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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Artificial Intelligence and Digital Business Journal of Pharmaceutical and Sciences. Scientica: Jurnal Ilmiah Sains dan Teknologi Science and Community Pharmacy Journal
Girsang, Valentina
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Journal : Science and Community Pharmacy Journal

 1 
Stability Testing Occurred On Piroxicam Cream Preparation By Using Stearic Acid And Triethanolamine As Emulsifying Agents Aldila, Silvy; Girsang, Valentina; Rahmawati, Ina Sonia; Maharai, Daniel; Sa’adah, Anifatus
Science and Community Pharmacy Journal Vol. 2 No. 2 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i2.482

Abstract

Preface: Piroxicam is classified as a Class 2 product in the Biopharmaceutic Classification System due to its limited solubility in water. The cream preparations underwent optimisation of the stearic acid and triethanolamine concentrations. The optimisation results indicate that the most favourable amounts of stearic acid and triethanolamine (TEA) are 16% and 4% respectively. The physical attributes test yielded positive findings for the formula, indicating a successful cream formulation that satisfied the specified criteria. Purpose: The cream formulation is thereafter submitted to a stability assessment. The purpose of the stability test is to ascertain the long-lasting quality of the preparation when subjected to various storage circumstances. Procedure: Stability tests were conducted over 6 cycles at temperatures of 4° C and 40° C. During the testing phase, various characteristics of the cream preparation were assessed, including organoleptic properties, homogeneity, viscosity, adhesive power, spreadability, and pH. Result: The formulated solution successfully fulfils the criteria of the physical characteristics test, with the following parameter values: pH of 6.8, viscosity of 11010 Cps, spreading power of 6.8 cm, adhesive power of 2.6 seconds, and protective power of 6.5 seconds. Conclusion: The t-test findings conducted before and after assessing the stability of the preparation indicated a p-value greater than 0.05, indicating the absence of a significant difference.
LITERATURE REVIEW : Cost Effective Analysis of Sitagliptin for the Treatment of Diabetes Mellitus Type 2 Vidiani, Anak Agung Pradnya Paramitha; Puspitaningrum, Anisa Nova; Girsang, Valentina; Adrianto, Madyo
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.546

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by increased glucose levels in the blood. The prevalence of type 2 DM is currently increasing. In pharmacological treatment, metformin is the first-line oral therapy for most patients with type 2 diabetes. Therapy with targeted incretin has been shown to stimulate glucose-dependent insulin secretion, reduce glucagon secretion, improve beta cell function, slow gastric emptying, increase satiety, reduce appetite, and provide general benefits beyond the pancreas. Search for scientific articles by utilizing internet searches through Google Scholar and PubMed. Using keywords related to "Cost Effective Analysis", "Diabetes Mellitus type 2", "Sitagliptine" with Boolean operator "AND". Sitagliptin is less cost-effective when compared to liraglutide. Sitagliptin is the first agent of the DPP-4 inhibitor with other substances following soon after. The evaluation shows that the prevention of complications in patients with type 2 diabetes and cardiovascular disease (CVD) in the SGLT2 inhibitor group is more recommended, namely empaglifozin as the second line compared to sitagliptin.
An Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants: Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants Bunga Eloystina, Laurencia Julia; Aldila, Silvy; Girsang, Valentina; Sa'adah, Anifatus
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.580

Abstract

Surfactant is one of the important things in making face clay cleanser preparations. Sodium Lauryl Sulfate (SLS) is an anionic type surfactant that is often used in cosmetic products. The use of Sodium Lauryl Sulfate (SLS) can cause irritation and dry skin. Combination with cocamidopropyl betaine (CAPB) which is amophoteric can reduce skin irritation. Based on this, a safety test is needed which aims to meet the preparation requirements before being marketed to the wider community. One of the safety tests that can be done is the skin irritation test. The test method used is the human patch test. The irritation test of the optimum preparation of face clay cleanser celery herb extract (Apium graviolens L.) with a concentration of 0.5% SLS and 9.5% CAPB was carried out on 6 volunteers consisting of men and women aged 20-35 years, the score of the degree of irritation was 0, which means that the preparation is not irritating. Based on the evaluation with SPSS, it can be concluded that there is no significant difference (p>0.05) for the irritation test results and the optimum preparation of celery herb extract face clay cleanser (Apium graviolens L.) meets the safety requirements.
A Literature Review: Effectiveness of NSAIDs in Osteoarthritis Patients Adrianto, Madyo; Anak Agung Pradnya Paramitha Vidiani; Puspitaningrum, Anisa Nova; Girsang, Valentina
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.582

Abstract

Pain, stiffness, swelling, and decreased joint function are some of the clinical signs of osteoarthritis, a disease that affects numerous anatomical and physiological aspects of joint tissue, cartilage degradation, bone remodeling, and osteophyte development. This literature review's objective is to ascertain the efficacy of NSAIDs in osteoarthritis by searching for journals from PubMed.. The method used was to search for articles through pubmed using the keywords "NSAID", "osteoarthritis", "Therapy" with a filter added for the last 5 years (2019-2024) obtained 103 articles. Then with the keywords "NSAID", "osteoarthritis", "therapy", "efficacy" obtained 71 articles. After analysis, there are 13 journals that can be include into inclusion requirement. NSAIDs preparations are particularly helpful for osteoarthritis therapy, both in knee and hip osteoarthritis. NSAIDs medications in a variety of dose forms, including oral, topical, spray, injection and plaster, are useful in relieving pain in osteoarthritis patients
Co-Authors Adrianto, Madyo Aldila, Silvy Anak Agung Pradnya Paramitha Vidiani Anisa Devi Kharisma Wibowo Ardiyanto, Ari Rizki Bunga Eloystina, Laurencia Julia Kusuma Dewi, Liestyani Maharai, Daniel Nufus , Nunky Nurwidianingsih, Silvia Puspitaningrum , Anisa Nova Puspitaningrum, Anisa Nova Rahmawati, Ina Sonia Rustaman , Heri Rustaman, Heri Sa'adah, Anifatus Sa’adah , Anifatus Sa’adah, Anifatus Tunik Saptawati Widiasari , Anggun