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Journal : Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran

Efek Stres terhadap Pengobatan Asthma Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4346

Abstract

Stress has long been identified as a factor associated with poor asthma treatment outcomes; however, the magnitude of its effects and the underlying mechanisms remain unclear. In this meta-analysis, we evaluated the impact of stress on asthma management across 32 studies (N=47,892) published between 2014 and 2023. The results demonstrate a significant negative correlation between stress and asthma control (r=-0.42, 95% CI: -0.48 to -0.36, p<0.001), a positive correlation with symptom severity (r=0.38, 95% CI: 0.33 to 0.43, p<0.001), and a negative correlation with medication adherence (r=-0.29, 95% CI: -0.34 to -0.24, p<0.001). Additionally, the effect of stress was found to be stronger in adults compared to children (Q=7.89, p=0.005) and among individuals with low socioeconomic status (β=-0.018, p=0.010). Mechanistic analyses revealed the role of HPA axis activation (10 studies), autonomic dysfunction (7 studies), and increased pro-inflammatory cytokines (6 studies). In contrast to the findings of Sandberg et al. (2018), which focused on children, this study identifies a more pronounced effect in adults. Furthermore, these results extend the work of Chen et al. (2020) by highlighting a bidirectional relationship between stress and asthma outcomes (χ²=12.34, p=0.015), indicating a complex feedback cycle. We assert that these findings strengthen and broaden the conclusions of Yamauchi et al. (2016) by providing more precise effect estimates and a deeper mechanistic analysis. Consequently, this study underscores the importance of integrating stress assessment and psychosocial interventions in asthma management, with significant implications for developing more holistic and personalized care approaches.
Hubungan antara Kepuasan Hidup dan Pengobatan Emfisema Milna Sari; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4348

Abstract

This study investigates the relationship between life satisfaction and adherence to emphysema treatment through a comprehensive meta-analysis. Out of 47 studies that met the inclusion criteria (N = 12,463 patients), the researchers found a significant positive correlation between life satisfaction and adherence to emphysema treatment (r = 0.58, p < 0.001). Additionally, hierarchical regression analysis revealed that life satisfaction predicted 34% of the variance in treatment adherence (β = 0.47, p < 0.001). Furthermore, patients with high levels of life satisfaction exhibited greater improvements in lung function (FEV1 +15.3%, p < 0.01) compared to those with low life satisfaction after 12 months of treatment. These findings extend the results of Johnson et al. (2019) and Zhang et al. (2021) by demonstrating the moderating effects of age (β = -0.22, p < 0.05) and disease duration (β = -0.18, p < 0.05) on this relationship. In contrast to the findings of Ramirez (2020), this study indicates that interventions aimed at enhancing life satisfaction (d = 0.76, 95% CI [0.62, 0.90]) significantly improve both treatment adherence and clinical outcomes for emphysema patients. Ultimately, the researchers emphasize the importance of integrating life satisfaction enhancement strategies into emphysema management, providing new insights into the complex interplay between psychosocial factors and treatment outcomes in this chronic condition.
Peran Kepuasan Hidup dalam Pengelolaan Penyakit Systemic Sclerosis Helsa Nasution; M. Agung Rahmadi; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4359

Abstract

This study examines life satisfaction's role in managing Systemic Sclerosis (SSc) through a comprehensive meta-analysis. Out of 1,247 identified articles, 42 studies met the inclusion criteria, encompassing 8,734 SSc patients. The findings reveal a significant positive correlation between life satisfaction and treatment adherence in Systemic Sclerosis (r = 0.39, 95% CI [0.32, 0.45], p < 0.001), utilizing adaptive coping strategies (r = 0.45, 95% CI [0.38, 0.51], p < 0.001). Additionally, life satisfaction was negatively correlated with depression (r = -0.52, 95% CI [-0.58, -0.45], p < 0.001) and anxiety (r = -0.47, 95% CI [-0.54, -0.39], p < 0.001). Social support emerged as a strong predictor of life satisfaction (r = 0.51, 95% CI [0.44, 0.57], p < 0.001). Furthermore, interventions aimed at enhancing life satisfaction demonstrated a significant positive effect (d = 0.62, 95% CI [0.45, 0.79], p < 0.001). Moderator analyses indicated that age and disease duration influenced the strength of the relationship between life satisfaction and SSc management. The researchers believe these findings extend previous studies by Kwakkenbos et al. (2015) and Malcarne et al. (2013) by quantifying the strength of the relationship between life satisfaction and various aspects of SSc management on a larger scale. Unlike the findings of Thombs et al. (2010), which focused primarily on depression, this study provides a broader perspective on the role of life satisfaction in SSc. Consequently, these results support the integration of life satisfaction assessment and interventions in SSc care, emphasizing the importance of a more comprehensive biopsychosocial approach. Finally, the researchers acknowledge limitations in this study, including high heterogeneity (I² = 62-78%) and potential publication bias. Future research should focus on longitudinal studies and the development of targeted interventions to enhance life satisfaction in SSc patients.
Hubungan Motivasi terhadap Keberhasilan Pengobatan Endometriosis M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4364

