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All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Syntax Literate: Jurnal Ilmiah Indonesia JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Bioscientist : Jurnal Ilmiah Biologi Sciences of Phytochemistry Journal of Natural Product for Degenerative Diseases
Yati Sumiyati, Yati
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Analisa Uji Beda Kadar Gula Darah & Tekanan Darah Serta Profil Pengobatannya pada Pasien Katarak & Non Katarak di RSUD Ciawi Tahun 2018 Kurniawan, Affandi; Sumarny, Ros; Sumiyati, Yati; Fernandez, Itha
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.551 KB) | DOI: 10.36418/syntax-literate.v6i2.5458

Abstract

Katarak merupakan penyakit lensa mata keruh, pada kondisi fisiologis normal lensa mata jernih dan transparan. Berdasarkan data rekam medis, penyakit katarak di RSUD Ciawi meningkat dari tahun 2016 sampai tahun 2018, sehingga peneliti ingin mengetahui faktor risiko dari kasus katarak tersebut. Tujuan penelitian ini, yaitu menganalisis data profil glukosa darah sewaktu, puasa, dan post prandial pada pasien katarak dan non katarak,menganalisis data tekanan darah diastolik dan tekanan darah sistolik pada pasien katarak dan non katarak, dan mengetahui profil obat antihipertensi dan antihiperglikemia pada pasien katarak dan non katarak. Prosedur penelitian ini, yaitu pengumpulan data pasien katarak dan non katarak RSUD Ciawi Bogor, pengumpulan data laboratorium pasien dengan nilai kadar glukosa darah dan tekanan darah yang mengarah ke katarak dan non katarak;data kadar glukosa darah diambil pada saat pasien pertama kali didiagnosa katarak atau sebelum didiagnosa katarak;data tekanan darah diambil pada saat pasien didiagnosa menderita katarak dan sebelum didiagnosa katarak, pengumpulan data, dan diolah secara statistik dengan SPSS. Hasil penelitian ini, yaitu tidak ada perbedaan yang signifikan gula darah sewaktu, gula darah puasa, gula darah post prandial, serta tekanan darah diastolik pada pasien katarak dan non katarak. Ada perbedaan yang signifikan tekanan darah sistolik pada pasien katarak dan non katarak. Tidak ada perbedaan yang signifikan gula darah puasa, gula darah sewaktu, tekanan darah sistolik, tekanan darah diastolik pada pasien katarak stadium ringan, sedang, berat katarak, dan non katarak. Ada perbedaan yang signifikan gula darah post prandial pada pasien katarak stadium II, katarak stadium III, dan non katarak.
Hubungan Karakteristik Klinik dan Profil Pengobatan dengan Parameter Hematologi dan Lama Rawat Pasien Covid-19 Di Rumah Sakit Yarsi Jakarta Arief, Ilham; Sumarny, Ros; Sumiyati, Yati; Kusuma, Indra
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.685 KB) | DOI: 10.36418/syntax-literate.v6i11.4556

