Article Per Year (5 Year)
p-Index From 2021 - 2026
0.659
P-Index
This Author published in this journals
All Journal International Journal Of Science, Technology & Management (IJSTM) Jurnal Buana Farma Molekul: Jurnal Ilmiah Kimia
Nasution, Halimah Raina
Unknown Affiliation
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Transportation

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Synergistic Antibacterial Activity of Curcuma domestica Val. Extract with Tetracycline Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani, Yuandani; Septama, Abdi Wira; Nugraha, Sony Eka; Sufitni, Sufitni; Khairunnisa, Nur Aini
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.8593

Abstract

Infections caused by multidrug-resistant (MDR) bacteria are on the rise globally. MDR is facilitated by overexpression of efflux pump and permeability changes of membrane. Acinetobacter baumannii is a pathogenic germ that causes a major problem in infection, also, there has been an increase in the incidence of resistance to various antibiotics. The present study highlights the synergistic of ethanolic extract of Curcuma domestica (EECD) rhizome with tetracycline against multidrug-resistant A. baumannii (MDR-Ab). Assessment of Minimum Inhibitory Concentration (MIC) was determined by microdilution using 96-well plates. The synergistic effect of EECD and tetracycline was determined by checkerboard method. The effect of EECD and tetracycline combination was investigated by bacteriolytic activity and inhibition of efflux pump by Ethidium Bromide (EtBr) accumulation assay. EECD presented the MIC value 250 µg/mL against MDR-Ab. Fractional Inhibitory Concentration Index (FICI) value of EECD and tetracycline combination was 0.4, which showed their synergistic effect. Additionally, the combination of EECD and tetracycline could inhibit the efflux pump in MDR-Ab. This combination can also compromise cell integrity by altering membrane permeability thus lysing the bacteria cells. According to these results, EECD and tetracycline combination has synergistic effects at some sites of action, and thus could be used as a breakthrough to overcome infection problems due to MDR-Ab. Keywords: Acinetobacter baumannii, antibacterial, Curcuma domestica, multidrug-resistant, tetracycline
Antibiofilm Formation Activities of Ethanol Extract of Curcuma domestica Val. Rhizome Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani; Abdi Wira Septama; Sony Eka Nugraha; Sufitni
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.883

Abstract

Abstract. Multidrug resistance is still a major health problem worldwide. Biofilm formation was related to the resistance of bacteria mechanism. Acinetobacter baumannii, one of the bacteria that cause nosocomial infections, is given particular attention due to its high prevalence of resistance. The current study address observing the antibacterial activity and antibiofilm formation activity of Curcuma domestica rhizome extract against multidrug-resistant Acinetobacter baumannii (MDR A.baumannii). Curcuma domestica rhizome was macerated by ethanol 96%. Determination of Minimum Inhibitory Concentration (MIC) was carried out by the microdilution method. Antibiofilm formation analysis was determined by standard quantitative using crystal violet-stained assay. Ethanol extract of C. domestica possesses antibacterial activity against MDR A. baumannii with MIC value 250 µg/mL. Additionally, the ethanol extract of C. domestica could inhibit the biofilm formation of MDR A.baumannii, thus percentage of biofilm formed only 23.7% and significance different with control after analyzed using ANOVA post hoc test Tukey. According to these results, ethanol extract of C. domestica revealed antibacterial activity and had the potency in suppressing the biofilm formation of MDR A.baumannii, thus could be utilized in clinical application, especially in MDR A.baumannii infection. Keywords: Antibiofilm, antibacterial, Curcuma domestica, multidrug-resistant, Acinetobacter baumannii
UJI AKTIVITAS ANTIDIABETES FRAKSI ETIL ASETAT DAUN PEPAYA (Carica papaya L.)TERHADAP TIKUS JANTAN WISTAR (Rattus norvegicus) Neswita, Elfia; Naldi, Jefri; Kinanti, Dara; Nasution, Halimah Raina; Pramudita, Rufina; Nurasni
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1375

Abstract

Diabetes mellitus is a serious chronic disease that occurs when the pancreas does not produce sufficient insulin or when the body is unable to effectively utilize the insulin produced. Papaya leaves (Carica papaya L.) have been reported to possess potential antidiabetic properties. The novelty of this study lies in evaluating the antidiabetic activity of the ethyl acetate fraction of papaya leaves in male Wistar rats. This study aimed to determine the antidiabetic activity of the ethyl acetate fraction of papaya leaves in alloxan-induced male Wistar rats. Papaya leaf simplicia powder was extracted using the maceration method with 70% ethanol as the solvent. The concentrated extract was subsequently fractionated using ethanol–water, n-hexane, and ethyl acetate. Antidiabetic activity was evaluated using alloxan induction at a dose of 150 mg/kg body weight. Blood glucose levels were measured before alloxan induction to determine baseline values, two days after induction to confirm hyperglycemia, and every seven days for 14 days of treatment to assess changes in glucose levels. Phytochemical screening revealed that the ethyl acetate fraction contained alkaloids, flavonoids, and saponins. The results showed that the ethyl acetate fraction at a dose of 300 mg/kg body weight exhibited the highest antidiabetic activity, with a 64% reduction in blood glucose levels, slightly higher than the positive control, which showed a 63% reduction. In conclusion, the ethyl acetate fraction of papaya leaves at a dose of 300 mg/kg body weight demonstrates promising antidiabetic potential, likely attributable to its bioactive compounds.
Co-Authors Abdi Wira Septama Abdi Wira Septama Eka Nugraha, Sony Khairunnisa, Nur Aini Kinanti, Dara Naldi, Jefri Neswita, Elfia Nurasni Pramudita, Rufina Sufitni Yuandani