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Fauzi, Muhammad Dzulfikar
Institut Teknologi Telkom
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Journal : Limits: Journal of Mathematics and Its Applications

 1 
Target Baru Pengobatan Meningitis berdasarkan Centrality Measure jaringan protein dan Self Oganizing Map. Siti Amiroch; Mohammad Hamim Zajuli Al Faroby; Muhammad Dzulfikar Fauzi
Limits: Journal of Mathematics and Its Applications Vol. 21 No. 3 (2024): Limits: Journal of Mathematics and Its Applications Volume 21 Nomor 3 Edisi No
Publisher : Pusat Publikasi Ilmiah LPPM Institut Teknologi Sepuluh Nopember

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Abstract

Meningitis is a serious threat to health with potentially fatal consequences. Understanding protein interactions related to chronic conditions is crucial for the development of effective treatments. In silico analysis is considered to have greater effectiveness because it simulates through computation and tries various possibilities at a lower cost. This study aims to analyze protein-protein interactions related to Meningitis with cluster analysis techniques on undirected graphs. The proposed method is the Self Organizing Map (SOM) algorithm as a cluster. This algorithm can cluster undirected graph-based protein interaction data. Protein data involved in Meningitis disease comes from OMIM. From this data, proteins belonging to the gene locus are explored for their interactions, resulting in interaction data in the form of an undirected graph. The combination of centrality measure is used for feature engineering on undirected graph data. The main protein candidates are potentially located in the Cluster 1 model with the largest silhouette score (0.359) and Davies-Bouldin Index (1.667). The cluster has 18 proteins with the highest significance to Meningitis. From the overall centrality ranking results, the three highest significance proteins are CISH (3.921222), TNFSF10 (3.403541), and ICAM3 (2.623702) which have the potential to become Meningitis target proteins. CISH protein has the highest overall centrality score value compared to the others, so CISH protein may be a new alternative in the treatment of Meningitis.
Co-Authors Abdul Kholik Agfianto Eko Putra Agung Fatwanto Agung Fatwanto Ahmad Wali Satria Bahari Johan Alqis Rausanfita Aprilliyanto, Tofik Arda Erico Yuda Arda Erico Yuda Ardian Yusuf Wicaksono Arifin, Hendra Dea Arip Ramadan Arliyanti Nurdin Arliyanti Nurdin , S.T., M.T Asyhab, Naufal Aulia Faqih Rifa’i Bambang Sugiantoro Bunga Pasha Maulidina Chasandra Puspitasari Desita Nur Rachmaniar Emilia Ramona Faisal Dharma Adhinata Granita Hajar Haq, Azizi Khoirul Hendra Dea Arifin Heni Hapsari Heri Setiawan Ida Ayu Putu Sri Widnyani Islami, Mega Cattleya P.A Kasliono Kasliono Khurin 'ien Mukhoyyaroh Laksono Kurnianggoro Maria Ulfah Siregar Matteo Ibastian Maulana, Rizky Fenaldo Mohammad Hamim Zajuli Al Faroby Mohammad Hamim Zajuli Al Faroby Montolalu, Billy Muhammad Akid Musyafa Muhammad Alfian Jauhari Muhammad Mustakim, Muhammad Muhammad Taufiq Nuruzzaman Musyafa, Muhammad Akid Nia Annisa Ferani Tanjung Nicko Nur Rakhmaddian, Nicko Nur Nisa Isrofi Nur Ghaniaviyanto Ramadhan Oktavianita, Annisa Dwi Pertiwi, Kharisma Monika Dian Qori Emalia Putri Mafidah Rachmadi, Andry Rahmaani, Amalia Ratna Rahmawati, Feri Rizky Fenaldo Maulana Rizky Novera Harnaningrum Shofwatul ‘Uyun Siti Amiroch, Siti son, Sumarsono Sri Lestari Sunu Pinasthika Fajar Suryana Wijaya T. Rasmana , Susijanto Wahyono Wahyono Wahyu Andy Prastyabudi Wahyu Sri Mulyani Yudha Mahardika Putra