Abstract

Pandemi penyakit virus korona 2019 (COVID-19) masih belum berakhir dan masih belum ada pengobatan spesifik dan efektif untuk melawan virus SARS-CoV-2 ini. Untuk itu, sebagai salah satu upaya deteksi dini dan pengobatan segera, diperlukan adanya analisa hubungan perawatan dan pengobatan yang sudah dilakukan terhadap perbaikan nilai parameter-parameter klinis pada kesembuhan pasien COVID-19. Tujuan penelitian ini adalah untuk menganalisa data hubungan karakteristik klinik berdasarkan tingkat keparahannya dan profil pengobatan terhadap parameter hematologi dan lama rawat pasien COVID-19 di Rumah Sakit Yarsi Jakarta. Penelitian ini merupakan penelitian observasional analitik dengan desain cohort dan pengambilan data retrospektif melalui rekam medis periode bulan Maret sampai dengan Oktober tahun 2020. Uji statistika menggunakan uji peringkat spearman dan uji tanda wilcoxon. Berdasarkan penelitian, 221 pasien yang memenuhi kriteria inklusi dengan gejala tertingginya adalah batuk dan demam sebanyak 61,09% dan 47,96%. secara statistik, karakteristik klinis berdasarkan tingkat keparahannya memiliki hubungan bermakna dengan lama rawat pasien (p=0,187) dan memiliki hubungan bermakna pada parameter eosinofil, neutrofil, limfosit, laju endap darah, dan rasio neutrofil-limfosit (RNL) (p<0,05). Hubungan kelompok penggunaan obat tidak memiliki hubungan signifikan dengan lama rawat pasien (p= 0,361) dikarenakan mayoritas pasien bergejala ringan dan usia produktif yang memiliki imunitas masih baik sedangkan pada uji beda sebelum dan sesudah penggunaan obat terhadap parameter hematologi menunjukan hasil memiliki perbedaan bermakna pada parameter hematologi eosinofil (p<0,05). Karakteristik klinis berdasarkan tingkat keparahannya mempengaruhi sel imunitas dan lama rawat pasien serta penggunaan obat-obatan memberikan perbaikan pada nilai parameter hematologi
Analisis Senyawa Bioaktif Averrhoa bilimbi L. sebagai Penghambat Enzim Siklooksigenase-2 Menggunakan Pendekatan in silico Mulatsari, Esti; Sumiyati, Yati; Warni, Warni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1284

Abstract

Averrhoa bilimbi L. is generally used as a food flavor enhancer and traditional medicine to treat inflammation, cancer sores, cough, fever, gout, rectal bleeding, and hemorrhoids. In vivo and in vitro studies on Averrhoa bilimbi L. have shown anti-inflammatory activity, but the active compounds that play a role in anti-inflammatory activity have not been reported. This study aimed to analyze sixtyfour (64) bioactive compounds in the Averrhoa bilimbi L. plant as cyclooxygenase-2 (COX-2) enzyme inhibitors using in silico approach and predict the pharmacokinetic and toxicological profiles of each compound. The cyclooxygenase-2 enzyme is an enzyme that plays a role in the inflammatory process by converting arachidonic acid into prostaglandin. Increased prostaglandins will cause inflammation. The research method used molecular docking with the application of YASARA, PLANTS, Marvinsketch, Pymol, visualization with PLIP and prediction of ADMET with pkCSM. Control compound used celecoxib. The results showed that there were 13 test compounds that were predicted to have better COX-2 inhibitor activity than celecoxib with good pharmacokinetic properties. Erucic acid has the best pharmacokinetic and toxicity profile. Erucic acid has the potential to be developed as a cyclooxygenase-2 enzyme inhibitor drug.
Edukasi Peningkatan Aspek Mutu Obat Tradisional bagi Pengguna dan Pelaku Usaha Obat Tradisional Desmiaty, Yesi; Nugroho, Gumilar Adhi; Okta, Fauzia Noprima; Sandhiutami, Ni Made Dwi; Sumiyati, Yati; Priyanti, Ike Ari
Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 2 (2023): Agustus 2023
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Bina Sarana Informatika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31294/jabdimas.v6i2.14627

Abstract

Adanya pandemi covid-19 membuat masyarakat berusaha lebih untuk menjaga kesehatan salah satunya dengan menggunakan obat herbal, sehingga terjadi peningkatan penggunaan obat herbal di Indonesia. Hal ini tentu harus diimbangi dengan mutu yang terjamin dari obat herbal di pasaran. Kegiatan pengabdian kepada masyarakat ini dalam rangka mengedukasi masyarakat sebagai pengguna obat herbal maupun pelaku usaha herbal agar memperhatikan aspek mutu obat herbal. Saat ini masih terdapat obat herbal yang beredar di masyarakat dan tidak memenuhi persyaratan. Metode edukasi dilakukan secara daring dengan menyebarkan kuisioner untuk mengetahui pengetahuan masyarakat, dilanjutkan dengan edukasi dan diskusi interaktif. Dari hasil survey menunjukkan responden umumnya belum terlalu memahami aspek mutu obat herbal sehingga perlu untuk dilakukan edukasi agar dapat memilih obat herbal yang bermutu baik serta bagi pelaku usaha herbal dapat meningkatkan mutu produknya sesuai dengan persyaratan yang diberlakukan oleh regulator yaitu Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM RI).
Colocasia esculenta L. Extract Increase Growth and Motility of Rotenone Induced Zebrafish (Danio rerio) Larvae Stunting Model Furqon, Muhammad; Kumala, Shirly; Farida, Yunahara; Zaidan, Sarah; Sumiyati, Yati
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.10670

