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All Journal Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Jurnal Inovasi Pendidikan MH Thamrin Jurnal Mandala Pengabdian Masyarakat Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Utami, Indah Kurnia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Safety Profile of Abelmoschus Manihot (L.) Medik Ethanol Leaf Extract: Acute Toxicity Study in Animal Models Pantua, Magfira B.; Anggi, Viani; Utami, Indah Kurnia; Rakanita, Yasinta
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.9172

Abstract

Abelmoschus Manihot (L.) Medik, commonly known as Abelmoschus manihot, is a traditional medicinal plant from Palu, Central Sulawesi, Indonesia, widely utilized for its potential health benefits. This research aims to evaluate the acute toxicity of ethanol extract from Abelmoschus manihot leaves, focusing on determining the lethal dose (LD50) in rats. The study involved extracts being administered at a range of doses of 500 mg/kg, 1000 mg/ kg, and 2000 mg/Kg of body weight (BB) in a rat population. Rats were observed for 24 hours to look for signs of toxicity and death. The LD50 value, which determines the dose required to cause death in 50% of the test population, is calculated based on the results. This research provides insights into the safety profile of ethanol extract from Abelmoschus manihot leaves and contributes to understanding its potential risks when used in traditional medicine. No significant deaths were observed at lower doses, but higher doses resulted in observable toxic effects, indicating the need for careful dosing in therapeutic applications. The results show that although Abelmoschus Manihot did not exhibit acute toxic effects on rats at doses of 500 mg/kg, 1000 mg/kg, and 2000 mg/kg body weight. No significant deaths or severe toxic symptoms were observed during the 24-hour observation period up to the 14-day observation, and there were no differences in the body weight of the rats during the 14-day observation
Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats Dewi, Niluh Puspita; Alaydrus, Syafika; Lestari, Widya Ayu; Magfirah, Magfirah; Utami, Indah Kurnia; Polontalo, Nani Astria; Tuldjanah, Muthmainah
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301173

Abstract

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.
Co-Authors Afdal, Faidil Alaydrus, Syafika Darmayanti Darmayanti Joni Tandi, Joni Lestari, Widya Ayu Letana, Trace Chintia MAFTUHAH Magfirah Magfirah, Magfirah Marzuki, Sitti Aisyah Niluh Puspita Dewi, Niluh Puspita Ocvinta, Sisca Pantua, Magfira B. Polakitan, Grace Polontalo, Nani Astria Praypelisa, Ipa Rakanita, Yasinta Recky Patala Syafika Alaydrus Tandi, Jony Tuldjanah, Muthmainah Viani Anggi Wawang Anwarudin Zahruddin