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All Journal Jurnal Abdi Insani KESANS : International Journal of Health and Science Sciences of Pharmacy Journal of Public Health and Pharmacy
Polontalo, Nani Astria
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Study of Treatment in Heart Disease Patients Installation in Undata Hospital, Central Sulawesi Puspita Dewi, Niluh; Kurnia Utami, Indah; Gunawan, Al'vira; Tahir, Muh. Thamrin; Alaydrus, Syafika; Polontalo, Nani Astria
Journal of Public Health and Pharmacy Vol. 4 No. 1: MARCH 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i1.4951

Abstract

Introduction: Heart diseasesis a disorder of heart functionsdue to lack of bloods in the heart muscles due to narrowingsof the coronary artery. The purposesof this study was to describe t he characteristics and use of heart disease drugs based on parameters of rationality of drug use in Undata Hospital, Central Sulawesi Province including gender, age, heart drug class, complementary drug class, length of hospitalization, laboratory data, comorbidities , appropriate indications, the right drugs and the right dose. Methods: This researchsis a non-experimental type of research conducted prospectively during February-April 2022. The sampling technique in this study was purposive sampling, namely sampling based on established criteria. All samples that met the requirements who came to the hospital were used as research samples according to the required sample size of 40 respondents and based on the available data collection time. Results: The results of the study were 40 patients with hearts disease, the most heart disease sufferers were male with a percentage of 67.5%, in the age range of 56-65 years 32.5%, the most commonly used companion drug was Alprazolam as much as 17%, the most length of hospitalization was 4-6 days (55%), the most laboratory results were Hemoglobin/HGB examination as many as 21 patients (14.38%), the most comorbidities namely Hypertension with a percentage of 60% Conclusion: Appropriate use of heart disease drugs based on drug rational parameters in hospitals Undata of the right indication 100%, the right drug selection 100% and the right dose 100%. Recommendedsfor further researchersscan conduct research on cardiac drug interactions.
Antidiarrheal Effectiveness Test of Ketapang Leaf Infusion (Terminalia catappa L.) Against Male Mice (musculus) Polontalo, Nani Astria; Marlina, Ni Ketut; Nuraisya, Nuraisya; Febrita, Veny
Jurnal KESANS : Kesehatan dan Sains Vol 4 No 12 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v4i12.452

Abstract

Introduction: Diarrhea is a common health problem that can be serious if not treated immediately. Ketapang leaves (Terminalia catappa L.) contain active compounds such as tannins and alkaloids which are known to have antibacterial activity and have the potential as an antidiarrheal drug. Objective: This study aims to evaluate the effectiveness of ketapang leaf infusion in treating diarrhea and to determine the most optimal dose in male mice (Mus musculus). Method: The experimental study was conducted using the infusion method on 15 male mice divided into five treatment groups, namely negative control (Na CMC), positive control (loperamide), and three test groups with ketapang leaf infusion at concentrations of 25%, 50%, and 75%. Diarrhea was induced using oleum ricini, and the number of stools was monitored 180 minutes after treatment. Analysis was performed using an independent T-test. Result and Discussion: The results showed that 50% and 75% ketapang leaf infusions provided the highest stool reduction effect compared to the other groups. Conclusion: In conclusion, ketapang leaf infusion has potential as an antidiarrheal agent, with concentrations of 50% and 75% as the most effective doses in this study.
Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats Dewi, Niluh Puspita; Alaydrus, Syafika; Lestari, Widya Ayu; Magfirah, Magfirah; Utami, Indah Kurnia; Polontalo, Nani Astria; Tuldjanah, Muthmainah
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301173

Abstract

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.
SOSIALISASI DAN EDUKASI DAGUSIBU OBAT DENGAN BENAR PADA MASYARAKAT KELURAHAN TATURA UTARA, PALU SELATAN Dewi, Niluh Puspita; Wirawan, Wayan; Rakanita, Yasinta; Polontalo, Nani Astria; Insani, Fadillah
Jurnal Abdi Insani Vol 12 No 10 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i10.2873

Abstract

Various health problems, particularly those related to drugs, persist in the community. This can be caused by a lack of public understanding of the proper use and handling of drugs. The DAGUSIBU program is one method for proper drug management. The goal of DAGUSIBU outreach is to increase public understanding of drugs and how to manage and monitor their proper use. The methods used include public education through counseling and practical training. The effectiveness of the outreach was tested using pre- and post-tests, as well as a community satisfaction questionnaire. The results showed an increase in public knowledge and understanding after the DAGUSIBU outreach and education activities. Overall, the average increase in knowledge and understanding of DAGUSIBU among participants was 84%. This can help the government provide better health services. By improving participants' understanding of proper drug management, this outreach is expected to enable them to utilize the knowledge they gain within their families and communities.
Co-Authors Alaydrus, Syafika Febrita, Veny Gunawan, Al'vira Insani, Fadillah Kurnia Utami, Indah Lestari, Widya Ayu Magfirah, Magfirah Marlina, Ni Ketut Niluh Puspita Dewi, Niluh Puspita Nuraisya, Nuraisya Puspita Dewi, Niluh Rakanita, Yasinta Syafika Alaydrus Tahir, Muh. Thamrin Tuldjanah, Muthmainah Utami, Indah Kurnia wirawan, Wayan