Article Per Year (5 Year)
p-Index From 2020 - 2025
0.947
P-Index
This Author published in this journals
All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Sciences of Pharmacy Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Abdimas Bencoolen
Okta, Fauzia Noprima
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Sciences of Pharmacy

 1 
Nanosuspension Formula of Curcuma xanthorriza Rhizome Dry Extract: Impact of Tween 80-PEG 400 Ratio Arifin, Moch Futuchul; Shafira, Elza; Noviani, Yuslia; Desmiaty, Yesi; Okta, Fauzia Noprima
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302222

Abstract

Our previous research investigated nanosuspension using the ionic gelation method with a 2:1 ratio of chitosan to sodium tripolyphosphate (TPP) and 0.44% Curcuma xanthorriza rhizome extract. The results indicated an unstable nanosuspension with a particle size of 399.3 nm, a polydispersity index of 0.60, and an entrapment efficiency of 73.37%. This study aims to develop a nanosuspension using Tween 80-PEG 400 to improve the characteristics and dissolution at pH 6.8. Curcuma rhizome was macerated with 96% ethanol and dried using a spray dryer. The nanosuspension formulation was designed using a 22 factorial design with Tween 80 (0.1%-0.4%) and PEG 400 (0.1%-0.4%) as factors, and the formulation was analyzed using Minitab 18. The dissolution of the optimum formulation was tested. The best formulation, comprising 0.1% Tween 80 and 0.4% PEG 400, provided a spherical shape, a particle size of 111.26 nm, a polydispersity index of 0.27, a zeta potential of 30.77 mV, an entrapment efficiency of 84.30%, and a desirability value of 0.9058. The release of curcumin at pH 6.8 after 180 minutes was 37.85% ± 0.1375 with a DE180 of 83.60% ± 0.1457. The 22 factorial design proved effective for enhancing formulation attributes. Based on the result obtained, it can be concluded that the best formulation contains 0.1% Tween 80 and 0.4% PEG 400, with zero-order release kinetics and a diffusion mechanism.
Effect of Combination of Porang and Moringa Flour on Blood Glucose Levels and Body Weight in Rats Laksmitawati, Dian Ratih; Marwati, Umi; Okta, Fauzia Noprima; Partana, Citra Prastuti
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302215

Abstract

Porang tuber is rich in fiber and low in calories of carbohydrates. Moringa oleifera leaf has a high protein and a low content of lipids. Obesity and diabetes mellitus are the risk factors of cardiovascular disease, also known as cardiovascular disease risk factors. Combining of porang and moringa as feed can increase nutrition without causing weight gain. This study aims to determine these two materials as antidiabetic and antiobesity agents. The samples are porang tuber, a combination of porang tuber and M. oleifera leaves, a combination of M. oleifera leaves and wheat flour, wheat flour, and standard feed of mice. The parameters tested in this study are analysis of macronutrients of feed, loss of weight of mice, average consuming feed in 28 days, and reduction of blood glucose with a glucometer. The results obtained are a combination of porang tuber and moringa had a low contain carbohydrates and a high contain lipids and protein, can reduction in body weight of 21%, the lowest consumption of feed, and the lowest fasting and postprandial blood glucose levels compared to the other feeds. A combination of porang and moringa can be an antidiabetic and antiobesity agent.
Co-Authors Aina Fatkhil Haque, Aina Fatkhil Dian Ratih Laksmitawati Dominica, Dwi FAIZATUN, FAIZATUN Gumilar Adhi Nugroho Hakim, Zainur Rahman Jasmadeti, Jasmadeti Larasinta, Nadia Marwati, Umi Moch Futuchul Arifin Nanda, Yogie Andika Tri Ni Made Dwi Sandhiutami Noviani, Yuslia Oktarini, Rizki Partana, Citra Prastuti Pratita, Rasta Naya Priyanti, Ike Ari Rahmawati, Reza Sari, Intan Pertama SEPTI WULANDARI Shafira, Elza Yati Sumiyati, Yati Yesi Desmiaty, Yesi Yesika, Relin