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All Journal Farmaka Jurnal Fitofarmaka Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains JHTS Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Ilmiah Dr. Aloei Saboe Journal of Innovative and Creativity Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy
Multiani S Latif
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Characterization of Tannic Acid Chemically Crosslinked PVA Chitosan Hydrogel Nana Nurindah Upara; Muhammad Taupik; Multiani S Latif; Nur Rasdianah; A. Mut’hi Andy Suryadi
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.287

Abstract

Hydrogel is a hydrophilic material that can absorb and retain large amounts of water through the formation of hydrogen bonds between polymer functional groups to form a stable three-dimensional network. The physicochemical characteristics of hydrogels are greatly influenced by the cross-linking process that determines the network density and stability of the preparation. This study aims to determine the effect of variations in the concentration of tannic acid as a chemical crosslinker on the physicochemical characteristics of polyvinyl alcohol (PVA)-chitosan-based hydrogels. Hydrogels were formulated with varying concentrations of tannic acid of 1%, 3%, and 5%, then evaluated including organoleptic tests, pH, viscosity, spreadability, adhesion, swelling index, irritation test, and characterization using Fourier Transform Infrared (FTIR). The results showed that increasing the concentration of tannic acid caused the formation of a denser hydrogel network, which was characterized by a decrease in the swelling index value and an increase in adhesion and changes in viscosity. The pH values ​​of all formulas were within the physiological pH range of the skin. Irritation tests on 20 panelists showed that all formulas did not cause irritation reactions. FTIR analysis confirmed the presence of molecular interactions between PVA, chitosan, and tannic acid through hydrogen bond formation. Overall, variations in the concentration of tannic acid as a chemical crosslinker affected the physicochemical characteristics of the PVA–chitosan hydrogel and resulted in stable preparations with good quality
The Potential of Kaledang (Artocarpus lanceifolius Roxb.) Stem Bark Fractions as an In Vitro Sunscreen Moh. Arya Avrilio Isa; Hamsidar Hasan; Widy Susanti Abdulkadir; Multiani S. Latif; Dizky Ramadani Putri Papeo
Jurnal Fitofarmaka Indonesia Vol 12, No 2 (2025): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v12i2.1400

Abstract

Exposure to ultraviolet (UV) radiation is a major factor causing skin damage that can trigger premature aging, inflammation, hyperpigmentation, and even skin cancer, thereby encouraging the development of natural-based sunscreens as safer and more environmentally friendly alternatives. The stem bark of kaledang (Artocarpus lanceifolius Roxb.) contains active compounds such as flavonoids and phenolics, which have potential as UV absorbers as well as antioxidants. This study aims to determine the in vitro sunscreen activity of kaledang stem bark fractions and to identify the concentration that produces the highest Sun Protection Factor (SPF) value. The research employed an experimental design by testing chloroform, ethyl acetate, and methanol fractions at concentrations of 50, 100, and 200 ppm, respectively, using the SPF assay with UV-Vis spectrophotometry.
Pengaruh Leaflet Terhadap Tingkat Pengetahuan Masyarakat Dalam Penggunaan Amoxicillin/Ampicillin di Desa Hutada’a Kecamatan Talaga Jaya Kabupaten Gorontalo Madania; Teti Sutriyati Tuloli; Nur Rasdianah; Multiani S. Latif; Chindy Marcela Mooduto
Journal of Community and Clinical Pharmacy Vol. 3 No. 2 (2026): Vol.3, No.2, 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i2.241

Abstract

Resistensi antibiotik merupakan masalah kesehatan diseluruh dunia. Resistensi antibiotik mengakibatkan bakteri tidak merespon obat yang akan membunuhnya. Hal ini mengakibatkan penurunan kemampuan antibiotik dalam mengobati penyakit infeksi pada manusia. Salah satu upaya mengurangi angka resistensi antibiotik yaitu dengan cara memberikan informasi melalui suatu media. Tujuan dari penelitian ini untuk mengetahui pengaruh leaflet terhadap tingkat pengetahuan masyarakat dalam penggunaan amoxicillin/ampicillin di Desa Hutada’a Kecamatan Talaga Jaya Kabupaten Gorontalo. Metode yang digunakan yaitu quasi eksperimental dengan bentuk one group pre test-post test. Penelitian ini dilakukan selama dua bulan dengan jumlah sampel sebanyak 266 responden. Data dianalisis dengan menggunakan uji Wilcoxon. Hasil penelitian menunjukkan bahwa sebelum diberikan media leaflet tingkat pengetahuan masyarakat dalam kategori kurang (24,10%), cukup (40,20%), dan baik (35,70%). Setelah diberikan media leaflet tingkat pengetahuan masyarakat dalam kategori cukup (25,60%) dan baik (74,40), yang artinya terdapat pengaruh media leaflet terhadap tingkat pengetahuan masyarakat di Desa Hutada’a Kecamatan Talaga Jaya Kabupaten Gorontalo (p<0,05).
Evaluasi Penggunaan Antibiotik Pada Pasien Pneumonia Anak di Puskesmas Kota Utara Madania Madania; Endah Nurrohwinta Djuwarno; Juliyanti Akuba; Multiani S. Latif; Putri Chahyani Lawani; Nur Rasdianah
Journal of Community and Clinical Pharmacy Vol. 3 No. 2 (2026): Vol.3, No.2, 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i2.243

