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All Journal Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Teknologi Informasi dan Ilmu Komputer Global Medical and Health Communication Molecular and Cellular Biomedical Sciences (MCBS) Chimica et Natura Acta Jurnal Endurance: Kajian Ilmiah Problema Kesehatan BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Savira Ekawardhani

Division Of Parasitology Department Of Biomedical Science Faculty Of Medicine Universitas Padjajaran, Jalan Raya Bandung Sumedang KM. 21, Hegarmanah, Kecamatan Jatinangor, Kabupaten Sumedang, Jawa Barat, Indonesia

Author-ID : 983200

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Community Willingness to Participate in A Mosquito Breeding Site Eradication Program: A Study in Bandung, West Java, Indonesia Faridah, Lia; Nuriyah, Eva; Ekawardhani, Savira; Fauzah, Nisa; Sukandar, Hadyana; Agoes, Ridad
Jurnal Endurance Vol 4, No 1 (2019): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : Lembaga Layanan Pendidikan Tinggi (LLDIKTI) Wilayah X

Despite many efforts to prevent dengue, vector control still promising specially through integrated vector management. This effort requires community participation. Therefore, it is crucial to understand the factors that are associated with the willingness of communities in high prevalence areas to participate in mosquito breeding eradication program. This study explored factors associated with the willingness of community members in Bandung to participate in the mosquito breeding eradication program initiated by Indonesian's government, called One House One Larvae Monitor. A community-based cross-sectional study was carried randomly at sub-district level in Bandung from January-November 2018. Interviews using a set of validated questionnaires were conducted to collect data on demography, socioeconomic status, knowledge, attitude and practice regarding implementation of the program. Among 210 participants, the proportion of low-to-middle knowledge, attitude, and practice (KAP) index is more prevalent. Yet, for attaining high-score on KAP, there are three main predictors observed; by being female, at least had attend undergraduate level of education, and being an entrepreneur. A good score in the attitude section does not necessarily translate to good score in the practice section. The results reflect the need for better tools for changing the behavior of society, and it should not be limited to enhancement of society’s knowledge.

Meningkatkan Keterampilan Kader Kesehatan dalam Melakukan Pemeriksaan Payudara Sendiri (SADARI) Lina Wiraswati, Hesti; Ekawardhani, Savira; Windria, Sarasati; Faridah, Lia
Jurnal Endurance Vol 4, No 2 (2019): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : Lembaga Layanan Pendidikan Tinggi (LLDIKTI) Wilayah X

Breast cancer is one of the most common cancer types suffered by women in the world. In 2018, the International Agency for Research on Cancer (IARC) estimated number of cancer cases in Indonesia was 42.1 per 100000 females, while the death rate was 17 per 100000 females. These conditions are worrisome and call for serious handling. For this purpose, the effectiveness of patient treatment and life quality must be improved. Therefore, this study aims to improve the knowledge and skills of breast cancer early detection. The method used is health training through audio-visual devices and demonstration. Qualitative and quantitative analysis was carried out using paired t-test. The sampling data was acquired by purposive sampling method using a questionnaire. The result showed that first, majority of health cadres (97%) had less knowledge about BSE, before the training was carrying out. Second, lack of knowledge about BSE apparently did not prevent health cadres from doing BSE (28%). Third, BSE training improves the skills of health cadres with an average increase of 31%. Fourth, the training has also increased the knowledge of all cadres about BSE with an average increase of 29%. In addition, all cadres stated that they would disseminate their BSE knowledge and skills to their families and others. Kanker payudara merupakan salah satu jenis kanker yang paling banyak di derita oleh wanita di dunia. International Agency for Reseach on Cancer (IARC) pada tahun 2018 memperkirakan insiden kanker payudara di Indonesia sebesar 42.1 per 100 ribu wanita, sedangkan angka kematiannya sebesar 17 per 100 ribu penduduk. Situasi seperti ini sangat mengkhawatirkan dan perlu penanganan serius dari berbagai pihak. Dengan demikian penelitian ini bertujuan untuk meningkatkan keterampilan kader kesehatan dalam melakukan pemeriksaan payudara sendiri (SADARI). Metode yang dilakukan adalah dengan melakukan pelatihan melalui perangkat audio visual dan alat peraga. Analisis kualitatif dan kuantitatif dilakukan menggunakan uji t-test berpasangan. Pengambilan sampel dilakukan secara purposive sampling dengan cara penetapan besar sampel berdasarkan jumlah kebutuhan minimal dengan menggunakan kuesioner. Hasil penelitian ini menunjukkan bahwa pertama, mayoritas kader kesehatan memiliki pengetahuan kurang tentang SADARI (97%). Kedua, pengetahuan yang kurang tentang SADARI rupanya tidak menghalangi kader kesehatan untuk melakukan SADARI (28%). Ketiga, pelatihan SADARI meningkatkan keterampilan kader kesehatan dengan rata-rata peningkatan 31%. Keempat, pelatihan SADARI juga meningkatkan pengetahuan kader dengan rata-rata peningkatan 29%. Disamping itu, semua kader menyatakan bahwa mereka akan menyebarkan pengetahuan dan keterampilan SADARI yang mereka miliki kepada keluarga dan orang lain

