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All Journal Jurnal Buana Farma Nursing Care and Health Technology Journal (NCHAT) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Nerly Juli Pranita Simanjuntak
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Pengaruh Kombinasi Ekstrak Etanol Bawang Putih dan Kunyit terhadap Histopatologi Jantung dan Pankreas Tikus Diabetes Ana Fiske Hotmaida Simanjuntak; Nerly Juli Pranita Simanjuntak; Razoki, Razoki
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6703

Abstract

Diabetes mellitus (DM) is a chronic condition characterized by increased blood glucose levels that require long-term treatment to maintain stable blood sugar levels. Garlic and turmeric rhizomes are known to contain secondary metabolite compounds that have the potential to lower blood glucose levels. This study aims to see how the combination of garlic and turmeric rhizome extracts affects the histopathological picture of the pancreas of male white rats (DM). This study uses an experimental design method with a designposttest only control group involving 30 white male rats divided into five groups: Negative control (K-), positive control (K+), and three treatment groups with extract doses of 100mg/kgBW (F1), 200mg/kgBW (F2), and 300mg/kgBW (F3). The results showed the most significant decrease in blood glucose levels in the 300mg/kgBW group (F3), namely (105mg/kgBW). The histopathological picture of the pancreas showed severe damage in group F1 (75% had necrosis), and moderate damage (50% with necrosis) in F2 and F3. The combination of garlic extract and turmeric rhizome has the potential to reduce blood glucose levels and improve the histopathological picture of the pancreas in DM rats.
Evaluasi Drug Related Problems (DRPs) pada Pasien Penyakit Jantung di Poli Penyakit dalam RSU Royal Prima Marelan Innaya Sabrina Sirait; Razoki Razoki; Nerly Juli Pranita Simanjuntak
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.6968

Abstract

Heart disease is the leading cause of death in Indonesia. The use of complex drugs in the treatment of heart disease increases the risk of Drug Related Problems (DRPs), especially due to the many comorbidities and drug interactions. The purpose of this study was to determine the incidence of Drug Related Problems (DRPs) in heart disease patients at the internal medicine clinic of Royal Prima Marelan Hospital. This study is a retrospective descriptive study of 50 outpatients diagnosed with heart disease in the period January-June 2024. Data obtained from medical records and patient prescriptions were analyzed to identify the types of DRPs based on the PCNE classification. Drug interactions were the most prevalent type of DRP (95,7%), with severity levels classified as moderate (80,5%), minor (12,6%), and major (4,4%). The most frequent interactions occurred between clopidogrel and omeprazole (major). Most patients were male (60%) and aged between 40-55 years (54%).
Pengaruh Edukasi Penggunaan Kontrasepsi Hormonal Terhadap Pengetahuan Wanita Usia Subur di Puskesmas Talang Bakung Nadia Raihana; Novi Erviana Harahap; Yova aditiatama; Nerly Juli Pranita Simanjuntak
Nursing Care and Health Technology Journal (NCHAT) Vol. 5 No. 2 (2025): Nursing and Health Care Technology-July to December Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v5i2.168

Abstract

Kontrasepsi hormonal adalah alat atau obat untuk mencegah terjadinya kehamilan mengandung preparat estrogen dan progesteron. BKKBN menyatakan bahwa terjadi penurunan penggunaan berbagai alat kontrasepsi di seluruh Indonesia pada April 2020 hingga 10%. Penurunan penggunaan kontrasepsi dapat menyebabkan peningkatan jumlah kehamilan tidak direncanakan sebanyak 15% pada tahun 2021. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dan sikap wanita usia subur terhadap pemakaian alat kontrasepsi hormonal di Puskesmas Talang Bakung Kota Jambi. Penelitian ini bersifat eksperimental dengan pendekatan studi cross-sectional. Teknik pengambilan sampel yang dilakukan dalam penelitian ini adalah dengan metode non-probability sampling dengan pendekatan accidental sampling. Hasil menunjukkan bahwa responden terbanyak yaitu usia 17-25 tahun (53.3%). Banyak dari responden yang memiliki riwayat penggunaan KB hormonal yaitu sebanyak 23 orang (76.7%). Sebelum diberikan edukasi, 13 responden memiliki pengetahuan kurang, 11 responden cukup, dan 6 responden dengan pengetahuan baik. Setelah edukasi, 15 responden memiliki pengetahuan cukup, 11 responden baik, dan 4 responden memiliki pengetahuan kurang. Dari 30 responden, 24 orang mengalami peningkatan dari Pre Test ke Post Test. Kesimpulan dari penelitian ini adalah pemberian edukasi penggunaan kontrasepsi hormonal berpengaruh signifikan terhadap pengetahuan wanita usia subur yang ada di lingkungan kerja Puskesmas Talang Bakung dengan p-value 0.000.  
FORMULASI SEDIAAN EMULGEL ANTIBAKTERI EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora L.) SEBAGAI PENYEMBUHAN LUKA DIABETES Ely Rosaulina Br Purba; Novitaria Br Sembiring; Nerly Juli Pranita Simanjuntak
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1690

Abstract

Diabetic wounds are one of the complications of diabetes mellitus and are often accompanied by bacterial infection, which may delay the healing process. The use of natural ingredients as topical antibacterial agents is considered a potential alternative. Robusta coffee beans (Coffea canephora L.) are known to contain bioactive compounds with potential antibacterial activity. This study aimed to formulate Robusta coffee bean extract into an emulgel dosage form and evaluate its antibacterial activity against Staphylococcus epidermidis. This research was an experimental laboratory study. Extraction was carried out using the maceration method with 70% ethanol as the solvent. The emulgel was formulated in three extract concentrations, namely 20%, 30%, and 50%, and its antibacterial activity was evaluated using the well diffusion method, with clindamycin gel as the positive control and emulgel base as the negative control. The results showed that Robusta coffee bean extract contained flavonoids, alkaloids, and tannins. The antibacterial activity test of the extract showed inhibition zone diameters ranging from 15.09 to 18.21 mm, while the emulgel preparation produced mean inhibition zone diameters of 8.03 ± 0.73 mm at 20%, 10.08 ± 0.34 mm at 30%, and 13.08 ± 0.11 mm at 50%. The 50% emulgel formula showed the best antibacterial activity, although it was still lower than the positive control. Based on these findings, Robusta coffee bean extract has the potential to be developed as a natural active ingredient in topical antibacterial emulgel preparations.
Co-Authors Ana Fiske Hotmaida Simanjuntak Astriani Natalia Astriani Natalia Br Ginting Caroline Theodora Christina Amelia Dhea Lovita Nasution Ely Rosaulina Br Purba Erida Novriani Fani Lolyta Br Sihotang Finna Piska Hikmad Elsi Enoni Harefa Innaya Sabrina Sirait Jennie Try Varian Laoli Marini Marini Nadia Raihana Novi Erviana Harahap Novitaria Br Sembiring Nuraisyah Amanda Razoki Razoki , Razoki Razoki Razoki Razoki, Razoki Rena Meutia Simran Kaur Tasya Melisa Br Purba Yova aditiatama