur tingkat pengetahuan 45 siswi SMK Baabul Kamil, Jatinangor, Sumedang. Penelitian ini dilaksanakan pada bulan Mei–Juni 2018. Responden diberikan 15 pertanyaan yang merupakan adaptasi dari kuesioner sebelumnya. Program ini dilakukan melalui penyuluhan tentang faktor risiko kanker serviks dan deteksi dininya. Selanjutnya, dilakukan pretest dan posttest untuk menganalisis tingkat pengetahuan aspek-aspek tersebut sebelum dan sesudah penyuluhan secara deskriptif. Responden yang terlibat dalam penelitian ini sebagian besar berusia 16 tahun (67%). Identifikasi pengetahuan tentang kanker serviks dan deteksi dininya rerata tidak tinggi. Pengetahuan tentang kanker serviks di kalangan siswa SMKBaabul Kamil tergolong sedang. Terdapat peningkatan yang bermakna tingkat pengetahuan responden setelah diberikan penyuluhan Efektivitas sosialisasi di kalangan siswa perempuan di SMK Baabul Kamil terlihat dari perubahan pengetahuan. Namun, kesadaran kanker yang baik, khususnya deteksi dini kanker serviks perlu diatur dan diintegrasikan melalui program pendidikan kanker yang efektif dalam kurikulum sekolah. Langkah strategis diperlukan untuk meningkatkan kesadaran tentang kanker demi mendukung tindakan pencegahan dan deteksi dini.
Correlation of Thrombocytopenia and Length of Hospitalization in Dengue Child Patient Riyadi Adrizain; Ananda Hanifah Husna; Andri Rezano
Global Medical & Health Communication (GMHC) Vol 8, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.754 KB) | DOI: 10.29313/gmhc.v8i2.5506

Abstract

Dengue virus infection (DVI) is one of the major health problems that cause 500 thousand patients hospitalized annually. Thrombocytopenia is one of the abnormal hematologic findings that is always found in DVI patients. This study aimed to determine the correlation of thrombocytopenia and length of hospitalization in dengue child patients. This retrospective analysis study used secondary data from seven major hospitals in Bandung with a total sampling method. The inclusion criteria were patients aged 0–18 years old diagnosed with dengue fever (DF), or dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS) who was admitted from January to December 2015 and excluded when there was comorbid as well as incomplete data. The correlation was analyzed by Spearman’s rank correlation test. There were 2,025 samples from a total of 5,712 DVI cases during 2015. Among those who admitted, most of the patients experienced severe thrombocytopenia (40%) with the average length of hospitalization was 4.84 days. This result was not much different from the patients with moderate (38.1%) and mild (21.9%) thrombocytopenia who were treated for an average of 4.13 days and 4.08 days, respectively. The analysis of correlation obtained a significant relationship between thrombocytopenia and length of hospitalization despite showing a weak correlation (r=0.231, p=0.001). In conclusion, there is a weak correlation between thrombocytopenia and length of hospitalization among dengue child patients. KORELASI TROMBOSITOPENIA DENGAN LAMA RAWAT INAP PADA PASIEN ANAK TERINFEKSI VIRUS DENGUEInfeksi virus dengue (IVD) merupakan salah satu masalah kesehatan utama yang menyebabkan 500 ribu pasien dirawat di rumah sakit setiap tahun. Trombositopenia adalah salah satu temuan abnormal hematologi yang selalu ditemukan pada pasien IVD. Penelitian ini bertujuan mengetahui korelasi trombositopenia dengan lama rawat inap pada pasien anak terinfeksi virus dengue. Penelitian analitik retrospektif ini menggunakan data sekunder tujuh rumah sakit besar di Kota Bandung dengan metode total sampling. Kriteria inklusi adalah pasien anak usia 0–18 tahun yang didiagnosis demam dengue (DD), atau demam berdarah dengue (DBD), atau sindrom syok dengue (SSD) yang dirawat dari bulan Januari hingga Desember 2015. Kriteria eksklusi meliputi komorbiditas dan data rekam medis yang tidak lengkap. Analisis dilakukan dengan uji korelasi rank Spearman. Terdapat 2.025 sampel dari total 5.712 kasus IVD selama tahun 2015. Di antara yang dirawat, sebagian besar pasien mengalami trombositopenia berat (40%) dengan lama rawat inap rerata 4,84 hari. Hasil ini tidak jauh berbeda dengan pasien dengan trombositopenia sedang (38,1%) dan ringan (21,9%) yang dirawat selama rerata 4,13 hari dan 4,08 hari masing-masing. Analisis korelasi diperoleh hubungan yang bermakna antara trombositopenia dan lama rawat inap meskipun dengan nilai korelasi lemah (r=0,231; p=0,001). Simpulan, terdapat korelasi lemah antara trombositopenia dan lama rawat inap pada pasien anak terinfeksi virus dengue.
Plasma Malondialdehid and Histopatology Healing Score Differences in Incised Old and Young Mice Zinc with Zinc Administration Moniq W. Aryantie; Rizqy D. Monica; Andri Rezano; Sudigdo Adi; Kiki A. Rizki; Yenni Zuhairini
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.125 KB) | DOI: 10.28932/jmh.v2i1.743

