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All Journal Jurnal Kedokteran dan Kesehatan Journal of Community Empowerment for Health Neurona Indonesian Journal of Biomedicine and Clinical Sciences Cermin Dunia Kedokteran
Yogik Onky Silvana Wijaya
Department Of Biochemistry Faculty Of Medicine, Public Health And Nursing Universitas Gadjah Mada, Sleman, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Neurona

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HUBUNGAN POLIMORFISME MTHFR c.677C>T DENGAN FUNGSI KOGNITIF PADA PASIEN STROKE ISKEMIK AKUT DI RSUP DR. SARDJITO Haq, Arinal; Gofir, Abdul; Ar Rochmah, Mawaddah; Amelia Nur Vidyanti; Yogik Onky Silvana Wijaya, Yogik Onky Silvana Wijaya
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.511

Abstract

Introduction: Ischemic stroke is an acute cerebrovascular event with cognitive impairment presents as its prevalent manifestation and complication. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism through an integral process of cellular metabolism in DNA, RNA and protein methylation. MTHFR c.677C>T polymorphism is considered an important genetic risk factor for stroke and cognitive dysfunction in some populations. Aim: This study aimed to investigate the association between the MTHFR c.677C>T polymorphism and cognitive function in acute ischemic stroke patients in Dr. Sardjito General Hospital Yogyakarta. Methods: We performed a cross-sectional study in 42 consecutive acute ischemic stroke patients. PCR R-FLP was used to examine MTHFR c.677C>T polymorphism. Cognitive function was determined using MoCA-Ina within 24 hours of each patient’s admission, with score 24 is the cut off for cognitive impairment. Results: Of 42 patients, 12 patients (28.6%) showed MTHFR c.677C>T variant. There were 3 patients (25%) with homozygous variant of MTHFR c.677C>T. Cognitive dysfunction was found in 7 patients (16.7%) with MTHFR c.677C>T variant and 18 patients (42.9%) with wild type MTHFR. However, no significant association was found between MTHFR c.677C>T with cognitive function in acute ischemic stroke patients (p=0.921). Discussion: The frequency of MTHFR c.677C>T polymorphism in this study was 28.6% with a quarter of them showing homozygous variant. There was no association between MTHFR c.677C>T polymorphism with cognitive function in acute ischemic stroke patients.
Co-Authors Abdul Gofir Amelia Nur Vidyanti Arta Farmawati Bira Arumndari Nurrahma Brilliant Alendra Adianfra Dianandha Septiana Rubi Dwiputro, Alfin Harjuno Edilburga Wulan Saptandari Haq, Arinal Insani, Dini Aura Irwan Supriyanto Loury Priskila Mawaddah Ar-Rochmah Mohamad Fay Faizal Najla, Aesha Pangesti, Rachma Widya Perdana, Taufik Mulya Priskila, Loury Risky Oktriani Sarair Maulidya Sunarti Sunarti Taftazani, Muhammad Rifqi Tengku Arief Buana Perkasa Tri Baskoro Tunggul Satoto