Abstract

Pneumonia adalah salah satu bentuk infeksi saluran pernapasan bagian atas yang menyerang paru-paru dimana respiratory syntical virus(RSV) menjadi penyebab utama pneumonia dengan penyebab bakteri streptococcus pneumoniae. Evaluasi penggunaan obat menjadi aspek utama dalam proses penggunaan antibiotik pada pasien pneumonia khususnyapasienanak.Penelitianinibertujuanuntukmengetahui penggunaan antibiotik yang meliputi tepat obat, tepat dosis dan tepat aturan pakai pada pasien pneumonia anak di Puskesmas Kota Utara Kota Gorontalo. Metode yang digunakan adalah penelitian observasional secara retrospektif dengan melakukan penelusuran catatan pengobatan pasien pneumonia dalam catatan rekam medis sebanyak 55 pasien, data dianalisis secara univariat. Hasil penelitian menunjukkan bahwa pneumonia anak lebih banyak dialami oleh perempuan52.7%danlebihbanyakterjadipadausia4tahun36.4%.Obat antibiotikyang digunakan adalah amoksisilin,tepatdosis berjumlah 49 pasien dan tidak tepatdosis berjumlah 6 pasien. Sesuai aturan pakai berjumlah 55 pasien. Kesimpulan dari penelitian ini evaluasi penggunaan antibiotik pada pasien pneumonia anak tepat obat sebasar 100%, tepat dosis 89.09%, tidak tepat dosis 10.91% dan tepat aturan pakai 100%.
Evaluasi Kelengkapan Obat pada Emergency Trolley di IGD Rumah Sakit Umum Daerah Sayang Rakyat Makassar: Evaluation of Medication Completeness in the Emergency Trolley at the Emergency Department of Sayang Rakyat Regional General Hospital Makassar Susilawaty Mantulangi; Widy Susanti Abdulkadir; Karunita Ika Astuti; Teti Sutriyati Tuloli; Multiani S. Latif
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Agustus 2026
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v9i8.11709

Abstract

Emergency trolley merupakan troli berisi obat-obatan dan alat kesehatan yang digunakan untuk penanganan kondisi darurat seperti henti jantung dan syok. Penelitian ini bertujuan untuk mengetahui kesesuaian kelengkapan obat pada emergency trolley di IGD RSUD Sayang Rakyat Makassar berdasarkan standar yang berlaku. Metode penelitian menggunakan kuantitatif deskriptif melalui observasi dan dokumentasi langsung periode Januari–Februari 2026. Sampel ditentukan dengan teknik total sampling terhadap unit emergency trolley dan seluruh stok obat di dalamnya. Hasil evaluasi kuantitas dari 21 jenis obat menunjukkan 17 jenis berkondisi lengkap (100%), namun terdapat defisit kuantitas pada 4 jenis sediaan (Amiodaron injeksi, Isosorbid dinitrat injeksi, Furosemid injeksi, dan Isosorbid dinitrat tablet 5 mg). Dari total 52 unit volume ideal, hanya tersedia 45 unit fisik di lapangan (capaian 86,54% dan defisit 13,46%). Dari aspek kualitas, ditemukan sediaan kedaluwarsa (Methyl prednisolon 125 mg injeksi dan Amiodaron injeksi) serta sediaan kritis dekat kedaluwarsa (Epinefrin injeksi dan Stesolid 5 mg), meskipun kemasan 100% baik. Kesimpulan penelitian menunjukkan bahwa kesesuaian kelengkapan obat belum sepenuhnya memenuhi standar yang telah ditentukan. ABSTRACT Emergency trolley is a cart containing medicines and medical devices used to manage emergency conditions such as cardiac arrest and shock. This study aims to determine the suitability of drug completeness in the emergency trolley at the Emergency Department (ED) of Sayang Rakyat Regional General Hospital Makassar based on applicable standards. The research method used descriptive quantitative through direct observation and documentation during January–February 2026. The sample was determined using a total sampling technique on the emergency trolley unit and all drug stocks within it. The quantity evaluation of 21 drug types showed that 17 types were complete (100%), yet a quantity deficit was found in 4 preparations (Amiodarone injection, Isosorbide dinitrate injection, Furosemide injection, and Isosorbide dinitrate tablet 5 mg). Of the total 52 ideal volume units, only 45 physical units were available in the field (achievement 86.54% and deficit 13.46%). In terms of quality, expired preparations (Methyl prednisolone 125 mg injection and Amiodarone injection) and critical near-expiry preparations (Epinephrine injection and Stesolid 5 mg) were found, although 100% of the packaging was in good condition. The study concludes that the drug completeness has not fully met the predetermined standards.
Uji Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Miana (Coleus atropurpureus L.) dan Daun Jambu Biji (Psidium guajava L.) terhadap Pertumbuhan Bakteri Escherichia coli Masayu Syarmila Putri Abas; La Ode Aman; Multiani S. Latif; Ishak Isa; Karunita Ika Astuti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 5 (2026): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i5.2392

