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All Journal Majalah Patologi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Maulana, Aries
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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STRATIFIKASI RISIKO HIPERPLASIA ENDOMETRIUM DAN KANKER ENDOMETRIUM TIPE ENDOMETRIOID BERDASARKAN FAKTOR DEMOGRAFI, GEJALA GINEKOLOGI DAN EKSPRESI BETA CATENIN Maulana, Aries; Masadah, Rina; Nelwan, Berti Julian; Ghaznawie, Mahmud; Miskad, Upik Anderiani; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1150

Abstract

Studi ini menganalisis hubungan antara faktor demografi, gejala ginekologi, dan ekspresi B-catenin di endometrium untuk mengembangkan stratifikasi risiko hiperplasia dan karsinoma endometrium. Studi ini menemukan bahwa distensi perut berhubungan dengan derajat patologi yang buruk, sedangkan peningkatan usia dan perdarahan uterus berhubungan dengan karsinoma. Namun, ekspresi B-catenin tidak dikaitkan dengan derajat patologis atau karsinoma. Penelitian ini juga mengembangkan model stratifikasi risiko pohon keputusan yang mampu membedakan antara hiperplasia non-atipikal dan hiperplasia/karsinoma atipikal dengan sensitivitas 80–94,8% dan spesifisitas 40,6–60%. Hal ini menunjukkan bahwa model stratifikasi risiko merupakan alat yang menjanjikan untuk mengidentifikasi wanita yang berisiko terkena hiperplasia dan karsinoma endometrium.
Thyroid Leiomyosarcoma: A Rare Case Report Juanita; Maulana, Aries; Yamin, Amalia; prihatni, Imeldi; Sungowati, Ni Ketut; Miskad, Upik Anderiani
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.553

Abstract

Background Primary thyroid leiomyosarcoma is a very rare tumor. The incidence is less than 0.01% of all primary thyroid tumors. Thyroid leiomyosarcoma are tumours showing smooth muscle differentiation, originating from thyroid gland vascular smooth muscle. Case Description Female, 47 years old, with lump on the left neck since 1 year ago, getting bigger in the last 3 months, no shortness of breath, no history of previous surgery. Physical examination revealed a mass was 13x6 cm in size, solid, firm.  Cytological features from fine needle aspiration biopsy (FNAB) showed cellular spindle cells with atypical, pleomorphic, hyperchromatic nuclei and  several normal thyroid follicles among them, sugesting  malignant thyroid tumor (Bethesda VI). Total thyroidectomy was performed, followed by histopathological examination. Microscopically showed proliferation of atypical, pleomorphic, hyperchromatic spindle cells with eosinophilic cytoplasm. The spindle cells arranged in fascicular and interlacing pattern. Several follicular thyroid are entrapped within this atypical spindle cells. Based on these finding, this case was diagnosed as anaplastic thyroid carcinoma. To confirm the diagnosis, immunohistochemical examination with cytokeratin, desmin and Ki-67 were performed and the result showed negative for cytokeratin, positive for desmin and Ki-67 was highly positive. Based on these results, a diagnosis of thyroid leiomyosarcoma was made. Discussion and Conclusion Differential diagnosis with other primary mesenchymal thyroid  tumors should be considered in the cases with atypical spindle cells microscopic appearance. The diagnosis of thyroid leiomyosarcoma based on cytology and histopathology is difficult to establish, therefore immunohistochemical staining is required to establish the accurate final diagnosis.
Co-Authors Juanita Mahmud Ghaznawie Nelwan, Berti Julian Ni Ketut Sungowati, Ni Ketut prihatni, Imeldi Rina Masadah Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yamin, Amalia