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All Journal Jurnal Mandala Pengabdian Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) JUKESHUM: Jurnal Pengabdian Masyarakat Sinteza Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Teknologi Informasi untuk Masyarakat (Jurnal Teknokrat)
Baiq Risma Fatmayanti
Universitas Hamzanwadi
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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SYNTHESIS OF CHALCONE AND PYRAZOLINE DERIVATIVES WITH ACETOPHENONE AND VERATRALDEHYDE AS PRECURSORS Fatmayanti, Baiq Risma; Habibie, Ahmad; Dhey, Anselmania Kartini
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1274

Abstract

Chalcones and pyrazolines are heterocyclic compounds with promising biological and pharmaceutical activities. Chalcone and pyrazoline can be found in different sources, such as natural and synthetic compounds. This study aimed to explore the synthesis of chalcone and pyrazoline derivatives with acetophenone and veratraldehyde as precursors. Chalcone was successfully synthesized through the Claissen-Schmidt reaction between acetophenone and veratraldehyde at room temperature 25-30 ºC and mediated by KOH as a base catalyst for 20 hours. The corresponding substituted pyrazoline derivative was also successfully synthesized through a cyclocondensation reaction between the synthesized chalcone and phenylhydrazine as starting materials under reflux conditions at temperatures of 75-80 ºC for 4 hours. The Chalcone A derivative compound obtained was (E)-3-(3,4-dimethoxy phenyl)-1-phenyl prop-2-en-1-one (Chalcone A). The Pyrazoline A derivative compound was obtained as pyrazole compound 5-(3,4-dimethoxy phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole (pyrazoline A). Chalcone A and Pyrazoline A obtained as yellowish and brownish-orange powders in 14.89 % and 66.57 % yields, respectively. The chastities of Chalcone A and Pyrazoline A was 98.55 % and 88.54 %, respectively. A qualitative identification for both synthesized compounds was performed using normal-phase thin-layer chromatography which revealed the Rf value for Chalcone A and Pyrazoline A was 0.43 (in mobile phase ethyl acetate:n-hexane 3:1 v/v) and 0.55 (in mobile phase DCM:n-hexane 3:1 v/v), respectively. Moreover, the elucidation structure of synthesized compounds using FTIR and GC-MS instruments revealed the structure of synthesized Chalcone A and Pyrazoline A agrees with the theoretical structure of Chalcone A and Pyrazoline A. Keywords: Synthesis, Chalcone, Pyrazoline, Acetophenone, Veratraldehyde
Identifikasi Boraks pada Jajanan Bakso Tusuk di Lombok Timur Gemantari, Baiq Maylinda; Fatmayanti, Baiq Risma; Ramadhan, Leny
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p60-64

Abstract

Meatballs are a processed meat-based food commonly processed by adding chemical preservatives. Many reports find the usage of borax as the chemical preservative in meatballs sold in large markets on Lombok Island. However, the use of borax in the type of meatball consumed as snacks called skewered meatballs has not been identified thoroughly in East Lombok. This study aimed to identify borax in skewered meatballs in East Lombok qualitatively by curcumin paper test and flame test colors using sodium tetraborate as standard. The result showed that 4 samples confirmed positive for borax through the curcumin paper test. Two of those four samples showed the same flame color as standard corresponding to the presence of borax as a preservative in skewered meatballs tested. These results indicate that the curcumin paper test and flame color test were compatible in identifying borax in skewered meatball samples qualitatively.
The Sosialisasi Pencegahan dan Penanganan Stunting untuk Mewujudkan Generasi Muda Sehat dan Unggul di Desa Masbagik Timur Fatmayanti, Baiq Risma; Karin, Nur Fadila; Olivia, Sherlyn; Saputri, Sifa Atul Nuvus; Hunafa, Siti Amalia; Muslimah, Tiara; Hasanah, Tira Fadilatul; Daniyantara, Didik
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 1 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i1.539