Abstract

This study aimed to determine the antibacterial activity of the combined ethanol extracts of miana leaves (Coleus scutellarioides L.) and guava leaves (Psidium guajava) against Escherichia coli and to evaluate their interaction using the CompuSyn method. This laboratory experimental study employed maceration extraction with 96% ethanol, followed by phytochemical screening, antibacterial testing using the disc diffusion method, One-Way ANOVA, and Combination Index (CI) analysis. The extraction yielded 11.11% for miana leaves and 24.92% for guava leaves. Phytochemical screening confirmed the presence of flavonoids and alkaloids in both extracts. All extract combinations inhibited E. coli growth, producing inhibition zones ranging from 8.10 to 12.75 mm, indicating moderate to strong antibacterial activity. One-Way ANOVA showed no significant differences among treatment groups (p = 0.837). CompuSyn analysis revealed that most combinations exhibited antagonistic interactions (CI > 1), whereas the combination of 10% guava extract and 20% miana extract showed synergistic effects (CI < 1) in two replicates. Overall, the combined extracts demonstrated antibacterial activity against E. coli, although most combinations did not exhibit synergistic interactions.
Preparation and Characterization of Moringa Leaf Extract in Ethosomal Vesicles with Variations in Phosphatidylcholine and Ethanol Concentrations Nur Utami Pobela; Robert Tungadi; Nurain Thomas; Juliyanty Akuba; Multiani S. Latif
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.24

Abstract

Moringa is a medicinal plant with antioxidant properties, and quercetin is one of the compounds considered to contribute to this activity. Quercetin is a hydrophobic compound classified as Biopharmaceutics Classification System (BCS) Class II, characterized by high permeability and low solubility. To overcome this limitation and improve the bioavailability of the active compound, the active compound can be encapsulated in a nanosized carrier system. Ethosomes are vesicular carrier systems suitable for lipophilic, hydrophilic, and amphiphilic compounds. This study aimed to prepare and characterize ethosomes containing Moringa leaf extract using different concentrations of phosphatidylcholine and ethanol. Three formulations were prepared: F1 containing 1% phosphatidylcholine and 20% ethanol, F2 containing 2% phosphatidylcholine and 30% ethanol, and F3 containing 3% phosphatidylcholine and 40% ethanol. Characterization using a Particle Size Analyzer (PSA) showed particle sizes of 202.3 nm, 185 nm, and 146.3 nm for F1, F2, and F3, respectively, with mean polydispersity index (PDI) values of 0.346, 0.293, and 0.196. The corresponding entrapment efficiencies were 36%, 35%, and 41%, respectively. F3 exhibited the most favorable characteristics, with the smallest particle size and the highest entrapment efficiency.
In Vitro and In Silico Evaluation of Butterfly Pea Flower (Clitoria ternatea) Extract in Fast-Disintegrating Tablets Mohamad Aprianto Paneo; Siti Eka Amalia; Multiani S Latif; Aris Purwanto; Firman Gustaman; Djayadi Azis
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1813