Abstract

This meta-analysis investigates the relationship between patient motivation and the success of endometriosis treatment, encompassing 25 studies with a total of 3,782 patients. A strong positive correlation was found (r = 0.68, p < 0.001) between motivation levels and treatment outcomes for endometriosis. Additional findings include: First, patients with high motivation exhibited a significantly greater reduction in pain (SMD = 1.24, 95% CI [0.98, 1.50]) and a more substantial improvement in quality of life (SMD = 0.89, 95% CI [0.67, 1.11]); Second, analysis of factors influencing motivation revealed scores related to understanding of the disease (β = 0.41, p < 0.001), social support (β = 0.38, p < 0.001), and the quality of the doctor-patient relationship (β = 0.45, p < 0.001); Third, motivational interventions were demonstrated to be effective in enhancing treatment outcomes for endometriosis (SMD = 0.94, 95% CI [0.73, 1.15], p < 0.001). Lastly, intrinsic motivation showed a stronger correlation with treatment outcomes for endometriosis (r = 0.73, 95% CI [0.65, 0.79]) compared to extrinsic motivation (r = 0.54, 95% CI [0.45, 0.62]). These findings extend the results of Facchin et al. (2017) regarding the role of psychological factors in the quality of life of endometriosis patients and support Deci and Ryan's (2000) theory on the importance of intrinsic motivation. Furthermore, in contrast to previous studies focusing on biomedical aspects, this research reveals the crucial role of psychological factors in the management of endometriosis treatment, underscoring the significance of Engel's (1977) proposed biopsychosocial approach. Consequently, these results provide a strong empirical foundation for integrating motivational enhancement strategies into standard care protocols for endometriosis and paving the way for a more holistic and effective approach to managing this condition.
Pengaruh Intervensi Emosi Positif pada Pengobatan Fibromyalgia Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4367

Abstract

This meta-analysis investigates the effectiveness of positive emotion-based interventions for patients with fibromyalgia. From a total of 1,247 identified articles, 32 studies (N=2,456 participants) met the inclusion criteria. The results indicate that positive emotion-based interventions significantly reduce pain intensity (g=-0.42, 95% CI [-0.56, -0.28], p<0.001), enhance quality of life (g=0.38, 95% CI [0.25, 0.51], p<0.001), and alleviate depressive symptoms (g=-0.35, 95% CI [-0.48, -0.22], p<0.001). Furthermore, moderator analysis reveals that the duration of the intervention significantly moderates its effects on pain intensity (β=-0.03, p=0.02) and quality of life (β=0.04, p=0.01) in fibromyalgia patients. Among the interventions, mindfulness-based approaches appear most effective in reducing pain (g=-0.51), while cognitive-behavioural therapy shows the greatest efficacy in improving quality of life (g=0.45). These findings extend Fredrickson's (2001) "broaden-and-build" theory to the context of chronic illness and support the biopsychosocial model of fibromyalgia proposed by Häuser et al. (2010). The researchers argue that these results align with Zautra et al. (2005) regarding the role of positive affect in resilience against chronic pain, offering a more precise and comprehensive effect estimation. Unlike previous meta-analyses focused on specific interventions (e.g., Bernardy et al., 2018; Lauche et al., 2013), this study highlights the general effectiveness of positive emotion-based approaches. Consequently, it underscores the potential for integrating strategies to enhance positive emotions into fibromyalgia treatment protocols, paving the way for a more holistic and personalized approach to managing this chronic condition.