Semi-quantitative Digital Analysis for Human Papillomavirus Detection from Environmental Specimens Adelina Siagian; Dicky Bagus Pratama; Fahmy Fathurrohman; Lia Faridah; Savira Ekawardhani
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1918

Background: Recently, human papillomavirus (HPV) deoxyribonucleic acid (DNA) has been detected in urban wastewater, indicating that the virus can reach the sewer and, eventually, other water environments. This study aimed to develop a semi-quantitative assay for HPV DNA detection from environmental specimens using the PCR gel electrophoresis method.Method: This was an experimental descriptive qualitative study conducted from July to November 2019 in a standard molecular laboratory and non-laboratory administration room without air conditioner. Three brands of PCR reagents and different annealing temperatures were compared to identify the best condition for conventional PCR of plasmid DNA containing the HPV L1 gene. The semi-quantitative data were obtained from densitometry digital analysis using an imaging software. The optimized protocol was then applied on DNA serial dilutions to seek for the lower limit of detection (LLOD) value and the linear range of the assay. To evaluate the robustness of the assay, the protocol was further applied to spiked specimens of wastewater. Finally, several wastewater samples were tested for the presence of HPV DNA using this protocol.Results: A broad linear range and HPV L1 gene detection ability were observed with an LLOD of less than 2pg plasmid DNA in field condition. Although the assay successfully detected HPV DNA from several spiked wastewater samples, certain wastewater could interfere with the assay and gave false negative result.Conclusion: A semi-quantitative conventional PCR method to detect HPVDNA from environmental samples has been established and proven to be robust in field condition with non-optimum cold chain.

PENINGKATAN PENGETAHUAN KANKER PAYUDARA PADA MASYARAKAT DESA RANCAMANYAR KABUPATEN BANDUNG Hesti Lina Wiraswati; Savira Ekawardhani; Sarasati Windria; Lia Faridah; Syafrizal Saragih; Muhammad Saifuddin B. S. Arif; Meri Alex Sandra; Astri Gloria Larwuy; Dini Oktaviani; Yasfira Aradella; Salma Nur Raidah
Dharmakarya Vol 7, No 4 (2018): Desember
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v7i4.19051

Meningkatnya kasus kanker dan kematian akibat kanker di Indonesia dari tahun ke tahun perlu mendapatkan perhatian serius. Faktor penting yang berkontribusi pada peningkatan kejadian ini adalah kurangnya sosialisasi tentang kanker, penyebab kanker dan aktivitas-aktivitas penurun resiko kanker, disamping kurang efektifnya pengobatan dan upaya peningkatan kualitas hidup penderita. Oleh karena itu penelitian ini bertujuan untuk meningkatkan wawasan masyarakat tentang penyakit kanker, termasuk penyebab kanker dan faktor-faktor penurun resiko kanker sehingga diharapkan akan meningkatkan kesadaran dan kewaspadaan masyarakat agar terhindar dari penyakit ini. Kegiatan yang dilakukan dalam penelitian ini adalah berupa penyuluhan yang berbasis metode pendidikan masyarakat dengan berbagai macam aktivitas diantaranya ceramah, diskusi, nonton video, dan tanya jawab berhadiah. Pre-test dan post-test digunakan sebagai alat ukur untuk melihat ketercapaian tujuan. Hasilnya pertama, terjadi peningkatan pemahaman peserta rata-rata 23%, dengan rentang pemahaman 34%-89%. Kedua, selama diskusi peserta menyatakan sikapnya untuk bergaya hidup sehat agar memperkecil resiko terkena kanker payudara. Hasil-hasil tersebut menunjukkan bahwa penyuluhan yang dilakukan mampu meningkatkan pemahaman masyarakat tentang kanker dan memunculkan kesadaran masyarakat untuk berpola hidup sehat sebagai bentuk upaya pencegahan kanker payudara.

