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All Journal Nursing Care and Health Technology Journal (NCHAT) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Nerly Juli Pranita Simanjuntak
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Antibacterial Activity of Abelmoschus manihot L. Leaf Extract Ointment Against Pseudomonas aeruginosa Fani Lolyta Br Sihotang; Nerly Juli Pranita Simanjuntak; Razoki
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.42

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance or deficiency. One of its severe complications is diabetic foot ulcers, which are prone to infection, especially by Pseudomonas aeruginosa—a Gram-negative opportunistic bacterium capable of forming biofilms and highly resistant to common antibiotics. This resistance complicates wound healing and increases the risk of amputation, emphasizing the need for alternative treatments. Abelmoschus manihot L. (Gedi leaves) contains bioactive compounds such as flavonoids, tannins, and phenolics, which are believed to possess antibacterial properties. This study aims to evaluate the potential of ethanolic Gedi leaf extract as an active ingredient in antibacterial ointment formulations. Ethanolic extracts were prepared and formulated into ointments at concentrations of 2%, 4%, 6%, and 8%. The formulations were tested for physical properties (pH, spreadability, organoleptic characteristics) and antibacterial activity against P. aeruginosa using the disk diffusion method. Results showed that the ointments had a uniform semi-solid texture, a characteristic herbal aroma, green color, and pH values ranging from 6.3 to 6.7—suitable for topical application. Spreadability ranged between 4.1 cm and 5.3 cm. The inhibition zones for the 2%, 4%, 6%, and 8% formulations were 6.67 mm, 8.00 mm, and 10.67 mm, respectively. No inhibition was observed with the negative control (DMSO), while the positive control (Bioplacenton) showed a 15.00 mm zone. In conclusion, Gedi leaf extract ointment demonstrated effective antibacterial activity against P. aeruginosa, with consistent physical properties across all concentrations. These findings suggest its potential as a natural topical therapy for treating bacterial infections in diabetic foot ulcers.
Pengaruh Kombinasi Ekstrak Etanol Bawang Putih dan Kunyit terhadap Histopatologi Jantung dan Pankreas Tikus Diabetes Ana Fiske Hotmaida Simanjuntak; Nerly Juli Pranita Simanjuntak; Razoki, Razoki
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6703

Abstract

Diabetes mellitus (DM) is a chronic condition characterized by increased blood glucose levels that require long-term treatment to maintain stable blood sugar levels. Garlic and turmeric rhizomes are known to contain secondary metabolite compounds that have the potential to lower blood glucose levels. This study aims to see how the combination of garlic and turmeric rhizome extracts affects the histopathological picture of the pancreas of male white rats (DM). This study uses an experimental design method with a designposttest only control group involving 30 white male rats divided into five groups: Negative control (K-), positive control (K+), and three treatment groups with extract doses of 100mg/kgBW (F1), 200mg/kgBW (F2), and 300mg/kgBW (F3). The results showed the most significant decrease in blood glucose levels in the 300mg/kgBW group (F3), namely (105mg/kgBW). The histopathological picture of the pancreas showed severe damage in group F1 (75% had necrosis), and moderate damage (50% with necrosis) in F2 and F3. The combination of garlic extract and turmeric rhizome has the potential to reduce blood glucose levels and improve the histopathological picture of the pancreas in DM rats.
Evaluasi Drug Related Problems (DRPs) pada Pasien Penyakit Jantung di Poli Penyakit dalam RSU Royal Prima Marelan Innaya Sabrina Sirait; Razoki Razoki; Nerly Juli Pranita Simanjuntak
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.6968

Abstract

Heart disease is the leading cause of death in Indonesia. The use of complex drugs in the treatment of heart disease increases the risk of Drug Related Problems (DRPs), especially due to the many comorbidities and drug interactions. The purpose of this study was to determine the incidence of Drug Related Problems (DRPs) in heart disease patients at the internal medicine clinic of Royal Prima Marelan Hospital. This study is a retrospective descriptive study of 50 outpatients diagnosed with heart disease in the period January-June 2024. Data obtained from medical records and patient prescriptions were analyzed to identify the types of DRPs based on the PCNE classification. Drug interactions were the most prevalent type of DRP (95,7%), with severity levels classified as moderate (80,5%), minor (12,6%), and major (4,4%). The most frequent interactions occurred between clopidogrel and omeprazole (major). Most patients were male (60%) and aged between 40-55 years (54%).
Pengaruh Edukasi Penggunaan Kontrasepsi Hormonal Terhadap Pengetahuan Wanita Usia Subur di Puskesmas Talang Bakung Nadia Raihana; Novi Erviana Harahap; Yova aditiatama; Nerly Juli Pranita Simanjuntak
Nursing Care and Health Technology Journal (NCHAT) Vol. 5 No. 2 (2025): Nursing and Health Care Technology-July to December Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v5i2.168

Abstract

Kontrasepsi hormonal adalah alat atau obat untuk mencegah terjadinya kehamilan mengandung preparat estrogen dan progesteron. BKKBN menyatakan bahwa terjadi penurunan penggunaan berbagai alat kontrasepsi di seluruh Indonesia pada April 2020 hingga 10%. Penurunan penggunaan kontrasepsi dapat menyebabkan peningkatan jumlah kehamilan tidak direncanakan sebanyak 15% pada tahun 2021. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dan sikap wanita usia subur terhadap pemakaian alat kontrasepsi hormonal di Puskesmas Talang Bakung Kota Jambi. Penelitian ini bersifat eksperimental dengan pendekatan studi cross-sectional. Teknik pengambilan sampel yang dilakukan dalam penelitian ini adalah dengan metode non-probability sampling dengan pendekatan accidental sampling. Hasil menunjukkan bahwa responden terbanyak yaitu usia 17-25 tahun (53.3%). Banyak dari responden yang memiliki riwayat penggunaan KB hormonal yaitu sebanyak 23 orang (76.7%). Sebelum diberikan edukasi, 13 responden memiliki pengetahuan kurang, 11 responden cukup, dan 6 responden dengan pengetahuan baik. Setelah edukasi, 15 responden memiliki pengetahuan cukup, 11 responden baik, dan 4 responden memiliki pengetahuan kurang. Dari 30 responden, 24 orang mengalami peningkatan dari Pre Test ke Post Test. Kesimpulan dari penelitian ini adalah pemberian edukasi penggunaan kontrasepsi hormonal berpengaruh signifikan terhadap pengetahuan wanita usia subur yang ada di lingkungan kerja Puskesmas Talang Bakung dengan p-value 0.000.  
Co-Authors Ana Fiske Hotmaida Simanjuntak Astriani Natalia Astriani Natalia Br Ginting Caroline Theodora Christina Amelia Dhea Lovita Nasution Erida Novriani Fani Lolyta Br Sihotang Finna Piska Hikmad Elsi Enoni Harefa Innaya Sabrina Sirait Jennie Try Varian Laoli Jesiska Muaratan Marini Marini Nadia Raihana Novi Erviana Harahap Nuraisyah Amanda Razoki Razoki , Razoki Razoki Razoki Razoki, Razoki Rena Meutia Simran Kaur Tasya Melisa Br Purba Yova aditiatama