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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa Jurnal Edukasi Pengabdian Masyarakat: EDUABDIMAS Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy E-Amal: Jurnal Pengabdian Kepada Masyarakat
Nurul Fajeriyati
Fakultas Farmasi Universitas Muhammadiyah Banjarmasin.
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Antibacterial and Antibiofilm Activity of the Extract and Fractions of Kelakai (Stenochlaena palustris (Burm.F) Bedd) against Methicillin-resistant Staphylococcus aureus Joko Priyanto Wibowo; Restu Dara Wewengkang; Medina Nurrahmah; Nurul Fajeriyati; Irfan Zamzani; Afif Pranaya Jati
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.8991

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major concern in healthcare due to its resistance to antibiotics and ability to form biofilms. This study investigated the antibacterial and antibiofilm activity of the extract and fractions of kelakai (Stenochlaena palustris) leaves against MRSA. Phytochemical screening revealed the presence of alkaloids, flavonoids, steroids, tannins, and triterpenoids in S. palustris leaves. The ethanolic extract of S. palustris leaves exhibited dose-dependent antibacterial activity against MRSA at concentrations up to 500 ppm. Among the fractions, the n-hexane fraction exhibited antibacterial activity at 500 and 1000 ppm, while the methanolic fraction showed inhibition only at 1000 ppm. The ethyl acetate fraction did not show any inhibition. All fractions and extract demonstrated antibiofilm activity, with the n-hexane fraction exhibiting the strongest activity (91.33 ± 1.52%) at 125 ppm. The crude extract of S. palustris leaves showed the weakest antibiofilm activity (32.66 ± 8.14%). These findings suggest that S. palustris leaves contain compounds with antibacterial and antibiofilm properties against MRSA, with the n-hexane fraction being the most promising. Further studies are needed to isolate and characterize the active compounds responsible for these activities.
GERAKAN HIDUP SEHAT BERBASIS HERBAL DI PANTI ASUHAN SENTOSA BANJARMASIN SEBAGAI SOLUSI PENCEGAHAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) Mi’rajunnisa Mi’rajunnisa; Risa Ahdyani; Yulianita Pratiwi Indah Lestari; Tuty Mulyani; Nita Triadisti; Rizka Mulya Miranti; Nurul Fajeriyati; Muhammad Chaidir Hafidz
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 9 (2026): Februari 2026
Publisher : Bajang Institute

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Abstract

Acute Respiratory Infection (ARI) is an infection that affects the upper and lower respiratory tracts and is commonly caused by viruses or bacteria. This infection frequently occurs in children. One preventive approach to ARI is the implementation of a healthy lifestyle based on herbal practices through the utilization of medicinal plants. The purpose of this community service activity was to improve participants’ knowledge and understanding of ARI and its prevention using medicinal plants at Sentosa Orphanage, Banjarmasin. The activity was conducted through interactive counseling sessions, pre-test and post-test assessments, and question-and-answer discussions. The participants consisted of 30 children from Sentosa Orphanage, Banjarmasin. The activity was carried out smoothly and successfully, with participants showing high enthusiasm and active engagement throughout the program. The results of the pre-test and post-test indicated an improvement in participants’ understanding of herbal-based healthy lifestyle practices that can be applied for the prevention of ARI
Computational Study of Flavonoid Compounds from Diplazium esculentum as Potential Anti-Acne Agents through Molecular Docking and ADMET Analysis Zannah, Fathul; Fajeriyati, Nurul
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.15

Abstract

Acne vulgaris is a common skin disorder influenced by multiple biological factors, including hormonal regulation, microbial activity, and inflammatory processes. The overactivation of androgen-regulated pathways contributes to excessive sebum production, which plays a central role in acne development. Although synthetic anti-acne drugs are widely used, their prolonged application may cause adverse effects, prompting growing interest in natural compounds as alternative therapeutic candidates. Diplazium esculentum, a medicinal fern traditionally used in Indonesia, has been reported to possess antibacterial activity; however, its molecular potential as an anti-acne agent remains insufficiently explored. This study aims to computationally investigate flavonoid compounds derived from Diplazium esculentum as potential anti-acne agents by evaluating their molecular interactions and pharmacokinetic properties. The research focuses on a molecular docking approach combined with pharmacokinetic and toxicity prediction to provide preliminary insights at the molecular level. Flavonoid compounds identified from liquid chromatography–mass spectrometry profiling, including apigenin, genistein, daidzein, and naringenin, were selected as ligands for computational analysis. Molecular docking simulations were performed to predict the interaction between these compounds and the androgen receptor, a key molecular target associated with hormone-regulated sebum production. In addition, pharmacokinetic and toxicity properties were evaluated using in silico absorption, distribution, metabolism, excretion, and toxicity prediction tools to assess drug-likeness and safety profiles. The results demonstrated that all evaluated flavonoids exhibited favorable binding interactions within the ligand-binding domain of the androgen receptor, with interaction patterns comparable to those of a reference compound. Pharmacokinetic predictions indicated acceptable absorption characteristics and low toxicity risk for the selected flavonoids. In conclusion, this computational study highlights the potential of flavonoid compounds from D. esculentum as promising natural candidates for anti-acne applications. The findings support the use of molecular docking and pharmacokinetic prediction as effective preliminary approaches for exploring drug potential and provide a scientific basis for further experimental validation.
Co-Authors Afif Pranaya Jati Akifah, Ghina Andika Andika Andika Andika Auliatul Adawiyah Dewi, Retna Eka Diah Safitri Farik, Azqi As Fathul Zannah Fatmasari, Erlina Fitriah Fitriah Iqbal Musthapa Irfan Zamzani Joko Priyanto Wibowo Medina Nurrahmah Mi’rajunnisa Mi’rajunnisa Mi’rajunnisa, Mi’rajunnisa Muhammad Chaidir Hafidz Muhammad Ridha Muhammad Rivaldo Mulyani, Tuty Mustharah, Mustika Nashihah, Siti Nazla, Tarisa Nita Triadisti Nofriansyah, M. Nur Maulidah Perdana, Farid Putri, Emiliyanda Rafiqa Zahra Rahmawati Rahmawati Restu Dara Wewengkang Rif’ah, Siti Risa Ahdyani Risma Aulia Saputri Rizka Amalia Rizka Mulya Miranti Rizka Mulya Miranti Rizqiannor, M. Safitri, Salsabila Nurlaila Salsabilla, Syifa Aulia Sari, Cindy Fransiska Sazidan, Akhbar Arya Jouraist Sofi Agustia Putri Tuty Mulyani Yulianita Pratiwi Indah Lestari Yulianita Pratiwi Indah Lestari Yulianita Pratiwi Indah Lestari Yulianita Pratiwi Indah Lestari