Abstract

Clitoria ternatea flowers contain flavonoids of interest for pharmaceutical development. This study examined a single fast-disintegrating tablet prototype containing a sequential methanol extract and explored quercetin docking against cyclooxygenase-2 (COX-2). Dried flower powder (100 g) was successively macerated with n-hexane, ethyl acetate, and methanol. The methanol extract was selected based on extraction yield and qualitative flavonoid screening. Tablets containing 250 mg extract at a theoretical mass of 490 mg were evaluated for hardness, disintegration, friability, and dissolution. Extraction yields were 2.15%, 7.35%, and 12.80%, respectively. Reported hardness was 4.25 ± 0.09 kg on the instrument scale, disintegration time was 42.8 ± 1.4 s, and friability was 0.41%. The reported UV–Vis dissolution response reached 93.7 ± 1.6% at 30 min. However, analytical marker, wavelength, calibration details, and replicate structure were insufficiently documented, limiting quantitative interpretation. Quercetin was selected from the literature and was not specifically identified or quantified in the extract. Docking scores were −9.7 kcal/mol for quercetin and −6.8 kcal/mol for the diclofenac comparator. Native-ligand redocking and RMSD results were unavailable, and the hardness summary requires verification against individual measurements. These findings describe an initial tablet prototype and a separate computational hypothesis. They do not establish an optimized formulation, quercetin-specific release, COX-2 inhibition, or anti-inflammatory efficacy. Further analytical characterization, process documentation, docking validation, and biological testing are needed.
Edukasi Gizi dan Pelatihan Pengolahan Cookies Berbasis Jagung untuk Mendukung Pemanfaatan Pangan Lokal bagi Ibu Hamil dan Anak di Desa Reksonegoro Nurain Thomas; Multiani S Latif; Muthmainnah Muthmainnah
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 5, No 3 (2026): Volume 5 Nomor 3 Tahun 2026
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v5i3.41617

Abstract

Pemenuhan gizi selama kehamilan dan masa awal kehidupan anak berperan penting bagi kesehatan ibu serta tumbuh kembang anak. Pemanfaatan pangan lokal yang mudah diperoleh dan diolah dapat mendukung pemenuhan gizi keluarga. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan mengenai gizi ibu hamil dan anak serta memperkenalkan pemanfaatan jagung sebagai pangan lokal melalui pembuatan cookies berbasis tepung jagung dan susu bubuk. Kegiatan dilaksanakan pada 11 Agustus 2026 di Desa Reksonegoro, Kecamatan Tibawa, Kabupaten Gorontalo, dengan sasaran kader posyandu, ibu hamil, ibu menyusui, ibu yang memiliki anak, dan masyarakat umum. Metode meliputi edukasi gizi, demonstrasi pengolahan jagung menjadi tepung, praktik pembuatan cookies, dan diskusi, dengan evaluasi pengetahuan menggunakan pre-test dan post-test yang dianalisis secara deskriptif. Sebanyak 21 peserta mengikuti evaluasi. Pada pre-test, 13 peserta (61,9%) berada pada kategori pengetahuan kurang dan 8 peserta (38,1%) pada kategori baik; setelah kegiatan, seluruh peserta (100%) berada pada kategori baik, atau meningkat 61,9 poin persentase. Integrasi edukasi gizi dan demonstrasi pengolahan pangan menjadi pendekatan pemberdayaan yang aplikatif untuk meningkatkan pengetahuan dan keterampilan pemanfaatan pangan lokal. Kandungan gizi dan penerimaan cookies belum diuji, sehingga memerlukan analisis laboratorium dan uji organoleptik pada tahap berikutnya.
Co-Authors A. Mut’hi Andy Suryadi Alecia Febriani Putri Andi Makkulawu Andi Makkulawu Ariani H. Hutuba Aris Purwanto Astuti, Karunita Ika Chindy Marcela Mooduto Djayadi Azis Djayadi Azis Djayadi Azis Dolih Gozali Dr. Apt. Hamsidar Hasan S.Si.,M.Si Egi Aulia Endah Nurrohwinta Djuwarno Firman Gustaman Ishak Isa Julianty Akuba Juliyanti Akuba La Ode Aman Larastiyas Pulukadang Madania, Madania Mahdalena Sy. Pakaya Masayu Syarmila Putri Abas Moh. Arya Avrilio Isa Mohamad Aprianto Paneo Mu'thi Andy Suryadi Muhammad Taupik Muthmainnah Muthmainnah Nana Nurindah Upara Nur Ain Thomas Nur Rasdianah Nur Utami Pobela Papeo, Dizky Ramadani Putri Pidyastuti Pakaya Pratiwi Abdullah Putri Chahyani Lawani Rini Daud Supu Robert Tungadi Selvi Marcellia Serly Daud Siti Eka Amalia Susilawaty Mantulangi Taofik Rusdiana Teti Sutriyati Tuloli Widy Susanti Abdulkadir Widy Susanti Abdulkadir