Abstract

Stunting merupakan salah satu masalah global termasuk di Indonesia. Stunting ditandai dengan tinggi badan yang lebih rendah dibandingkan rata-rata tinggi badan anak di usia yang sama. Kecamatan Masbagik menjadi salah satu kecamatan penyumbang angka stunting yang tinggi di Lombok Timur. Pengabdian kepada masyarakat yang dilakukan oleh tim KKN Bina Desa Universitas Hamzanwadi 2024 ini bertujuan untuk melaksanakan kegiatan sosialisasi untuk memberikan edukasi mengenai pencegahan dan penanganan stunting di Desa Masbagik Timur. Kegiatan tersebut telah dilaksanakan dengan aktivitas yang berurutan dimulai dari kegiatan observasi dan diskusi, perencanaan aktivitas dan pembuatan leaflet edukasi, koordinasi dan komunikasi, implementasi program, dan evaluasi serta monitoring pelaksanaan kegiatan sosialisasi. Berdasarkan hasil observasi tercatat 13 orang balita di Desa Masbagik Timur memiliki indikasi stunting berdasarkan pengukuran tinggi badan dan usia yang termasuk kriteria stunting berdasarkan WHO child growth standards. Hasil kegiatan sosialisasi dan diskusi antara pemateri dan masyarakat di Masbagik Timur ditemukan faktor utama penyebab masih adanya balita stunting di Masbagik Timur adalah faktor sosial budaya. Faktor sosial budaya yang dimaksud yaitu tradisi perkawinan pada usia <20 tahun, pemenuhan gizi ibu hamil yang masih kurang, dan pola asuh turun-temurun yang kurang tepat. Kesadaran masyarakat yang masih minim untuk menyediakan makanan bergizi seimbang bagi keluarga karena keterbatasan ekonomi juga menjadi perhatian. Selain kegiatan edukasi, pemberian sumber makanan bergizi telah dilakukan untuk meningkatkan kesadaran masyarakat tentang gizi yang baik. Secara umum, kegiatan sosialisasi pencegahan dan penanganan stunting telah berhasil dilaksanakan dengan catatan pengetahuan, sikap, keterampilan dan kesadaran masyarakat mengenai stunting harus ditingkatkan secara berkala di Desa Masbagik Timur.
The Influence of Socialization on Students' Knowledge Levels About Antibiotic Resistance in Selong District, East Lombok: Pengaruh Edukasi Terhadap Tingkat Pengetahuan Siswa Tentang Resistensi Antibiotik di Kecamatan Selong, Lombok Timur Risma Fatmayanti, Baiq; Ramadhan, Leny; Rafsanjani, Arief; Marlita, Jeli; Azim, Muhlisun; Febriani, Yuyun
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i2.1277

Abstract

Antibiotics are drugs used to treat bacterial infections. Irrational use of antibiotics without a doctor's prescription causes antibiotic resistance. West Nusa Tenggara province is ranked sixth with the largest number of antibiotic consumption without a doctor's prescription so the incidence of antibiotic resistance increases. This community service aims to provide antibiotic resistance education to high school students in Selong District. The community service method was carried out at SMAN 1 Selong and SMAN 2 Selong which started with pretest, socialization, and posttest activities to measure students' knowledge of antibiotic resistance before and after socialization. The significance test of changes in students' knowledge levels before and after socialization was conducted using a paired sample t-test. The socialization participants from SMAN 1 Selong and SMAN 2 Selong consisted of 141 high school students in grade XI with an average age of 16. The pretest and posttest data analysis showed that students' knowledge levels regarding antibiotic resistance increased from 41% to 59% at SMAN 1 Selong and 42% to 58% at SMAN 2 Selong after socialization. The average value of students' knowledge about antibiotic resistance increased from 10.04 points to 14.73 points for SMAN 1 Selong and 10.33 points to 14.16 points for SMAN 2 Selong after the socialization was given from a total of 17 maximum points that could be obtained. The results of data analysis using paired sample t-test showed a significant difference (p<0.05) in the average level of student knowledge before and after the socialization activity was carried out. Thus, the antibiotic resistance socialization activity has successfully increased student knowledge in Selong District, especially at SMAN 1 Selong and SMAN 2 Selong effectively.
Edukasi dan Pendampingan Pengelolaan Sampah Anorganik Berprinsip Zero Waste System di Desa Bagik Payung Selatan Kecamatan Suralaga Febriani, Yuyun; Azim, Muhlisun; Rafsanjani, Arief; Ramadhan, Leny; Risma Fatmayanti, Baiq
Jurnal Teknologi Informasi untuk Masyarakat Vol. 2 No. 1 (2024): Jurnal Teknologi Informasi untuk Masyarakat (Teknokrat)
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/jt.v2i1.26422