Knowledge Level towards Breast Cancer and Breast Self-Examination among Medical Students of Indonesia Andri Rezano; Marhendra Satria Utama; Hesti Lina Wiraswati; Savira Ekawardhani; Melia Juwita Adha; Nurul Mufliha Patahuddin; Veronica Oladitha Siagian; Siti Silvia Nur Shofa Shamantri; Erlangga Ing Geni Bisma Pratama; Liana Awalia Lutfunnisa; Asep Wiryasa; Hansen Wangsa Herman
Global Medical & Health Communication (GMHC) Vol 10, No 1 (2022)
Publisher : Universitas Islam Bandung

Breast cancer is a life-threatening disease among Indonesian women. The etiology of breast cancer is still uncertain, and therefore adequate primary prevention is difficult. Early diagnosis improves cancer prognosis while also reducing medical costs, substantially reducing mortality rates. Knowledge and awareness of breast cancer risk factors and their screening may help women take preventive measures. The community service program aimed to assess the level of understanding of undergraduate medical students on breast cancer and breast self-examination (BSE). It was a one-group pretest-postest quasi-experimental study to measure the level of knowledge of 100 medical students in Indonesia from August 20th, 2020, to February 27th, 2021. The participants were asked 36 questions, which was an adaptation of previous questionnaires. A mini-lecture managed the program that focuses on risk factors and early detection. Furthermore, pretest and post-test were conducted to analyze the knowledge level before and after the dissemination. The participants included in this study were mostly 20 years and above (62%). The average recognition of breast cancer and its early detection was not high. The knowledge of breast cancer among medical students was found to be moderate. The efficacy of dissemination among medical students was apparent in knowledge change. However, good cancer awareness, especially breast cancer, needs to be established and integrated through effective cancer educational programs in the medical curricula. Hence, modification of the medical curriculum through extensive training on breast cancer preventive measures and early diagnosis is required.

Knowledge Level of Community Participant on Dengue Fever Symptoms and Early Treatment in Bandung City Lia Faridah; Nisa Fauziah; Savira Ekawardhani
BALABA: JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA Volume 15 Nomor 1 Juni 2019
Publisher : Balai Penelitian dan Pengembangan Kesehatan Banjarnegara Badan Litbangkes Kemenkes RI

In tropical countries, dengue fever is often confused with other common tropical infections. There are no specific therapeutic treatment for dengue infections, and the key of successful dengue case management are a timely and judicious supportive care. Community knowledge about dengue fever and treatment at home, particularly for children is crucial to reduce the burden of dengue infection. Unfortunately, studies on community's knowledge of dengue fever are still very limited. The aims of this study are to measure people's knowledge about dengue fever and to determine the main predictors of a high index on dengue knowledge, in Bandung City. Data collection was carried out by interviewing respondents from each household. Multivariate analysis with logistic regression was used to determine the odds-ratio demographic factors that reached a high index. Study participants generally showed medium-to-high level of knowledge regarding Dengue fever symptoms and its first aid. This group accounts for more than 70% of all respondents This study also showed that the likeliness of having high-score of knowledge was correlated with being a female, having at least an undergraduate level of education, and being an entrepreneur

Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.

Arbovirus Detection of Adult Female Aedes aegypti for Dengue Surveillance: a Cohort Study in Bandung City, Indonesia Faridah, Lia; Ekawardhani, Savira; Fauziah, Nisa; Djati, Imam Damar; Putra, Ramadhani Eka; Watanabe, Kozo
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12749

Dengue surveillance is an important activity to prevent dengue outbreaks. This activity becomes a significant challenge for the region with limited logistic capabilities. Developing a simple mathematical model to predict the possibility of dengue incidence provides a reliable early warning system. This study compared the correlation between vector (adult female Aedes aegypti) and arbovirus detection on a vector to dengue incidence, which generalized linear mixed models tested. The incidence of adult female Aedes aegypti and dengue fever cases were interpolated through third-power inverse distance weighting (IDW). A spatial correlation between female Aedes aegypti incidence and dengue incidence was obtained from polynomial regression. Collection sites were 16 villages in Bandung city, one of the significant dengue endemic areas in January–December 2017. A total of 8,402 mosquitoes of Aedes aegypti, Aedes albopictus, and Culex sp., with 17% belonging to Aedes aegypti as the subject of the dengue virus (DENV) infection test. Data analysis only showed a weak correlation between the numbers of adult female Aedes aegypti and dengue incidence. On the other hand, there is no correlation between positive dengue infection of vector and dengue incidence. This study highlights the importance of constant arbovirus surveillance and integrated surveillance methods on all possible dengue vectors to develop an early warning system for dengue incidence.

Cytotoxicity Effect of Aqueous Propolis Extract of Geniotrigona thoracica Sumatrans on Colo-201 Colon Cancer Cell Line and Senescence Colo-201 Colon Cancer Cell Line Induced by Low-dose Doxorubicin Latama, Zahra Nabila; Achadiyani, Achadiyani; Kamilah, Mutiara Mila; Putra, Ramadhani Eka; Kinasih, Ida; Faridah, Lia; Ekawardhani, Savira
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13760