Abstract

This study aims to determine the effect of Colocasia esculenta L on the growth and motility of zebrafish (Danio rerio) larvae after induction of rotenone as a stunting model. The Zebrafish have divided 3 groups i.e Normal (embryonic medium without rotenone induction), Negative Control (embryonic medium with rotenone induction), and Treatment Groups (embryonic medium with rotenone induction and Colocasia esculenta extracts, dose 30-60-90 ppm). The stunting model is designed by induction of 12.5 ppb rotenone to Zebrafish larvae. The growth of the larvae was observed by using a microscope to measure the body and head length. Evaluation of motility was carried out by recording the movement of the fish for 1 minute, and the pace was analyzed by using Video Tracker. The evaluations were observed at 3, 6, 9 dpf (day post-fertilization). Colocasia Esculenta Extract (CEE) groups have higher body lengths compared to the Negative Control Group. The lengths were 125.4 µm for CEE30, 119.4 µm for CEE60, and 121.4 µm CEE90 while the length for the Negative Control Group was 118.3 µm at 9 dpf. However, there were no different values for the ratio of head length to body length of all groups. The ratio was 1:6 at 3 dpf, and 1:4 at 6 and 9 dpf. Moreover, the motility was higher in CEE groups compared to the Negative Control at 3, 6, 9 dpf. The body length and motility of Zebrafish larvae higher compare to the Negative Control Group showing the potential of Colocasia esculenta extract on growth and enhancement of motoric activity.
Phenolic Content and Antioxidant Activity of Colocasia esculenta in Commercial Herbal Products Nugroho, Gumilar Adhi; Desmiaty, Yesi; Sumiyati, Yati; Suherman, Sandra Loretta; Lim, Helsa
Sciences of Phytochemistry Volume 4 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0401288

Abstract

Taro (Colocasia esculenta L.) is a plant with a long history of use in traditional medicine in several countries worldwide. The corm of taro and two commercial products were analysed due to total phenolic, flavonoid, luteolin, and antioxidant properties. Taro corm was extracted with water and analysed for phytochemical screening, total flavonoids, total phenolic, luteolin, and antioxidant properties. The phytochemical screening of taro showed that it contains secondary metabolites of flavonoids, tannins, saponins, triterpenoids, and quinones. The results of the determination of total flavonoid content of taro extract, Product 1, and Product 2 capsule obtained 19.34 ± 0.26 mg QE/g extract, 18.58 ± 0.18 mg QE/g extract, and 16.29 ± 0.23 mg QE/g extract. The results of determining the total phenolic content of taro, Product 1, and Product 2 capsules obtained 39.75 ± 0.95 mg GAE/g extract, 38.46 ± 0.46 mg GAE/g extract, and 35.91 mg GAE/g extract. ± 0.82 mg GAE/g extract. The results of the determination of luteolin from taro, Product 1, and Product 2 capsules obtained 0.83 ± 0.05 %, 0.39 ± 0.04 %, and 0.18 ± 0.08 %. The results of the antioxidant activity test obtained IC50 of vitamin C of 4.6780 ± 0.0319 ppm, corm dry extract and ginger rhizome 141.2383 ± 3.4995 ppm and 97.6685 ± 7.8760 ppm, respectively, and capsule products 2; 126.0724± 1.3672 ppm. The water extract of corm and available products containing CE extract have met the quality standard parameters required for non-specific parameters, luteolin content, and antioxidant properties.
The ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC: ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC Karlina, Lina; Sumiyati, Yati; Utami Ramadaniati, Hesty; S. Mardiko, Etty
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2307

