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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Mandala Pengabdian Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) JUKESHUM: Jurnal Pengabdian Masyarakat Sinteza Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Teknologi Informasi untuk Masyarakat (Jurnal Teknokrat)
Baiq Risma Fatmayanti
Universitas Hamzanwadi
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Sinteza

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2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Analysis and Antibacterial Activities of Renggak Seed (Amomum Dealbatum Roxb) Muhlisun Azim; Puspawan Hariadi; Baiq Risma Fatmayanti; Yuyun Febriani; Annisa Rizqita Wazni; Virta Dwi Anggraini
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.28683

Abstract

Natural sources have complex interaction mechanisms in providing inhibitory effects against various radical reactions and multi-drug resistance (MDR). Amomum dealbatum (Renggak in Lombok) seed phytochemistry and bioactivities have the potential to be investigated. This study aims to explore the bioactivity of extracts and fractions of renggak seeds in reducing reactive oxygen species and inhibiting bacterial growth to overcome MDR. The methods used to determine the level of free radical scavenging and antibacterial activity in this study were the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar diffusion methods. The results of the phytochemical tests of the ethanolic extract of Renggak seeds contain triterpenoids, alkaloids, saponins, and phenolics. Meanwhile, in the hexane fraction were found alkaloids, saponins, and phenolics. The results of antibacterial tests on Staphylococcus aureus using the agar diffusion method for ethanol and hexane extracts at concentrations of 20, 40 and 60% were 12.50±1.00, 19.00±0.00, and 21.8±0.76 for ethanol extracts, respectively. The hexane fraction was 5.33±0.57, 10.83±0.57, and 14.33±0.28 mm. For Salmonella sp bacteria, it was 9.00±1.00, 14.16±0.29, and 18.16±1.04 mm for ethanol extracts than was 7.50±0.50, 12.67±0.76, and 15.67±0.76 mm for hexane fractions. Moreover, the ethyl acetate fraction contains triterpenoids, alkaloids, saponins and phenolics which are responsible for giving antioxidant effects with an IC50 value of 66.515±2.37 ppm and is classified as a strong antioxidant to scavenging free radicals of DPPH. The higher the concentration of the fraction, the higher the inhibition of the growth of Salmonella sp and Staphylococcus aureus bacteria. The ability of the extract and fraction to inhibit bacterial growth and reduce free radicals makes renggak seeds very potential for further investigation.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Mouthwash Fraksi Metanol Daun Seledri (Apium graveolens L.) terhadap Pertumbuhan Bakteri Streptococcus mutans Penyebab Karies Gigi Zulhijjati, Mirzalina; Yuliana, Tri Puspita; Fatmayanti, Baiq Risma; Oktresia, Erma Ewisa
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.31994

Abstract

Streptococcus mutans is a bacterium found in the human oral cavity and is the primary cause of tooth decay. The effects of Streptococcus mutans bacteria can be eliminated with mouthwash formulated with natural ingredients, one of which is celery leaves, which are known to have antibacterial properties against the growth of Streptococcus mutans. The purpose of this study was to determine the best concentration of a mouthwash formulation using the methanol fraction of celery leaves based on the results of the physical properties evaluation test and to determine the antibacterial activity of a mouthwash formulation using the methanol fraction of celery leaves in inhibiting the growth of Streptococcus mutans bacteria. This study was a quantitative study using a laboratory experimental method with a posttest-only control group design. This study is a quantitative study using a laboratory experiment method with a posttest-only control group design by observing the area of ​​the inhibition zone as the dependent variable. The area of ​​the inhibition zone of each formula was compared with the control using the ANOVA test. The results of the physical properties evaluation test, including ogrnanoleptic tests, pH tests, homogeneity tests, specific gravity tests, and cycling tests, met the requirements for good physical quality. The highest antibacterial activity results were found in formula III with a concentration of 1.5% celery leaf methanol fraction with an average inhibitory power of 23.63 mm with a Very Strong category.
Co-Authors Ahmad Habibie, Ahmad Annisa Rizqita Wazni Arief Rafsanjani Baiq Maylinda Gemantari Dhey, Anselmania Kartini Didik Daniyantara Erma Ewisa Oktresia Hasanah, Tira Fadilatul Hunafa, Siti Amalia Jeli Marlita Karin, Nur Fadila Leny Ramadhan Muhlisun Azim Muslimah, Tiara Olivia, Sherlyn Puspawan Hariadi Saputri, Sifa Atul Nuvus Tri Puspita Yuliana Virta Dwi Anggraini Yuyun Febriani Zulhijjati, Mirzalina