Propolis, a resinous compound honeybees produce, demonstrates an extensive spectrum of powerful biological properties. However, the anti-cancer activity of propolis derived from Geniotrigona thoracica Sumatrans has yet to be reported. Thus, we sought to investigate the cytotoxicity of aqueous propolis extracts from Geniotrigona thoracica Sumatrans against Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin. This study was conducted at the Parasitology Laboratory of Human, Safety, and Environment, Universitas Padjadjaran Bandung from January to May 2024. This study assessed cell viability using the WST-1 test. Non-induced Colo-201 cells were treated with an aqueous extract of propolis (AEP) 100 ppm, or 5-fluorouracil (5-FU) 5 mg/ml as the positive control or water as a vehicle on untreated control. Colo-201 senescence was induced by doxorubicin 0.1 µM for three days. Doxorubicin-induced Colo-201 senescence was then treated with AEP 100 ppm, with 5-FU 5 mg/ml as the positive control, or with the combination of AEP 100 ppm and 5-FU 5 mg/ml, or water as a vehicle on untreated control. The data were analyzed using SPSS version 25.0, a one-way ANOVA, and Tukey’s post hoc test. The results showed that AEP has cancer-killing effects on Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin. AEP-treated Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin viability were significantly reduced to 37.15% and 13.72%, respectively, although slightly higher than those of the 5-FU-treated one at this concentration. There was also a decrease in the cancer-killing effect of 5-FU from 88.55% in non-induced Colo-201 cells to 41.5% in the doxorubicin-induced Colo-201 senescence model. In conclusion, aqueous extract of propolis from Geniotrigona thoracica Sumatrans showed cancer-killing-effects both on the Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin.

Promotion of Crypt-like Structures in Intestinal Organoid Development through the Addition of Graphene Oxide in Cell-based Assays Sulaksono, Haura Labibah Salsabil; Kamilah, Mutiara Mila; Faridah, Lia; Joni, I Made; Watanabe, Kozo; Ekawardhani, Savira
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.13386

The intestinal organoid represents a miniature organ that can mimic functional physiology and pathology. However, there are several challenges to developing the organoid system, such as the limited survival of cells. Based on theory, matrix addition is a factor that can support survival in cells. As a result, graphene oxide (GO) addition is used in this study. As an artificial matrix, GO has been successfully shown to encourage good cell behavior and is well known for having good biocompatibility. Herein, we fabricate GO characterized with FT-IR and PSA. Crypt-like structures (CLS) are isolated from small intestinal mice in GO addition as a matrix. The gene expression and cell viability of CLS are investigated. RT-PCR examined the gene expression in CLS, while cell viability of CLS was carried out using the staining method. This study was conducted at FiNder U-CoE and Parasitology Laboratory of HSE Universitas Padjadjaran Bandung during February and December 2023. Our results show that Vil-1 as an identity for cells in the intestinal epithelium has been expressed in CLS primary significantly higher than intestinal tissue (p=0.01). However, identifying Lgr5 in CSL isolates is tricky. Thes in the crypt may be limited. Besides that, cell viability of CLS with GO addition can be maintained for four days. The GO addition as a matrix may provide support to maintain CLS. These findings are promising as cell-based assays for developing organoid models.

Co-Authors Achadiyani Ade Zuhrotun Adelina Siagian Agoes, Ridad Andri Rezano Arimdayu, Annisa Retno Arimdayu, Annissa Retno Asep Wiryasa Astri Gloria Larwuy Baasin, Rusdi Toriq Bashari, Muhammad Hasan Dewi, Sumartini Dicky Bagus Pratama Dini Oktaviani Dini Wahyuni Djati, Imam Damar Enny Rohmawaty Erlangga Ing Geni Bisma Pratama Eva Nuriyah, Eva Fahmy Fathurrohman Fauzah, Nisa Fauziah, Nisa Fauziah, Nisa Gaga Irawan Nugraha Hadyana Sukandar Hansen Wangsa Herman Hesti Lina Wiraswati I Made Joni Ida Kinasih Kamilah, Mutiara Mila Khaq, Arina Al Latama, Zahra Nabila Lia Faridah Liana Awalia Lutfunnisa Marhendra Satria Utama Melia Juwita Adha Meri Alex Sandra Muhammad Begawan Bestari Muhammad Saifuddin B. S. Arif Nenny Agustanti Nurfitri, Fauzia Nurul Mufliha Patahuddin PUTRI, RAFIKA Rachmawati, Nadya Ramadhani Eka Putra Rini Hendriani Rosdianto, Aziiz Mardanarian Safri Ishmayana Salma Nur Raidah Saragih, Winda A. M. Sarasati Windria Shabarni Gaffar -, Shabarni Gaffar Shabrinna, Hanif Siti Silvia Nur Shofa Shamantri Sulaksono, Haura Labibah Salsabil Syafrizal Saragih Usman, Hermin A. Veronica Oladitha Siagian Watanabe, Kozo Wijaya, Muhammad Palar Yasfira Aradella Yeni Wahyuni Hartati Yoga Windhu Wardhana Yuliarni, Dinda

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