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All Journal Jurnal Buana Farma Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Nerly Juli Pranita Simanjuntak
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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FORMULASI SEDIAAN EMULGEL ANTIBAKTERI EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora L.) SEBAGAI PENYEMBUHAN LUKA DIABETES Ely Rosaulina Br Purba; Novitaria Br Sembiring; Nerly Juli Pranita Simanjuntak
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1690

Abstract

Diabetic wounds are one of the complications of diabetes mellitus and are often accompanied by bacterial infection, which may delay the healing process. The use of natural ingredients as topical antibacterial agents is considered a potential alternative. Robusta coffee beans (Coffea canephora L.) are known to contain bioactive compounds with potential antibacterial activity. This study aimed to formulate Robusta coffee bean extract into an emulgel dosage form and evaluate its antibacterial activity against Staphylococcus epidermidis. This research was an experimental laboratory study. Extraction was carried out using the maceration method with 70% ethanol as the solvent. The emulgel was formulated in three extract concentrations, namely 20%, 30%, and 50%, and its antibacterial activity was evaluated using the well diffusion method, with clindamycin gel as the positive control and emulgel base as the negative control. The results showed that Robusta coffee bean extract contained flavonoids, alkaloids, and tannins. The antibacterial activity test of the extract showed inhibition zone diameters ranging from 15.09 to 18.21 mm, while the emulgel preparation produced mean inhibition zone diameters of 8.03 ± 0.73 mm at 20%, 10.08 ± 0.34 mm at 30%, and 13.08 ± 0.11 mm at 50%. The 50% emulgel formula showed the best antibacterial activity, although it was still lower than the positive control. Based on these findings, Robusta coffee bean extract has the potential to be developed as a natural active ingredient in topical antibacterial emulgel preparations.
Uji Total Flavonoid dan Aktivitas Antioksidan Fraksi Aktif Kulit Kayu Manis (Cinnamomi burmannii cortex) sebagai Diabetic Ulcer Anggi Septya Insan; Novitaria Br Sembiring; Nerly Juli Pranita Simanjuntak
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 2 (2026): Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i2.9614

Abstract

Diabetes mellitus is a chronic disease that can cause complications, one of which is diabetic ulcer, a wound that is difficult to heal due to increased oxidative stress. The use of natural ingredients such as cinnamon bark (Cinnamomi burmannii cortex), which is rich in flavonoids and phenolic compounds, has the potential to be an alternative supportive therapy due to its antioxidant activity. This research seeks to identify overall flavonoid levels and antioxidant properties within cinnamon bark active fractions while assessing its effectiveness for healing diabetic ulcers. The investigation involved laboratory experiments utilizing specific extraction techniques. Primary processing employed the maceration approach using 70% ethanol solvent, which was subsequently followed by a secondary liquid-liquid separation procedure to isolate desired chemical compounds. Total flavonoid amounts underwent analysis through AlCl3 colorimetry with UV-Vis spectrophotometry, while free radical scavenging capacity was evaluated employing DPPH methods and documented as IC50 values. The study revealed the ethyl acetate fraction contained peak flavonoid percentages (0.8637%) and exhibited the most effective antioxidant strength IC50 12.2716 ppm). These data imply that ethyl acetate extracts from cinnamon bark offer substantial viability for development as supplementary medicinal agents for diabetic ulcer care by effectively neutralizing oxidative damage during healing.
Co-Authors Anggi Septya Insan Astriani Natalia Caroline Theodora Christina Amelia Dhea Lovita Nasution Ely Rosaulina Br Purba Erida Novriani Fani Lolyta Br Sihotang Finna Piska Ginting, Astriani Natalia Br Hikmad Elsi Enoni Harefa Jennie Try Varian Laoli marini, marini marini Novitaria Br Sembiring Nuraisyah Amanda Razoki Razoki , Razoki Razoki Razoki Rena Meutia Simran Kaur Tasya Melisa Br Purba