Abstract

Free radical plays role in wound healing. This study was conducted to determinedifferences in level of plasma malondialdehyde (MDA), and histopathological score of woundhealing by administering zinc in old and young mice. We used 24 old mice and 24 young miceincision wound model, randomized into two groups, with and without zinc administration. Wefound plasma MDA level was lower in old mice with zinc administration but not statisticallysignificant. The plasma MDA level was significantly higher by administering zinc in young mice(p=0.004). The plasma MDA level of young mice was higher than old mice in zincadministration group (p=0.010). Reepitelialization, inflammatory cells, fibroblasts andangiogenesis did not differ by administering zinc both in old mice and young mice.Reepitelialization, inflammatory cells and angiogenesis did not differ between old and youngmice in mice that were given zinc; while fibroblast of young mice is more than old mice(p=0.010). We concluded  plasma MDA level is higher in young mice with zincadministration. Plasma MDA level in young mice is higher than old mice with zincadministration. Young mice with zinc administration have higher fibroblast than oldmice.Keywords: aging, free radical, histopathologic score, malondialdehid, wound healing, zinc
EFEK EKSTRAK ETANOL DAUN PETAI CINA (Leucaena glauca. Benth.) TERHADAP FUNGSI DAN GAMBARAN HISTOPATOLOGIS HATI TIKUS (Rattus novergicus) GALUR WISTAR MODEL FIBROSIS HATI Ardella Tri Novianti; Endry Septiadi; Vita Murniati Tarawan; Andri Rezano; Achadiyani Achadiyani
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 1 No 1 (2017): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (686.033 KB)

Abstract

Kerusakan hati kronis berkaitan kerusakan sel hati, aktifnya sel stelat, akumulasi protein matriks ekstraselular, dan menyebabkan fibrosis hati. Petai cina (Leucaena glauca, Benth.) secara empiris digunakan untuk mengobati penyakit hati. Daun petai cina mengandung antioksidan dan zat aktif seperti tanin, saponin, alkaloid, dan saponin yang dapat membantu perbaikan fungsi hati pada fibrosis. Penelitian ini bertujuan menganalisis efek ekstrak etanol daun petai cina terhadap perbaikan fungsi dan histolopatologis hati tikus model fibrosis. Kelompok uji dibagi menjadi kontrol negatif yang diberi aquades, kelompok perlakuan 1, 2 dan 3 diberikan ekstrak etanol daun petai cina selama 14 hari dengan dosis 2,25; 4,5 dan 9 mg/200gBB. Uji Analisis data SGOT, SGPT, dan jumlah sel hepatosit normal menggunakan ANOVA, dilanjutkan dengan uji a Scheffe. Data perubahan derajat fibrosis menggunakan uji Kruskall-Wallis dan dilanjutkan uji Mann Whitney. Terdapat perbedaan signifikan kelompok perlakuan dengan kelompok kontrol terhadap penurunan kadar SGOT (p=0,001), SGPT (p=0,000), peningkatan jumlah hepatosit normal (p=0,000), dan penurunan derajat fibrosis (p=0,04). Hasil uji Krusskall Wallis menunjukkan derajat fibrosis pada kelompok kontrol berbeda bermakna (p=0,04) dengan kelompok perlakuan. Hasil uji Mann Whitney menunjukkan derajat fibrosis pada kelompok kontrol berbeda bermakna (p<0,05) dengan kelompok perlakuan 3 (p=0,015). Ekstrak etanol daun petai cina (Leucaena glauca,Benth.) memiliki efek memperbaiki fungsi hati dengan menurunkan kadar SGOT dan SGPT, meningkatkan proliferasi sel hati yang normal, serta menurunkan derajat fibrosis. DOI : 10.35990/mk.v1n1.p1-14
THE EFFECT OF LASER-ASSISTED HATCHING ON PREGNANCY OUTCOMES OF VITRIFICATION FROZEN EMBRYO TRANSFER Vellyana Lie; Andri Rezano; Tono Djuwantono; Maitra Djiang Wen
Majalah Biomorfologi Vol. 34 No. 2 (2024): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v34i2.2024.114-122

