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All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Surabaya Biomedical Journal Surabaya Biomedical Journal
Sukmana, Judya
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Surabaya Biomedical Journal

 1 
PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Dagradi, Eric Mayo; Sukmana, Judya; Rahayu, Indri Ngesti
Surabaya Biomedical Journal Vol 2 No 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Abstract

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol
Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Rahayu, Indri N.; Kumala, Asami Rietta; Taruna, Dody; Husodo, Stefanus Djoni; Dagradi, Eric Mayo; Sukmana, Judya
Surabaya Biomedical Journal Vol 3 No 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Abstract

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.
Co-Authors Anindya, Pramita Eric Mayo Dagradi Handajani, Fitri Indri Ngesti Rahayu Kharizmatika, Kharizmatika Mulyadi, Angelina Prawesty Diah Utami Purwoko, Suliman Rahayu, Indri N. Roostantia Indrawati, Roostantia STEFANUS DJONI HUSODO Sulistio, Christian Bambang TARUNA, DODY Wulandari, Ni Made Diah