Abstract

The COVID-19 pandemic has caused changes to pharmaceutical services activities in community pharmacies, due to various adjustments that must be made. To analyze the impact of COVID-19 pandemic on pharmaceutical service activities in community pharmacies. Cross-sectional approach involving community pharmacist in DKI Jakarta. The quantitative data were collected through distributing online questionnaires in November 2022, while qualitative data were obtained through online in-depth interviews. The quantitative data was analyzed descriptively whereas qualitative data was analyzed using content analysis. Research revealed an increase of 29.4% of pharmacies experiencing out of stock in pharmaceutical supplies compared to before the pandemic. There was a 42.1% decrease indirect Drug Information Services (DIS) compared to before the pandemic. Meanwhile, during the pandmeic a 42.1% increase in online DIS. There were various innovations and strategies done by pharmacies including maximizing the use of digitalization both in the implementation of pharmaceutical services, as well as in promotional activities and online sales of pharmacy productsand. It can be concluded that there are considerable differences in managerial activities and clinical pharmacy services before and during the COVID-19 pandemic, with more digital-based technology involvement in managerial activities and clinical pharmacy services during the pandemic. Keywords: Pharmaceutical services, Pharmacy, COVID-19, Innovations, Strategic
Pneumonia ANALISIS RASIONALITAS PENGGUNAAN ANTIBIOTIK DAN PENGARUHNYA TERHADAP LAMA RAWAT INAP PASIEN PNEUMONIA DI RSUD AHMAD YANI METRO, LAMPUNG: ANALYSIS OF THE RATIONALITY OF ANTIBIOTIC USE AND ITS EFFECT ON THE LENGTH OF HOSPITAL STAY IN PNEUMONIA PATIENTS AT RSUD JENDERAL AHMAD YANI METRO, LAMPUNG Asti, Windi; Sarnianto, Prih; Sumiyati, Yati; Syahputri, Devina Harti; Suri, Nurma
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2521

Abstract

Pneumonia is an acute infectious disease that affects lung tissue and is caused by bacteria, fungi, viruses, and parasites, leading to inflammation of the lung parenchyma and accumulation of inflammation in the respiratory tract. In Lampung Province, there was an increase in pneumonia case detection coverage, from 39.8% in 2020 to 40.6% in 2021. At RSUD Ahmad Yani in Metro City, Lampung, pneumonia ranks among the top 10 most common diseases. The purpose of this study was to evaluate the rationality and appropriateness of antibiotic use according to treatment guidelines in pneumonia patients. This study employed an observational descriptive-analytic design with a cross-sectional approach and data collection from patient medical records using purposive sampling. The samples consisted of inpatient records diagnosed with pneumonia infection at RSUD Ahmad Yani in Metro City during January–December 2023. Data were obtained retrospectively through medical record reviews of inpatients. Quantitative analysis of antibiotic use was conducted using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method, while qualitative analysis utilized the Gyssens algorithm. Statistical calculations were performed using SPSS software with Spearman’s correlation test. In this study, from 190 antibiotic prescriptions, the ATC/DDD value was 138.18 DDD per 100 patient-days. The correlation between the rationality of antibiotic use and length of hospital stay showed a Spearman correlation coefficient of 0.42, indicating a moderate positive correlation; however, the significance value of 0.567 indicated that this relationship was not statistically significant.   Keywords : ATC/DDD, Gyssens, Length of Stay (LOS), Pneumonia, Hospital
ANALISIS KUALITATIF DAN KUANTITATIF PENGGUNAAN ANTIBIOTIK PADA PASIEN PASCA OPERASI LAPAROTOMI DI RUANG ICU RSUD JENDERAL AHMAD YANI METRO LAMPUNG TAHUN 2023: ANALISIS KUALITATIF DAN KUANTITATIF PENGGUNAAN ANTIBIOTIK PADA PASIEN PASCA OPERASI LAPAROTOMI DI RUANG ICU RSUD JENDERAL AHMAD YANI METRO LAMPUNG TAHUN 2023 Kurniati, Rizki; Sumiyati, Yati; Ramadaniati, Hesty Utami; Syahputri, Devina Harti
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2522