Abstract

Highlights LAH might effectively increase pregnancy outcomes for frozen-thawed embryo transfer. Zona pellucida drilling might help increase pregnancy outcomes in FET.   Abstract Background:  Zona Pellucida (ZP)  thickness of less than 16 mm is better for embryo implantation inside the endometrium. Laser Assisted Hatching (LAH) is commonly used, especially in non-contact mode, using a 1.48-um infrared diode laser beam because of its short exposure time, accurate positioning, simple operation, indirect contact, safety, and effectiveness. Objective:  This paper describes the potential of laser-assisted hatching in biochemical pregnancy outcomes in Frozen Embryo Thawed transfers. Material and Method: The total number of patients enrolled in this study was 141. Patients were prospectively treated during embryo transfers at Pusat Fertilitas Bocah Indonesia, Primaya Hospital at Tangerang, Indonesia, from December 2020 until December 2021. Result:  There were no significant differences between the LAH and no-LAH groups regarding average age, infertility duration, infertility type, and etiology of infertility (p>0.05). In the same line, the blastocyst (0.76 ± 0.87; 1.25 ± 1.08) compared with cleavage (0.72 ± 0.84; 0.67 ± 0.98) (p<0.534 and p< .032). There was no significant difference, even though clinically, the proportions of live births, multiple pregnancies, biochemical pregnancies, and ongoing pregnancies in the LAH group were not exceptions to the outcomes of failures and miscarriages. Conclusion:  LAH did not appear to increase the pregnancy rate in this study. However, the methodology seems to reduce bias in this study by considering methodology for selecting FET embryos based on the cryopreserved condition, embryo quality, and precise LAH.
Plasma Malondialdehid and Histopatology Healing Score Differences in Incised Old and Young Mice Zinc with Zinc Administration Moniq W. Aryantie; Rizqy D. Monica; Andri Rezano; Sudigdo Adi; Kiki A. Rizki; Yenni Zuhairini
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.743

Abstract

Free radical plays role in wound healing. This study was conducted to determinedifferences in level of plasma malondialdehyde (MDA), and histopathological score of woundhealing by administering zinc in old and young mice. We used 24 old mice and 24 young miceincision wound model, randomized into two groups, with and without zinc administration. Wefound plasma MDA level was lower in old mice with zinc administration but not statisticallysignificant. The plasma MDA level was significantly higher by administering zinc in young mice(p=0.004). The plasma MDA level of young mice was higher than old mice in zincadministration group (p=0.010). Reepitelialization, inflammatory cells, fibroblasts andangiogenesis did not differ by administering zinc both in old mice and young mice.Reepitelialization, inflammatory cells and angiogenesis did not differ between old and youngmice in mice that were given zinc; while fibroblast of young mice is more than old mice(p=0.010). We concluded  plasma MDA level is higher in young mice with zincadministration. Plasma MDA level in young mice is higher than old mice with zincadministration. Young mice with zinc administration have higher fibroblast than oldmice.Keywords: aging, free radical, histopathologic score, malondialdehid, wound healing, zinc
Co-Authors Achadiyani Afrida Aizzatun Istiqomah Agustinus Agustinus Almira Zada Ananda Hanifah Husna Ardella Tri Novianti Asep Wiryasa Chen En Pan Chrestella Odillia Christian Christopher Sunnu Dahlan, Mohamad Rinaldi Diah Dhianawaty Endry Septiadi Eni Maria Sisca Erlangga Ing Geni Bisma Pratama Hansen Wangsa Herman Herry Herman Hesti Lina Wiraswati I'tishom, Reny Irma Ruslina Jefry Albari Tribowo Juanarta, Pieter Kiki A. Rizki Latifah Rahman Nurfazriah Liana Awalia Lutfunnisa Maharani Simanjuntak Maitra Djiang Wen Maitra Djiang Wen Marhendra Satria Utama Maulida Hayati Melia Juwita Adha Mohamad Rinaldi Dahlan Monica Risnadena Priyas Moniq W. Aryantie Nabila Alifia Ahmad Nadiyah Nadiyah Ninik Darsini Nur Agustina Ningsih Nurul Mufliha Patahuddin Pakpahan, Cennikon Pieter Juanarta Pitaloka, Pritha Praditya Virza Ramadhan Qhonita Anif Febian Ramadhan, Praditya Virza Ria Margiana Ria Margiana Rina Puspasari Herdiawan Riyadi Adrizain Riyadi Adrizain Rizqy D. Monica Savira Ekawardhani Siti Silvia Nur Shofa Shamantri Sudigdo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Supardi Supardi Supardi Supardi Syamsul Arifin Tiara Kirana Tono Djuwantono Vellyana Lie Veronica Oladitha Siagian Vita Murniati Tarawan Vitriana Vitriana Widya Juwita Windi Nurdiawan Wiryawan Permadi Wiryawan Permadi Yenni Zuhairini Yosefa Resti Radinda