Abstract

Bagik Payung Selatan Village is one of the villages in Suralaga District, East Lombok Regency with a dense population of over 1.2 million people spread across 10 hamlets. The high population in Bagik Payung Selatan Village causes quite high amounts of waste production which can be seen from the large amount of rubbish piled up on the side of the road and environmental cleanliness still neglected. The community in Bagik Payung Selatan Village has a low level of awareness and knowledge regarding inorganic waste management. Most of the inorganic waste is plastic waste produced daily from household waste. This community service activity aims to provide education on inorganic waste management using ecobrick techniques with zero waste system principles in Bagik Payung Selatan Village so that the local community can manage inorganic waste well. The method of educating the community is carried out by providing outreach and training in skills to make handicraft products from inorganic waste which has previously been prepared using the ecobrick technique. The results of this community service activity include public knowledge and awareness regarding ecobrick techniques, the zero waste system principles, and community creativity in managing inorganic waste increased. The community is very enthusiastic about turning household waste into multiple useful handcraft products that can be reused and sold since they have high economic value to help the local community's economy.
2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Analysis and Antibacterial Activities of Renggak Seed (Amomum Dealbatum Roxb) Azim, Muhlisun; Hariadi, Puspawan; Fatmayanti, Baiq Risma; Febriani, Yuyun; Wazni, Annisa Rizqita; Anggraini, Virta Dwi
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.28683

Abstract

Natural sources have complex interaction mechanisms in providing inhibitory effects against various radical reactions and multi-drug resistance (MDR). Amomum dealbatum (Renggak in Lombok) seed phytochemistry and bioactivities have the potential to be investigated. This study aims to explore the bioactivity of extracts and fractions of renggak seeds in reducing reactive oxygen species and inhibiting bacterial growth to overcome MDR. The methods used to determine the level of free radical scavenging and antibacterial activity in this study were the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar diffusion methods. The results of the phytochemical tests of the ethanolic extract of Renggak seeds contain triterpenoids, alkaloids, saponins, and phenolics. Meanwhile, in the hexane fraction were found alkaloids, saponins, and phenolics. The results of antibacterial tests on Staphylococcus aureus using the agar diffusion method for ethanol and hexane extracts at concentrations of 20, 40 and 60% were 12.50±1.00, 19.00±0.00, and 21.8±0.76 for ethanol extracts, respectively. The hexane fraction was 5.33±0.57, 10.83±0.57, and 14.33±0.28 mm. For Salmonella sp bacteria, it was 9.00±1.00, 14.16±0.29, and 18.16±1.04 mm for ethanol extracts than was 7.50±0.50, 12.67±0.76, and 15.67±0.76 mm for hexane fractions. Moreover, the ethyl acetate fraction contains triterpenoids, alkaloids, saponins and phenolics which are responsible for giving antioxidant effects with an IC50 value of 66.515±2.37 ppm and is classified as a strong antioxidant to scavenging free radicals of DPPH. The higher the concentration of the fraction, the higher the inhibition of the growth of Salmonella sp and Staphylococcus aureus bacteria. The ability of the extract and fraction to inhibit bacterial growth and reduce free radicals makes renggak seeds very potential for further investigation.
Co-Authors Ahmad Habibie, Ahmad Anggraini, Virta Dwi Arief Rafsanjani Baiq Maylinda Gemantari Dhey, Anselmania Kartini Didik Daniyantara Hasanah, Tira Fadilatul Hunafa, Siti Amalia Jeli Marlita Karin, Nur Fadila Leny Ramadhan Muhlisun Azim Muslimah, Tiara Olivia, Sherlyn Puspawan Hariadi Saputri, Sifa Atul Nuvus Wazni, Annisa Rizqita Yuyun Febriani