Abstract

Laparotomy is a surgery performed to open the abdomen, a form of major surgery by cutting the layers of the abdominal wall, risking causing infection of the surgical wound where antibiotics are given as treatment. Antibiotic resistance can lead to increased morbidity, mortality and health costs, therefore there needs to be an analysis for the use of antibiotics. The analysis of the use of antibiotics was carried out in the ICU room of the General Ahmad Yani Metro Lampung Hospital with the aim of analyzing how to use antibiotics qualitatively and quantitatively. The method used is descriptive with retrospective data collection from the period of January 1 to December 31, 2023. The qualitative analysis of the use of antibiotics used the Gyssens method and quantitatively with the ATC/DDD du 90% method. The sample of this study consisted of 52 patients after laparotomy surgery in the ICU room of General Ahmad Yani Metro Hospital Lampung, where based on the inclusion and exclusion criteria determined. Based on the results of the analysis of antibiotic use with the Gyssens method, 83.8% used antibiotics non-adherence (category 0) and 16.2% used antibiotics adherence (categories VIA and V). Analysis of the use of antibiotics using the ATC/DDD method obtained that Seftriaxone had the highest DDD with DDD/100 patients – 76.4 DDD per day and those in the DU segment of 90% were Seftriaxone and Metronidazole.    Keywords: ATC/DDD du 90%, Gyssens, Laparotomy, Quantitative, Qualitative
Pharmacognostic and Phytochemical Characterization of Colocasia esculenta var. antiquorum Corm (Araceae) and Preliminary Evaluation of Its Antimicrobial Activity Sumiyati, Yati; Yesi Desmiaty; Gumilar Adhi Nugroho; Fauzia Noprima Okta
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i1.9218

Abstract

Colocasia esculenta has been reported in reputable journals to exhibit various bioactivities, including antioxidant, anti-inflammatory, and antidiabetic properties. This study aimed to investigate the pharmacognostic characteristics and phytochemical profile of Colocasia esculenta var. antiquorum corm (Araceae). The corms were collected, authenticated, oven-dried, and subjected to preliminary pharmacognostic and phytochemical analyses. Pharmacognostic evaluations included organoleptic, microscopic, and physicochemical examinations. The dried corm powder was extracted with distilled water, followed by qualitative phytochemical screening. The extract was found to contain saponins, flavonoids, tannins, and triterpenoids. Antimicrobial activity was further evaluated against Staphylococcus aureus, Escherichia coli, and Candida albicans, which were selected as representative pathogenic microorganisms for Gram-positive bacteria, Gram-negative bacteria, and fungi, respectively. These microorganisms were chosen based on previous reports demonstrating that the ethanolic leaf extract of taro exhibited antifungal activity against Candida albicans and antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, and Escherichia coli. However, no inhibitory effect was observed in this study. All analyses were performed in accordance with the guidelines of the Indonesian Herbal Pharmacopeia. The findings provide reference data for the pharmacognostic identification of Colocasia esculenta corm and highlight its phytochemical constituents. Further investigations on other biological activities are required to validate its therapeutic potential. 
Co-Authors Arief, Ilham Asti, Windi Fachry Abda El Rahman Farida, Yunahara Fauzia Noprima Okta Fernandez, Itha Gumilar Adhi Nugroho Indra Kusuma Kurniati, Rizki Kurniawan, Affandi Lim, Helsa Lina Karlina Mulatsari, Esti Ni Made Dwi Sandhiutami Okta, Fauzia Noprima Priyanti, Ike Ari Ramadaniati, Hesty Utami Ros Sumarny S. Mardiko, Etty Sarnianto, Prih Sembiring, Rinawati Shirly Kumala Suherman, Sandra Loretta Suri, Nurma Syahputri, Devina Harti Warni Warni, Warni Yesi Desmiaty, Yesi Zaidan, Sarah